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| 1 | Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis显示文摘BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe hypertriglyceridemia.METHODS:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum triglycerides.The APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being taken.The patients' progression,etiological diagnosis,hospital stay and clinical and radiological severity were all recorded.RESULTS:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) origin.Compared with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes mellitus.They usually consumed alcohol or consumed it excessively on the days before admission.Also,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption. | Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos Pedro González-Santos Pedro Valdivielso | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 26 |
| 2 | 典型黑土区村级尺度侵蚀沟演变显示文摘侵蚀沟的演变是东北水土流失过程的重要方面。利用1968和2009年亚米级遥感影像,获取典型黑土区村级尺度的侵蚀沟分布、耕地垄向和土地利用数据,基于1∶1万地形图获取等高线、坡度、坡长和垄向坡度数据,在地理信息系统和遥感技术的支持下,分析典型黑土区41 a村级尺度侵蚀沟的动态变化及其影响因素。结果表明:1)41 a间,典型黑土区侵蚀沟密度有明显增加的趋势,基于分辨率为亚米级遥感影像解译的侵蚀沟密度较以往研究结果大幅增加;2)自然坡度0.25°~1.5°范围内为该区域侵蚀沟密度变化最大的区域,8°以上区域由于实施退耕还林措施,侵蚀沟密度降低;3)300~500 m坡长区域侵蚀沟密度出现极值;4)由于实施改垄措施,41 a后垄向坡度在0~0.25°范围内耕地面积增加,大于0.25°范围内耕地面积均减少。 | 李浩 张兴义 刘爽 Yury Kravchenko Kateryna Ivanova 李续峰 陈强 | 2012 | 中国水土保持科学2012，10，2： | 17 |
| 3 | Use of Sorghum Crops for in Situ Phytoremediation of Polluted Soils显示文摘 | V. R. Angelova R. V. Ivanova V. A. Delibaltova K. I. Ivanov | 2011 | Journal of Agricultural Science and Technology(A)2011，1，5： | 10 |
| 4 | Modelling of microbial enhanced oil recovery application using anaerobic gas-producing bacteria显示文摘Microbial enhanced oil recovery(MEOR) methods apply injection of bacteria to depleted oil reservoirs to produce oil, which had remained unrecovered after the conventional methods of production. The ability of thermophilic anaerobic bacteria to produce gas as the main mechanism in potential MEOR in high salinities of 70-100 g/L was investigated in this study. Maximum gas production of up to 350 mL per 700 mL of salty solution was produced at a salinity of 90 g/L stably during 2-4 days of experiment. The experimental results were upscaled to the Snorre Oilfield, Norway, and simulated using ECLIPSE software for 27 months. The best scenarios showed that the increase in oil recovery on average was at 21% and 17.8% respectively. This study demonstrated that anaerobic bacteria used in biogas plants could be an attractive candidate for MEOR implementation due to their ability to withstand high temperature and salinity, and produce gas in large volumes. | Pavel Spirov Yanina Ivanova Svetlana Rudyk | 2014 | Petroleum Science2014，11，2： | 4 |
| 5 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 6 | Overproduction of reactive oxygen species–obligatory or not for induction of apoptosis by anticancer drugs显示文摘Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species(ROS) and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS-independent pathways. We try to answer the question: 'Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues?' The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress. | Donika Ivanova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Tatsuya Higashi | 2016 | Chinese Journal of Cancer Research2016，28，4： | 3 |
| 7 | Chronic overexpression of PNPLA3^sup I148M^ in mouse liver causes hepatic steatosis显示文摘 | Li John Zhong Huang Yongcheng Karaman Ruchan Ivanova Pavlina T Brown H Alex Roddy Thomas Castro-Perez Jose Cohen Jonathan C Hobbs Helen H | 2012 | EN2012，，11： | 3 |
| 8 | Identification of Molecular Subtypes of Gastric Cancer with Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil显示文摘 | Zhengdeng Lei Iain Beehuat Tan Kakoli Das Niantao Deng Hermioni Zouridis Sharon Pattison Clarinda Chua Zhu Feng Yeoh Khay Guan Chia Huey Ooi Tatiana Ivanova Shenli Zhang Minghui Lee Jeanie Wu Anna Ngo Sravanthy Manesh Elisabeth Tan Bin Tean Teh Jimmy Bok | 2013 | Gastroenterology2013，，： | 2 |
