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| 1 | Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage显示文摘AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine the accuracy of MR imaging features in predicting their biological behavior.METHODS This study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 Pan NEN patients(29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTS Ill defined margins were more common in G2-3 and stage Ⅲ-Ⅳ PanN ENs than in G1 and low-stage tumors(P < 0.001); this feature had high specificity in the identification of G2-3 and stage Ⅲ-Ⅳ tumors(90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage Ⅲ-Ⅳ lesions compared to well differentiated and low-stage tumors(1.09 × 10-3 mm2/s vs 1.45 × 10-3 mm2/s and 1.10 × 10-3 mm2/s vs 1.53 × 10-3 mm2/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cutoffs of 1.21 and 1.28 × 10-3 mm2/s for the identification of G2-3 and stage Ⅲ-Ⅳ tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64%(95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSION MR features of PanN ENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors. | Riccardo De Robertis Sara Cingarlini Paolo Tinazzi Martini Silvia Ortolani Giovanni Butturini Luca Landoni Paolo Regi Roberto Girelli Paola Capelli Stefano Gobbo Giampaolo Tortora Aldo Scarpa Paolo Pederzoli Mirko D'Onofrio | 2017 | World Journal of Gastroenterology2017，23，2： | 16 |
| 2 | Implications of small-bowel transit time in the detection rate of capsule endoscopy: A multivariable multicenter study of patients with obscure gastrointestinal bleeding显示文摘AIM To define the role of small-bowel transit time in the detection rate of significant small-bowel lesions.METHODS Small-bowel capsule endoscopy records, prospectively collected from 30 participating centers in the Lombardy Registry from October 2011 to December 2013, were included in the study if the clinical indication was obscure gastrointestinal bleeding and the capsule reached the cecum. Based on capsule findings, we created two groups: P2(significant findings) and P0-1(normal/negligible findings). Groups were compared for age, gender, small-bowel transit time, type of instrument, modality of capsule performance(outpatients vs inpatients), bowel cleanliness, and center volume.RESULTS We retrieved and scrutinized 1,433 out of 2,295 capsule endoscopy records(62.4%) fulfilling the inclusion criteria. Patients were 67 ± 15 years old, and 815(57%) were males. In comparison with patients in the P0-1 group, those in the P2 group(n = 776, 54%) were older(P < 0.0001), had a longer small-bowel transit time(P = 0.0015), and were more frequently examined in low-volume centers(P < 0.001). Age and smallbowel transit time were correlated(P < 0.001), with age as the sole independent predictor on multivariable analysis. Findings of the P2 group were artero-venous malformations(54.5%), inflammatory(23.6%) and protruding(10.4%) lesions, and luminal blood(11.5%).CONCLUSION In this selected, prospectively collected cohort of small-bowel capsule endoscopy performed for obscure gastrointestinal bleeding, a longer small-bowel transit time was associated with a higher detection rate of significant lesions, along with age and a low center volume, with age serving as an independent predictor. | Carlo Maria Girelli Marco Soncini Emanuele Rondonotti | 2017 | World Journal of Gastroenterology2017，23，4： | 10 |
| 3 | Percutaneous ablation of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is a highly aggressive tumor with an overall 5-year survival rate of less than 5%. Prognosis and treatment depend on whether the tumor is resectable or not, which mostly depends on how quickly the diagnosis is made. Chemotherapy and radiotherapy can be both used in cases of nonresectable pancreatic cancer. In cases of pancreatic neoplasm that is locally advanced, non-resectable, but non-metastatic, it is possible to apply percutaneous treatments that are able to induce tumor cytoreduction. The aim of this article will be to describe the multiple currently available treatment techniques(radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation), their results, and their possible complications, with the aid of a literature review. | Mirko D'Onofrio Valentina Ciaravino Riccardo De Robertis Emilio Barbi Roberto Salvia Roberto Girelli Salvatore Paiella Camilla Gasparini Nicolò Cardobi Claudio Bassi | 2016 | World Journal of Gastroenterology2016，22，44： | 7 |
| 4 | Radiofrequency ablation of locally advanced pancreatic adenocarcinoma:An overview显示文摘Radiofrequency ablation(RFA)of pancreatic neoplasms is restricted to locally advanced,non-resectable but nonmetastatic tumors.RFA of pancreatic tumors is nowadays an ultrasound-guided procedure performed during laparotomy in open surgery.Intraoperative ultrasound covers the mandatory role of staging,evaluation of feasibility,guidance and monitoring of the procedure.Different types of needle can be used.The first aim in the evaluation of RFA as a treatment for locally advanced pancreatic ductal adenocarcinoma,in order of evaluation but not of importance,is to determine the feasibility of the procedure.The second aim is to establish the effect of RFA on tumoral mass in terms of necrosis andcytoreduction.The most important aim,third in order of evaluation,is the potential improvement of quality of life and survival rate.Nowadays,only a few studies assess the feasibility of the procedure.The present paper is an overview of RFA for pancreatic adenocarcinoma. | Mirko D’Onofrio Emilio Barbi Roberto Girelli Enrico Martone Anna Gallotti Roberto Salvia Paolo Tinazzi Martini Claudio Bassi Paolo Pederzoli Roberto Pozzi Mucelli | 2010 | World Journal of Gastroenterology2010，16，28： | 6 |
