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| 1 | ERCP in acute pancreatitis:What takes place in routine clinical practice?显示文摘AIM:To evaluate the data from a survey carried out in Italy regarding the endoscopic approach to acute pancreatitis in order to obtain a picture of what takes place after the release of an educational project on acute pancreatitis sponsored by the Italian Association for the Study of the Pancreas.METHODS:Of the 1 173 patients enrolled in our survey,the most frequent etiological category was biliary forms(69.3%) and most patients had mild pancreatitis(85.8%).RESULTS:344/1 173(29.3%) underwent endoscopic retrograde cholangiopancreatography(ERCP).The mean interval between the onset of symptoms and ERCP was 6.7 ± 5.0 d;only 89 examinations(25.9%) were performed within 72 h from the onset of symptoms.The main indications for ERCP were suspicion of common bile duct stones(90.3%),jaundice(44.5%),clini cal worsening of acute pancreatitis(14.2%) and cho langitis(6.1%).Biliary and pancreatic ducts were visua lized in 305 patients(88.7%) and in 93 patients(27.0%) respectively.The success rate in obtaining a cholangio gram was statistically higher(P = 0.003) in patients with mild acute pancreatitis(90.6%) than in patients with severe disease(72.2%).Biliary endoscopic sphinc terotomy was performed in 295 of the 305 patients(96.7%) with no difference between mild and severe disease(P = 0.985).ERCP morbidity was 6.1% and mortality was 1.7%;the mortality was due to the complications of acute pancreatitis and not the endoscopic procedure.CONCLUSION:The results of this survey,as with those carried out in other countries,indicate a lack of compliance with the guidelines for the indications for interventional endoscopy. | Armando Gabbrielli Raffaele Pezzilli Generoso Uomo Alessandro Zerbi Luca Frulloni Paolo De Rai Laura Castoldi Guido Costamagna Claudio Bassi Valerio Di Carlo | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，9： | 14 |
| 2 | Pancreaticoduodenectomy in patients ≥ 75 years of age:Are there any differences with other age ranges in oncological and surgical outcomes? Results from a tertiary referral center显示文摘AIM To compare surgical and oncological outcomes after pancreaticoduodenectomy(PD) in patients ≥ 75 years of age with two younger cohorts of patients. METHODS The prospectively maintained Institutional database of pancreatic resection was queried for patients aged ≥ 75 years(late elderly, LE) submitted to PD for any disease from January 2010 to June 2015. We compared clinical, demographic and pathological features and survival outcomes of LE patients with 2 exact matched cohorts of younger patients [≥ 40 to 64 years of age(adults, A) and ≥ 65 to 74 years of age(young elderly, YE)] submitted to PD, according to selected variables. RESULTS The final LE population, as well as the control groups, were made of 96 subjects. Up to 71% of patients was operated on for a periampullary malignancy and pancreatic cancer(PDAC) accounted for 79% of them. Intraoperative data(estimated blood loss and duration of surgery) did not differ among the groups. The overall complication rate was 65.6%, 61.5% and 58.3% for LE, YE and A patients, respectively, P = NS). Reoperation and cardiovascular complications were significantly more frequent in LE than in YE and A groups(P = 0.003 and P = 0.019, respectively). When considering either all malignancies and PDAC only, the three groups did not differ in survival. Considering all benign diseases, the estimated mean survival was 58 and 78 mo for ≥ and < 75 years of age(YE + A groups), respectively(P = 0.012). CONCLUSION Age is not a contraindication for PD. A careful selection of LE patients allows to obtain good surgical and oncological results. | Salvatore Paiella Matteo De Pastena Tommaso Pollini Giovanni Zancan Debora Ciprani Giulia De Marchi Luca Landoni Alessandro Esposito Luca Casetti Giuseppe Malleo Giovanni Marchegiani Massimiliano Tuveri Enrico Marrano Laura Maggino Erica Secchettin Deborah Bonamini Claudio Bassi Roberto Salvia | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 3 | Efficacy of an Absorbable Fibrin Sealant Patch (TachoSil) After Distal Pancreatectomy: A Multicenter, Randomized, Controlled Trial显示文摘 | Marco Montorsi Alessandro Zerbi Claudio Bassi Lorenzo Capussotti Roberto Coppola Matteo Sacchi | 2012 | Annals of Surgery2012，，5： | 1 |
| 4 | Parenchyma-Preserving Resections for Small Nonfunctioning Pancreatic Endocrine Tumors显示文摘 | Massimo Falconi MD Alessandro Zerbi MD Stefano Crippa MD Gianpaolo Balzano MD Letizia Boninsegna MD Vanessa Capitanio MD Claudio Bassi MD Valerio Di Carlo MD Paolo Pederzoli MD | 2010 | Annals of Surgical Oncology2010，，6： | 1 |
| 5 | Parenchyma-Preserving Resections for Small Nonfunctioning Pancreatic Endocrine Tumors显示文摘 | Massimo Falconi MD Alessandro Zerbi MD Stefano Crippa MD Gianpaolo Balzano MD Letizia Boninsegna MD Vanessa Capitanio MD Claudio Bassi MD Valerio Di Carlo MD Paolo Pederzoli MD | 2010 | Annals of Surgical Oncology2010，，6： | 1 |
