|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cellular and molecular mechanisms in the pathogenesis of liver fibrosis:An update显示文摘There have been considerable recent advances towards a better understanding of the complex cellular and molecular network underlying liver fibrogenesis.Recent data indicate that the termination of fibrogenic processes and the restoration of deficient fibrolytic pathways may allow the reversal of advanced fibrosis and even cirrhosis.Therefore,efforts have been made to better clarify the cellular and molecular mechanisms that are involved in liver fibrosis.Activation of hepatic stellate cells(HSCs)remains a central event in fibrosis,complemented by other sources of matrix-producing cells,including portal fibroblasts,fibrocytes and bone marrow-derived myofibroblasts.These cells converge in a complex interaction with neighboring cells to provoke scarring in response to persistent injury.Defining the interaction of different cell types,revealing the effects of cytokines on these cells and characterizing the regulatory mechanisms that control gene expression in activated HSCs will enable the discovery of new therapeutic targets.Moreover,the characterization of different pathways associated with different etiologies aid in the development of disease-specific therapies.This article outlines recent advances regarding the cellular and molecular mechanisms involved in liver fibrosis that may be translated into future therapies.The pathogenesis of liver fibrosis associated with alcoholic liver disease,non-alcoholic fatty liver disease and viral hepatitis are also discussed to emphasize the various mechanisms involved in liver fibrosis. | Gülsüm ?zlem Elpek | 2014 | World Journal of Gastroenterology2014，20，23： | 82 |
| 2 | Clinical role and importance of fluorescence in situ hybridization method in diagnosis of H pylori infection and determination of clarithromycin resistance in H pylori eradication therapy显示文摘H pylori is etiologically associated with gastritis, gas-tric and duodenal ulcers, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Eradicating H pylori may convert rapidly the outcome of related diseases with the use of more accurate diagnostic molecular tests. Indeed some of the tests cannot give the evidence of current infection; H pylori can be detected by noninvasive and invasive methods, the latter requiring an endoscopy. Eradication failure is a big problem in H pylori infection. Recently, clarithromycin resistance in H pylori strains is increasing and eradicati-on therapy of this bacterium is becoming more difficult. Molecular methods have frequently been applied besides phenotypic methods for susceptibility testing to detect clarithromycin resistance due to mutations in the 2143 and 2144 positions of 23S rRNA gene. Fluorescence in situ hybridization (FISH) method on paraffin embedded tissue is a rapid, accurate and cost-effective method for the detection of H pylori infection and to determine clarithromycin resistance within three hours according to the gold standards as a non-culture method. This method can also be applied to fresh biopsy samples and the isolated colonies from a culture of H pylori, detecting both the culturable bacillary forms and the coccoid forms of H pylori, besides the paraffin embedded tissue secti-ons. This technique is helpful for determining the bac-terial density and the results of treatment where clarith-romycin has been widely used in populations to increase the efficacy of the treatment and to clarify the treatment failure in vitro. | zlem Yilmaz Ebru Demiray | 2007 | World Journal of Gastroenterology2007，13，5： | 10 |
| 3 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis显示文摘AIM:To investigate the significance of Thrombospondin-1 (TSP-1) expression and its relationship with angiogenesis during experimental fibrosis. METHODS:Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN). The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS:Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis (GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P < 0.05). Moreover, TSP-1 expression was found to be correlated with angiogenesis (P < 0.05). CONCLUSION:The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 (TGF-β1), TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver. | Gülsüm zlem Elpek Güzide Ayse Gkhan Sevgi Bozova | 2008 | World Journal of Gastroenterology2008，14，14： | 7 |
