|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Accuracy of magnetic resonance cholangiography compared to operative endoscopy in detecting biliary stones, a single center experience and review of literature显示文摘AIM: To compare diagnostic sensitivity, specificity and accuracy of magnetic resonance cholangiopancreatography(MRCP) without contrast medium and endoscopic ultrasound(EUS)/endoscopic retrograde cholangiopancreatography(ERCP) for biliary calculi. METHODS: From January 2012 to December 2013, two-hundred-sixty-three patients underwent MRCP at our institution, all MRCP procedure were performed with the same machinery. In two-hundred MRCP was done for pure hepatobiliary symptoms and these patients are the subjects of this study. Among these two-hundred patients, one-hundred-eleven(55.5%) underwent ERCP after MRCP. The retrospective study design consisted in the systematic revision of all images from MRCP and EUS/ERCP performed by two radiologist with a long experience in biliary imaging, an experienced endoscopist and a senior consultant in Hepatobiliopancreatic surgery. A false positive was defined an MRCP showing calculi with no findings at EUS/ERCP; a true positive was defined as a concordance between MRCP and EUS/ERCP findings; a false negative was defined as the absence of images suggesting calculi at MRCP with calculi localization/extraction at EUS/ERCP and a true negative was defined as a patient with nocalculi at MRCP ad at least 6 mo of asymptomatic followup. Biliary tree dilatation was defined as a common bile duct diameter larger than 6 mm in a patient who had an in situ gallbladder. A third blinded radiologist who examined the MRCP and ERCP data reviewed misdiagnosed cases. Once obtained overall data on sensitivity, specificity, accuracy, positive predictive value(PPV) and negative predictive value(NPV) we divided patients in two groups composed of those having concordant MRCP and EUS/ERCP(Group A, 72 patients) and those having discordant MRCP and EUS/ERCP(Group B, 20 patients). Dataset comparisons had been made by the Student's t-test and χ2 when appropriate.RESULTS: Two-hundred patients(91 men, 109 women, mean age 67.6 years, and range 25-98 years) underwent MRCP. All patients attended regular follow-up for at least 6 mo. Morbidity and mortality related to MRCP were null. MRCP was the only exam performed in 89 patients because it did show only calculi into the gallbladder with no signs of the presence of calculi into the bile duct and symptoms resolved within a few days or after colecistectomy. The patients remained asymptomatic for at least 6 mo, and we assumed they were true negatives. One hundred eleven(53 men, 58 women, mean age 69 years, range 25-98 years) underwent ERCP following MRCP. We did not find any difference between the two groups in terms of race, age, and sex. The overall median interval between MRCP and ERCP was 9 d. In detecting biliary stones MRCP Sensitivity was 77.4%, Specificity 100% and Accuracy 80.5% with a PPV of 100% and NPV of 85%; EUS showed 95% sensitivity, 100% specificity, 95.5% accuracy with 100% PPV and 57.1% NPV. The association of EUS with ERCP performed at 100% in all the evaluated parameters. When comparing the two groups, we did not find any statistically significant difference regarding age, sex, and race. Similarly, we did not find any differences regarding the number of extracted stones: 116 stones in Group A(median 2, range 1 to 9) and 27 in Group B(median 2, range 1 to 4). When we compared the size of the extracted stones we found that the patients in Group B had significantly smaller stones: 14.16 ± 8.11 mm in Group A and 5.15 ± 2.09 mm in Group B; 95% confidence interval = 5.89-12.13, standard error = 1.577; P < 0.05. We also found that in Group B there was a significantly higher incidence of stones smaller than 5 mm: 36 in Group A and 18 in Group B, P < 0.05.CONCLUSION: Major finding of the present study is that choledocholithiasis is still under-diagnosed in MRCP. Smaller stones(< 5 mm diameter) are hardly visualized on MRCP. | Francesco A Polistina Mauro Frego Marco Bisello Emy Manzi Antonella Vardanega Bortolo Perin | 2015 | World Journal of Radiology2015，7，4： | 14 |
