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| 1 | Use of Biochar as an Amendment for Remediation of Heavy Metal-Contaminated Soils:Prospects and Challenges显示文摘Biochar(BC), known as the new black gold, is a stable, novel carbonaceous by-product that is synthesized through pyrolysis of biological materials in the absence of O_2.Recently, an emerging interest in the application of BC as a robust soil amendment has given rise to a broad research area in science and technology.It is considered a promising remediation option for heavy metal(HM)-contaminated soils to reduce HM bioavailability to plants.Remediation efficacy of BC depends on the porosity, composition,pyrolysis temperature, feedstock, and residence time of pyrolysis.This review article aimed to present an overview of BC use in the immobilization of HMs, i.e., Cd, As, Pb, Zn, Ni, Cu, Mn, Cr, and Sb, in contaminated soils.The remaining uncertain factors, including the specific soil HM immobilization mechanisms, long-term beneficial effects, and potential environmental risks associated with BC application are analyzed.Future research must be conducted to ensure that the management of environmental pollution is in accord with ecological sustainability and adaptation of the black gold biotechnology on a commercial basis for immobilization of HMs in contaminated soils. | Altaf Hussain LAHORI GUO Zhanyu ZHANG Zengqiang LI Ronghua Amanullah MAHAR Mukesh Kumar AWASTHI SHEN Feng Tanveer Ali SIAL Farhana KUMBHAR WANG Ping JIANG Shuncheng | 2017 | Pedosphere2017，27，6： | 28 |
| 2 | Gestational diabetes mellitus: An update on the current international diagnostic criteria显示文摘The approach to screening and diagnosis of gestational diabetes mellitus(GDM) around the world is disorderly. The protocols for diagnosis vary not only in-between countries, but also within countries. Furthermore, in any country, this disparity occurs in-between its hospitals and often exists within a single hospital. There are many reasons for these differences. There is the lack of an international consensus among preeminent health organizations(e.g., American College of Gynecologists and World Health Organization). Often there is a disagreement between the country's national diabetes organization, its local health society and its regional obstetric organization with each one recommending a different option for approaching GDM. Sometimes the causes for following an alternate approach are very obvious, e.g., a resource strapped hospital is unable to follow the ivory-tower demanding recommendation of its obstetric organization. But more often than not, the rationale for following or not following a guideline, or following different guideline within the same geographic area is without any perceivable explanation. This review is an attempt to understand the problems afflicting the screening and diagnosis of GDM globally. It traces the major temporal changes in the diagnostic criteria of(1) some respected health organizations; and(2) a few selected countries. With an understanding of the reasons for this disparity, a way forward can be found to reach the ultimate goal: a single global guideline for GDM followed worldwide. | Mukesh M Agarwal | 2015 | World Journal of Diabetes2015，6，6： | 21 |
