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| 1 | Comparison of imaging-based and pathological dimensions in pancreatic neuroendocrine tumors显示文摘AIM To establish the ability of magnetic resonance(MR) and computer tomography(CT) to predict pathologic dimensions of pancreatic neuroendocrine tumors(Pan NET) in a caseload of a tertiary referral center.METHODS Patients submitted to surgery for Pan NET at the Surgical Unit of the Pancreas Institute with at least 1 preoperative imaging examination(MR or CT scan) from January 2005 to December 2015 were included and data retrospectively collected. Exclusion criteria were: multifocal lesions, genetic syndromes, microadenomas or mixed tumors, metastatic disease and neoadjuvant therapy. Bland-Altman(BA) and Mountain-Plot(MP) statistics were used to compare size measured by each modality with the pathology size. Passing-Bablok(PB) regression analysis was used to check the agreement between MR and CT.RESULTS Our study population consisted of 292 patients. Seventy-nine(27.1%) were functioning Pan NET. The mean biases were 0.17 ± 7.99 mm, 1 ± 8.51 mm and 0.23 ± 9 mm, 1.2 ± 9.8 mm for MR and CT, considering the overall population and the subgroup of non-functioning-Pan NET, respectively. Limits of agreement(LOA) included the vast majority of observations, indicating a good agreement between imaging and pathology. The MP further confirmed this finding and showed that the two methods are unbiased with respect to each other. Considering ≤ 2 cm non-functioning-Pan NET, no statistical significance was found in the size estimation rate of MR and CT(P = 0.433). PBR analysis did not reveal significant differences between MR, CT and pathology.CONCLUSION MR and CT scan are accurate and interchangeable imaging techniques in predicting pathologic dimensions of Pan NET. | Salvatore Paiella Harmony Impellizzeri Elisabetta Zanolin Giovanni Marchegiani Marco Miotto Anna Malpaga Riccardo De Robertis Mirko D'Onofrio Borislav Rusev Paola Capelli Sara Cingarlini Giovanni Butturini Maria Vittoria Davì Antonio Amodio Claudio BassiAldo Scarpa Roberto Salvia Luca Landoni | 2017 | World Journal of Gastroenterology2017，23，17： | 4 |
| 2 | Pancreaticoduodenectomy in patients ≥ 75 years of age:Are there any differences with other age ranges in oncological and surgical outcomes? Results from a tertiary referral center显示文摘AIM To compare surgical and oncological outcomes after pancreaticoduodenectomy(PD) in patients ≥ 75 years of age with two younger cohorts of patients. METHODS The prospectively maintained Institutional database of pancreatic resection was queried for patients aged ≥ 75 years(late elderly, LE) submitted to PD for any disease from January 2010 to June 2015. We compared clinical, demographic and pathological features and survival outcomes of LE patients with 2 exact matched cohorts of younger patients [≥ 40 to 64 years of age(adults, A) and ≥ 65 to 74 years of age(young elderly, YE)] submitted to PD, according to selected variables. RESULTS The final LE population, as well as the control groups, were made of 96 subjects. Up to 71% of patients was operated on for a periampullary malignancy and pancreatic cancer(PDAC) accounted for 79% of them. Intraoperative data(estimated blood loss and duration of surgery) did not differ among the groups. The overall complication rate was 65.6%, 61.5% and 58.3% for LE, YE and A patients, respectively, P = NS). Reoperation and cardiovascular complications were significantly more frequent in LE than in YE and A groups(P = 0.003 and P = 0.019, respectively). When considering either all malignancies and PDAC only, the three groups did not differ in survival. Considering all benign diseases, the estimated mean survival was 58 and 78 mo for ≥ and < 75 years of age(YE + A groups), respectively(P = 0.012). CONCLUSION Age is not a contraindication for PD. A careful selection of LE patients allows to obtain good surgical and oncological results. | Salvatore Paiella Matteo De Pastena Tommaso Pollini Giovanni Zancan Debora Ciprani Giulia De Marchi Luca Landoni Alessandro Esposito Luca Casetti Giuseppe Malleo Giovanni Marchegiani Massimiliano Tuveri Enrico Marrano Laura Maggino Erica Secchettin Deborah Bonamini Claudio Bassi Roberto Salvia | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 3 | Polymorphic variants of insulin-like growth factor Ⅰ receptor and phosphoin- ositide 3-kinase genes affect IGF-1 plasma levels and human longevity: cues for an evolutionarily conserved mechanismof life span controle显示文摘 | Bonafe M Barbieri M Marchegiani F | 2003 | The journal of clinical endocrinology and meta- bolism2003，88，7： | 1 |
