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| 1 | Clinical efficacy of the over-the-scope clip device: A systematic review显示文摘BACKGROUND The over-the-scope clip(OTSC)system has been increasingly utilized as a nonsurgical option to endoscopically manage refractory gastrointestinal(GI)hemorrhage,perforations/luminal defects and fistulas.Limited data exist evaluating the efficacy and safety of OTSC.AIM To determine the clinical success and adverse event(AE)rates of OTSC across all GI indications.METHODS A PubMed search was conducted for eligible articles describing the application of the OTSC system for any indication in the GI tract.Any article or case series reporting data for less than 5 total patients was excluded.The primary outcome was the rate of clinical success.Secondary outcomes included:Technical success rate,OTSC-related AE rate and requirement for surgical intervention despite-OTSC placement.Pooled rates(per-indication and overall)were calculated as the number of patients with the event of interest divided by the total number of patients.RESULTS A total of 85 articles met our inclusion criteria(n=3025 patients).OTSC was successfully deployed in 94.4%of patients(n=2856/3025).The overall rate of clinical success(all indications)was 78.4%(n=2371/3025).Per-indication clinical success rates were as follows:(1)86.0%(1120/1303)for GI hemorrhage;(2)85.3%(399/468)for perforation;(3)55.8%(347/622)for fistulae;(4)72.6%(284/391)for anastomotic leaks;(5)92.8%(205/221)for defect closure following endoscopic resection(e.g.,following endoscopic mucosal resection or endoscopic submucosal dissection);and(6)80.0%(16/20)for stent fixation.AE’s related to the deployment of OTSC were only reported in 64 of 85 studies(n=1942 patients),with an overall AE rate of 2.1%(n=40/1942).Salvage surgical intervention was required in 4.7%of patients(n=143/3025).CONCLUSION This systematic review demonstrates that the OTSC system is a safe and effective endoscopic therapy to manage GI hemorrhage,perforations,anastomotic leaks,defects created by endoscopic resections and for stent fixation.Clinical success in fistula management appears limited.Further studies,including randomized controlled trials comparing OTSC with conventional and/or surgical therapies,are needed to determine which indication(s)are the most effective for its use. | Nicholas Bartell Krystle Bittner Vivek Kaul Truptesh H Kothari Shivangi Kothari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Practical strategies for increasing efficiency and effectiveness in critical care education显示文摘Technological advances and evolving demands inmedical care have led to challenges in ensuring adequate training for providers of critical care. Reliance on the traditional experience-based training model alone is insufficient for ensuring quality and safety in patient care. This article provides a brief overview of the existing educational practice within the critical care environment. Challenges to education within common daily activities of critical care practice are reviewed. Some practical evidence-based educational approaches are then described which can be incorporated into the daily practice of critical care without disrupting workflow or compromising the quality of patient care. It is hoped that such approaches for improving the efficiency and efficacy of critical care education will be integrated into training programs. | Maurice F Joyce Sheri Berg Edward A Bittner | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 3 | Vitamin C in the critically ill-indications and controversies显示文摘Ascorbic acid(vitamin C) elicits pleiotropic effects in thebody. Among its functions, it serves as a potent antioxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that highdose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential. | Christoph S Nabzdyk Edward A Bittner | 2018 | World Journal of Critical Care Medicine2018，7，5： | 3 |
| 4 | LAPAROSCOPIC HERNIOPLASTY显示文摘这篇来自德国的文章 ,作者是德国微创外科学会主席、南德外科学会主席 ,德国《外科胃肠病学杂志》主编BITTNER教授。他及他的同事共计施行了腹腔镜疝修补术近 1万例 ,取得了巨大的成就 ,目前在腹外疝的微创外科治疗领域中处于世界领先地位。作者的这篇文章是专为本刊而作 ,文章中有许多新概念、新理论和新技术 。 | Bittner R Leibl BJ Kraft K Schmedt CG | 2003 | 实用临床医药杂志2003，7，5： | 3 |
| 5 | Cell biology of molybdenum显示文摘 | Ralf R. Mendel Florian Bittner | 2006 | BBA - Molecular Cell Research2006，，7： | 2 |
