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| 1 | Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro显示文摘Cross-talk has been shown to occur between the immune system and bone metabolism pathways.In the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone resorption.Treg cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent manner.In cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 antibodies.Treatment of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 expression.These data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these cells.Therefore,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO). | CY Luo L Wang C Sun DJ Li | 2011 | Cellular & Molecular Immunology2011，8，1： | 33 |
| 2 | 西藏日喀则地区德村-昂仁蛇绿岩内基性岩的元素与Sr-Nd-Pb同位素地球化学及其揭示的特提斯地幔域特征显示文摘系统研究了西藏雅鲁藏布江蛇绿岩带中部日喀则地区德村、吉丁和昂仁蛇绿岩中基性岩石的元素与 Sr-Nd-Pb 同位素地球化学特征。这些基性岩石,包括玄武岩、辉长岩和辉绿岩,属于低钾拉斑玄武岩系列,球粒陨石标准化稀土元素分配模式为轻稀土元素亏损的 N-MORB 型,(La/Yh)_N=0.31~0.65(除样品 DC993为1.17)。在原始地幔标准化微量元素图上,亏损高度不相容元素,与 N-MORB 配分模式一致。相对于 Th,无 Nb、Ta的亏损,显示样品不是产于 SSZ 环境。经构造环境图解判别,样品落入了 N-MORB 区域内;这些元素成分特征表明样品具有洋中脊环境或成熟的弧后盆地环境属性。Sr、Nd 和 Pb同位素组成特征表明特提斯地幔源区以 DM(亏损地幔)为主,同时存在少量 EMⅡ(富集地幔类型Ⅱ)、Sr,Nd 和 Pb 同位素组成特征还表明特提斯地幔域具有印度洋 MORB 型的 Sr-Nd-Pb 同位素组成特征。本文的结果进一步支持 Zhang et al.(2005)的研究结果,现今印度洋不仅在地理位置上占据了曾经是特提斯洋的大部分,而且它的地幔域还继承了曾经特提斯的地幔域的地球化学特征。 | 牛晓露 赵志丹 莫宣学 DEPAOLO DJ 董国臣 张双全 朱弟成 郭铁鹰 | 2006 | 岩石学报2006，22，12： | 29 |
| 3 | Synthesis and Structure of A Novel Caged Bicyclic Phosphate Flame Retardant显示文摘A novel caged bicyclic phosphate flame retardant tri(1-oxo-2,6,7-trioxa-l-phosphabicyclo [2.2.2] octane-methyl) phosphate (Trimer) was synthesized from 1-oxo-4-hydroxymethyl-2,6,7-trioxa-l-phosphabicyclo [2.2.2] octane (PEPA) and phosphorus oxychloride in this paper. Its structure was characterized by elemental analysis, FTIR, 1H NMR, 31P NMR and X-ray diffraction analysis. | Li, X Ou, YX Zhang, YH Lian, DJ | 2000 | Chinese Chemical Letters2000，11，10： | 28 |
| 4 | 断层分形分布之间的相关关系显示文摘根据断层几何和其物理机理与特征,分析了断层数目分布、位移分布和间距分布的分形维之间的相关性。建立了断层系统表面迹的分形模型,研究了断层分形分布的分形维数与断层系统表面迹线分维的相关关系。只要测定出任意两种分布的分维就能推算出其它分布的分维值。 | 谢和平 S.,DJ | 1994 | 煤炭学报1994，19，5： | 23 |