| 3 | Mechanism of Action of Natural Products Used in the Treatment of Diabetes Mellitus显示文摘糖尿病 mellitus (DM ) 是不够或低效的胰岛素秘书反应引起的新陈代谢的混乱,它被增加的血葡萄糖层次(多糖症) 描绘。DM 是症候群的一个 heterogonous 组。葡萄糖是为身体的主要精力来源,并且在 DM 的情况中,葡萄糖的管理变得不规则。在在 DM,也就是增加的肝的葡萄糖生产,减少的胰岛素分泌物,和损害胰岛素行动的多糖症的发作有三个关键缺点。常规药由改进胰岛素敏感治疗糖尿病,增加胰岛素生产或减少在血的葡萄糖的数量。这篇文章提供很流行的血糖过低的植物的行动的模式的全面评论,例如人参,痛苦的甜瓜,胡芒巴, banaba, Gymnema sylvestre 和黄连属 chinensis。植物由增加胰岛素分泌物行动,提高由脂肪质、骨胳的肌肉纸巾的葡萄糖举起,禁止肠的葡萄糖吸收并且禁止肝的葡萄糖生产。尽管从动物和人的证据一致地支持这些 phytomedicines 的治疗学的效果, multicenter 当同时管理了时,大规模临床的审判没被进行评估有常规药的这些草药的药和他们的相互作用的安全和功效。 | Pranav Kumar Prabhakar Mukesh Doble | 2011 | Chinese Journal of Integrative Medicine2011，17，8： | 16 |
| 4 | Heat Shock Factors HsfB 1 and HsfB2b Are Involved in the Regulation of Pdf1.2 Expression and Pathogen Resistance in Arabidopsis显示文摘以便估计热的功能的角色在 Arabidopsis 的导致压力的班 B 热吃惊因素,我们调查了 AtHsfB1 和 AtHsfB2b 的 T-DNA 猛烈异种。在异种的 defensin 基因 Pdf1.2a/b 的基础 mRNA 水平的一条起来规定种的作为强壮揭示的两倍猛烈 hsfB1/hsfB2b 植物的 Micorarray 分析。Pdf 表示被 jasmonic 酸处理或感染进一步与 necrotrophic 真菌 Alternaria brassicicola 提高。单个变异的 hsfB2b 和双变异的 hsfB1/B2b 显著地在 A 以后在疾病抵抗被改进。brassicicola 感染。为和 Pdf1.2 的倡导者的 Hsf 的一个直接相互作用没有指示,它缺乏完美的 HSE 一致 Hsf 有约束力的序列。然而,在形成变化近来 HsfA2 依赖的 HSE 绑定在 hsfB1/B2b 植物被检测。这建议 HsfB1/B2b 可以在调整热吃惊反应的用以遮闭之物与班 A-Hsf 交往。Pdf 基因的鉴定作为 Hsf 依赖的否定规定的目标是为在关於生命、不能生活的回答的规定的 Hsf 的互联的第一条证据。 | Mukesh Kumar Wolfgang Busch Hannah Birke Birgit Kemmerling Thorsten Nurnberger Friedrich Schoffl | 2009 | Molecular Plant2009，2，1： | 15 |
| 5 | 碱性固体对污泥的调质堆肥影响及产品对土壤的改良潜力显示文摘为了科学评判不同碱性固体物质对调质污泥高温堆肥的影响及其有机肥对贫瘠土壤的改良潜力,通过用质量分数为10%的秸秆(干)炭、硬木炭、粉煤灰和石灰等碱性固体物质对污泥和锯末混合物料进行了调质,运用好氧堆肥的方式研究了不同碱性固体物质对调质污泥高温堆肥的影响,并用小青菜盆栽试验法探讨了有机肥对贫瘠土壤的改良潜力.结果表明,污泥经外源碱性固体调质后,可以延长高温期的时间,促进堆肥物料的热灭活无害化;秸秆炭和硬木炭调质能显著促进有机质矿化,达21.65%和18.16%;堆肥过程中各处理堆肥pH先降低后升高最终逐渐稳定在6.78~7.33之间,但粉煤灰和石灰调质会使得堆肥初期pH较高;碱性固体调质有利于降低堆肥产品的水溶性盐分含量,至堆肥结束各处理EC均低于3 000μS·cm-1;污泥经过调质后,堆肥的总氮含量逐渐增加,但粉煤灰和石灰调质会导致堆肥初期存在一定的氮素损失,而秸秆炭和硬木炭调质可以减少堆肥初期氮素损失;各调质处理中NH+4-N含量先增加后降低,NO_3^--N均呈现出逐渐增加的趋势,秸秆炭和硬木炭调质可以促进污泥NO_3^--N的转化,而石灰和粉煤灰调质则对NO_3^--N的转化和种子发芽产生一定的抑制作用,但均不会影响堆肥的腐熟;贫瘠土壤经过调质堆肥改良后,土壤有机质和NPK含量显著增加,小青菜生物量增加显著;与未调质堆肥相比,虽然调质后的堆肥对小青菜Cu、Zn的吸收具有一定的抑制作用,但相比于原贫瘠土壤而言,本研究获得的各种堆肥仍能促进小青菜对微量元素Cu、Zn的吸收.研究表明,相比于硬木炭、粉煤灰和石灰等碱性固体物质,秸秆炭更适合于污泥堆肥调质,其堆肥产品具有较好的贫瘠土壤改良潜力. | 蔡函臻 宁西翠 王权 张增强 任秀娜 李荣华 王美净 Mukesh Kumar Awasthi | 2016 | 环境科学2016，37，12： | 12 |
| 6 | 钙基膨润土辅助对堆肥及土壤Cu、Zn形态转化和白菜吸收的影响显示文摘通过好氧堆肥和盆栽试验,探究不同比例(0%、2.5%、5%、7.5%和10%)钙基膨润土(CB)辅助猪粪堆肥过程及盆栽土壤中Cu、Zn形态的变化,并分析CB对白菜生物量及吸收Cu、Zn的影响.结果表明,在所有处理的堆肥过程中,可交换态Cu、Zn的分布比例逐渐下降,而可氧化态和残渣态逐渐升高,与0%CB相比,2.5%~10%CB可使堆肥结束时生物可利用态(可交换态和可还原态)Cu、Zn的分布比例分别降低19.84%~48.90%和4.94%~16.39%,并以10%CB的效果最为显著.进而开展的盆栽试验显示,施用堆肥后,土壤有机质和EC显著升高,而pH有所下降;CB辅助堆肥能够促使土壤EC的降低及pH的升高,稳定土壤有机质.与纯土处理相比,施用堆肥可显著提升白菜的生物量,且10%CB处理中的生物量最大(6.51 g·盆^(-1)±0.34 g·盆^(-1)).施用CB辅助堆肥后,种后土壤中生物可利用态Cu含量增加;但各处理中可交换态Zn含量分别降低38.91%、43.69%、46.02%、45.12%和54.65%.白菜在施用堆肥后Cu、Zn的吸收量显著降低,并且随着CB辅助比例的增加Zn的吸收量随之减少,而Cu的吸收量呈增加趋势.本研究表明,钙基膨润土能够降低堆肥过程中Cu、Zn活性,在堆肥施入土壤后仍对Zn有持续的固定作用,同时CB辅助堆肥可以提高白菜的生物量,减少重金属Zn在白菜中的累积,并以10%CB的效果最为显著. | 赵军超 王权 任秀娜 李荣华 Mukesh Kumar Awasthi Altaf Hussain Lahori 张增强 | 2018 | 环境科学2018，39，4： | 12 |
