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| 1 | Laparoscopic fundoplication for gastroesophageal reflux disease显示文摘Gastroesophageal reflux disease(GERD) is a condition that develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms and/or complications. Heartburn is the cardinal symptom, often associated with regurgitation. In patients with endoscopy-negative heartburn refractory to proton pump inhibitor(PPI) therapy and when the diagnosis of GERD is in question, direct reflux testing by impedance-pH monitoring is warranted. Laparoscopic fundoplication is the standard surgical treatment for GERD. It is highly effective in curing GERD with a 80% success rate at 20-year follow-up. The Nissen fundoplication, consisting of a total(360°) wrap, is the most commonly performed antireflux operation. To reduce postoperative dysphagia and gas bloating, partial fundoplications are also used, including the posterior(Toupet) fundoplication, and the anterior(Dor) fundoplication. Currently, there is consensus to advise laparoscopic fundoplication in PPI-responsive GERD only for those patients who develop untoward side-effects or complications from PPI therapy. PPI resistance is the real challenge in GERD. There is consensus that carefully selected GERD patients refractory to PPI therapy are eligible for laparoscopic fundoplication, provided that objective evidence of reflux as the cause of ongoing symptoms has been obtained. For this purpose, impedance-pH monitoring is regarded as the diagnostic gold standard. | Marzio Frazzoni Micaela Piccoli Rita Conigliaro Leonardo Frazzoni Gianluigi Melotti | 2014 | World Journal of Gastroenterology2014，20，39： | 10 |
| 2 | Effects of full replacement of dietary fishmeal with insect meal from Tenebrio molitor on rainbow trout gut and skin microbiota显示文摘Background:Aquaculture must continue to reduce dependence on fishmeal(FM)and fishoil in feeds to ensure sustainable sector growth.Therefore,the use of novel aquaculture feed ingredients is growing.In this regard,insects can represent a new world of sustainable and protein-rich ingredients for farmed fish feeds.Accordingly,we investigated the effects of full replacement of FM with Tenebrio molitor(TM)larvae meal in the diet of rainbow trout(Oncorhynchus mykiss)on fish gut and skin microbiota.Methods:A feeding trial was conducted with 126 trout of about 80 g mean initial weight that were fed for 22 weeks with two isonitrogenous,isolipidic,and isoenergetic extruded experimental diets.Partially defatted TM meal was included in one of the diets to replace 100%(TM 100)of FM,whereas the other diet(TM 0)was without TM.To analyse the microbial communities,the Illumina MiSeq platform for sequencing of 16S rRNA gene and Qiime pipeline were used to identify bacteria in the gut and skin mucosa,and in the diets.Results:The data showed no major effects of full FM substitution with TM meal on bacterial species richness and diversity in both,gut mucosa-and skin mucus-associated microbiome.Skin microbiome was dominated by phylum Proteobacteria and especially by Gammaproteobacteria class that constituted approximately half of the bacterial taxa found.The two dietary fish groups did not display distinctive features,except for a decrease in the relative abundance of Deefgea genus(family Neisseriaceae)in trout fed with insect meal.The metagenomic analysis of the gut mucosa indicated that Tenericutes was the most abundant phylum,regardless of the diet.Specifically,within this phylum,the Mollicutes,mainly represented by Mycoplasmataceae family,were the dominant class.However,we observed only a weak dietary modulation of intestinal bacterial communities.The only changes due to full FM replacement with TM meal were a decreased number of Proteobacteria and a reduced number of taxa assigned to Ruminococcaceae and Neisseriaceae families.Conclusions:The data demonstrated that TM larvae meal is a valid alternative animal protein to replace FM in the aquafeeds.Only slight gut and skin microbiota changes occurred in rainbow trout after total FM replacement with insect meal.The mapping of the trout skin microbiota represents a novel contribution of the present study.Indeed,in contrast to the increasing knowledge on gut microbiota,the skin microbiota of major farmed fish species remains largely unmapped but it deserves thorough consideration. | Genciana Terova Elisabetta Gini Laura Gasco Federico Moroni Micaela Antonini Simona Rimoldi | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 6 |
| 3 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 4 | Ambient air quality and the risk for Chronic Obstructive Pulmonary Disease among Metro Manila Development Authority traffic enforcers in Metro Manila:An exploratory study显示文摘Background::Air pollution and poor ambient air quality are significantly related to multiple health risks.One associated disease is chronic obstructive pulmonary disease(COPD),a preventable disease with several contributing factors and one of the leading causes of morbidity/mortality locally and globally.A potentially high-risk population are traffic enforcers who are constantly exposed to air pollution.In the Philippines,the MMDA has the widest coverage in traffic management.The study determined the risk of COPD among Metro Manila Development Authority(MMDA)traffic enforcers in relation to ambient air quality level,as well as identified other factors that increase the risk of developing COPD.Methods::Fifty-two MMDA traffic enforcers deployed in PM 2.5 air quality sensor areas in Metro Manila from 2016 to 2018 were recruited through stratified sampling.The International Primary Airways Guidelines(IPAG)questionnaire