| 5 | 内蒙古温都尔庙和巴彦敖包-交其尔蛇绿岩的元素与同位素地球化学:对古亚洲洋东部地幔域特征的限制显示文摘内蒙古中部发育的三条蛇绿岩带是华北板块和西伯利亚板块之间的缝合带。本文系统研究了其中的温都尔庙和巴彦敖包-交其尔两个蛇绿岩带中变质玄武岩的元素和 Sr、Nd、Pb 同位素地球化学。苏右旗温都尔庙碱性玄武岩为轻稀土富集型;岩石具有板内和大陆裂谷区玄武岩的特征,可能代表了600Ma 左右,温都尔庙地区开始发育的新洋盆。采自苏左旗的巴彦敖包-交其尔玄武岩分为两类,一类呈现轻稀土富集型,呈洋岛玄武岩特征;另一类具有明显的 Nb、Ta 负异常,显示大洋岛弧玄武岩特征,洋岛玄武岩的存在表明古亚洲洋曾经发育洋盆,大洋岛弧玄武岩的存在表明古亚洲洋内部有大洋岩石圈之间的俯冲。将本文的古亚洲洋洋岛玄武岩与中国西南地区的特提斯洋岛玄武岩进行系统的元素和同位素地球化学特征对比表明,古亚洲洋的洋岛玄武岩显示高 U/Pb(HU)和北大西洋和太平洋省的特征,而特提斯洋岛玄武岩属于印度洋省。这些说明古亚洲洋地幔域与特提斯地幔域是两个独立的构造域,它们代表了长期演化的两个不同的地幔地球化学域。 | 黄金香 赵志丹 张宏飞 侯青叶 陈岳龙 张本仁 DEPAOLO DJ | 2006 | 岩石学报2006，22，12： | 23 |
| 6 | 喷涂聚脲弹性体技术在我国的发展显示文摘喷涂聚脲弹性体(又名100%固含量喷涂聚脲弹性体)技术在我国研发成功后,以其优异的综合性能和先进的施工工艺 ,引起了国内材料界和工程界的极大关注。着重从国外发展简史、国内情况、市场需求等方面,介绍该技术在我国的应用前景。 | 黄微波 Prim.,DJ | 2000 | 涂料工业2000，30，11： | 17 |
| 7 | 大鼠离体肝再灌注模型(IPRL)的建立及其在肝移植器官保存液实验中的意义显示文摘目的 为肝脏保存液的研究提供离体肝脏再灌注模型。方法 用大鼠肝移植供体手术方法获取供肝 ,离体再循环 2小时 ,同健康活体大鼠进行对比 ,观察胆汁分泌量、胆汁中胆酸及胆红素水平。结果 健康活体大鼠肝和保存时间为 0小时的离体再灌注肝的 2小时胆汁分泌量分别为 2 0 6 0± 74 8μl·(gliver) -1和 179 0± 11 4 μl·(gliver) -1,两组结果无显著性差异 (P >0 .0 5 )。结论 大鼠离体肝循环再灌注是研究评价肝脏保存液的理想模型。 | 徐东波 杜智 Potts DJ Lodge JAP Ahmad N | 2001 | 生物医学工程与临床2001，5，1： | 13 |
| 8 | 腹腔镜结肠癌切除术疗效并不亚于开腹手术——基于COST的5年完整随访资料显示文摘目的通过多中心随机对照试验比较腹腔镜结肠癌切除与开腹手术在切口复发率、无病生存率以及总体生存率等疗效指标上有无差异。方法来自48个不同中心的872名的结肠癌患者被随机分成腹腔镜组和开腹组,分别接受手术治疗。随访8年,其中90%的病例获随访5年以上。主要终点指标为复发时间,分析方法采⒚非劣效性检验,次要终点指标为无病生存率和总体生存率,统计方法采⒚Kaplan-Meier检验。结果截至2007年3月1日,共有170例复发,252例死亡。随访时间为5~10年(中位时间为7年),两组的5年无病生存率(开腹组68.4%,腹腔镜组69.2%,P=0.94)和5年总体生存率(开腹组74.6%,腹腔镜组76.4%,P=0.93)无统计学差异,两组总的复发率无统计学差异(开腹组21.8%,腹腔镜组19.4%,P=0.25)。复发位置分布相似(开腹组:切缘0.5%,肝5.8%,肺4.6%,其它组织8.4%;腹腔镜组:切口0.9%,肝5.5%,肺4.6%,其它组织6.1%)。结论对于可切除的结肠癌而言,腹腔镜手术的效果并不亚于开腹手术。 | 陈志辉 Fleshman J Sargent DJ Green E | 2009 | 中华普通外科学文献(电子版)2009，3，1： | 13 |
| 9 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement显示文摘 | M Dominici K Le Blanc I Mueller I Slaper-Cortenbach Fc Marini Ds Krause Rj Deans A Keating Dj Prockop Em Horwitz | 2006 | Cytotherapy2006，，4： | 11 |
| 10 | 吉非替尼结合化放疗治疗局部晚期头颈癌显示文摘该文旨在评价表皮生长因子受体抑制剂吉非替尼结合同期放化疗治疗局部晚期头颈癌(LA—HNC)的效果及毒性.研究治疗效果和EGFR基因拷贝数目的关系。方法:Ⅲ-Ⅳ期LA—HNC患者先行卡铂及紫杉醇诱导化疗,再给以5-FU及羟基脲(FHX)同期放化疗。同时给以吉非替尼,持续2a。初步疗效终点为肿瘤临床CR。EGFR基因的拷贝数应用荧光原位杂交确定。 | Cohen EE Haraf DJ Kunnavakkam R | 2010 | 中国口腔颌面外科杂志2010，8，4： | 10 |
| 11 | 20世纪本科生医学教育中的基础医学课程显示文摘本文论述了过去100年中基础医学科学在本科生医学课程中的作用和课程改革,讨论了进入21世纪之际仍然反映在医学教育中科学与技艺之间的紧张关系。 | Weatherall DJ 梅人朗 | 2006 | 复旦教育论坛2006，4，4： | 9 |
