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| 1 | Imaging and interventions in hilar cholangiocarcinoma: A review显示文摘Hilar cholangiocarcinoma is a common malignant tumor of the biliary tree. It has poor prognosis with very low 5-year survival rates. Various imaging modalities are available for detection and staging of the hilar cholangiocarcinoma. Although ultrasonography is the initial investigation of choice, imaging with contrast enhanced computed tomography scan or magnetic resonance imaging is needed prior to management. Surgery is curative wherever possible. Radiological interventions play a role in operable patients in theform of biliary drainage and/or portal vein embolization. In inoperable cases, palliative interventions include biliary drainage, biliary stenting and intra-biliary palliative treatment techniques. Complete knowledge of application of various imaging modalities available and about the possible radiological interventions is important for a radiologist to play a critical role in appropriate management of such patients.We review the various imaging techniques and appearances of hilar cholangiocarcinoma and the possible radiological interventions. | Kumble Seetharama Madhusudhan Shivanand Gamanagatti Arun Kumar Gupta | 2015 | World Journal of Radiology2015，7，2： | 18 |
| 2 | Diffusion weighted imaging: Technique and applications显示文摘Diffusion weighted imaging(DWI) is a method of signal contrast generation based on the differences in Brownian motion. DWI is a method to evaluate the molecular function and micro-architecture of the human body. DWI signal contrast can be quantified by apparent diffusion coefficient maps and it acts as a tool for treatment respon-se evaluation and assessment of disease progression. Ability to detect and quantify the anisotropy of diffusion leads to a new paradigm called diffusion tensor imaging(DTI). DTI is a tool for assessment of the organs with highly organised fibre structure. DWI forms an integral part of modern state-of-art magnetic resonance imaging and is indispensable in neuroimaging and oncology. DWI is a field that has been undergoing rapid technical evolution and its applications are increasing every day. This review article provides insights in to the evolution of DWI as a new imaging paradigm and provides a summary of current role of DWI in various disease processes. | Vinit Baliyan Chandan J Das Raju Sharma Arun Kumar Gupta | 2016 | World Journal of Radiology2016，8，9： | 18 |
| 3 | Perfusion computed tomography in renal cell carcinoma显示文摘Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma(RCC). While contrast enhanced computed tomography(CT) is used as the standard of imaging for size, morphological evaluation and response assessment in RCC, a new functional imaging technique like perfusion CT(p CT), goes down to the molecular level and provides new perspectives in imaging of RCC. p CT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using p CT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of p CT in staging and response assessment in patients with RCCs. | Chandan J Das Usha Thingujam Ananya Panda Sanjay Sharma Arun Kumar Gupta | 2015 | World Journal of Radiology2015，7，7： | 8 |
| 4 | CT patterns of nodal disease in pediatric chest tuberculosis显示文摘AIM:To highlight various patterns of nodal involvement and post treatment changes in pediatric chest tuberculosis based on contrast enhanced computed tomography(CECT) scans of chest.METHODS:This was a retrospective study consisting of 91 patients aged less than 17 years,who attended Paediatrics OPD of All India Institute of Medical Sciences with clinically diagnosed tuberculosis or with chest radiographs suggestive of chest tuberculosis.These patients had an initial chest radiograph as well as CECT of the chest and follow up imaging after 6 mo,and in some cases 9 mo,of completion of anti-tubercular treatment(ATT).CECT of these patients was reviewed for the location and extent of nodal involvement along with determination of site,size,enhancement pattern and calcification.RESULTS:Enlargement of mediastinal or hilar lymph nodes was found in 88/91 patients(96.7%),with the most common locations being paratracheal(84.1%),and subcarinal(76.1%).The most common pattern of enhancement was found to be inhomogenous.The nodes were conglomerate in 56.8% and discrete in 43.2%.In addition,perinodal fat was obscured in 84.1% of patients.In the post-treatment scan,there was 87.4% reduction in the size of the nodes.All nodes post-treatment were discrete and homogenous with perinodal fat present.Calcification was found both pre-and post-treatment,but there was an increase in incidence after treatment(41.7%).There was hence a reduction in size,change in enhancement pattern,and appearance of perinodal fat with treatment.CONCLUSION:Tubercular nodes have varied appearance and enhancement pattern.Conglomeration and obscuration of perinodal fat suggest activity.In residual nodes decision to continue ATT requires clinical correlation. | Amar Mukund Rashmi Khurana Ashu S Bhalla Arun K Gupta Sushil K Kabra | 2011 | World Journal of Radiology2011，3，1： | 5 |