was utilized to measure risk of COPD.Respiratory health and working history were obtained through questionnaires.Department of environment and natural resources provided PM 2.5 ambient air quality data which aided in the construction of the Exposure-Month Index.Ordinal logistic regression was used to examine the association of PM 2.5 together with the relevant factors and the risk of COPD.Results::We found statistically significant associations between PM 2.5 and COPD among high risk category[odds risk(OR):1.24,95%confidence interval(CI):1.07-1.44].Age(Moderate,OR:1.16,95%CI:0.98-1.38 and High,OR:10.06,95%CI:4.02-25.17)and chest pain(Moderate,OR:68.65,95%CI:1.71-2.75×103)were potential risk factors,whereas body mass index(BMI)(OR:0.05,95%CI:0.01-0.53)exhibited protective effect.Conclusions::Exposure to PM 2.5 was associated with an increased risk of COPD among high-risk category MMDA traffic enforcers.Age and chest pain were potential risk factors to risk of COPD,whereas BMI exhibited a potential protective effect.Results of this study can be used for clinical management of high-risk populations,such that of MMDA traffic enforcers. | Xerxes Seposo Audrey Lynn A.Arcilla Jose Guillermo N.De Guzman III Enrico Miguel S.Dizon Andrea Nova R.Figuracion Christina Micaela M.Morales Pauleena Katriona A.Tugonon Geminn Louis C.Apostol | 2021 | Chronic Diseases and Translational Medicine2021，7，2： | 3 |
| 5 | Neuroendocrine differentiation:The mysterious fellow of colorectal cancer显示文摘Neuroendocrine differentiation in sporadic colorectal cancer has been recognized since decades, but its clinical impact is still controversially discussed. Detailed parameter analyses hint at the possibility that probablynot neuroendocrine differentiation itself, but its association with poor grade of tumor differentiation, lymph node metastases, distant metastases and other unfavorable features contribute to worse clinical outcome. However, other studies deny a relationship between neuroendocrine differentiation and prognosis of colorectal cancer. This review elucidates, whether new insights into the origin of neuroendocrine differentiation in the intestinal epithelium, its regulation by m TOR pathway components and its possible link to the intestinal stem cell compartment could determine a role of neuroendocrine cells as prognostic marker and putative therapeutic target in sporadic colorectal cancer. | Britta Kleist Micaela Poetsch | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 6 | Particulate phosphorus bioavailability as a function of stream flow and land cover显示文摘 | Micaela E. Ellison Michael T. Brett | 2006 | Water Research2006，，6： | 2 |
| 7 | Etodolac a reappraisal of its pharmacology and therapeutic use in rheumatic disease and pain states显示文摘 | Balfour M Micaela T | 1991 | Drugs1991，42，2： | 1 |
| 8 | Validation of 3D Ultrasound Vessel Wall Volume: An Imaging Phenotype of Carotid Atherosclerosis显示文摘 | Micaela Egger J. David Spence Aaron Fenster Grace Parraga | 2007 | Ultrasound in Medicine & Biology2007，，6： | 1 |
| 9 | ISO 9000/1994,ISO 9001/2000 and TQM:the perfor- mance debate revisited 显示文摘 | Micaela MC | 2009 | Journal of Operations Management2009，27，6： | 1 |
| 10 | Particulate phosphorus bioavailability as a function of stream flow and land cover显示文摘 | Micaela E. Ellison Michael T. Brett | 2006 | Water Research2006，，6： | 1 |
| 11 | Heavy Metal Distribution and Controlling Factors within Coastal Plain Sediments,Bells Creek Catchment,Southeast Queensland,Australia显示文摘 | Tania L Micaela P Malcolm C | 2003 | Environment International2003，29，： | 1 |
| 12 | The complete sequence of botulinum neurotoxin type A and comprison with other Clostrklial neurotoxins 显示文摘 | THOMAS B HISAO K MICAELA W | 1990 | The Journal of Biological Chemistry1990，265，16： | 1 |
| 13 | Current Status of Idiopathic Nonspecific Interstitial Pneumonia显示文摘 | Venerino Poletti Micaela Romagnoli Sara Piciucchi Marco Chilosi | 2012 | Semin Respir Crit Care Med2012，，05： | 1 |
| 14 | Bioabsorbable Synthetic Plug in the Treatment of Anal Fistulas显示文摘 | Afshin Heydari Grazia Maria Attinà Enrico Merolla Micaela Piccoli Reza Fazlalizadeh Gianluigi Melotti | 2013 | Diseases of the Colon & Rectum2013，，6： | 1 |
| 15 | Evaluation of phenol detoxification by Brassica napus hairy roots, using Allium cepa test显示文摘 | Paola S. González Guillermo A. Maglione Micaela Giordana Cintia E. Paisio Melina A. Talano Elizabeth Agostini | 2012 | Environmental Science and Pollution Research2012，，2： | 1 |
| 16 | Ligasure vessel sealing system in laparoscopic palomo varicocele ligation in children and adolescent显示文摘 | Antonio M Maria DS Micaela B | 2007 | J Laparoendosc Adv Surg Tech A2007，17，2： | 1 |
| 17 | Heavy metal distribution and con trolling factors within coastal plain sediments, bells creek catch ment, southeast Queensland, Australia显示文摘 | Tania L Micaela P Malcolm C | 2003 | Environment Interna tional2003，29，： | 1 |
| 18 | Hemostasis Alterations in Patients With Acute Aortic Dissection显示文摘 | Domenico Paparella Crescenzia Rotunno Pietro Guida Pietro Giorgio Malvindi Giuseppe Scrascia Micaela De Palo Emanuela de Cillis Alessandro S. Bortone Luigi de Luca Tupputi Schinosa | 2011 | The Annals of Thoracic Surgery2011，，5： | 1 |
| 19 | Fermentation of quinoa and wheat slurries by Lactobacillus plantarum CRL 778: proteolytic activity显示文摘 | Andrea Micaela Dallagnol Micaela Pescuma Graciela Font Valdez Graciela Rollán | 2013 | Applied Microbiology and Biotechnology2013，，7： | 1 |
| 20 | Graft union formation in tomato plants:peroxidase and catalase involve ment显示文摘 | Nieves F G Micaela C Enrique O | | 0，，01： | 1 |
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