|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Coronary thrombus in patients undergoing primary PCI for STEMI:Prognostic significance and management显示文摘Acute ST-elevation myocardial infarction(STEMI) usually results from coronary atherosclerotic plaque disruption with superimposed thrombus formation. Detection of coronary thrombi is a poor prognostic indicator,which is mostly proportional to their size and composition. Particularly,intracoronary thrombi impair both epicardial blood flow and myocardial perfusion,by occluding major coronary arteries and causing distal embolization,respectively. Thus,although primary percutaneous coronary intervention is the preferred treatement strategy in STEMI setting,the associated use of adjunctive antithrombotic drugs and/or percutaneous thrombectomy is crucial to optimize therapy of STEMI patients,by improving either angiographical and clinical outcomes. This review article will focus on the prognostic significance of intracoronary thrombi and on current antithrombotic pharmacological and interventional strategies used inthe setting of STEMI to manage thrombotic lesions. | Sabine Vecchio Elisabetta Varani Tania Chechi Marco Balducelli Giuseppe Vecchi Matteo Aquilina Giulia Ricci Lucchi Alessro Dal Monte Massimo Margheri | 2014 | World Journal of Cardiology2014，6，6： | 18 |
| 2 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 3 | Decreased col- lagen production in chronologically aged skin: roles of age- dependent alteration in fibroblast function and defective mechanical stimulation 显示文摘 | Varani J Dame M K Rittie L | 2006 | Am J Pathol2006，168，6： | 1 |
| 4 | Autoantibody appearance in cytomegalovirus infected liver transplant recipients: correlation with antigenemia显示文摘 | Varani S | 2002 | J Med Virol2002，66，1： | 1 |
| 5 | Protection of human umbilical vein endothelial cells by glycine and structurally similar amino acids against calcium and hydrogen peroxide-induced lethal cell injury 显示文摘 | Weinberg JM Varani J Johnson KJ | 1992 | Am J Pathol1992，140，2： | 1 |
| 6 | Mechanisms of photoaging and chronological skin aging 显示文摘 | Fisher GJ Kang S Varani J | 2002 | Arch Dermatol2002，138，11： | 1 |
| 7 | Effects of 5-fluorouracil and mitomycin-C on cultured rabbit subconjunctival fibroblacts 显示文摘 | Yamamoto T Varani J Soong HK | 1990 | Ophthamology1990，97，9： | 1 |
| 8 | Endocrine-disrupting agents on healthy human tissues显示文摘 | Paganetto G Campi F Varani K et 81 | 2000 | Annual Review of Pharmacology and Toxicology2000，86，1： | 1 |
| 9 | Vitamin Aantagonizes decreased cell growth and elevated collagen-de-grading matrix metalloproteinases and stimulates collagen ac-cumulation in naturally aged human skin显示文摘 | Varani J Warner RL Gharaee-Kermani M | 2000 | J Invest Der-matol2000，114，3： | 1 |
| 10 | Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields 显示文摘 | Varani K Mattei M De Vincenzi F | 2007 | Osteoarthritis and Cartilage2007，7，4： | 1 |
| 11 | Role of steomelysin Ⅰ and gelatinase B in experimental acute lung injury 显示文摘 | Warner RL Beltran L Younkin EM Lewis CS Weiss SJ Varani J | 2001 | Am J Respir Cell Mol Biol2001，24，5： | 1 |
| 12 | Platelet alpha2-adrenoceptor alterations in patients with essential hypertension显示文摘 | Varani K Gessi S Caiazza A | 1999 | Br J Clin Pharmacol1999，47，2： | 1 |
| 13 | A case of furuncular myiasis associated with systemic inflammation显示文摘 | Varani S Tassinari D Elleri D | 2007 | Parasitol Int2007，56，4： | 1 |
| 14 | All - trans- retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture显示文摘 | Lateef H Stevens MJ Varani J | 2004 | Am J Pathol2004，165，1： | 1 |
| 15 | Mechanisms of photoaging and chronological skin aging显示文摘 | Fisher G J Kang S Varani J | | 0，，11： | 1 |
| 16 | Changes in hippocampaland cortical B1 bradykininreceptor biological activity in two experimental models ofepilepsy显示文摘 | Bregola G Varani K Beani C | 1999 | Neuroscience1999，92，3： | 1 |
| 17 | Complete replication ofhuman cytomegalovirus in explants of first trimester humanplacenta显示文摘 | Gabrielli L Losi L Varani S | 2001 | J Med Virol2001，64，4： | 1 |
| 18 | Cytotoxicity of tumor necrosis factor-alpha for human umbilical vein endothelial cells显示文摘 | Schuger L Varani J Marks RM | 1989 | Lab Invest1989，61，1： | 1 |
| 19 | Troglitazone improves psoriasis and normalizes models of proliferative skin disease:ligandsfor peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation显示文摘 | Ellis CN Varani J Fisher GJ | 2000 | Arch Dermatol2000，136，5： | 1 |
| 20 | Mechanisms of photoaging and chronological skin aging 显示文摘 | Fisher G J Kang S Varani J | 2002 | Archives of Dermatology2002，138，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员