| 6 | 前蛋白转化酶枯草溶菌素9变异、低密度脂蛋白胆固醇与神经认知功能损害的关系显示文摘尽管之前的研究引发了对抑制前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexintype9,PCSK9)造成神经认知功能损害事件的关注,但近期一个第3期随机试验并没有发现药物性PCSK9抑制与神经认知损害有关。 | 黄洁 叶鹏 Mefford MT Rosenson RS Cushman M Farkouh ME McClure LA Wadley VG Irvin MR Bittner VA Safford MM Somaratne R Monda KL Muntner P Levitan EB | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 7 | 2013年美国心脏病学会/美国心脏协会胆固醇管理指南在美国心脏病学实践中的应用显示文摘2013年美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)胆固醇管理指南建议在符合治疗标准的患者中采用中等强度至高强度他汀类药物治疗。该研究的目的在于审查2013年ACC/AHA指南在美国心脏病学实践中的应用情况。 | 刘莉 叶鹏 Pokharel Y Tang F Jones PG Nambi V Bittner VA Hira RS Nasir K Chan PS Maddox TM Oetgen WJ Heidenreich PA Borden WB Spertus JA Petersen LA Ballantyne CM Virani SS | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 8 | Blood-brain barrier modeling: challenges and perspectives显示文摘The blood-brain barrier(BBB)forms a highly selective interface between blood and brain.Extensive research efforts have completely changed our view of the BBB in the last years,from a static,impermeable barrier to a dynamic,highly regulated and specific cellular system.The BBB ultrastructurally consists of specialized brain microvascular endothelial cells(BMEC)characterized by low pinocytic activity,absent fenestrations and expression of specific and polarized transcellular transport systems.BMECs are interconnected by protein complexes consisting of tight and adherens junctions leading to high electrical resistance and low paracellular permeability.Attached | Tobias Ruck Stefan Bittner Sven G.Meuth | 2015 | Neural Regeneration Research2015，10，6： | 2 |
| 9 | Prospective evaluation of the hemorrhoid energy treatment for the management of bleeding internal hemorrhoids显示文摘BACKGROUND The hemorrhoid energy treatment(HET)system is a non-surgical bipolar electrotherapy device,which has previously demonstrated efficacy in the management of bleeding Grade I and II internal hemorrhoids;however,data is limited.AIM To prospectively assess the safety and efficacy of the HET device.METHODS This was an IRB-approved prospective study of 73 patients with Grade I or II internal hemorrhoids who underwent HET from March 2016 to June 2019.Patient factors and procedural data were obtained.A post-procedure questionnaire was administered by telephone to all patients at 1-wk and 3-mo following HET to assess for improvement and/or resolution of rectal bleeding and adherence to a stool softener regimen.A chart review was performed to observe recurrent symptoms and durability of response.Statistical analyses were performed using SPSS software(IBM;SPSS Version 25.0).RESULTS Seventy-three patients underwent HET during the study period.Mean post-HET follow-up was 1.89 years.Complete resolution of bleeding was reported in 65%at 1 wk(n=48),with improvement in bleeding in 97.2%(n=71)of patients.At 3-mo,resolution and/or improvement in bleeding was reported in 90%(n=64)of patients.No procedure-related pain or adverse events were reported.CONCLUSION HET is well tolerated,safe and highly effective in the majority of our patients presenting with Grade I and II symptomatic internal hemorrhoids. | Truptesh H Kothari Krystle Bittner Shivangi Kothari Vivek Kaul | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，8： | 2 |
| 10 | Vagueness and rough location显示文摘 | BITTNER T STELL J G | 2002 | Geoinformatica2002，6，2： | 2 |
| 11 | Comparison of endoscopic procedures vs Lichtenstein and other open mesh techniques for inguinal hernia repair, a meta-analysis of randomized controlled trials显示文摘 | SCHMEDT CG SAUERLAND S BITTNER R | 2004 | Surg Endosc2004，12，2： | 1 |
| 12 | Bovine serum albumin loaded poly (lactide-co-glycolide) microspheres, the influence of polymer purity on particle charaeteristies显示文摘 | BITTNER B RONNEBERGER B ZANGE R etal | 1998 | J Microencapsul1998，15，4： | 1 |
| 13 | Intensive lipid lowering with atorvastatin in patients with coronary heart disease and chronic kidney disease: the TNT (Treating to New Targets ) study 显示文摘 | Shepherd J Kastelein J J Bittner V | 2008 | J Am Coil Cardiol2008，51，15： | 1 |
| 14 | Biotemplate synthesis of 3nm nickel and cobalt nanowires显示文摘 | Kenz M Bittner A M Boes F | 2003 | Nano Lett2003，3，8： | 1 |
| 15 | Recombinant human erythropoietin(rHEPO)loaded poly-(lactide-co-glycolide)microspheres:influence of theencapsulation technique and polymer purity on microspheres characteristics显示文摘 | BITTNER B MORLOCK M KOLL H G | 1998 | Eur J Pharm Biopharm1998，45，： | 1 |
| 16 | Impact of Solutol HS 15 on the pharmacokinetic behavior of midazolam upon intravenous administration to male Wistar rats 显示文摘 | Bittner B Bravo Gonzalez RC lsel H | 2003 | Eur J Pharm Biopharm2003，56，： | 1 |
| 17 | Expression profiling using cD2 NA microarrays显示文摘 | Duggan DJ Bittner M Chen Y | 1999 | Nat Genet1999，21，1： | 1 |
| 18 | Quality criteria for treatment of colorectal cancer:From a surgeon's viewpoint显示文摘 | Link KH Kommann M Bittner R | 2010 | Chirurg2010，81，3： | 1 |
| 19 | Expression profiling using cDNA microarrays显示文摘 | Duggan DJ Bittner M Chen Y | 1999 | Nat Genet1999，21，1： | 1 |
| 20 | Perspectives on dyslipidemia and coronary heartdisease in women显示文摘 | Bittner V | 2005 | J Am Coll Cardiol2005，46，9： | 1 |
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