| 6 | Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy显示文摘 | Francesca D’Addio Stefano La Rosa Anna Maestroni Peter Jung Elena Orsenigo Moufida Ben Nasr Sara Tezza Roberto Bassi Giovanna Finzi Alessandro Marando Andrea Vergani Roberto Frego Luca Albarello Annapaola Andolfo Roberta Manuguerra Edi Viale Carlo Staudac | 2015 | Cell Stem Cell2015，，4： | 1 |
| 7 | From Today's Intranet of Things to A Future Internet of Things; A Wireless and Mobility-Related View显示文摘 | Miehele Zorzi Alexander Gtuhak Sebastian Lange Alessandro Bassi | 2010 | IEEE Wireless Communications2010，，05： | 1 |
| 8 | Triple approach strategy for patients with locally advanced pancreatic carcinoma显示文摘 | Alessandro Giardino Roberto Girelli Isabella Frigerio Paolo Regi Maurizio Cantore Auriemma Alessandra Annita Lusenti Roberto Salvia Claudio Bassi Paolo Pederzoli | 2013 | HPB2013，，8： | 1 |
| 9 | Parenchyma-Preserving Resections for Small Nonfunctioning Pancreatic Endocrine Tumors显示文摘 | Massimo Falconi Alessandro Zerbi Stefano Crippa Gianpaolo Balzano Letizia Boninsegna Vanessa Capitanio Claudio Bassi Valerio Di Carlo Paolo Pederzoli | 2010 | Annals of Surgical Oncology2010，，6： | 1 |
| 10 | High-orderdiscontinuous Galerkin RANS solution of the incompressibleflow over a delta wing 显示文摘 | Crivellini A Alessandro V Bassi F | 2013 | Computer & Fluids2013，88，1： | 1 |
| 11 | Perioperative management of patients undergoing pancreatic resection: Implementation of a care plan in a tertiary‐care center显示文摘 | Roberto Salvia Giuseppe Malleo Giovanni Butturini Marco Dal Molin Alessandro Esposito Giovanni Marchegiani Salvatore Paiella Anna Malpaga Martina Fontana Beatrice Personi Claudio Bassi | 2012 | J Surg Oncol2012，，1： | 1 |
| 12 | Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas显示文摘Objective:Squamous cell carcinoma(SCC)represents the most common histotype of all head and neck malignancies and includes oropharyngeal squamous cell carcinoma(OSCC),a tumor associated with different clinical outcomes and linked to human papilloma virus(HPV)status.Translational research has few available in vitro models with which to study the different pathophysiological behavior of OSCCs.The present study proposes a 3-dimensional(3 D)biomimetic collagen-based scaffold to mimic the tumor microenvironment and the crosstalk between the extracellular matrix(ECM)and cancer cells.Methods:We compared the phenotypic and genetic features of HPV-positive and HPV-negative OSCC cell lines cultured on common monolayer supports and on scaffolds.We also explored cancer cell adaptation to the 3 D microenvironment and its impact on the efficacy of drugs tested on cell lines and primary cultures.Results:HPV-positive and HPV-negative cell lines were successfully grown in the 3 D model and displayed different collagen fiber organization.The 3 D cultures induced an increased expression of markers related to epithelial–mesenchymal transition(EMT)and to matrix interactions and showed different migration behavior,as confirmed by zebrafish embryo xenografts.The expression of hypoxia-inducible factor 1α(1α)and glycolysis markers were indicative of the development of a hypoxic microenvironment inside the scaffold area.Furthermore,the 3 D cultures activated drug-resistance signaling pathways in both cell lines and primary cultures.Conclusions:Our results suggest that collagen-based scaffolds could be a suitable model for the reproduction of the pathophysiological features of OSCCs.Moreover,3 D architecture appears capable of inducing drug-resistance processes that can be studied to better our understanding of the different clinical outcomes of HPV-positive and HPV-negative patients with OSCCs. | Giacomo Miserocchi Claudia Cocchi Alessandro De Vita Chiara Liverani Chiara Spadazzi Sebastiano Calpona Giandomenico Di Menna Massimo Bassi Giuseppe Meccariello Giovanni De Luca Angelo Campobassi Maria Maddalena Tumedei Alberto Bongiovanni Valentina Fausti Franco Cotelli Toni Ibrahim Laura Mercatali | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 13 | Changing trends in acute upper-GI bleeding: a population-based study显示文摘 | Silvano Loperfido Vincenzo Baldo Elena Piovesana Ludovica Bellina Katia Rossi Marzia Groppo Alessandro Caroli Nadia Dal Bò Fabio Monica Luca Fabris Helena Heras Salvat Nicolò Bassi Lajos Okolicsanyi | 2009 | Gastrointestinal Endoscopy2009，，2： | 1 |
| 14 | Parenchyma-Preserving Resections for Small Nonfunctioning Pancreatic Endocrine Tumors显示文摘 | Massimo Falconi MD Alessandro Zerbi MD Stefano Crippa MD Gianpaolo Balzano MD Letizia Boninsegna MD Vanessa Capitanio MD Claudio Bassi MD Valerio Di Carlo MD Paolo Pederzoli MD | 2010 | Annals of Surgical Oncology2010，，6： | 1 |
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