| 7 | Synergistic effects of biochar/microbial inoculation on the enhancement of pig manure composting显示文摘With the aim to comparatively investigate the effect of the addition of additives such as biochar(BC),microbial inoculation(MI)and biochar/microbial inoculation(BCMI)on composting enhancement,nitrogen conservation,greenhouse gas emissions,the quality improvement of pig manure compost were comparatively investigated in a 42-day aerobic pig manure composting experiment.The results showed that the duration of the thermophilic stage,the degradation of organic matter and the detoxification of the compost were enhanced in the BC,MI and BCMI treatments compared with those in the control(without additive).Moreover,the content of total Kjeldahl nitrogen in the BC,MI and BCMI treatments was increased by 38.1,48.9 and 59.0%,respectively,through the reduction of NH_(3) volatilization and N_(2)O production,which were higher than those of the control(31.8%).A reduction in CH_(4) release during composting was not observed with the MI and BCMI treatments.Following 42 days of composting,the final product of the three treatments exhibited acceptable potential for use as a fertilizer in agriculture;the BCMI treatment showed an especially synergistic effect on pig manure composting enhancement. | Zhineng Tu Xiuna Ren Junchao Zhao Sanjeev Kumar Awasthi Quan Wang Mukesh Kumar Awasthi Zengqiang Zhang Ronghua Li | 2019 | Biochar2019，1，1： | 8 |
| 8 | 添加钙基膨润土对猪粪堆肥中水溶性有机物光谱特征的影响显示文摘为了探究添加钙基膨润土(CB)对猪粪好氧堆肥过程中水溶性有机物(DOC)动态变化的影响,向猪粪和木屑混合物料中添加不同质量比的CB,采用自制的强制通风好氧发酵装置,进行了为期60天的好氧堆肥试验。定期采集堆肥样品并进行冷冻干燥,通过紫外-可见光谱(UV-Vis),傅里叶变换红外光谱(FTIR)和荧光光谱(FS)相结合的方法,对堆肥样品中DOC光谱特征的变化进行研究。结果表明,在堆肥过程中DOC呈降低趋势,且随着CB添加量的增多,DOC的降解率为49.11%~62.92%;堆肥DOC相应的UV-Vis和FS光谱分析显示,类腐殖质的特征峰强度不断升高,而碳水化合物、类蛋白的特征峰强度逐渐降低;且与对照相比,添加钙基膨润土使类腐殖质特征峰的强度增大,峰位置红移。堆肥结束时,相较于对照,添加CB处理的光谱特征参数SUVA_(254),SUVA_(280)和腐殖化系数分别增加了16.51%~47.72%,8.58%~44.02%和23.16%~88.22%,且5%添加比例最佳,这被FTIR解析峰密度进一步证实;相关性分析显示,SUVA_(254)与堆肥腐熟度呈极显著相关,可指示堆肥腐熟度。综上所述,随着堆肥的进行,有机物由非腐殖质向腐殖质转化,DOC的分子质量及芳构化程度逐渐增加,且添加CB对这一过程具有促进作用,并以5%添加比例最佳。 | 任秀娜 王权 赵军超 李荣华 Mukesh Kumar Awasthi 王美净 张增强 | 2018 | 光谱学与光谱分析2018，38，6： | 8 |
| 9 | 用于低频振荡抑制的MMC的能量补偿控制显示文摘传统的模块化多电平换流器(modular multilevel converter,MMC)的控制系统包括功率、电压控制等上层控制和控制环流的下层控制。直流系统可配合功率振荡抑制(power oscillation damping,POD)控制器为交流系统提供阻尼,但直流功率会根据POD控制器的输出而振荡。MMC桥臂电容器的能量可以用来平衡交流系统功率变化,从而保证直流功率的稳定。MMC的能量控制,可以控制环流电流的直流分量,从而灵活控制MMC桥臂电容器的能量。基于能量控制,该文设计一种能量补偿控制,数学分析MMC电容器上可利用的能量,并在PSCAD/EMTDC仿真平台上模拟MMC-HVDC为2机交流系统提供阻尼,可以验证能量补偿控制可以暂态解耦直流系统两端功率传输,从而将能量补偿控制用来解决嵌入式直流的3机系统使用传统POD控制方式时会导致振荡加剧的问题,证明采用能量补偿控制的必要性。 | 翟冬玲 韩民晓 Mukesh Kumar Das Aniruddha M.Gole | 2019 | 中国电机工程学报2019，39，10： | 8 |
| 10 | Gestational diabetes mellitus: Screening with fasting plasma glucose显示文摘Fasting plasma glucose(FPG) as a screening test for gestational diabetes mellitus(GDM) has had a checkered history. During the last three decades, a few initial anecdotal reports have given way to the recent well-conducted studies. This review:(1) traces the history;(2) weighs the advantages and disadvantages;(3) addresses the significance in early pregnancy;(4) underscores the benefits after delivery; and(5) emphasizes the cost savings of using the FPG in the screening of GDM. It also highlights the utility of fasting capillary glucose and stresses the value of the FPG in circumventing the cumbersome oral glucose tolerance test. An understanding of all the caveats is crucial to be able to use the FPG for investigating glucose intolerance in pregnancy. Thus, all health professionals can use the patient-friendly FPG to simplify the onerous algorithms available for the screening and diagnosis of GDM-thereby helping each and every pregnant woman. | Mukesh M Agarwal | 2016 | World Journal of Diabetes2016，7，14： | 7 |
