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| 1 | Overweight and obesity in hip and knee arthroplasty:Evaluation of 6078 cases显示文摘AIM: To evaluate a possible association between thevarious levels of obesity and peri-operative characteristics of the procedure in patients who underwent endoprosthetic joint replacement in hip and knee joints. METHODS: We hypothesized that obese patients were treated for later stage of osteoarthritis, that more conservative implants were used, and the intraand perioperative complications increased for such patients. We evaluated all patients with body mass index(BMI) ≥ 25 who were treated in our institution from January 2011 to September 2013 for a primary total hip arthroplasty(THA) or total knee arthroplasty(TKA). Patients were split up by the levels of obesity according to the classification of the World Health Organization. Average age at the time of primary arthroplasty, preoperative Harris Hip Score(HHS), Hospital for Special Surgery score(HSS), gender, type of implanted prosthesis, and intra-and postoperative complications were evaluated.RESULTS: Six thousand and seventy-eight patients with a BMI ≥ 25 were treated with a primary THA or TKA. Age decreased significantly(P < 0.001) by increasing obesity in both the THA and TKA. HHS and HSS were at significantly lower levels at the time of treatment in the super-obese population(P < 0.001). Distribution patterns of the type of endoprostheses used changed with an increasing BMI. Peri- and postoperative complications were similar in form and quantity to those of the normal population. CONCLUSION: Higher BMI leads to endoprosthetic treatment in younger age, which is carried out at significantly lower levels of preoperative joint function. | Daniel Guenther Stefan Schmidl Till O Klatte Harald K Widhalm Mohamed Omar Christian Krettek Thorsten Gehrke Daniel Kendoff Carl Haasper | 2015 | World Journal of Orthopedics2015，6，1： | 4 |
| 2 | Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants显示文摘The 1,4-naphthoquinones(1,4-NQs)are a diverse group of natural products found in every kingdom of life.Plants,including many horticultural species,collectively synthesize hundreds of specialized 1,4-NQs with ecological roles in plant–plant(allelopathy),plant–insect and plant–microbe interactions.Numerous horticultural plants producing 1,4-NQs have also served as sources of traditional medicines for hundreds of years.As a result,horticultural species have been at the forefront of many basic studies conducted to understand the metabolism and function of specialized plant 1,4-NQs.Several 1,4-NQ natural products derived from horticultural plants have also emerged as promising scaffolds for developing new drugs.In this review,the current understanding of the core metabolic pathways leading to plant 1,4-NQs is provided with additional emphasis on downstream natural products originating from horticultural species.An overview on the biochemical mechanisms of action,both from an ecological and pharmacological perspective,of 1,4-NQs derived from horticultural plants is also provided.In addition,future directions for improving basic knowledge about plant 1,4-NQ metabolism are discussed. | Joshua R Widhalm David Rhodes | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Probiotika in der Pr?vention der Antibiotika-induzierten Diarrh?显示文摘 | A. Eser F. Thalhammer F. Burghuber C. H?genauer F. Stockenhuber C. Wenisch K. Widhalm W. Reinisch | 2012 | Z Gastroenterol2012，，10： | 2 |
| 4 | Evaluating patterns of co-operation:Application of a bibliometric visualization tool to the Fourth Framework Programme and the Transport Research Programme显示文摘 | Widhalm C Toplnik M Kopesa A | 2001 | Research Evaluation2001，10，： | 1 |
| 5 | Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia 显示文摘 | Widhalm G Dietrich W Mullauer L | 2006 | J Neurosurg2006，105，6： | 1 |
| 6 | Relationship between body fat distribution and blood lipids in obese adolescents显示文摘 | Zwiauer K Widhalm K Kerbl B | 1990 | Int J Obes1990，14，3： | 1 |
