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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Magnetic resonance imaging after anterior cruciate ligament reconstruction:A practical guide显示文摘Anterior cruciate ligament(ACL) reconstruction is one of the most common orthopedic procedures performed worldwide. In this regard, magnetic resonance imaging(MRI) represents a useful pre-operative tool to confirm a disruption of the ACL and to assess for potential associated injuries. However, MRI is also valuable postoperatively, as it is able to identify, in a non-invasive way, a number of aspects and situations that could suggest potential problems to clinicians. Graft signal and integrity, correct tunnel placement, tunnel widening, and problems with fixation devices or the donor site could all compromise the surgical outcomes and potentially predict the failure of the ACL reconstruction. Furthermore, several anatomical features of the knee could be associated to worst outcomes or higher risk of failure. This review provides a practical guide for the clinician to evaluate the post-surgical ACL through MRI, and to analyze all the parameters and features directly or indirectly related to ACL reconstruction, in order to assess for normal or pathologic conditions. | Alberto Grassi James R Bailey Cecilia Signorelli Giuseppe Carbone Andy Tchonang Wakam Gian Andrea Lucidi Stefano Zaffagnini | 2016 | World Journal of Orthopedics2016，7，10： | 4 |
| 3 | State of the art biological therapies in pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC) is one of the most lethal malignancies with a five-year survival rate of approximately 5%. Several target agents have been tested in PDAC, but almost all have failed to demonstrate efficacy in late phase clinical trials, despite the better understanding of PDAC molecular biology generated by large cancer sequencing initiatives in the past decade. Eroltinib(a small-molecule tyrosine-kinase inhibitor of epidermal growth factor receptor) plus gemcitabine is the only schedule with a biological agent approved for advanced pancreatic cancer, but it has resulted in a very modest survival benefit in unselected patients. In our work, we report a summary of the main clinical trials(closed and ongoing) that refer to biological therapy evaluation in pancreatic cancer treatment. | mariacristina di marco elisa grassi sandra durante silvia vecchiarelli andrea palloni marina macchini riccardo casadei claudio ricci riccardo panzacchi donatella santini guido biasco | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 3 |
| 4 | An Elevated Number of Differentiated Osteoblast Colonies Can Be Obtained from Rat Bone Marrow Stromal Cells Using a Gradient Isolation Procedure显示文摘 | Gina Lisignoll Giulia Remiddi Luca Cattini Barbara Cocchini Nicoletta Zini Milena Fini Francesco Grassi Anna Piacentini Andrea Facchini | 2001 | Connective Tissue Research2001，，1： | 1 |
| 5 | Multi-attribute classification method for spare parts inventory management显示文摘 | Marcello Braglia Andrea Grassi Roberto Montanari | 2004 | Journal of Quality in Maintenance Engineering2004，10，1： | 1 |
| 6 | Multi-attribute classification method for spare parts inventory management显示文摘 | Marcello Braglia Andrea Grassi and Roberto Montanari | 2004 | Journal of Quality in Maintenance Engineering2004，101，： | 1 |
| 7 | A fuzzy multi-attribute model for risk evaluation in workplaces显示文摘 | ANDREA GRASSI RITA GAMBERINI CRISTINA MORA | 2009 | Safety Science2009，47，5： | 1 |
| 8 | Requirement for a standardised definition of advanced gastric cancer显示文摘 | Angelo De Sol Stefano Trastulli Veronica Grassi Alessia Corsi Ivan Barillaro Andrea Boccolini Micol Di Patrizi Giorgio Di Rocco Alberto Santoro Roberto Cirocchi Carlo Boselli Adriano Redler Giuseppe Noya Seong-Ho Kong | 2014 | Oncology Letters2014，，1： | 1 |
| 9 | Multi - attribute classification method for spare parts inventory management 显示文摘 | Marcello Braglia Andrea Grassi Roberto Montanari | 2004 | Journal of Quality in Maintenance Engineering2004，10，1： | 1 |
| 10 | Multi-attribute classification method for spare parts inventory management显示文摘 | MARCELLO BRAGLIA ANDREA GRASSI ROBERT MONTANARI | 2004 | Journal of Quality in Maintenance Engineering2004，10，1： | 1 |
| 11 | A fuzzy multi-attribute model for risk evaluation in workplaces显示文摘 | Andrea Grassi Rita Gamberini Cristina Mora | 2009 | Safety Science2009，47，5： | 1 |
| 12 | Dual-source dual-energy CT: dose reduction after endovascular abdominal aortic aneurysm repair显示文摘 | Vitaliano Buffa Antonio Solazzo Valeria D’Auria Alessandra Prete Andrea Vallone Monica Luzietti Manuela Madau Roberto Grassi Vittorio Miele | 2014 | La radiologia medica2014，，： | 1 |
| 13 | Mult- attribute classification method for spare parts inventory management显示文摘 | Braglia Marcello Grassi Andrea Montanari Roberto | 2004 | Journal of Quality in Maintance Engineering2004，10，1： | 1 |
