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| 1 | Effects of protein deprivation and re-feeding on P2X_2 receptors in enteric neurons显示文摘AIM:To investigate the effects of malnutrition and refeeding on the P2X2 receptor,nitric oxide synthase(NOS),calretinin,calbindin and choline acetyltransferase(ChAT) in neurons of the rat ileum.METHODS:We analyzed the co-localization,numbers and sizes of P2X2-expressing neurons in relation to NOS-immunoreactive(IR),calbindin-IR,ChAT-IR,and calretinin-IR neurons of the myenteric and submucosal plexus.The experimental groups consisted of:(1) rats maintained on normal feed throughout pregnancy until 42 d post-parturition(N);(2) rats deprived of protein throughout pregnancy and 42 d post-parturition(D);and(3) rats undernourished for 21 d post-parturition and then given a protein diet from days 22 to 42(DR).The myenteric and submucosal plexuses were evaluated by double labeling by immunohistochemical methods for P2X2 receptor,NOS,ChAT,calbindin and calretinin.RESULTS:We found similar P2X2 receptor immunoreactivity in the cytoplasm and surface membranes of myenteric and submucosal neurons from the N,D and DR groups.Double labeling of the myenteric plexus demonstrated that approximately 100% of NOS-IR,calbindin-IR,calretinin-IR and ChAT-IR neurons in all groups also expressed the P2X2 receptor.In the submucosal plexus,the calretinin-IR,ChAT-IR and calbindin-IR neurons were nearly all immunoreactive for the P2X2 receptor.In the myenteric plexus,there was a 19% increase in numbers per cm2 for P2X2 receptor-IR neurons,64% for NOS-IR,84% for calretinin-IR and 26% for ChAT-IR neurons in the D group.The spatial density of calbindin-IR neurons,however,did not differ among the three groups.The submucosal neuronal density increased for calbindin-IR,calretinin-IR and ChAT-IR neurons.The average size of neurons in the myenteric plexus neurons in the D group was less than that in the controls and,in the re-fed rats;there was a 34% reduction in size only for the calretinin-IR neurons.CONCLUSION:This work demonstrates that expression of the P2X2 receptor is present in inhibitory,intrinsic primary afferent,cholinergic secretomotor and vasomotor neurons.Undernutrition affected P2X2 receptor expression in the submucosal plexus,and neuronal and size.These changes were rescued in the re-fed rats. | Rúbia Misawa Priscila Azevedo Girotti Márcia Sanae Mizuno Edson Aparecido Liberti John Barton Furness Patricia Castelucci | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 2 | Role of 5-aminolevulinic acid in the diagnosis and treatment of superficial bladder cancer:improvement in diagnostic sensitivity显示文摘 | De Dominicis C Liberti M Perugia G | 2001 | Urology2001，57，6： | 1 |
| 3 | Lidocaine-prilocaine (EMLA) cream as analgesia for hysterosalpingography:a prospective,randomized,controlled,double blinded study显示文摘 | Liberty G Gal M Halevy-Shalem T | | 0，，： | 1 |
| 4 | Development of an immunoassay-based lateral flow dipstick for the rapid detection of aflatoxin B1 in pig feed显示文摘 | BARBARA S D SARAH M D G S LIBERTY S | 2005 | Agric Food Chem2005，53，： | 1 |
| 5 | Smart Antennas for Wireless Communica tions显示文摘 | Rappaport T S | 1999 | Prentice Hall PTR1999，4，12： | 1 |
| 6 | Analytical results for capacity improvements in CDMA显示文摘 | LIBERTI J C RAPPAPORT T H | 1994 | IEEE Transactions on Vehicular Technology1994，43，3： | 1 |
| 7 | Health risk assessment of air emissions from a municipal solid waste incineration plant – A case study显示文摘 | Federico Cangialosi Gianluca Intini Lorenzo Liberti Michele Notarnicola Paolo Stellacci | 2007 | Waste Management2007，，5： | 1 |
| 8 | Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein显示文摘 | Vijayaraghavan S Liberty G A Mohan J | 1999 | Mol Endocrinol1999，13，5： | 1 |
| 9 | Role of 5-aminolevulinic acid in the diagnosis and treatment of superficial bladder cancer:improvement in diagnostic sensitivity显示文摘 | De Dominicis C Liberti M Perugia G | 2001 | Urology2001，57，： | 1 |
| 10 | Does day -3 LH/FSH ratio influ- ence in vitro fertilization outcome in PCOS patients undergoing con- trolled ovarian hyperstimulation with different GnRH - analogue 显示文摘 | Orvieto R Meltcer S Liberty G | 2012 | Gynecological Endocrinology2012，28，6： | 1 |
| 11 | Is hEXO1 a cancer predisposing gene?显示文摘 | LIBERTI S E RASMUSSEN L J | 2004 | Mol Cancer Res2004，2，8： | 1 |
| 12 | Gas Chromatography of Isotopic Molecules on Open Tubular Columns显示文摘 | Bruner F Cartoni GP Liberti A | 1966 | Anal Chem1966，38，： | 1 |
| 13 | Thyroxine-induced cardiac hypertrophy:influence of adrenergic nervous system versus reninangiotensin system on myocyte remodeling显示文摘 | Hu LW Benvenuti LA Liberti EA | 2003 | Am J Physiol Regul Integr Comp Physiol2003，285，6： | 1 |
| 14 | Microdosimetry in the Microwave Range:A Quantitative Assessment at Single Cell Level显示文摘 | Liberti M Apollonio F Merla C | | 0，，： | 1 |
| 15 | A geometrically based model for line of- sight multipath radio channels显示文摘 | Liberti J C Rappaport T S | 1996 | Vehicular Technology Conference ''Mobile Technology for the Human Race'' IEEE 46th1996，844，： | 1 |
| 16 | Quantitative assessment of dielectric parameters for membrane lipid bi-layers from RF permittiv- ity measurements显示文摘 | Merla C Liberti M Apollonio F | 2009 | Bioelectromagnetics2009，30，4： | 1 |
| 17 | Advanced treatment and disinfection for municipal wastewater reuse in agriculture显示文摘 | Notarnicola M | 1999 | War Sci Tech1999，40，5： | 1 |
| 18 | Air pollution from a large steel factory: polycyclic aromatic hydrocarbon emissions from coke-oven batteries 显示文摘 | Liberti L Notarnicola M Primerano R | 2006 | Journal of Air & Waste Management Association2006，56，3： | 1 |
| 19 | Anticancer activities ofcranberry phytochemicals:an update显示文摘 | Neto C C Amoroso J W Liberty A M | 2008 | Molecular Nutrition andFood Research2008，52，1： | 1 |
| 20 | Estimation of vegetation cover resilience from satellite time series显示文摘 | SIMONIELLO T LANFREDI M LIBERTI M | 2008 | Hydrol Earth Syst Sci2008，12，4： | 1 |
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