| 7 | Diet does not ensure normal development in galactosemia 显示文摘 | Widhalm K Miranda da Cruz B D Koch M | 1997 | J Am Coll Nutr1997，16，3： | 1 |
| 8 | Optimal in plane orbital evasive maneuvers using continuous low thrust propulsion显示文摘 | Widhalm J W Heise S A | 1991 | Journal of Guidance Control and Dynamics1991，14，6： | 1 |
| 9 | Underestimation of percentage fat mass measured by bioelectrical impedance analysis compared to dual energy X-ray absorptiometry method in obese children 显示文摘 | Eisenkolbl J Kartasurya M Widhalm K | 2001 | Eur J Clin Nutr2001，55，6： | 1 |
| 10 | Long-term follow-up of 12 patients with the late-onset variant of argi- ninosuccinic acid lyase deficiency: no impairment of in- tellectual and psychomotor development during therapy 显示文摘 | Widhalm K Koch S Scheibenreiter S | 1992 | Pediatrics1992，89，62： | 1 |
| 11 | ALK gene translocations and amplifications in brain metastases of non-small cell lung cancer显示文摘 | Matthias Preusser Anna S. Berghoff Ayseguel Ilhan-Mutlu Manuel Magerle Carina Dinhof Georg Widhalm Karin Dieckmann Christine Marosi Adelheid W?hrer Monika Hackl Sabine Z?chbauer-Müller Andreas von Deimling Sebastian F. Schoppmann Christoph C. Zielinski Be | 2013 | Lung Cancer2013，，： | 1 |
| 12 | The association between nonalcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents显示文摘 | Widhalm K | 2007 | Acta Paediatr2007，96，1： | 1 |
| 13 | Value of 1 H-magnetic reso- nance spectroscopy chemical shift imaging for de-tection of anaplastic fo- ci in diffusely infiltrating gliomas with non-significant contrast enhance- ment 显示文摘 | Widhalm G Krssak M Minchev G | 2011 | J Neurol Neurosurg Psychiatry2011，82，5： | 1 |
| 14 | 来自于极早期发作性心肌梗死患病家族的儿童和青少年中ApoB-100及ApoB/ApoA-1的比值显示文摘Aim: The relationship between apolipoprotein B, LDL/ApoB,ApoB/ApoA-1, lipids and a family history of very early myocardial infarction (parent and/or grandparent < 45 years) was studied in 46 children compared with 64 controls. Methods:19 children came out of families with a myocardial infarction(MI) of the father and 27 children with MI of a grandparent. Results:In the whole risk group LDL-C,ApoB and ApoB/ApoA-1 ratio showed the most significant relationship, whereas in children from families with MI of the father ApoB level showed the strongest association with family history of MI. No relationship could be found for ApoA1, HDL-C and LDL/ApoB.Conclusio-n: Our results show that levels of ApoB, LDL-C and ApoB/ApoA-1 might be better predictors in children from families of very early MI as compared with ApoA-1, HDL-C and LDL/ApoB. | Dirisamer A. Stadler A. Bucek R.A. Widhalm K. 李开 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，0，11： | 1 |
| 15 | Does the BMI re- flect body fat in obese children and adolescents? A study using the TO- BEC method 显示文摘 | Widhalm K SchoEnegger K Huemer C & Auterith A | 2001 | International Journal of Obesity2001，25，： | 1 |
| 16 | O ( 6 ) -methylguanine in nonfunctioning pituitary adenomas: are progressive tumors potential candidates for temozolomide treatment? 显示文摘 | Widhalm G Wolfsberger S Preusser M DNA methyltransferase | 2009 | Cancer2009，115，5： | 1 |
| 17 | The value of intraoperative motor evoked potential monitoring during surgical intervention for thoracic idiopathicspinal cord herniation显示文摘 | Novak K Widhalm G de Camargo AB | 2012 | J Neurosurg Spine2012，16，2： | 1 |
| 18 | The association between nonalcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents显示文摘 | Ciba I Widhalm K | 2007 | Acta Paediatr2007，96，1： | 1 |
| 19 | Value of lh-mag- netic resonance spectroscopy chemical shift imaging for detection of anaplastic loci in diffusely infiltrating gliomas with non-signif- icant contrast-enhancement 显示文摘 | Widhalm G Krssak M Minchev G | 2011 | Journal of neurology neuro- surgery and psychiatry2011，82，5： | 1 |
| 20 | A chiral phosphepine- olefin rhodium complex as an efficient catalyst for the asymmetric conjugate addition显示文摘 | Kas6k P Arion V B Widhalm M | 2006 | Tetrahedron :Asymme- try2006，17，22： | 1 |
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