| 14 | A fuzzy multi-attribute model for risk evaluation in workplaces显示文摘 | Andrea Grassi Rita Gamberini Cristina Mora Bianca Rimini | 2008 | Safety Science2008，，5： | 1 |
| 15 | Ultrasonography (US) in the assessment of pediatric non traumatic gastrointestinal emergencies显示文摘 | Paolo Fonio Francesco Coppolino Anna Russo Alfredo D’Andrea Antonella Giannattasio Alfonso Reginelli Roberto Grassi Eugenio Annibale Genovese | 2013 | Critical Ultrasound Journal2013，，： | 1 |
| 16 | Alexithymia in the medically ill. Analysis of 1190 patients in gastroenterology, cardiology, oncology, and dermatology显示文摘 | Piero Porcelli Jenny Guidi Laura Sirri Silvana Grandi Luigi Grassi Fedra Ottolini Paolo Pasquini Angelo Picardi Chiara Rafanelli Marco Rigatelli Nicoletta Sonino Giovanni Andrea Fava | 2013 | General Hospital Psychiatry2013，，： | 1 |
| 17 | Local ablation of pancreatic tumors: State of the art and future perspectives显示文摘BACKGROUND Currently,the technologies most commonly used to treat locally advanced pancreatic cancer are radiofrequency ablation(RFA),microwave ablation,and irreversible(IRE)or reversible electroporation combined with low doses of chemotherapeutic drugs.AIM To report an overview and updates on ablative techniques in pancreatic cancer.METHODS Several electronic databases were searched.The search covered the years from January 2000 to January 2021.Moreover,the reference lists of the found papers were analysed for papers not indexed in the electronic databases.All titles and abstracts were analysed.RESULTS We found 30 studies(14 studies for RFA,3 for microwave therapy,10 for IRE,and 3 for electrochemotherapy),comprising 1047 patients,which were analysed further.Two randomized trials were found for IRE.Percutaneous and laparotomy approaches were performed.In the assessed patients,the median maximal diameter of the lesions was in the range of 2.8 to 4.5 cm.All series included patients unfit for surgical treatment,but Martin et al assessed a subgroup of patients with borderline resectable tumours who underwent resection with margin attenuation with IRE.Most studies administered chemotherapy prior to ablative therapies.However,several studies suggest that the key determinant of improved survival is attributable to ablative treatment alone.Nevertheless,the authors suggested chemotherapy before local therapies for several reasons.This strategy may not only downstage a subgroup of patients to curative-intent surgery but also support to recognize patients with biologically unfavourable tumours who would likely not benefit from ablation treatments.Ablation therapies seem safe based on the 1047 patients assessed in this review.The mortality rate ranged from 1.8%to 2%.However,despite the low mortality,the reported rates of severe post procedural complications ranged from 0%-42%.Most reported complications have been self-limiting and manageable.Median overall survival varied between 6.0 and 33 mo.Regarding the technical success rate,assessed papers reported an estimated rate in the range of 85%to 100%.However,the authors reported early recurrence after treatment.A distinct consideration should be made on whether local treatments induce an immune response in the ablated area.Preclinical and clinical studies have shown that RFA is a promising mechanism for inducing antigen-presenting cell infiltration and enhancing the systemic antitumour T-cell immune response and tumour regression.CONCLUSION In the management of patients with pancreatic cancer,the possibility of a multimodal approach should be considered,and conceptually,the combination of RFA with immunotherapy represents a novel angle of attack against this tumour. | Vincenza Granata Roberta Grassi Roberta Fusco Andrea Belli Raffaele Palaia Gianpaolo Carrafiello Vittorio Miele Roberto Grassi Antonella Petrillo Francesco Izzo | 2021 | World Journal of Gastroenterology2021，27，23： | 1 |
| 18 | Health-related quality of life in older adults with symptomatic hip and knee osteoarthritis: a comparison with matched healthy controls显示文摘 | Fausto Salaffi Marina Carotti Andrea Stancati Walter Grassi | 2005 | Aging Clinical and Experimental Research2005，，4： | 1 |
| 19 | A New Multi-objective Heuristic Algorithm for Solving the Stochastic Assembly Line Re-balancing Problem显示文摘 | Rita GAMBERINI Andrea GRASSI Bianca RIMINI | 2006 | International Journal of Production Economics2006，102，2： | 1 |
| 20 | A Consensus Panel Review of Central Nervous System Effects of the Exposure to Low-Intensity Extremely Low-Frequency Magnetic Fields显示文摘 | Vincenzo Di Lazzaro Fioravante Capone Francesca Apollonio Pier Andrea Borea Ruggero Cadossi Lorenzo Fassina Claudio Grassi Micaela Liberti Alessandra Paffi Marta Parazzini Katia Varani Paolo Ravazzani | 2013 | Brain Stimulation2013，，4： | 1 |
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