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| 1 | Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management显示文摘Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)therapy.The optimal management of liver injury related to antiTNF therapy is still a matter of debate.Although some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver injury.Bibliographical searches were performed in Pub Med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;infliximab.According to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual outcome.Anti-TNF agents seem to be safe with a low risk of causing severe drugrelated liver injury.According to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate analyses.An algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of transaminases.However,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception. | Roberta Elisa Rossi Ioanna Parisi Edward John Despott Andrew Kenneth Burroughs James O'Beirne Dario Conte Mark Ian Hamilton Charles Daniel Murray | 2014 | World Journal of Gastroenterology2014，20，46： | 7 |
| 2 | Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Aymer Postgate Edward Despott David Burling Arun Gupta Robin Phillips James O’Beirne David Patch Chris Fraser | 2008 | Gastrointestinal Endoscopy2008，，6： | 3 |
| 3 | Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus显示文摘 | A. Bourreille A. Ignjatovic L. Aabakken E. Loftus Jr R. Eliakim M. Pennazio Y. Bouhnik E. Seidman M. Keuchel J. Albert S. Ardizzone S. Bar-Meir R. Bisschops E. Despott P. Fortun R. Heuschkel J. Kammermeier J. Leighton G. Mantzaris D. Moussata S. Lo V. Pau | 2009 | Endoscopy2009，，07： | 1 |
| 4 | Effective dilation of small-bowel strictures by double-balloon enteroscopy in patients with symptomatic Crohn’s disease (with video)显示文摘 | Edward J. Despott Arun Gupta David Burling Eric Tripoli Krysia Konieczko Ailsa Hart Chris Fraser | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 5 | Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Aymer Postgate Edward Despott David Burling Arun Gupta Robin Phillips James O’Beirne David Patch Chris Fraser | 2008 | Gastrointestinal Endoscopy2008，，6： | 1 |
| 6 | Significant small- bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Postgate A Despott E Burling D | 2008 | Gastrointest Endosc2008，68，6： | 1 |
| 7 | Antibiotic therapy:a major cause of drug-induced jaundice in southwest England 显示文摘 | Hussaini SH O' Brien CS Despott EJ | 2007 | European journal of gastroenterology & hepatology2007，19，1： | 1 |
| 8 | Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus显示文摘 | A. Bourreille A. Ignjatovic L. Aabakken E. Loftus Jr R. Eliakim M. Pennazio Y. Bouhnik E. Seidman M. Keuchel J. Albert S. Ardizzone S. Bar-Meir R. Bisschops E. Despott P. Fortun R. Heuschkel J. Kammermeier J. Leighton G. Mantzaris D. Moussata S. Lo V. Pau | 2009 | Endoscopy2009，，07： | 1 |
| 9 | Antibiotic therapy:a major cause of drug-induced jaundice in southwest England显示文摘 | Hussaini SH 0'Brien CS Despott EJ | 2007 | Eur J Gastroenterol Hepatol2007，19，1： | 1 |
| 10 | Effective dilation of small - bowel strictures by double -ballon enteroscopy in patients with s,mptmatic Crohn' s disease ( with wideo) 显示文摘 | Despott E J Gupta A Burling D | 2009 | Gastrointest Endosc2009，70，5： | 1 |
| 11 | Signicant small-bowl lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Postgate A Despott E Burling D | 2008 | Gastrointest Endosc2008，68，6： | 1 |
| 12 | An unusual cause of diarrhea: diffuse intestinal nodular lymphoid hyperplasia in association with selective immunoglobulin A deficiency (with video)显示文摘 | Aymer Postgate Edward Despott | 2009 | Gastrointestinal Endoscopy2009，，1： | 1 |
| 13 | Antibiotic therapy:a major cause of drug-induced jaundice in southwest England显示文摘 | Hussaini SH O'Brien CS Despott EJ | 2007 | Eur J Gastroenterol Hepatol2007，19，1： | 1 |
| 14 | First report of endoscopic closure of a gastrocolic fistula using an over-the-scope clip system (with video)显示文摘 | Alberto Murino Edward J. Despott | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
| 15 | Tracheal Aspiration of Capsule Endoscopes: Detection, Management, and Susceptibility显示文摘 | Edward J. Despott Aine O’Rourke Vladimir Anikin Carolyn Davison Simon Panter Jonathan Bromley Jane Plaice Michael Corbett Chris Fraser | 2012 | Digestive Diseases and Sciences2012，，7： | 1 |
| 16 | Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Aymer Postgate Edward Despott David Burling Arun Gupta Robin Phillips James O’Beirne David Patch Chris Fraser | 2008 | Gastrointestinal Endoscopy2008，，6： | 1 |
| 17 | Antibiotic therapy: a major cause of drug-induced jaundice in southwest England 显示文摘 | Hussaini SH O'Brien CS Despott EJ | 2007 | EurJ Gastroenterol Hepatol2007，19，1： | 1 |
| 18 | Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline显示文摘 | Marco Pennazio Cristiano Spada Rami Eliakim Martin Keuchel Andrea May Chris Mulder Emanuele Rondonotti Samuel Adler Joerg Albert Peter Baltes Federico Barbaro Christophe Cellier Jean Charton Michel Delvaux Edward Despott Dirk Domagk Amir Klein Mark McAlin | 2015 | Endoscopy2015，，04： | 1 |
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