| 2 | Neoadjuvant strategies for pancreatic cancer显示文摘Pancreatic cancer(PC)is the fourth cause of cancer death in Western countries,the only chance for long term survival is an R0 surgical resection that is feasible in about 10%-20%of all cases.Five years cumulative survival is less than 5%and rises to 25%for radically resected patients.About 40%has locally advanced in PC either borderline resectable(BRPC)or unresectable locally advanced(LAPC).Since LAPC and BRPC have been recognized as a particular form of PC neoadjuvant therapy(NT)has increasingly became a valid treatment option.The aim of NT is to reach local control of disease but,also,it is recognized to convert about40%of LAPC patients to R0 resectability,thus providing a significant improvement of prognosis for responding patients.Once R0 resection is achieved,survival is comparable to that of early stage PCs treated by upfront surgery.Thus it is crucial to look for a proper patient selection.Neoadjuvant strategies are multiples and include neoadjuvant chemotherapy(nCT),and the association of nCT with radiotherapy(nCRT)given as either a combination of a radio sensitizing drug as gemcitabine or capecitabine or and concomitant irradiation or as upfront nCT followed by nRT associated to a radio sensitizing drug.This latter seem to be most promising as it may select patients who do not go on disease progression during initial treatment and seem to have a better prognosis.The clinical relevance of nCRT may be enhanced by the application of higher active protocols as FOLFIRINOX. | Francesco Polistina Giuseppe Di Natale Giorgio Bonciarelli Giovanni Ambrosino Mauro Frego | 2014 | World Journal of Gastroenterology2014，20，28： | 3 |
| 3 | Ultrasonic aspiration in the surgical treatment of intracranial tumors 显示文摘 | Zeme S Frego L Gunetti R | 1981 | J Neurosurg Sci1981，25，1： | 1 |
| 4 | Surgical treatment of ureteral obstruction from edometriosis:our experience with thirteen cases显示文摘 | Antonelli A Simeone C Frego E | 2004 | Int Urogynecol Jpelvic Floor Dysfunct2004，15，： | 1 |
| 5 | Ureteral endometriosis:urological features显示文摘 | Frego E Antonelli A Tralce L | 2002 | Arch Ital Urol Androl2002，74，1： | 1 |
| 6 | Abdominal aortic aneurysm with coexistent horseshoe kidney显示文摘 | Frego M Bianchera G Angriman I | 2007 | Surg Today2007，37，7： | 1 |
| 7 | Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis显示文摘AIM: To focus on the role of CD40 and CD40L in their pathogenesis.METHODS: We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CD40 by B lymphocytes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy controls.RESULTS: Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlatedwith the presence of spondyloarthropathy, but not with pouchitis, or inflammatory indices.CONCLUSION: High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations. | Lino Polese Imerio Angriman Giuseppe De Franchis Attilio Cecchetto Giacomo C.Sturniolo Renata D'Incà Marco Scarpa Cesare Ruffolo Lorenzo Norberto Mauro Frego Davide F D'Amico | 2005 | World Journal of Gastroenterology2005，11，34： | 1 |
| 8 | Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy显示文摘 | Francesca D’Addio Stefano La Rosa Anna Maestroni Peter Jung Elena Orsenigo Moufida Ben Nasr Sara Tezza Roberto Bassi Giovanna Finzi Alessandro Marando Andrea Vergani Roberto Frego Luca Albarello Annapaola Andolfo Roberta Manuguerra Edi Viale Carlo Staudac | 2015 | Cell Stem Cell2015，，4： | 1 |
| 9 | Ureteral endometriosis: urological features 显示文摘 | Frego E Antonelli A Tralce L | 2002 | Arch Ital Urol Androl2002，74，1： | 1 |
| 10 | Ureteral endometriosis:urological features显示文摘 | Frego E Antonelli A Tralce L Micheli E Cunico SC | 2003 | Urol Clin North Am2003，29，6： | 1 |
| 11 | Endovascuiar treat- ment of acute pseudoaneurysm associated to pancreaticoduo- denectomy 显示文摘 | Frego M Bern M Broiese A | 2009 | Hepatogastroenteroiogy2009，56，96： | 1 |
| 12 | Surgical treatment of ureteral obstruction from endometriosis:our experience with thirteen case显示文摘 | Antonelli A Simeone C Frego E | 2004 | Int Urolgynecol J Pelvic Floor Dysfunct2004，15，6： | 1 |
| 13 | Ruptured aneurysms of the abdominal aortic: from the First Aid to the Operating Room 显示文摘 | Frego M Bianchera G Angriman I | 2007 | Ann Ital Chir2007，78，4： | 1 |
| 14 | Ureteral endome- triosis: urological features 显示文摘 | Frego E Antonelli A Tralce L | 2002 | Arch Ital Urol Androl2002，74，1： | 1 |
| 15 | Surgical treatment of ureteral obstruction from endometriosis: our experience with thirteen cases显示文摘 | Antonelli A Simeone C Frego E | 2004 | Int Urogynecol J Pelvic Floor Dysfunct2004，15，6： | 1 |
| 16 | Ruptured aneurysms of the abdominal aorta : from the first aid to the operating room 显示文摘 | Frego M Biancheras G Angriman I | 2007 | Ann hal chir2007，78，4： | 1 |
| 17 | Surgical treatment of ureteral obstruction from endometriosis: our experience with thirteen cases 显示文摘 | Antonelli A Simeone C Frego E | 2004 | Int Urogynecol J Pelvic Floor Dysfunct2004，15，6： | 1 |
| 18 | Endovascular treatment of acute pseudoaneurysm associated to pancreaticoduodenectomy 显示文摘 | Frego M Bertin M Brolese A | 2009 | Hepato- gastroenterology2009，56，96： | 1 |
| 19 | Ruptured aneurysms of the abdominal aorta: from the First Aid to the Operating Room 显示文摘 | Frego M Biancheras G Angriman I | 2007 | Ann Ital Chir2007，78，4： | 1 |
| 20 | Surgical treatment of ureteral obstruction from endometiosis:our experience with thirteen cases显示文摘 | Antonelli A Simeone C Frego E | | 0，，06： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员