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| 1 | Performance of liver stiffness measurements by transient elastography in chronic hepatitis显示文摘AIM:To compare results of liver stiffness measurements by transient elastography(TE) obtained in our patients population with that used in a recently published meta-analysis.METHODS:This was a single center cross-sectional study.Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled.TE was carried out by using FibroScan(Echosens,Paris,France).Liver biopsy was performed on the same day as TE,as day case procedure.Fibrosis was staged according to the Metavir scoring system.The diagnostic performance of TE was assessed by using receiver operating characteristic(ROC) curves and the area under the ROC curve analysis.RESULTS:Two hundred and fifty-two patients met the inclusion criteria.Six(2%) patients were excluded due to unreliable TE measurements.Thus,246(171 men and 75 women) patients were analyzed.One hundred and ninety-five(79.3%) patients had chronic hepatitis C,41(16.7%) had chronic hepatitis B,and 10(4.0%) were coinfected with human immunodeficiency virus.ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa forF ≥ 2;7.9 kPa forF ≥ 3;9.6 kPa for F = 4 in all patients(n = 246),and as high as 6.9 kPa for F ≥ 2;7.3 kPa for F ≥ 3;9.3 kPa for F = 4 in patients with hepatitis C(n = 195).Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2;9.6 kPa for F ≥ 3;12.2 kPa for F = 4 in all patients(n = 246),and as high as 7.0 kPa forF ≥ 2;9.3 kPa forF ≥ 3;12.3 kPa forF = 4 in patients with hepatitis C(n = 195).CONCLUSION:The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies. | Giovanna Ferraioli Carmine Tinelli Barbara Dal Bello Mabel Zicchetti Raffaella Lissandrin Gaetano Filice Carlo Filice Elisabetta Above Giorgio Barbarini Enrico Brunetti Willy Calderon Marta Di Gregorio Roberto Gulminetti Paolo Lanzarini Serena Ludovisi Laura Maiocchi Antonello Malfitano Giuseppe Michelone Lorenzo Minoli Mario Mondelli Stefano Novati Savino FA Patruno Alessandro Perretti Gianluigi Poma Paolo Sacchi Domenico Zanaboni Marco Zaramella | 2013 | World Journal of Gastroenterology2013，19，1： | 18 |
| 2 | NGR-tagged nano-gold: A new CD13-selective carrier for cytokine delivery to tumors显示文摘胶体的黄金(Au ) ,容忍得好的 nanomaterial,当前在 nanomedicine 为几个应用程序被利用。我们显示出与包含 Asn-Gly-Arg (NGR ) 的新奇肿瘤家肽标注的那金 nanoparticles, CD13 的 ligand 由肿瘤 neovasculature 表示了,能为 cytokine 交货作为搬运人被利用到肿瘤。生物化学、功能的研究证明为金 functionalization 使用的 NGR 分子的支架 / 连接器为 CD13 识别是批评的。用忍受纤维肉瘤的老鼠,标注 NGR 的 nanodrugs 能交付极其低,还肿瘤坏死因素(TNF ) 的 pharmacologically 活跃的剂量, anticancer cytokine,到没有毒性的证据的肿瘤。机械学的研究证实指向的 CD13 是药交货的主要机制并且排除了对 NGR deamidation 作为结果的指向的 integrin 的一个主要角色,产生 isoAsp-Gly-Arg (isoDGR ) 的降级反应 integrin ligand。原则上,标注 NGR 的金 nanoparticles 罐头为癌症治疗为 single-cytokine 或 multi-cytokine 交货被用作一个新奇平台到肿瘤 endothelial 房间。 | Flavio Curnis Martina Fiocch Angelina Sacchi Alessandro Gori Anna Gasparri Angelo Corti | 2016 | Nano Research2016，9，5： | 5 |
| 3 | Risk of postoperative recurrence and postoperative management of Crohn's disease显示文摘Crohn's disease (CD) is a chronic inflammatory disease of the digestive tract with systemic manifestations. Etiology is unknown, even if immunological, genetic and environmental factors are involved. The majority of CD patients require surgery during their lifetime due to progressive bowel damage, but, even when all macroscopic lesions have been removed by surgery, the disease recurs in most cases. Postoperative management represents therefore a crucial mean for preventing