| 11 | Strategy and Future Prospects to Develop Room-Temperature-Recoverable NO2 Gas Sensor Based on Two-Dimensional Molybdenum Disulfide显示文摘Nitrogen dioxide(NO2),a hazardous gas with acidic nature,is continuously being liberated in the atmosphere due to human activity.The NO2 sensors based on traditional materials have limitations of high-temperature requirements,slow recovery,and performance degradation under harsh environmental conditions.These limitations of traditional materials are forcing the scientific community to discover future alternative NO2 sensitive materials.Molybdenum disulfide(MoS2)has emerged as a potential candidate for developing next-generation NO2 gas sensors.MoS2 has a large surface area for NO2 molecules adsorption with controllable morphologies,facile integration with other materials and compatibility with internet of things(IoT)devices.The aim of this review is to provide a detailed overview of the fabrication of MoS2 chemiresistance sensors in terms of devices(resistor and transistor),layer thickness,morphology control,defect tailoring,heterostructure,metal nanoparticle doping,and through light illumination.Moreover,the experimental and theoretical aspects used in designing MoS2-based NO2 sensors are also discussed extensively.Finally,the review concludes the challenges and future perspectives to further enhance the gas-sensing performance of MoS2.Understanding and addressing these issues are expected to yield the development of highly reliable and industry standard chemiresistance NO2 gas sensors for environmental monitoring. | Abhay V.Agrawal Naveen Kumar Mukesh Kumar | 2021 | Nano-Micro Letters2021，13，2： | 7 |
| 12 | Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry显示文摘Rauwolfia species(Apocynaceae) are medicinal plants well known worldwide due to its potent bioactive monoterpene indole alkaloids(MIAs) such as reserpine,ajmalicine,ajmaline,serpentine and yohimbine.Reserpine,ajmalicine and ajmaline are powerful antihypertensive,tranquilizing agents used in hypertension.Yohimbine is an aphrodisiac used in dietary supplements.As there is no report on the comparative and comprehensive phytochemical investigation of the roots of Rauwolfia species,we have developed an efficient and reliable liquid chromatography-tandem mass spectrometry(LC–MS/MS) method for ethanolic root extract of Rauwolfia species to elucidate the fragmentation pathways for dereplication of bioactive MIAs using highperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC–ESI–QTOF–MS/MS) in positive ion mode.We identified and established diagnostic fragment ions and fragmentation pathways using reserpine,ajmalicine,ajmaline,serpentine and yohimbine.The MS/MS spectra of reserpine,ajmalicine,and ajmaline showed C-ring-cleavage whereas E-ring cleavage was observed in serpentine via Retro Diels Alder(RDA).A total of 47 bioactive MIAs were identified and characterized on the basis of their molecular formula,exact mass measurements and MS/MS analysis.Reserpine,ajmalicine,ajmaline,serpentine and yohimbine were unambiguously identified by comparison with their authentic standards and other 42 MIAs were tentatively identified and characterized from the roots of Rauwolfia hookeri,Rauwolfia micrantha,Rauwolfia serpentina,Rauwolfia verticillata,Rauwolfia tetraphylla and Rauwolfia vomitoria.Application of LC–MS followed by principal component analysis(PCA) has been successfully used to discriminate among six Rauwolfia species. | Sunil Kumar Awantika Singh Vikas Bajpai Mukesh Srivastava Bhim Pratap Singh Brijesh Kumar | 2016 | Journal of Pharmaceutical Analysis2016，6，6： | 7 |