| 4 | Inflammation,chronic obstructive pulmonary disease and aging显示文摘 | Provinciali M Cardelli M Marchegiani F | | 0，，01： | 1 |
| 5 | Pancreatic resections for cystic neoplasms : from the surgeon' s presumption to the pa-thologist' s reality显示文摘 | Salvia R Malleo G Marchegiani G | 2012 | Surgery2012，152，31： | 1 |
| 6 | Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly显示文摘 | Fabiola Olivieri Roberto Antonicelli Maurizio Cardelli Francesca Marchegiani Luca Cavallone Eugenio Mocchegiani Claudio Franceschi | 2006 | Mechanisms of Ageing and Development2006，，6： | 1 |
| 7 | Radiological and surgical implications of neoadjuvant treatment with FOLFIRI- NOX for locally advanced and borderline resectable pancreatic cancer显示文摘 | Ferrone CR Marchegiani G Hong TS | 2015 | Ann Surg2015，261，1： | 1 |
| 8 | Inflammation, chronic obstructive pulmonary disease and aging显示文摘 | Provinciali M Cardelli M Marchegiani F | 2011 | Curt Opin Pulm Med2011，17，1： | 1 |
| 9 | Recurrent mutations in the basic domain of TWIST2 cause AblepharonMacrostomia and Barber-Say syndromes显示文摘 | Marchegiani S Davis T Tessadori F | 2015 | Am J Hum Genet2015，97，2： | 1 |
| 10 | Radiological and surgical implications of neoadjuvant treatment with FOLFIRI- NOX for locally advanced and borderline resectable pancreatic cancer显示文摘 | Ferrone CR Marchegiani G Hong TS | 2015 | Ann Surg2015，261，1： | 1 |
| 11 | Children With Sensorineural Hearing Loss And Referral To Early Intervention 显示文摘 | Giordano T Marchegiani AM Germiller JA | 2015 | ORL Head Neck Nuts2015，33，3： | 1 |
| 12 | Credibility of Online Reviews and Initial Trust: The Roles of Reviewer's Identity and Review Valence显示文摘 | Kusumasondjaja S Shanka T Marchegiani C | 2012 | Journal of Vacation Marketing2012，18，3： | 1 |
| 13 | Polymorphic variants of insulin-like growth factor I(IGF-I)receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity:cues for an evolutionarily conserved mechanism of life span control显示文摘 | Bonafè M Barbieri M Marchegiani F | | 0，，07： | 1 |
| 14 | Polymorphic variants ofinsulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues foran evolutionarily conserved mechanism of life span control显示文摘 | BonafeM Barbieri M Marchegiani F | 2003 | J ClinEndocrinol Metab2003，88，： | 1 |
| 15 | Effects ofpersonal nostalgic response intensity on cogni-tions,attitudes,and intentions显示文摘 | Christopher Marchegiani Ian Phau | 2010 | Journal ofResearch in Interactive Marketing2010，，1： | 1 |
| 16 | Inflammation, chronic obstructive pulmonary disease and aging显示文摘 | Provinciali M Cardelli M Marchegiani F | 2011 | Curr Opin Pulm Med2011，17，1： | 1 |
| 17 | Awayfrom“unified nostalgia”:conceptual differencesof personal and historical nostalgia appeals inadvertising显示文摘 | Marchegiani Christopher Phau Ian | 2010 | Journal of Promotion Manage-ment2010，，1： | 1 |
| 18 | Pancreaticoduodenectomy for pancreatic cancer: The Verona experience 显示文摘 | Malleo G Marchegiani G Salvia R | 2011 | Surg Today2011，41，4： | 1 |
| 19 | Natural killer cell activity in patients with gynecologic malignancies: correlation with histologic grading and stage of disease 显示文摘 | Garzetti GG Cignitti M Marchegiani F | 1992 | Gynecol Obstet Invest1992，34，1： | 1 |
| 20 | Polymorphic variants of insulin-like growth factor 1 (IGF-1) receptor and phosphoinositide 3- kinase genes affect IGF-1 plasma levels and human longevity:cues for an evolutionarily conserved mechanism of life span control 显示文摘 | Bonafe M Barbiefi M Marchegiani F | 2003 | J Clin Endocrinol Metab2003，88，： | 1 |
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