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| 1 | 极高强度他汀治疗对冠状动脉粥样硬化消退的影响——ASTEROID试验显示文摘背景:以前的血管内超声(intravascular ultrasound,IVUS)试验证实,他汀治疗可减缓或阻止动脉粥样硬化的进展,但是迄今尚无应用动脉粥样斑块体积百分比(percent atheroma volume,PAV)证实粥样硬化消退的确切证据。PAV是最严格的评价病变进展和消退的IVUS测量指标。
目标:评价极高强度他汀治疗是否能逆转IVUS确定的冠状动脉粥样硬化。
设计和地点:于美国、加拿大、欧洲和澳大利亚53个社区和3级保健中心进行前瞻性开标盲法终点试验(A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden,ASTEROID)。应用马达驱动回撤IVUS评价基线和治疗24个月时冠状动脉粥样斑块负荷。每对基线和随访IVUS测量结果均进行盲法分析。
病例:从2002年11月到2003年10月,507例患者有基线IVUS检查结果,并接受至少1个剂量的研究药物。在24个月后,349例患者具有可用于评估的系列IVUS检查结果。
干预:所有患者均接受瑞舒伐他汀40ms/d强化治疗。
主要观测指标:预先设定了两个一级疗效指标:PAV变化和基线最严重病变10min节段动脉粥样斑块体积变化。二级疗效指标为整个动脉标准化总斑块体积的变化。结果:平均(SD)LDL—C水平由基线时的130.4(34.3)ms/dL降至60.8(20.0)ms/扎,平均下降了53.2%(P〈0.001)。平均(SD)HDL-C水平从基线时的43.1(11.1)ms/dL升至49.0(12.6)ms/dL,平均增加了14.7%(P〈0.001)。整个血管PAV平均(SD)变化为-0.98%(3.15%),中位数为-0.79%(97.5%CI,-1.21%~-0.53%)(与基线比较,P〈0.001)。最严重病变10min节段斑块体积平均(SD)变化为-6.1(10.1)mm^3,中位数为-5.6mm^3(97.5%CI,-6.8~-4.0mm^3)(与基线比较,P〈0.001)。总斑块体积变化中位数降低了6.8%,平均减少了-14.7(25.7)mm^3,中位数为-12.5mm^3(95%CI,-15.1~-10.5mm^3)(与基线比较,P〈0.001)。不良事件少见,与其他他汀试验相似。
结论:应用瑞舒伐他汀40ms/d进行极高强度他汀治疗可使LDL-C平均水平达到60.8ms/dL,使HDL—C增加14.7%。这导致所有3个预先设定的IVUS斑块负荷指标均显示动脉粥样硬化消退。因此,将LDL-C降至低于目前指南规定的水平,同时显著提高HDL-C,可以使冠心病患者动脉粥样硬化斑块消退。这些变化对临床预后的影响尚需进一步研究确定。 | Steven E. Nissen Stephen J. Nicholls Ilks Sipahi Peter Libby Joel S. Raichlen Christie M. Ballantyne Jean Davignon Raimund Erbel Jean Charles Fruchart Jean-Claude Tardif Paul Schoenhagen Tim Crowe Valerie Cain Kathy Wolski Marlene Coormastic E. Murat Tuzcu 仝其广(译) 王淑敏(译) 胡大一(校) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 341 |
| 2 | The clinical impact of bacterial biofilms显示文摘Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis. | Niels Hoiby Oana Ciofu Helle Krogh Johansen Zhi-jun Song Claus Moser Peter Ostrup Jenser Soren Molin Michael Givskov Tim Tolker-Nieisen Thomas Bjamsholt | 2011 | International Journal of Oral Science2011，3，2： | 48 |
| 3 | Drought Responses of Leaf Tissues from Wheat Cultivars of Differing Drought Tolerance at the Metabolite Level显示文摘干旱在谷物庄稼的生理学上有严肃的效果。在细胞并且明确地代谢物水平,许多单个混合物被增加提供 osmoprotective 功能,并且减少,阻止酶的分离在房间在场的反应的氧种类的数字。我们使用了一条指向的 GCMS 途径识别在忍耐的不同层次在干旱应力下面描绘到干旱的面包小麦的三不同栽培变种不同的混合物(反曲刀的一种,偏狭;Excalibur 和 RAC875,容忍) 。氨基酸,最尤其是脯氨酸,色氨酸,和分叉的链氨基酸白氨酸,异白氨酸,和缬氨酸的层次在所有栽培变种在干旱应力下面被增加。在二容忍的栽培变种,在很多器官的酸的小减少也是明显的。Excalibur,栽培变种 genotypically 与反曲刀的一种有关,显示出更类似于在浇得好的条件下面的反曲刀的一种的反应的一个模式。在干旱应力下面, Excalibur 和 RAC875 有类似的回答;然而, Excalibur 没有象 RAC875 的反应的一样的大小。这里,结果在以前的工作的上下文被讨论在生理并且在干旱应力下面的这些栽培变种的 proteomic 分析。 | Jairus B. Bowne Tim A. Erwin Juan Juttner Thorsten Schnurbusch Peter Langridge Antony Bacic Ute Roessner | 2012 | Molecular Plant2012，5，2： | 25 |