| 13 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 14 | A role of computer vision in fruits and vegetables among various horticulture products of agriculture fields: A survey显示文摘Computer vision is a consistent and advanced technique for image processing,with the propitious outcome,and enormous potential.A computer vision has been strongly adopted in the heterogeneous domain including agriculture.During the study of existing research on the role of computer vision in fruits and vegetables among various horticulture products of agriculture fields it is noticed that,the existing survey paper has not focused properly on mathematical framework,feature descriptor,defect detection on multiple datasets of fruits and vegetables elaborately.This has motivated us to undertake an extensive survey.In this paper,we examine the paper broadly related to fruits and vegetables among various horticulture products of agriculture fields,specific model,data pre-processing,data analysis method and overall value of performance accuracy by using a particular performance metric.Moreover,we study the different type of disease present in various fruit and vegetable.We have also focused on the comparison of different machine learning approach with respect to different performance metrics on the same dataset.Thus,we have found that among all existing machine learning techniques SVM give better classification accuracy.A generalized framework to grade the quality and defect detection of multiple fruits and vegetables is also proposed in this survey.This paper covers the survey of ninety-eight papers closely related to computer vision in the agricultural field.By the survey,we have found that computer vision plays an important role and has a large potential to address the challenges related to the agricultural fields. | Mukesh Kumar Tripathi Dr.Dhananjay D.Maktedar | 2020 | Information Processing in Agriculture2020，7，2： | 5 |
| 15 | Quantitative study of prostate cancer using three dimensional fiber tractography显示文摘AIM:To investigate feasibility of a quantitative study of prostate cancer using three dimensional(3D)fiber tractography.METHODS:In this institutional review board approved retrospective study,24 men with biopsy proven prostate cancer underwent prostate magnetic resonance imaging(MRI)with an endorectal coil on a 1.5 T MRI scanner.Single shot echo-planar diffusion weighted images were acquired with b = 0.600 s/mm^2,six gradient directions.Open-source available software Track Vis and its Diffusion Toolkit were used to generate diffusion tensor imaging(DTI)map and 3D fiber tracts.Multiple 3D spherical regions of interest were drawn over the areas of tumor and healthy prostatic parenchyma to measure tract density,apparent diffusion coefficient(ADC)and fractional anisotropy(FA),which were statistically analyzed.RESULTS:DTI