| 5 | Transarterial chemoembolization for liver metastases from solid pseudopapillary epithelial neoplasm of pancreas: A case report显示文摘Solid pseudo-papillary epithelial neoplasm(SPEN) is a rare epithelial tumor of pancreas with a low malignant potential occurs most commonly in young females. We report a case of 40 years old woman presented withextensive liver metastasis from SPEN of pancreatic body for which she was operated four years ago. Due to the extensive nature of metastatic disease she was offered Transarterial chemoembolisation(TACE) using gemcitabine as chemotherapeutic agent. Short term follow up after a month of TACE with multiphase computed tomography showed > 90% resolution in the viable tumor with significant clinical improvement. TACE ensures targeted delivery of chemotherapeutic drugs in higher doses with least systemic toxicity and is more effective and safe than systemic chemotherapy. TACE with gemcitabine was found to be very effective in our patient with numerous liver metastasis. | TV Prasad KS Madhusudhan Deep N Srivastava Nihar R Dash Arun K Gupta | 2015 | World Journal of Radiology2015，7，3： | 5 |
| 6 | Diffusion weighted imaging in gynecological malignancies-present and future显示文摘The management of gynaecological malignancies has undergone a significant change in recent years with our improved understanding of cancer biogenetics, development of new treatment regimens and enhanced screening. Due to the rapid blooming of newer methods and techniques in gynaecology, surgery and oncology the scope and the role of imaging has also widened. Functional imaging in the form of diffusion weighted imaging(DWI) has been recently found to be very useful in assessing various tumours. Its ability to identify changes in the molecular level has dramatically changed the diagnostic approach of radiologists which was solely based on morphological criteria. It can improve the diagnostic accuracy of conventional magnetic resonance imaging, lend a hand in assessing tumour response to treatment regimens and detect tumour recurrence with better spatial resolution, negative radiation and diagnostic accuracy compared to positron emission tomography scan. The ability to quantify the diffusion has also lead to potential prediction of tumour aggressiveness and grade which directly correlate with the patient prognosis and management. Hence, it has become imperative for a radiologist to understand the concepts of DWI and its present and evolving role. In this article we present a brief description of the basics of DWI followed by its role in evaluation of female gynaecological malignancies. | Dinesh Manoharan Chandan J Das Ankita Aggarwal Arun K Gupta | 2016 | World Journal of Radiology2016，8，3： | 4 |
| 7 | Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Aymer Postgate Edward Despott David Burling Arun Gupta Robin Phillips James O’Beirne David Patch Chris Fraser | 2008 | Gastrointestinal Endoscopy2008，，6： | 3 |
| 8 | Radiological interventions in malignant biliary obstruction显示文摘Malignant biliary obstruction is commonly caused by gall bladder carcinoma, cholangiocarcinoma and metastatic nodes. Percutaneous interventions play an important role in managing these patients. Biliary drainage, which forms the major bulk of radiological interventions, can be pal iative in inoperable patients or pre-operative to improve liver function prior to surgery. Other interventions include cholecystostomy and radiofrequency ablation. We present here the indications, contraindications, technique and complications of the radiological interventions performed in patients with malignant biliary obstruction. | Kumble Seetharama Madhusudhan Shivanand Gamanagatti Deep Narayan Srivastava Arun Kumar Gupta | 2016 | World Journal of Radiology2016，8，5： | 2 |
| 9 | Pediatric vs adult pulmonary tuberculosis:A retrospective computed tomography study显示文摘AIM: To compare the manifestations of chest tuberculosis(TB) in pediatric and adult patients based on contrast enhanced computed tomography of chest.METHODS: This was a retrospective study consisting of 152 patients of chest TB including 48 children and 104 adults who had undergone contrast enhanced computed tomography of chest prior to treatment. The patterns and severity of parenchymal, mediastinal and pleural manifestations were analyzed and compared among different age groups.RESULTS: Parenchymal changes observed include consolidation, air space nodules, miliary TB, cavitation, bronchiectasis and fibrosis and these were noted in 60% of children, 71% of adolescents and 76.9% of adults. These changes were more common in right upper lobe in all age groups. There was no significant difference in the frequency of these changes(except nodules) in different age groups. Centrilobular nodules were seen less commonly in children less than 10 years(P = 0.028). Pleural effusion was noted in 28(18.42%) patients and pericardial effusion in 8(5.3%) patients. No significant difference in the serosal involvement is seen among children and adults. Mediastinal adenopathy was seen 70% of children, 76.3% adolescents and 76.9% of adults and paratracheal nodes were seen most frequently. Nodes had similar features(except matting) among all age groups. Matting of nodes was seen more commonly in children(P = 0.014). CONCLUSION: Pediatric chest tuberculosis can have severe parenchymal lesions and nodal involvement similar to adults. The destructive lung changes observed in children needs immediate attention in view of the longer life span they have and hence in formulating optimal treatment strategies. | Prasad Thotton Veedu Ashu Seith Bhalla Sreenivas Vishnubhatla Sushil Kumar Kabra Arundeep Arora Divya Singh Arun Kumar Gupta | 2013 | World Journal of Clinical Pediatrics2013，2，4： | 2 |