recurrence. Several drugs and approaches have been proposed to achieve this aim. Endoscopic inspection of the ileocolic anastomosis within 1 year from surgery is widely encouraged, given that endoscopic recurrence is one of the greatest predictors for clinical recurrence. A strategy should be planned only after stratifying patients according to their individual risk of recurrence, avoiding unnecessary therapies when possible benefits are reduced, and selecting high-risk patients for more aggressive intervention. | Antonino Spinelli Matteo Sacchi Gionata Fiorino Silvio Danese Marco Montorsi | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 4 | Multivariate statistical and GIS-based approach to identify heavy metal sources in soils显示文摘 | A Facchinelli E Sacchi L Mallen | 2001 | Environmental Pollution2001，，3： | 3 |
| 5 | Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis显示文摘 | Nardinocchi L Puca R Sacchi A | 2009 | Molecular Cancer2009，8，： | 1 |
| 6 | A review of the effect of winemaking techniques on phenolic extraction in red wines 显示文摘 | SACCHI KL BISSON LF ADAMS DO | 2005 | Am Soc Enol Vitieuit2005，56，3： | 1 |
| 7 | Activated Vgamma9Vdelta2Tcells trigger granulocyte functions via MCP-2release显示文摘 | Agrati C Cimini E Sacchi A Bordoni V Gioia C Casetti R Turchi F Tripodi M Martini F | 2009 | J Immunol2009，182，1： | 1 |
| 8 | Single step method of RNA isolation by acid guanidnium thiocyanate=phend-chloroform extraction 显示文摘 | chornczynski P Sacchi N | 1987 | Analytical Biochemistry1987，162，： | 1 |
| 9 | Single-step method of RNA isolation by acid guanidinium thioeyanate-phenol-chloroform extraction显示文摘 | Chomczynski P Sacchi N | | Anal Biochem0，162，： | 1 |
| 10 | A bootstrap procedure for high2resolution velocity analysis显示文摘 | Sacchi M D | 1998 | Geophysics1998，63，5： | 1 |
| 11 | The cost of treating relapsed indolent non-Hodgkin's lymphoma in an international setting: retrospective analysis of resource use显示文摘 | Herold M Sacchi S Hieke K | 2002 | Haematologica2002，87，7： | 1 |
| 12 | Single-step method of RNA isolation by acid guanidinium thicyanate-phenolchloroform extracton显示文摘 | Chomczynski P Sacchi N | 1987 | Analyti Biochem1987，162，： | 1 |
| 13 | The role of alpha-interferon in essential thrombocythaemia,polycythaemia vera and myelofibrosis with myeloid metaplasia (MMM):a concise update显示文摘 | Sacchi S Related | 1995 | Leuk Lymphoma1995，19，12： | 1 |
| 14 | Model re-weighted leastsquares Radon operators显示文摘 | Sacchi M D Ulrych T J | 1995 | Expanded Abstracts of 65^th Annual Internat SEG Mtg1995，，： | 1 |
| 15 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction显示文摘 | Chomczynski P Sacchi N | 1987 | Anal Biochem1987，162，： | 1 |
| 16 | Design Experimental Characterization of EDFA-based WDM Ring Networks with Free ASE Light Recirculation and Link Control for Network Survivabillty显示文摘 | Sacchi G Sugliani S Bogoni A | 2005 | IEEE Journal on Lightwave Technology2005，23，3： | 1 |
| 17 | 查看详情显示文摘 | Forlini F Fan Z Sacchi M | | 0，，： | 1 |
| 18 | Treatment of B-cell non-Hodgkin's lymphoma with anti CD 20 monoclonal antibody rituximab显示文摘 | SACCHI S FEDERICO M DASTOLI G | 2001 | Crit Rev Oncol Hematol2001，37，： | 1 |
| 19 | Single step method of RNA isolation by acid guanidinium thiocyanate-phenolchloro-form extration 显示文摘 | Choczyski P Sacchi N | 1987 | Analytical Biochemistry1987，102，： | 1 |
| 20 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction显示文摘 | Sacchi N | 1987 | Anal Biochem1987，162，： | 1 |
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