tractography showed rich fiber tract anatomy with tract heterogeneity.Mean tumor region and normal parenchymal tract densities were 2.53 and 3.37 respectively(P < 0.001).In the tumor,mean ADC was 0.0011 × 10^(-3 )mm^2/s vs 0.0014 × 10^(-3) mm^2/s in the normal parenchyma(P < 0.001).The FA values for tumor and normal parenchyma were 0.2047 and 0.2259 respectively(P = 0.3819).CONCLUSION:DTI tractography of the prostate is feasible and depicts congregate fibers within the gland.Tract density may offer new biomarker to distinguish tumor from normal tissue. | Sandeep Hedgire Alexey Tonyushkin Aoife Kilcoyne Jason A Efstathiou Peter F Hahn Mukesh Harisinghani | 2016 | World Journal of Radiology2016，8，4： | 4 |
| 16 | The role of the service sector in the process of industrialization显示文摘 | Mukesh Eswaran Ashok Kotwal | 2002 | Journal of Development Economics2002，，2： | 4 |
| 17 | 超声辅助多组分反应:水介质中以β-环糊精为可重复使用的超分子催化剂绿色合成氮取代的1,8-二氧-十氢吖啶(英文)显示文摘以可生物降解和可重复使用的β-环糊精为超分子催化剂,在水介质中采用简易方法合成了氮取代的1,8-二氧-十氢吖啶,所得产物的收率很高,选择性也为中等到较高.该过程为双甲酮、芳香醛和芳香胺三组分通过串联Michael加成反应一步合成得到产物.本文提供了一个高效且环境友好的合成氮取代的1,8-二氧-十氢吖啶的新方法. | asha v.chate umesh b.rathod jagdish s.kshirsagar pradip a.gaikwad kishor d.mane pravin s.mahajan mukesh d.nikam charansingh h.gill | 2016 | Chinese Journal of Catalysis2016，37，1： | 3 |
| 18 | Synergism between natural products and antibiotics against infectious diseases显示文摘 | Shanmugam Hemaiswarya Anil Kumar Kruthiventi Mukesh Doble | 2008 | Phytomedicine2008，，8： | 3 |
| 19 | Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity显示文摘Astrocytes protect neurons by modulating neuronal function and survival.Astrocytes support neurons in several ways.They provide energy through the astrocyte-neuron lactate shuttle,protect neurons from excitotoxicity,and internalize neuronal lipid droplets to degrade fatty acids for neuronal metabolic and synaptic support,as well as by their high capacity for glutamate uptake and the conversion of glutamate to glutamine.A recent reported astrocyte system for protection of dopamine neurons against the neurotoxic products of dopamine,such as aminochrome and other o-quinones,were generated under neuromelanin synthesis by oxidizing dopamine catechol structure.Astrocytes secrete glutathione transferase M2-2 through exosomes that transport this enzyme into dopaminergic neurons to protect these neurons against aminochrome neurotoxicity.The role of this new astrocyte protective mechanism in Parkinson´s disease is discussed. | Juan Segura-Aguilar Bengt Mannervik JoséInzunza Mukesh Varshney Ivan Nalvarte Patricia Muñoz | 2022 | Neural Regeneration Research2022，17，9： | 3 |
| 20 | Future directions of clinical laboratory evaluation ol pregnancy显示文摘在最近的年里,我们免疫系统怎么与发展中的胎儿和胎盘交往的理解极大地膨胀了。有许多实验室,在有周期性的怀孕损失(RPL ) 或子间前的女人为怀孕结果的诊断提供测试。这些测试基于对胎儿的有免疫力的反应等价于的前提对的适应有免疫力的反应一 transplant。新理解导致激活的天生的反应为怀孕是重要的,这能导致以后阻止反常怀孕的更有效的测试和处理的概念。我们这里为未来测试描述仅仅三个如此的区域:一个区域包含精子和精液和为成功的授精必要的因素;另一个区域将在子宫为为培植必要的生长因素的生产决定条件;最后,最后区域将是由激活的生来的杀手(NK ) 决定为胎盘和成长胎儿的 vascularization 必要的条件房间(漂亮房间的联合有 HLA-C haplotypes 的像免疫球蛋白的受体(KIR ) 家庭基因) 导致 secreting angiogenic 生长因素的能力。这些区域是新奇的,但是理解他们在怀孕的角色能导致进怎么与复杂化因素维持并且对待怀孕的卓见。 | Kenneth D Beaman Mukesh K Jaiswal Svetlana Dambaeva Alice Gilman-Sachs | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
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