| 4 | An unusual cause of cholecystitis:Heterotopic pancreatic tissue in the gallbladder显示文摘Gallbladder localization of heterotopic pancreas (HP) is uncommon and very rarely gives rise to symptoms. Herein we report a case of HP found in the gallbladder neck presented with signs and symptoms of cholecystitis. The patient was a 40-year old male, suffering from epigastric pain, abdominal fullness and fever. On physical examination, the right upper abdomen was tender with a positive Murphy’s sign. Ultrasonographic examination showed a hydropic gallbladder without stones and he underwent a cholecystectomy. Pathological examination revealed an intramural nodule (9 mm) in the neck region which is consisted of acini, ducts and islet cells of an aberrant pancreatic tissue. Although HP is encountered rarely in the gallbladder and is found incidentally during pathological studies, this case emphasizes that HP might cause symptoms and present clinically as cholecystitis. For this reason, in patients presenting with symptomatic gallbladder diseases, including cholecystitis without any other pathology, HP should be taken into consideration before it is diagnosed as 'idiopathic’’. | Glsm zlem Elpek Sevgi Bozova Gkben Y■d■r■m Kpesiz Mehmet ■■ | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 5 | Adhesion and fatigue properties of Ti/TiB2/MoS2 graded-composite coatings deposited by closed-field unbalanced magnetron sputtering显示文摘 | Faruk Bidev (o)zlem Baran Ersin Arslan | | 0，，： | 1 |
| 6 | Erythrocyte Membrane Anionic Content and Urinary Glycosaminoglycan Excretion in Type 1 Diabetes: Association with Retinopathy显示文摘 | ? zlem Yenice Haluk Kazoko&gbreve lu Eda ? zcan Meral Yü ksel G? ksenin Adigü zel Goncagü l Haklar Dilek Gogas Yavuz | 2006 | Current Eye Research2006，，11： | 1 |
| 7 | Effect of Angiotensin-converting Enzyme Inhibition on Experimental Hepatic Fibrogenesis显示文摘 | Cansel Türkay ?zlem Y?nem Sema Ar?c? Ayhan Koyuncu Mehmet Kanbay | 2008 | Digestive Diseases and Sciences2008，，3： | 1 |
| 8 | Effect of Microwaves on Some Gram Negative and Gram Positive Bacteria显示文摘 | GEDIKLI S TABAK?ZGE TOMSUK?ZLEM | 2008 | Journal of Applied Biological Sciences2008，2，1： | 1 |
| 9 | Saponins:Properties,applications and processing显示文摘 | Gü(c)lü-(U)stünda(O)zlem Mazza G | 2007 | Crit Rev Food Sci2007，47，3： | 1 |
| 10 | Effect of MDR modulators vempamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells 显示文摘 | Yaprak DN Laila AO Zlem D | 2011 | Cancer Chemother Pharmacol2011，67，2： | 1 |
| 11 | The physicochemical, microbiological, organoleptic properties and antioxidant activities of functional cream cheeses fortified with lutein显示文摘 | ?zlem Toku?o?lu | 2013 | Int J Dairy Technol2013，，4： | 1 |
| 12 | Diagnostie and prognostic value of procalcitonin and sTREM-I levels in sepsis 显示文摘 | Halim B zlem T Melek | 2015 | Turk J Med Sci2015，45，3： | 1 |
| 13 | Prognostic Importance of Fibroblast Growth Factor-23 in Dialysis Patients显示文摘 | Nilgül Akalin Y?ld?z Okuturlar ?zlem Harmankaya Asuman Ged?kba?i Sel?uk Sez?kl? Sibel Ko?ak Yücel Laszlo Rosivall | 2014 | International Journal of Nephrology2014，，： | 1 |
| 14 | Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK显示文摘 | Neufert Clemens Becker Christoph Türeci ?zlem Waldner Maximilian J Backert Ingo FIoh Katharina Atreya lmke Leppkes Moritz Jefremow Andre Vieth Michael Schneider-Stock Regine Klinger Patricia Greten Florian R Threadgill David W Sahin Ugur Ne | 2013 | Journal of Clinical Investigation2013，，4： | 1 |
| 15 | Pickup and Delivery Problem with Split Load显示文摘 | Maciek N (O)zlem E Chelsea C | | 0，，01： | 1 |
| 16 | Hyperparathyroid crisis presenting with hyperemesis gravidarum显示文摘 | Banu Akta? Y?lmaz Mustafa Altay Ceyla Konca De?ertekin Ali R?za ?imen ?zlem Turhan ?yidir Aydan Biri Osman Yüksel Füsun Balo? T?rüner Metin Arslan | 2014 | Archives of Gynecology and Obstetrics2014，，： | 1 |
| 17 | The electromagnetic shielding properties of some conductive knitted fabrics produced on single or double needle bed of a flat knitting machine显示文摘 | Fatma ?eken ?zlem Kayacan Ahmet ?zkurt ?ebnemSe?kin U?urlu | 2012 | Journal of The Textile Institute2012，，9： | 1 |
| 18 | A microarray based expression profiling of paclitaxel and vincristine resistant MCF-7 cells显示文摘 | Meltem Demirel Kars ?zlem Darcansoy I?eri Ufuk Gündüz | 2010 | European Journal of Pharmacology2010，，1： | 1 |
| 19 | A survey of very large-scale neighborhood search techniques显示文摘 | Ahuja Ravindra K Ö zlem E | 2002 | Discrete Applied Mathematics2002，123，1： | 1 |
| 20 | Antioxidant effect of mint, laurel and myrtle leaves essential oils on pomegranate kernel, poppy, grape and linseed oils显示文摘 | ?zlem ?nan Mehmet Musa ?zcan Fahad Y. Al Juhaimi | 2012 | Journal of Cleaner Production2012，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员