| 12 | 联合用药可作为初诊高血压患者的起始治疗方案显示文摘美国预防、检测、评估与治疗高血压全国联合委员会第7次报告(the seventh report of the joint national committee on prevention,detection,evaluation,and treatment of high blood pressure,JNC7)建议临床医师,高血压起始治疗时应考虑使用多药物联合治疗,特别是当血压高于治疗目标值20/10mmHg时,以增加使血压得到控制的可能性。 | Byrd JB Tavel HM Magid DJ | 2011 | 中华高血压杂志2011，19，12： | 9 |
| 13 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement显示文摘 | M Dominici K Le Blanc I Mueller I Slaper-Cortenbach Fc Marini Ds Krause Rj Deans A Keating Dj Prockop Em Horwitz | 2006 | Cytotherapy2006，，4： | 9 |
| 14 | Marrow stromal cells as stem cells for nonhematopoietic tissues显示文摘 | Prockop DJ | | 0，，： | 8 |
| 15 | 模拟软件stella在小麦生长发育模拟中的应用显示文摘本文以stella的应用为基础,重点介绍了一个小麦生长发育的模拟模型。该模型由四个子模型组成,即气象子模型、物候期子模型、生长子模型及土壤水分子模型。为便于初学者学习和应用,模型中的一些计算已经简化,同时附上stella模型关系图(Program)及模型方程(equation)。 | Coma.,DJ 穆兴民 | 1996 | 河北农业大学学报1996，19，1： | 8 |
| 16 | Physical activity, obesity and gastroesophageal reflux disease in the general population显示文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) 'high' (several times/week); (2) 'intermediate' (approximately once weekly); and (3) 'low' (1-3 times/mo or less). Analyses were stratified for participants with 'normal weight' (BMI < 25 kg/m 2 ), 'overweight' (BMI 25 to ≤ 30 kg/m 2 ) and 'obese' (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after adjustment for potential confounding factors, neither intermediate (OR: 1.30, 95% CI: 0.75-2.26) nor high (OR: 0.99, 95% CI: 0.62-1.60) frequency of physical activity was followed by decreased risk of GERD. Sleeping problems and high comorbidity were identified as potential confounders. Among the 1859 overweight participants, crude point estimates indicated no increased or decreased risk of GERD among individuals with intermediate or high frequency of physical activity, compared to low frequency. After adjustment for confounding, neither intermediate (OR: 0.75, 95% CI: 0.46-1.22) nor high frequency of physical activity were followed by increased or decreased risk of GERD compared to low frequency among nonobese participants. Sleeping problems and high comorbidity were identified as potential confounders for overweight participants. In obese individuals, crude ORs were similar to the adjusted ORs and no particular confounding factors were identified. Intermediate frequency of physical activity was associated with a decreased occurrence of GERD compared to low frequency of physical