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| 1 | 经腹机器人辅助腹腔镜肾部分切除术治疗T2期肾肿瘤的国际多中心临床研究显示文摘目的通过国际多中心研究探讨临床T2期肾肿瘤行经腹机器人辅助腹腔镜肾部分切除术的安全性及有效性。方法回顾性分析2012年1月至2017年12月国际19家泌尿中心378例临床T2期肾肿瘤行经腹机器人肾部分切除术和经腹机器人根治性肾切除术患者的临床资料。根据手术方式不同,分为部分切除组和根治组。部分切除组159例,男118例,女41例;年龄(59.3±13.2)岁,体重指数(28.7±5.4) kg/m^2,术前GFR (77.3±22.1)ml/min;肿瘤位于左侧72例,右侧87例;肿瘤直径(83±16)mm;R.E.N.A.L.评分(8.6±2.2)分。根治组219例,男156例,女63例;年龄(62.0±12.9)岁,体重指数(28.7±6.1) kg/m^2,术前GFR (71.4±20.3)ml/min;肿瘤位于左侧112例,右侧105例,双侧2例;肿瘤直径(92±25)mm;R.E.N.A.L.评分(9.7±1.5)分。两组患者性别、体重指数、肿瘤位置的差异均无统计学意义(P〉0.05)。部分切除组患者年龄、肿瘤直径、R.E.N.A.L.评分均低于根治组(P〈0.05),术前GFR优于根治组(P=0.012)。比较两组围手术期资料、肿瘤病理类型、随访时间、复发时间及术后GFR等。结果378例手术均顺利完成。部分切除组手术时间中位值150 min(65-353 min),短于根治组[180 min(85-361 min),P〈0.001],术中出血量中位值150 ml(40-3 000 ml),多于根治组[100 ml (10-1 100 ml),P〈0.001]。术中并发症发生率部分切除组为5.7%(9/159),根治组为3.2%(7/219),两组差异无统计学意义(P=0.240)。部分切除组术后并发症发生率高于根治组[19.5%(31/159)与10.5%(23/219),P=0.014],但≥3级并发症发生率的差异无统计学意义[4.4%(7/159)与2.3%(5/219),P=0.246]。部分切除组无复发生存率高于根治组[91.4%(117/128)与81.9%(167/204),P=0.013]。部分切除组术后GFR降低值16.9 ml/min(10.4-84.7 ml/min)明显少于根治组29.0 ml/min(14.0-54.0 ml/min),肾部分切除术更利于术后肾功能的保护(P〈0.001)。结论临床T2期肾肿瘤行机器人肾部分切除术可获得有效的肿瘤控制率,同时可以更好地保护肾功能,可作为临床T2期肾肿瘤有效的手术方式。 | 过菲 张超 王富博 王林辉 杨庆 叶华茂 吕晨 肖成武 汪洋 Giuseppe Simone Ithaar Derweesh Andrea Minervini Daniel Eun Francesco Porpiglia Sisto Perdona James Porter Matteo Ferro Alexandre Mottrie Robert Uzzo Luigi Schips Wesley White Ken Jacobsohn Prokar Dasgupta Riccardo Autorino Clayton Lau Chandru Sundaram Umberto Capitanio 孙颖浩 杨波 | 2018 | 中华泌尿外科杂志2018，39，6： | 8 |
| 2 | Comparisons between glucose analogue 2-deoxy-2-(^(18)F)fluoro-D-glucose and ^(18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions显示文摘AIM: To compare 2-deoxy-2-(^(18)F)fluoro-D-glucose(^(18)FFDG) and ^(18)F-sodium(^(18)F-NaF) positron emission tomography/computed tomography(PET/CT) accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases.METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent ^(18)F-FDG and ^(18)F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year. For each technique we calculated: Sensitivity(Se), specificity(Sp), overall accuracy, positive and negative predictive values, error rate, and Youden's index. Mc Nemar's χ~2 test was used to test the difference in sensitivity and specificity between the two diagnostic methods. All analyses were computed on a patient basis, and then on a lesion basis, with consideration ofthe density of independent lesions on the coregistered CT(sclerotic, lytic, mixed, no-lesions) and the divergent site of disease(skull, spine, ribs, extremities, pelvis). The impact of adding ^(18)F-Na F PET/CT to the work-up of patients was also measured in terms of change in their management due to ^(18)F-Na F PET/CT findings. RESULTS: The two imaging methods of ^(18)F-FDG and ^(18)F-fluoride PET/CT were significantly different at the patient-based analysis: Accuracy was 86.7% and 84.4%, respectively(Mc Nemar's χ~2 = 6.23, df = 1, P = 0.01). Overall, 244 bone lesions were detected in our analysis. The overall accuracy of the two methods was significantly different at lesion-based analysis(Mc Nemar's χ~2 = 93.4, df = 1, P < 0.0001). In