| 4 | Molecular markers of phase transition in locusts显示文摘提炼伴随转变从的变化对在蝗虫的独居的阶段状态群居是那么激烈的很长时间,这些阶段被看作不同种类。是鲍里斯·乌瓦罗夫介绍了 polyphenism 的概念。研究的十年表明阶段转变在 morphometry,表皮的颜色,行为和生理学的几个方面暗示变化。在最近的十年,特别地,相当很多分子的研究被承担了揭开阶段相关的差别。他们导致了新奇卓见进 corazonin 的角色, neuroparsins,一些朊酶禁止者, phenylacetonitrile 等等。蝗虫的 EST 数据库的来临(例如坑等, 2004 ) 是在生理、行为的蝗虫研究的很令人鼓舞的新奇开发。然而,最吸引人的问题的答案,也就是是否有阶段转变的初发的分子的 inducer,在不久的将来可能不在活动范围以内。 | ARNOLD DE LOOF ILSE CLAEYS GERT SIMONET PETER VERLEYEN TIM VANDERSMISSEN FILIP SAS JURGEN HUYBRECHTS | 2006 | Insect Science2006，13，1： | 3 |
| 5 | A RANDOMIZED TRIAL COMPARING TRANSURETHRAL RESECTION OF THE PROSTATE, LASER THERAPY AND CONSERVATIVE TREATMENT OF MEN WITH SYMPTOMS ASSOCIATED WITH BENIGN PROSTATIC ENLARGEMENT: THE CLasP STUDY显示文摘 | JENNY L. DONOVAN TIM J. PETERS DAVID E. NEAL SARA T. BROOKES SANDEEP GUJRAL K. NINAN CHACKO MARK WRIGHT L. GAIL KENNEDY PAUL ABRAMS | 2000 | The Journal of Urology2000，，1： | 3 |
| 6 | Optimal Contraction Intensity During Proprioceptive Neuromuscular Facilitation for Maximal Increase of Range of Motion显示文摘 | Peter W Sheard Tim J Paine | 2010 | Journal of Strength and Conditioning Research2010，，2： | 2 |
| 7 | Characterization of a spruce budworm chitin deacetylase gene: Stage- and tissue-specific expression, and inhibition using RNA interference显示文摘 | Guoxing Quan Tim Ladd Jun Duan Fayuan Wen Daniel Doucet Michel Cusson Peter J. Krell | 2013 | Insect Biochemistry and Molecular Biology2013，，8： | 2 |
| 8 | Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity显示文摘Dear Editor,Next-generation sequencing revealed that the majority of the human genome is transcribed but has no coding function.It is estimated that.30000 long noncoding RNAs(lncRNAs)are expressed in humans,but their functions are largely unknown(Suckau et al.,2009;Rinn and Chang,2012;Poller et al.,2013).Consideration of noncoding genomic elements in pathogenetic studies is warranted and enabled by technological advances allowing comprehensive transcriptome mapping of protein-coding genes as well as small and long ncRNAs. | Martina Gast Blanche Schroen Antje Voigt Jan Haas Uwe Kuehl Dirk Lassner Carsten Skurk Felicitas Escher Xiaomin Wang Adelheid Kratzer Katharina Michalik Anna Papageorgiou Tim Peters Madlen Loebel Sabrina Wilk Nadine Althof Kannanganattu VPrasanth Hugo Katus Benjamin Meder Shinichi Nakagawa Carmen Scheibenbogen Heinz-Peter Schultheiss Ulf Landmesser Stefanie Dimmeler Stephane Heymans Wolfgang Poller | 2016 | Journal of Molecular Cell Biology2016，8，2： | 2 |
| 9 | Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g显示文摘 | Junius Salendo Melanie Spitzner Frank Kramer Xin Zhang Peter Jo Hendrik A. Wolff Julia Kitz Silke Kaulfu? Tim Bei?barth Matthias Dobbelstein Michael Ghadimi Marian Grade Jochen Gaedcke | 2013 | Radiotherapy and Oncology2013，，： | 2 |