| 10 | Hepatic Artery Pseudoaneurysms: A Single-Center Experience显示文摘 | Raghavendra Nagaraja Mahendran Govindasamy Vibha Varma Amitabh Yadav Naimish Mehta Vinay Kumaran Arun Gupta Samiran Nundy | 2013 | Annals of Vascular Surgery2013，，6： | 2 |
| 11 | Experience with hemoadsorption (CytoSorb~?) in the management of septic shock patients显示文摘BACKGROUND Cytokines and inflammatory mediators are the hallmarks of sepsis.Extracorporeal cytokine hemoadsorption devices are the newer clinical support system to overcome the cytokine storm during sepsis.AIM To retrospectively evaluate the clinical outcomes of patients admitted in intensive care unit with septic shock with different etiologies.METHODS The laboratory parameters including biomarkers such as procalcitonin,serum lactate and C-reactive protein;and the hemodynamic parameters;mean arterial pressure,vasopressor doses,sepsis scores,cytokine levels and other vital parameters were evaluated.We evaluated these outcomes among survivors and non-survivors.RESULTS Of 100 patients evaluated,40 patients survived.Post treatment,the vasopressors dosage remarkably decreased though it was not statistically different;34.15%(P=0.0816)for epinephrine,20.5%for norepinephrine(P=0.3099)and 51%(P=0.0678)for vasopressin.In the survivor group,a remarkable reduction of biomarkers levels;procalcitonin(65%,P=0.5859),C-reactive protein(27%,P=0.659),serum lactate(27%,P=0.0159)and bilirubin(43.11%;P=0.0565)were observed from baseline after CytoSorb^® therapy.A significant reduction in inflammatory markers;interleukin 6 and interleukin 10;(87%and 92%,P<0.0001)and in tumour necrosis factor(24%,P=0.0003)was also seen.Overall,28(28%)patients who were given CytoSorb^® therapy less than 48 h after onset of septic shock survived and the maximum duration of stay for 70%of these patients in intensive care unit was less than 15 d.CONCLUSION CytoSorb^® is a safe and well tolerated rescue therapy option in patients with septic shock.However,early(preferably within<48 h after onset of septic shock)initiation could result in better clinical outcomes.Further randomized trials are needed to define the potential benefits of this new treatment modality. | Yatin Mehta Chitra Mehta Ashish Kumar Joby Varghese George Aditi Gupta Saurabh Nanda Gourav Kochhar Arun Raizada | 2020 | World Journal of Critical Care Medicine2020，9，1： | 2 |
| 12 | Feasibility of Video Capsule Endoscopy in the Management of Children With Peutz-Jeghers Syndrome: A Blinded Comparison With Barium Enterography for the Detection of Small Bowel Polyps显示文摘 | Aymer Postgate Warren Hyer Robin Phillips Arun Gupta David Burling Clive Bartram Michelle Marshall Stuart Taylor Gregor Brown Gill Schofield Paul Bassett Christine Spray Aine Fitzpatrick Chris Fraser A Latchford | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，4： | 1 |
| 13 | Effective dilation of small-bowel strictures by double-balloon enteroscopy in patients with symptomatic Crohn’s disease (with video)显示文摘 | Edward J. Despott Arun Gupta David Burling Eric Tripoli Krysia Konieczko Ailsa Hart Chris Fraser | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 14 | Endovascular treatment of direct carotid cavernous fistulae: a pictorial review显示文摘 | Arun K. Gupta Sukalyan Purkayastha T. Krishnamoorthy Narendra K. Bodhey T. R. Kapilamoorthy C. Kesavadas Bejoy Thomas | 2006 | Neuroradiology2006，，11： | 1 |
| 15 | Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Aymer Postgate Edward Despott David Burling Arun Gupta Robin Phillips James O’Beirne David Patch Chris Fraser | 2008 | Gastrointestinal Endoscopy2008，，6： | 1 |
| 16 | A two gene – two promoter system for enhanced expression of a restorer gene (barstar) and development of improved fertility restorer lines for hybrid seed production in crop plants显示文摘 | Naveen Chandra Bisht Arun Jagannath Vibha Gupta Pradeep Kumar Burma Deepak Pental | 2004 | Molecular Breeding2004，，2： | 1 |
| 17 | A novel synthesis of sulfonated polybutadiene ionomer by a phasetransfer catalyst 显示文摘 | Arun Nandi Maya Duta Gupta Ajit K Banthia | 1999 | Macromol Rapid Commun1999，20，： | 1 |
| 18 | Breakthrough analysisfor adsorption of sulfur-dioxide over zeolites 显示文摘 | Arun Gupta Vivekanand Gaur Nishith Verma | 2004 | ChemicalEngineering and Processing2004，43，： | 1 |
| 19 | Biodiversity in the barnyard millet ( Echinochloa frumentacea Link, Poaceae) germplasm in India显示文摘 | Arun Gupta Vinay Mahajan Mukesh Kumar H. S. Gupta | 2009 | Genetic Resources and Crop Evolution2009，，6： | 1 |
| 20 | Barnyard millet – a potential food and feed crop of future显示文摘 | Salej Sood Rajesh K. Khulbe Arun K. Gupta Pawan K. Agrawal Hari D. Upadhyaya Jagdish C. Bhatt | 2015 | Plant Breed2015，，2： | 1 |
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