the lesion density-based and site-based analysis, ^(18)F-FDG PET/CT provided more accurate results in the detection of CT-negative metastasis(P < 0.002) and vertebral localizations(P < 0.002); ^(18)F-Na F PET/CT was more accurate in detecting sclerotic(P < 0.005) and rib lesions(P < 0.04). ^(18)F-Na F PET/CT led to a change of management in 3 of the 45 patients(6.6%) by revealing findings that were not detected at ^(18)F-FDG PET/CT. CONCLUSION: ^(18)F-FDG PET/CT is a reliable imaging tool in the detection of bone metastasis in most cases, with a diagnostic accuracy that is slightly, but significantly, superior to that of ^(18)F-Na F PET/CT in the general population of breast cancer patients. However, the extremely high sensitivity of ^(18)F-fluoride PET/CT can exploit its diagnostic potential in specific clinical settings(i.e., small CT-evident sclerotic lesions, high clinical suspicious of relapse, and negative ^(18)F-FDG PET and conventional imaging). | Selene Capitanio Francesca Bongioanni Arnoldo Piccardo Claudio Campus Roberta Gonella Lucia Tixi Mehrdad Naseri Michele Pennone Vania Altrinetti Ambra Buschiazzo Irene Bossert Francesco Fiz Andrea Bruno Andrea DeCensi Gianmario Sambuceti Silvia Morbelli | 2016 | World Journal of Radiology2016，8，2： | 3 |
| 3 | Nephron-sparing Surgery Is Equally Effective to Radical Nephrectomy for T1BN0M0 Renal Cell Carcinoma: A Population-based Assessment显示文摘 | Maxime Crépel Claudio Jeldres Paul Perrotte Umberto Capitanio Hendrik Isbarn Shahrokh F. Shariat Daniel Liberman Maxine Sun Giovanni Lughezzani Philippe Arjane Hugues Widmer Markus Graefen Francesco Montorsi Jean-Jacques Patard Pierre I. Karakiewicz | 2010 | Urology2010，，： | 2 |
| 4 | Increased expression of specific thioredoxin family proteins; a pilot immtmohistochemical study on human hepatocellular carcinoma显示文摘 | Cunnea P Fernandes AP Capitanio A | 2007 | Int J Immunopathol Pharmacol2007，20，： | 1 |
| 5 | Rearing environment and hypothalamic-pituitary-adrenal regulation in young rhesus monkeys (Macaca mulatta) 显示文摘 | CAPITANIO J P MENDOZA S P MASON W A | 2005 | Developmental Psychobiology2005，46，： | 1 |
| 6 | Increased expression of specific thioredoxin family proteins; a pilot immunohistochernical study on human hepatocellulm' carcinoma显示文摘 | Cunnea P Fernandes AP Capitanio A | 2007 | lnt J lmmunopathol Pharmacol2007，20，1： | 1 |
| 7 | HIV-related stigma and knowledge in the United States: prevalence and trends, 1991-1999 显示文摘 | Herek GM Capitanio JP Widaman KF | 2002 | Am J PublicHealth2002，92，3： | 1 |
| 8 | HIVrelated stigma andknowledge in the united state:Prevalence and trends,1991-1999显示文摘 | HEREK GM CAPITANIO JP WIDAMAN KF | 2002 | Am J Public Health2002，92，3： | 1 |
| 9 | Dynamic models of downgoing plate-buoyancy driven subduction: Subduction motions and energy dissipation 显示文摘 | Capitanio F A Morra G Goes S | 2007 | Earth and Planetary Science Letters2007，262，： | 1 |
| 10 | Differential detection of B virus and rhesus cytomegalovirus in rhesus macaques显示文摘 | Huff J L Eberle R Capitanio J | 2003 | J Gen Virol2003，84，1： | 1 |
| 11 | Acne and smoking显示文摘 | Capitanio B Sinagra JL Ottaviani M | 2009 | Der- mato- Endocrinology2009，1，5： | 1 |