| 9 | Assessing Drought Vulnerability of Bulgarian Agriculture through Model Simulations显示文摘 | Zomitsa Popova Maria Ivanova Luis Santos Pereira Vesselin Alexandrov Katerina Doneva Petra Alexandrova Milena Kercheva | 2012 | Journal of Environmental Science and Engineering(B)2012，1，8： | 2 |
| 10 | Porous Structure, Salt Component Distribution and Catalytic Preference of Zinc Acetate Catalysts for Vinylacetate Synthesis on Modified Carbon Supports显示文摘 | Hoang Kim Bong Oleg Naumovich Temkin Hoang Huu Binh Dorina Ivanova Yamandiy | 2011 | Journal of Chemistry and Chemical Engineering2011，5，5： | 2 |
| 11 | Technological properties of candidate probiotic Lactobacillus plantarum strains显示文摘 | Ralitsa Georgieva Ilia Iliev Thomas Haertlé Jean-Marc Chobert Iskra Ivanova Svetla Danova | 2009 | International Dairy Journal2009，，11： | 2 |
| 12 | Intimal pericytes as the second line of immune defence in atherosclerosis显示文摘Inflammation plays an essential role in the development of atherosclerosis. The initiation and growth of atherosclerotic plaques is accompanied by recruitment of inflammatory and precursor cells from the bloodstream and their differentiation towards pro-inflammatory phenotypes. This process is orchestrated by the production of a number of pro-inflammatory cytokines and chemokines. Human arterial intima consists of structurally distinct leaflets, with a proteoglycan-rich layer lying immediately below the endothelial lining. Recent studies reveal the important role of stellate pericyte-like cells(intimal pericytes) populating the proteoglycan-rich layer in the development of atherosclerosis. During the pathologic process, intimal pericytes may participate in the recruitment of inflammatory cells by producing signalling molecules and play a role in the antigen presentation. Intimal pericytes are also involved in lipid accumulation and the formation of foam cells. This review focuses on the role of pericytelike cells in the development of atherosclerotic lesions. | Ekaterina A Ivanova Yuri V Bobryshev Alexander N Orekhov | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 13 | Synchroni zation of motor units in human soleus muscle during standing postural tasks显示文摘 | G MOCHIZUKI T D IVANOVA S J GARLAND | 2005 | J Neurophysiol2005，，2： | 1 |
| 14 | Cylindrical GaAs quantum wires incorporated within chrysotile asbestos nanotubes : Fabrication and polarized optical absorption spectra显示文摘 | Poborchii V V Ivanova M S Salamatina I A | 1994 | Superlattices and Microstructures1994，16，2： | 1 |
| 15 | On the microwave digestion of soils and sediments for determination of lanthanides and some toxic and essential elements by inductively coupled plasma source mass spectrometry 显示文摘 | IVANOVA J DJINGOVA R KORHAMMER S | 2001 | Talanta2001，14，2： | 1 |
| 16 | Vagus nerve stimulationattenuates the systemic inflammatory responses to endotoxin显示文摘 | Borovikova LV Ivanova S Zhang M | 2000 | Nature2000，405，6785： | 1 |
| 17 | A new preparation method for the formation of gold nanoparticles on an oxide support显示文摘 | IVANOVA S PETIT C PITCHON V | 2004 | Appl Catal A:General2004，267，： | 1 |
| 18 | Formation and Investigation of Sol-Gel TiO2-V2O5 System 显示文摘 | Ivanova T Harizanova A Surtchev M | 2002 | Materials Letters2002，55，5： | 1 |
| 19 | Synthesis and catalytic properties of hierarchical micro/mesoporous materials based on FER zeolite 显示文摘 | Khitev Yu P Kolyagin Yu G Ivanova I I | 2011 | Microporous Mesoporous Mater2011，146，13： | 1 |
| 20 | Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin 显示文摘 | Borovikova LV Ivanova S Zhang M | 2000 | Nature2000，405，6785： | 1 |
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