|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 3 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 4 | Simultaneous measurement of CO_2 sorption and swelling of phosphate-based ionic liquid显示文摘The development of alternative CO_2 capture solvents such as ionic liquids(ILs) and nanoparticle organic hybrid materials(NOHMs) have provided interesting options for CO_2 capture. In this study, CO_2 interactions with 1,3-dimethylimidazolium dimethylphosphate([MMIM]DMP),1-ethyl-3-methylimidazolium dimethylphosphate([EMIM]DMP) and 1-ethyl-3-methylimidazolium diethylphosphate([EMIM]DEP) that contain inorganic ester groups based on phosphate, were investigated using ATR FT-IR spectroscopy. CO_2-induced swelling, CO_2 diffusivity and CO_2 capture capacity were simultaneously measured to identify CO_2 capture mechanisms, kinetics and diffusion behaviors as a function of the alkyl chain length of the cation. Henry's law constants of CO_2 were found to be in the range of 4-11 MPa, which is in agreement with those reported in other studies. | Junfeng Wang Camille Petit Xiangping Zhang Ah-Hyung Alissa Park | 2016 | Green Energy & Environment2016，1，3： | 3 |
| 5 | Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression显示文摘 | Chi-Chiu Lau Tingting Sun Arthur K.K. Ching Mian He Jing-Woei Li Alissa M. Wong Ngai Na Co Anthony W.H. Chan Pik-Shan Li Raymond W.M. Lung Joanna H.M. Tong Paul B.S. Lai Henry L.Y. Chan Ka-Fai To Ting-Fung Chan Nathalie Wong | 2014 | Cancer Cell2014，，3： | 2 |
| 6 | Basic pathogenetic mechanisms in silicosis: current understanding显示文摘 | Binaya Rimal Alissa K Greenberg William N Rom | 2005 | Current Opinion in Pulmonary Medicine2005，，2： | 2 |
| 7 | Integrated Life Cycle Assessment and Life Cycle Cost Analysis Model for Concrete Bridge Deck Applications显示文摘 | Alissa K Gregory A Gloria E | 2005 | Journal of Infrastructure Systems2005，14，3： | 1 |
| 8 | School refusal behavior associated with separation anxiety Ddisorder:A cognitive-behavioral approach to treatment显示文摘 | Alissa F Doobay | 2008 | Psychology in the School2008，45，4： | 1 |
| 9 | Medicinal Herbs and Therapeutic Drugs Interactions显示文摘 | Alissa EM | 2014 | Ther Drug Monit2014，，： | 1 |
| 10 | Quantification of the re- lationship between the environment and Fusarlum head blight, Fusarium pathogen density, and mycotoxins in winter wheat in Europe 显示文摘 | Alissa B K Paul P A Xu X M etal | 2012 | Europe Plant Pathol2012，133，97： | 1 |
| 11 | Social Media, Administrative Agencies, and the First A- mendment 显示文摘 | Alissa A | 2013 | Administrative Law Review2013，65，2： | 1 |
| 12 | Life cycle greenhouse gas assessment of infrastructure construction for California' s high-speed rail system 显示文摘 | BRENDA C ALISSA K | 2011 | Transportation Research Part D : Transport and Environment2011，16，6： | 1 |
| 13 | Life Cycle Greenhouse Gas Assessment of Infrastructure Construction for California's High-speed Rail System显示文摘 | Brenda C Alissa K | | 0，，： | 1 |
| 14 | Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment显示文摘 | Alexander R.A. Anderson Alissa M. Weaver Peter T. Cummings Vito Quaranta | 2006 | Cell2006，，5： | 1 |
| 15 | The effects of coadminis-tration of dietary copper and zinc supplements on atherosclero-sis,antioxidant enzymes and indices of lipid peroxidation in the cholesterol-fed rabbit显示文摘 | Alissa EM Bahijri SM Lamb DJ | | 0，，05： | 1 |
| 16 | Integrating Urbanization into Landscape-level Ecological Assessments显示文摘 | Jeffrey D. Kline Alissa Moses Ralph J. Alig | 2001 | Ecosystems2001，，1： | 1 |
| 17 | Update on Progressive Familial Intrahepatic Cholestasis显示文摘 | Feras T Alissa Ronald Jaffe Benjamin L Shneider | 2008 | Journal of Pediatric Gastroenterology and Nutrition2008，，3： | 1 |
| 18 | Integrating urbanization into landscape-level ecological assessments 显示文摘 | Jeffrey D K alissa M Ralph J A | 2001 | Ecosystems2001，4，： | 1 |
| 19 | Antihypertensive Medication Use During Pregnancy and the Risk of Cardiovascular Malformations显示文摘 | Alissa R. Caton Erin M. Bell Charlotte M. Druschel Martha M. Werler Angela E. Lin Marilyn L. Browne Louise-Anne McNutt Paul A. Romitti Allen A. Mitchell Richard S. Olney Adolfo Correa | 2009 | Hypertension2009，，1： | 1 |
| 20 | Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 显示文摘 | Esposito M Grusovin MG Rees J Karasoulos D Felice P Alissa R | 2010 | Cochrane Database Syst Rev2010，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员