| 12 | Acneiform follicular mucinosis of the head and neck region 显示文摘 | Muscardin LM Capitanio B Concetta FM | 2003 | Eur J Dermatol2003，13，2： | 1 |
| 13 | Cortisol responses to immobilization with Telazol or ketarnine in baboons (Papio eynocephalus/anubis) and rhesus macaques (Macaca mulatta) 显示文摘 | BENTSON K L CAPITANIO J P MENDOZA S P | 2003 | Journal of Medical Primatology2003，32，3： | 1 |
| 14 | Influence of obesity on tumour volume in patients with prostate cancer显示文摘 | CAPITANIO U SUARDI N BRIGANTI A | 2012 | BJU Int2012，109，5： | 1 |
| 15 | early roentgen observations in acute osteomyelitis显示文摘 | Kirkpatrick JA | 1970 | Am J Roentgenol Radium Ther Nucl Med1970，108，： | 1 |
| 16 | DisWibutions generated by perturba- tion of symmetry with emphasis on a multivariate skew t-dis- tribution显示文摘 | A Azzalini A Capitanio | 2003 | Journal of the Royal Statistical Society: Series B (Statistical Methodology)2003，65，2： | 1 |
| 17 | Mitochondrial oxidative stress and respiratory chain dysfunction account for liver toxicity during amiodarone but not dronedarone administration显示文摘 | Gaetano Serviddio Francesco Bellanti Anna Maria Giudetti Gabriele Vincenzo Gnoni Nazzareno Capitanio Rosanna Tamborra Antonino Davide Romano Maurizio Quinto Maria Blonda Gianluigi Vendemiale Emanuele Altomare | 2011 | Free Radical Biology and Medicine2011，，12： | 1 |
| 18 | Hepatitis C virus,mitochondria and auto/mitophagy:Exploiting a host defense mechanism显示文摘Hepatitis C virus(HCV)is the major reason for liver transplantation and the main cause of liver-related morbidity and mortality in a great number of countries.As for the other viruses,this pathogen interferes in more than one process and in more than one way with host cell biology.A mounting body of evidence points,in particular,toward the drastic alterations of mitochondrial physiology and functions that virus is able to induce,albeit the mechanisms have partly remained elusive.Role of the mitochondria in immunity and in quality control systems,as autophagy,as well as the strategies that HCV has evolved to evade and even to manipulate mitochondrial surveillance for its benefit,highlights the importance of deepening the mechanisms that modulate this virus-mitochondrion interaction,not only to intensify our knowledge of the HCV infection pathogenesis but also to design efficient antiviral strategies. | Vitalba Ruggieri Carmela Mazzoccoli Valerio Pazienza Angelo Andriulli Nazzareno Capitanio Claudia Piccoli | 2014 | World Journal of Gastroenterology2014，20，10： | 1 |
| 19 | Comparison of oncologic outcomes for open and laparoscopic nephroureterectomy , a multi-institutional analysis of 1249 cases显示文摘 | Capitanio U Shariat SF Isbarn H | 2009 | EurUrol2009，56，1： | 1 |
| 20 | Parenchyma-Preserving Resections for Small Nonfunctioning Pancreatic Endocrine Tumors显示文摘 | Massimo Falconi MD Alessandro Zerbi MD Stefano Crippa MD Gianpaolo Balzano MD Letizia Boninsegna MD Vanessa Capitanio MD Claudio Bassi MD Valerio Di Carlo MD Paolo Pederzoli MD | 2010 | Annals of Surgical Oncology2010，，6： | 1 |
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