| 10 | Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g<!-- MicroRNA chemoradiosensitivity signature -->显示文摘 | Junius Salendo Melanie Spitzner Frank Kramer Xin Zhang Peter Jo Hendrik A. Wolff Julia Kitz Silke Kaulfu? Tim Bei?barth Matthias Dobbelstein Michael Ghadimi Marian Grade Jochen Gaedcke | 2013 | Radiotherapy and Oncology2013，，： | 2 |
| 11 | High frequency of t(11;18) in gastric mucosa‐associated lymphoid tissue lymphomas in Taiwan, including one patient with high‐grade transformation显示文摘 | Shih‐SungChuang ChuanLee Rifat A.Hamoudi HongxiangLiu Po‐ShingLee HongtaoYe Tim C.Diss AhmetDogan Peter G.Isaacson Ming‐QingDu | 2002 | British Journal of Haematology2002，，1： | 1 |
| 12 | Association Between Acute Statin Therapy, Survival, and Improved Functional Outcome After Ischemic Stroke: The North Dublin Population Stroke Study显示文摘 | Danielle Ní Chróinín Elizabeth L. Callaly Joseph Duggan áine Merwick Niamh Hannon órla Sheehan Michael Marnane Gillian Horgan Emma B. Williams Dawn Harris Lorraine Kyne Patricia M.E. McCormack Joan Moroney Tim Grant David Williams Leslie Daly Peter J. Kel | 2011 | Stroke2011，，： | 1 |
| 13 | Generation of activated and antigen-specific T cells with cytotoxic activity after co-culture with dendritic cells显示文摘 | Angela M?rten Tim Greten Carsten Ziske Sabine Renoth Bj?rn Sch?ttker Peter Buttgereit Frank Schakowski Alexander von Rücker Tilman Sauerbruch Ingo G. Schmidt-Wolf | 2002 | Cancer ImmunologyImmunotherapy2002，，1： | 1 |
| 14 | Influence of moisture content and temperature on methane adsorption isotherm analysis for coals from a low-rank, biogenically-sourced gas reservoir显示文摘 | Peter J. Crosdale Tim A. Moore Tennille E. Mares | 2008 | International Journal of Coal Geology2008，，1： | 1 |
| 15 | Overcoming barriers to innovation and diffusion of cleaner technologies:some features of a sustainable innovation policy regime:Journal of Cleaner Production显示文摘 | Tim Foxon Peter Pearson | 2008 | (16):148-1612008，，16： | 1 |
| 16 | Long-term retrograde amnesia… the crucial role of the hippocampus显示文摘 | Lisa Cipolotti Tim Shallice Dennis Chan Nick Fox Rachel Scahill Gail Harrison John Stevens Peter Rudge | 2001 | Neuropsychologia2001，，2： | 1 |
| 17 | Financial Risk Measurement for Financial Risk Management显示文摘 | Torben G. Andersen Tim Bollerslev Peter F. Christoffersen Francis X. Diebold | 2013 | Handbook of the Economics of Finance2013，，： | 1 |
| 18 | The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells显示文摘 | Collin R B Tim E Peter P | 2006 | J Immunol2006，176，： | 1 |
| 19 | Glycosylation and the Immune System 显示文摘 | Pauline M Rudd Tim Elliott Peter Cresswell | 2001 | Science2001，291，： | 1 |
| 20 | Influence of moisture con- tent and temperature on methane adsorption isotherm analy- sis for coals from a low-rank,biogenically sourced gas reser- voir显示文摘 | Peter J C Tim A M Tennille E M | 2008 | International Journal of Coal Geology2008，76，1： | 1 |
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