activity (adjusted OR: 0.41, 95% CI: 0.22-0.77). CONCLUSION: Intermediate frequency of physical activity might decrease the risk of GERD among obese individuals, while no influence of physical activity on GERD was found in non-obese people. | Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren | 2012 | World Journal of Gastroenterology2012，18，28： | 8 |
| 17 | Thiazolidinedione increases serum soluble receptor for advanced glycation end-products in type 2 diabetes显示文摘 | Tan, KCB Chow, WS Tso, AWK Xu, A Tse, HF Hoo, RLC Betteridge, DJ Lam, KSL | 2007 | 中国生物学文摘2007，21，11： | 7 |
| 18 | Low-grade gliomas:do changes in rCBV measurements at longitudinal perfusion-weighted MR imaging predict malignant transformation?显示文摘Radiology. 2008 Apr;247(1):170-8.PURPOSE: To prospectively perform longitudinal magnetic resonance (MR) perfusion imaging of conservatively treated low-gradegliomas to determine whether relative cerebral blood volume (rCBV) changes precede malignant transformation as defined | Danchaivijitr N Waldman AD Tozer DJ Benton CE Brasil Caseiras G Tofts PS Rees JH J?ger HR | 2008 | 中国神经肿瘤杂志2008，6，2： | 7 |
| 19 | MRI预测急性脑梗死后出血的价值显示文摘目的探讨急性脑梗死患者 MR 早期增强 T_1WI 中脑实质强化及大脑中动脉高信号(HMCA)征与继发性脑出血(HT)的关系。方法回顾性分析24例发病6.0 h 内[平均(4.3±1.4)h]的急性脑梗死患者首次 T_1WI 及随后1周内复查的 MRI和(或)CT 资料,了解首次增强 T_1WI脑实质强化和 HMCA 征与 HT 的关系。早期脑实质强化为脑梗死6.0 h 内缺血的脑组织区域在增强T_1WI 出现高信号;HMCA 征为增强 T_1WI 上大脑中动脉增粗(与对侧相比)、出现边缘模糊的高信号。结果 24例患者中10例发展为 HT(出血组),其中6例首次 T_1WI 可见脑实质强化,5例出现 HMCA征;14例未出现 HT(无出血组),均未发现脑实质强化和(或)HMCA 征。2组相比,T_1WI 脑实质强化、HMCA 征出现率差异均有统计学意义(P 值均<0.01)。结论 T_1WI 早期脑实质强化和 HMCA征有可能预测急性脑梗死后 HT。 | 郭岗 吴仁华 Mikulis DJ | 2007 | 中华放射学杂志2007，41，10： | 6 |
| 20 | 开放与腹腔镜下腹壁切口疝修补术术后并发症的分级和评估:前瞻性随机对照研究显示文摘目的介绍一种针对腹部切口疝修补术后并发症的评估方法。方法 2004-2006年间,146例病人被随机分为两组,一组接受腹腔镜切口疝修补术(腹腔镜组,n=73),另一组接受传统开放式切口疝修补术(传统组,n=73)。研究对象是术后8周内出现的并发症。利用'三步法'来评价并发症的严重性。首先,将所有并发症根据Clavien分级分类。第二步,5位研究员分别独自运用直观叙述问卷模式对并发症的严重程度分级:0表示无术后并发症,100表示术后死亡。第三步,分别用中位数、最低和最高值对腹腔镜组与传统组术后并发症进行评价。结果传统组术后并发症发生率要显著高于腹腔镜组(47.9%vs.31.5%,P=0.026),而腹腔镜组术后并发症的严重度高于传统组。非参数分析显示传统组术后并发症发生率较高(四分位数间距为:开放组0-20对比腹腔镜组0-10;P=0.049)。在敏感性比较中,中位数、最高值和最低值获得了类似结果。结论该方法可以对两种术式术后并发症的发生做出直接评价。评估方法的合法性、可靠性和普遍性有待进一步的研究证实。 | Kaafarani HMA Hur K Campasano M Reda DJ Itani KMF | 2011 | 中国实用外科杂志2011，31，4： | 4 |
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