| 5 | Hepcidin modulation in human diseases: From research to clinic显示文摘By modulating hepcidin production, an organism controls intestinal iron absorption, iron uptake and mobilization from stores to meet body iron need. In recent years there has been important advancement in our knowledge of hepcidin regulation that also has implications for understanding the physiopathology of some human disorders. Since the discovery of hepcidin and the demonstration of its pivotal role in iron homeostasis, there has been a substantial interest in developing a reliable assay of the hormone in biological fluids. Measurement of hepcidin in biological fuuids can improve our understanding of iron diseases and be a useful tool for diagnosis and clinical management of these disorders. We reviewed the literature and our own research on hepcidin to give an updated status of the situation in this rapidly evolving fi eld. | Alberto Piperno Raffaella Mariani Paola Trombini Domenico Girelli | 2009 | World Journal of Gastroenterology2009，15，5： | 6 |
| 6 | First report of splenic rupture following deep enteroscopy显示文摘Splenic rupture is a rare complication of diagnostic and therapeutic gastrointestinal endoscopy procedures.Herein,we report for the first time a case of splenic rupture following therapeutic retrograde double-balloon enteroscopy,which occurred in an 85-year-old man who was treated for recurrent mid-intestinal bleeding that resulted from ileal angioectasia.This patient promptly underwent an operation and eventually recovered. | Carlo Maria Girelli Roberta Pometta Corinna Facciotto Roberto Mella Giordano Bernasconi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，9： | 3 |
| 7 | Dietary Iron Overload Induces Visceral Adipose Tissue Insulin Resistance显示文摘 | Paola Dongiovanni Massimiliano Ruscica Raffaela Rametta Stefania Recalcati Liliana Steffani Stefano Gatti Domenico Girelli Gaetano Cairo Paolo Magni Silvia Fargion Luca Valenti | 2013 | The American Journal of Pathology2013，，6： | 3 |
| 8 | Interaction between smoking and PON2 Ser311Cys polmorphism as a determinant of the risk of myocardial infaretion显示文摘 | Matinelli M Girelli D Olivieri O | 2004 | Eur J Clin Invest2004，34，1： | 1 |
| 9 | Methylenetetrahydrofolate reductase C677T mutation,plasma homocysteine,and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease:evidence for an important genetic-environmental interaction显示文摘 | Girelli D Friso S Trabetti E | 1998 | Blood1998，91，： | 1 |
| 10 | Small bowel cap- sule endoscopy in clinical practice: a multicenter 7-year survey 显示文摘 | Rondonotti E Soncini M Girelli C | 2010 | Eur J Gastroenterol Hepatol2010，22，11： | 1 |
| 11 | Sleep disorders in advanced cancer patients: prevalence and factors associated显示文摘 | Mercadante S Girelli D Casuceio A | 2004 | Support Care Cancer2004，12，5： | 1 |
| 12 | A common mutation in the 5, 10-methylenetetrahydro folate reductase gene affects genomic DNA methylation through an interaction with folate status 显示文摘 | Friso S Choi SW Girelli D | 2002 | Proc Nat Acad Sci USA2002，99，8： | 1 |
| 13 | ALOX5AP gene variants and risk of coronary artery disease: an angiography- based study显示文摘 | Girelli D Maxtinelli N Trabetti E | 2007 | Eur J Hun Genet2007，15，9： | 1 |
| 14 | Modulation of factor Ⅶ levels byintron 7 polymorphlsm: populantion and in vitro stodles显示文摘 | Pinotti M Toso R Girelli D | 2000 | Blood2000，95，11： | 1 |
| 15 | FADS genotypes and de saturase activity estimated by the ratio of arachidonic acid to lino leic acid are associated with inflammation and coronary artery dis ease显示文摘 | Martinelli N Girelli D Malerba G | 2008 | Am J Clin Nutr2008，88，4： | 1 |
| 16 | Human vasculogenesisex vivo:embryonal aorta as a tool for isolation of endothelial cell progenitors显示文摘 | Girelli M Taccagni G | 2001 | Lab Invest2001，81，： | 1 |
| 17 | Isolation and characterization of neural stem cells,from the adult human olfactory bulb显示文摘 | Pagano SF Impagnatiello F Girelli M | 2000 | Stem Cells2000，18，4： | 1 |
| 18 | A common mutation in the 5,10-methyl enetetrahydro folate reductase gene affects genomic DNA methylation through an interaction with folate status显示文摘 | Friso S Choi SW Girelli D | 2002 | Proc Natl Acad Sci U S A2002，99，8： | 1 |
| 19 | Clinical outcome of patients examined by capsule endoscopy for suspected small bowel Crohn' s disease显示文摘 | GIRELLI CM PORTA P MALACRIDA V | 2007 | Dig Liver Dis2007，39，2： | 1 |
| 20 | New high performance phos-phites显示文摘 | Costanzi S Farris R Girelli D | 2001 | Polymer Degradation and Stability2001，73，3： | 1 |
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