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| 1 | Chronic functional constipation is strongly linked to vitamin D deficiency显示文摘BACKGROUND Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined.AIM To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders.METHODS We performed a prospective case-control study, from May-June to November2017. Glucose/lactulose breath tests, radiopaque markers(multiple capsule techniques) and wireless motility capsule analysis were used to assess colonicand oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life(IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14(HADS-14 A and HADS-14 D).RESULTS We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels(P < 0.001), and they showed a significant impairment of all health-related quality of life and psychological tests(IBS-QOL, Short Form Health Survey 12-Physical Component Summary, Short Form Health Survey 12-Mental Component Summary, HADS-14 A and HADS-14 D), as compared to the control group(P < 0.001), which significantly correlated with low vitamin D levels(r =-0.57, P < 0.001; r = 0.21, P = 0.01; r =-0.48, P < 0.001; r =-0.57, P < 0.001; r =-0.29, P < 0.001, respectively). At multivariate analysis vitamin D low levels remained a significant independent risk factor for the occurrence of intestinal motility disorder(odds ratio = 1.19; 95% confidence interval: 1.14-1.26, P < 0.001).CONCLUSION Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients. | Alba Panarese Francesco Pesce Piero Porcelli Giuseppe Riezzo Palma Aurelia Iacovazzi Carla Maria Leone Massimo De Carne Caterina Mammone Rinaldi Endrit Shahini | 2019 | World Journal of Gastroenterology2019，25，14： | 8 |
| 2 | Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer显示文摘AIM: To identify suitable biomarkers of response to bevacizumab(BV)- it remains an open question. The measurement of serum vascular endothelial growth factor(VEGF) has been proposed as a predictive factor for this drug, even if literature data are contradictory. METHODS: We prospectively evaluated the role of BV, total and not BV-bound VEGF and angiopoietin-2(Ang-2) serum levels as potential predictive factors of response for BV in combination with an oxaliplatinbased chemotherapy. BV, Ang-2, total and not BVbound VEGF levels were measured at baseline, before 2^(nd) and 5^(th) cycle of oxaliplatin-based chemotherapy in 20 consecutive metastatic colorectal cancer patients. RESULTS: Results were correlated to response to treatment. Variability in BV levels have been found, with decreased level in less responding patients. In particular, the concentration of BV increased of 3.96 ± 0.69 folds in serum of responsive patients after 3 more cycles of therapy compared to those with stable or progressive disease with a 0.72 ± 0.25 and 2.10 ± 0.13 fold increase, respectively. The determination of free and total VEGF demonstrated that the ratio between the two values, evaluated immediately before the 2^(nd) and the 5^(th) cycle of therapy, decreased from 26.65% ± 1.33% to 15.50% ± 3.47% in responsive patients and from 53.41% ± 4.75 to 34.95% ± 2.88% in those with stable disease. Conversely, in those with progression of disease, the ratio showed the opposite behavior coming up from 25.99% ± 5.23% to 51.71% ± 5.28%. The Ang-2 levels did not show any relationship. CONCLUSION: Our data show that the ratio of not BV-bound VEGF to total VEGF serum and BV plasma concentrations for predicting the response to BV plus oxaliplatin-based chemotherapy could be a promising biomarker of response to BV. | Amalia Azzariti Letizia Porcelli Oronzo Brunetti Marzia Del Re Vito Longo Patrizia Nardulli Michele Signorile Jian-Ming Xu Angela Calabrese Anna Elisa Quatrale Evaristo Maiello Vito Lorusso Nicola Silvestris | 2016 | World Journal of Gastroenterology2016，22，27： | 4 |
| 3 | Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity显示文摘 | Letizia Porcelli Anna E. Quatrale Paola Mantuano Maria G. Leo Nicola Silvestris Jean F. Rolland Enza Carioggia Marco Lioce Angelo Paradiso Amalia Azzariti | 2013 | Molecular Oncology2013，，3： | 2 |
| 4 | Nutrient and heavy metal concentration and distribution in corn, soybean and wheat as affected by different tillage systems in the Argentine Pampas显示文摘 | Raúl S Lavado Claudia A Porcelli Roberto Alvarez | 2001 | Soil & Tillage Research2001，，1： | 2 |
| 5 | Mass transfer of helium,neon,argon and xenon through a steady-state upper mantle 显示文摘 | Porcelli D Wasserburg G J | 1995 | Geochim Cosmochim Acta1995，59，23： | 2 |
| 6 | Enhanced 3He/4He ratios and cosmogenic helium in ultramafic xenoliths 显示文摘 | Porcelli D R Stone JOH O′Nions R K | 1987 | Chem Geol1987，64，： | 2 |
| 7 | SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells显示文摘 | De Falco E Porcelli D Torella AR Straino S Iachininoto MG Orlandi A | 2004 | Blood2004，104，12： | 1 |
| 8 | The hafnium isotope composition of Pacific Ocean water显示文摘 | ZIMMERMANN B PORCELLI D FRANK M | 2009 | Geochimet Cosmochim Acta2009，73，1： | 1 |
| 9 | Recognition of a lipid antigen by CD1-restricted alpha beta^+ T cells显示文摘 | Beckman EM Porcelli SA Morita CT | 1994 | Nature1994，372，： | 1 |
| 10 | Treatment of Cushing disease: overview and recent findings 显示文摘 | Mancini T Porcelli T Giustina A | 2010 | Ther Clin Risk Manag2010，6，： | 1 |
| 11 | Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells显示文摘 | Kaye J Porcelli S Tite J Jones B Janeway CA | | 0，，03： | 1 |
| 12 | Serum TSH values and risk of vertebral fractures in euthyrnid post-menopausal women with low bone mineral density显示文摘 | Mazziotti G Porcelli T Patelli I ct al | 2010 | Bone2010，46，3： | 1 |
| 13 | Lactobacillus helveticus glycosyltransferases: from genes to carbohydrate synthesis显示文摘 | JOLLY L NEWELL J PORCELLI I | 2002 | Glycobiology2002，12，5： | 1 |
| 14 | Respiratory eom-plex I dysfunction due to mitoehondrial DNA mutations shifts the voltage threshold for opening of the permeability transi- tion pore toward resting levels 显示文摘 | Porcelli A M Angenlin A Ghelli A | 2008 | J Biol Chem2008，284，4： | 1 |
| 15 | Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c显示文摘 | Sieling PA Porcelli SA Duong BT | 2000 | J Immunol2000，165，： | 1 |
| 16 | Hafnium isotopes in Arctic Ocean water显示文摘 | ZIMMERMANN B PORCELLI D FRANK M | 2009 | Geochimet Cosmochim Acta2009，73，11： | 1 |
| 17 | Note on the effects of winter and spring waterlogging on growth,chemical composition and yield of rapeseed显示文摘 | Gutierrez Boem F H Lavado R S Porcelli C A | 1996 | Field Crops Res1996，47，： | 1 |
| 18 | NKT ceils from normal and tumor-bearing human livers are phenotypically and functionally distinct from Murine NKT Cells 显示文摘 | Kenna T Golden-Mason L Porcelli SA | 2003 | J Immunol2003，171，4： | 1 |
| 19 | Evaluation of the efficacy of collaborative learning in face-to-face and computer-supported university contexts显示文摘 | Francescato D Porcelli R Mebane M | 2006 | Computers in Human Behavior2006，22，2： | 1 |
| 20 | Recognition of a lipid antigen by CD1 -restricted αβ +T cells 显示文摘 | Porcelli S A Morita C T | 1994 | Nature1994，372，： | 1 |
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