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| 1 | Type 2 diabetes mellitus and CA 19-9 levels显示文摘AIM:To prospectively investigate serum CA 19-9 levels in type 2 diabetic patients in comparison with age-and gender-matched control subjects. METHODS:We recorded duration of diabetes and examined fasting glucose levels,HbA1c levels and serum CA 19-9 levels in 76 type 2 diabetic patients and 76 controls.Abdominal CT was performed in order to eliminate abdominal malignancy in the diabetic and control groups. RESULTS:The average CA 19-9 level was 46.0±22.4 U/mL for diabetic patients whereas it was 9.97±7.1 U/mL for the control group(P<0.001).Regression analysis showed a positive correlation between diabetes and CA 19-9 independent from age,gender,glucose level and HbA1c level(t=8.8,P<001).Two of the diabetic patients were excluded from the study because of abdominal malignancy shown by CT at the initial evaluation.For all patients,abdominal CT showed no pancreatic abnormalities. CONCLUSION:CA 19-9 is a tumor-associated antigen, which is elevated in pancreatic,upper gastrointestinal tract,ovarian hepatocellular,and colorectal cancers,as well as in inflammatory conditions of the hepatobiliary system,biliary obstruction and in thyroid diseases. Diabetes has been claimed to be a risk factor for pancreatic cancer,which is increasing its incidence and has one of the lowest survival rates of all cancers.CA 19-9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.We propose that a higher cut- off value of CA 19-9 should be used in diabetics to differentiate benign and malignant pancreatic disease, and subtle elevations of CA 19-9 in diabetics should be considered as the indication of exocrine pancreatic dysfunction. | Oya Uygur-Bayramicli Resat Dabak Ekrem Orbay Can Dolapclo■lu Mehmet Sargin Gamze Kilico■lu Yüksel Güleryüzlü Alpaslan Mayada■li | 2007 | World Journal of Gastroenterology2007，13，40： | 63 |
| 2 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 3 | Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey显示文摘AIM: To investigate and compare frequencies of serum positive cagA in patients from two separate regions of Turkey who were grouped according to the presence of peptic ulcer disease or non-ulcer dyspepsia.METHODS: One hundred and eighty Helicobacter pyloripositive patients with peptic ulcer disease or non-ulcer dyspepsia were included in the study. One hundred and fourteen patients had non-ulcer dyspepsia and 66 had peptic ulcer disease (32 with gastric ulcers and/or erosions and 34with duodenal ulcers). Each patient was tested for serum antibody to H. pylori cagA protein by enzyme immunoassay.RESULTS: The total frequency of serum positive cagA in the study group was 97.2 %. The rates in the patients with peptic ulcers and in those with non-ulcer dyspepsia were 100% and 95.6%, respectively. These results were similar to those reported in Asian studies, but higher than those that have been noted in other studies from Turkey and Western countries.CONCLUSION: The high rates of serum positive cagA in these patients with peptic ulcer disease and non-ulcer dyspepsia were similar to results reported in Asia. The fact that there was high seroum prevalence regardless of ulcer status suggests that factors other than cagA might be responsible for ulceration or other types of severe pathology in H. pylori-positive individuals. | Ender Serin Uur Yilmaz Ganiye Künefeci Birol zer Yüksel Gümürdülü Mustafa Gülü Fazilet Kayaseluk Sedat Boyaciolu | 2003 | World Journal of Gastroenterology2003，9，4： | 10 |
| 4 | Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment显示文摘AIM: To assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats.METHODS: Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL). Ginkgo administered for 28 d. At the end of the treatment period,all rats were killed. Serum aspartate aminotransferase (AST),alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined to assess liver functions and tissue damage, respectively. Tumor necrosis factor-α (TNF-α) was also assayed in serum samples. Liver tissues were taken for determination of the hepatic malondialdehyde (MDA) and glutathione (GSH) levels,myeloperoxidase (MPO) activity and collagen content.Production of reactive oxidants was monitored by chemiluminescence (CL) assay. Serum AST, ALT, LDH, and TNF-α levels were elevated in the BDL group as compared to control group and were significantly decreased by EGb treatment.RESULTS: Hepatic GSH level, depressed by BDL, was elevated back to control level in EGb-treated BDL group.Increase in tissue MDA level, MPO activity and collagen content due to BDL were also attenuated by EGb treatment.Furthermore, luminol and lucigenin CL values in BDL group increased dramatically compared to control and reduced by EGb treatment.CONCLUSION: Our results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue. | Gksel pener Levent Kabasakal Meral Yüksel Nursal Gedik Ynci Alican | 2005 | World Journal of Gastroenterology2005，11，35： | 7 |
| 5 | Meshless Method for Analysis of Permeable Breakwaters in the Proximity of A Vertical Wall显示文摘In the present work, the improved version of the meshless singular boundary method(ISBM) is developed for analyzing the performance of bottom standing submerged permeable breakwaters in regular normally incident waves and in the proximity of a vertical wall. Both single and dual prismatic breakwaters of rectangular and trapezoidal forms are examined. The physical problem is cast in terms of the Laplace equation governing an irrotational flow and incompressible fluid motion with appropriate mixed type boundary conditions, and solved numerically using the ISBM. To model the permeability of the breakwaters fully absorbing boundary conditions are assumed. Numerical results are presented in terms of hydrodynamic quantities of the reflection coefficients. These are firstly validated against the results of a multi-domain boundary element method(BEM) developed independently for a previous study. The agreement between the results of the two methods is excellent. The coefficients of reflection are then computed and discussed for a variety of structural conditions including the breakwaters height, width, spacing, and absorbing permeability. Effects of the proximity of the vertical plane wall are also investigated. The breakwater's width is found to have only marginal effects compared with its height. Permeability tends to decrease the minimum reflections. These coefficients show periodic variations with the spacing relative to the wavelength. Trapezoidal breakwaters are found to be more cost-effective than the rectangular breakwaters. Dual breakwater systems are confirmed to perform much better than single structures. | Nadji CHIOUKH Karim OUAZZANE Yal??n YüKSEL Benameur HAMOUDI Esin ?EVIK | 2019 | China Ocean Engineering2019，33，2： | 6 |
| 6 | Comparison of visual and topographic outcomes of deep-anterior lamellar keratoplasty and penetrating keratoplasty in keratoconus显示文摘AIM:To compare visual,surgical and topographic outcomes of deep anterior lamellar keratoplasty(DALK)and penetrating keratoplasty(PK)for keratoconus(KC).METHODS:In this multicenter,prospective,randomized clinical trial 76 eyes of 71 KC patients operated between January 2011 and July 2014 in 2 tertiary referral hospitals were included. Consecutive patients were alternately selected to receive one of the two surgical methods. Thirty eight eyes underwent DALK with the big-bubble technique and 38 eyes underwent PK.RESULTS:Mean best spectacle corrected visual acuity(BSCVA)at the first postoperative week(P=0.012)and the first postoperative month(P<0.001)was statistically significantly higher in DALK group. The mean BSCVA at12 mo was not significantly different for DALK(0.30±1.99 log MAR)versus PK(0.40±0.33 log MAR)(P=0.104). The76.3% of the eyes had a BSCVA over 0.5 in DALK and 47.4%in PK group(P=0.009). The 7.9% of the eyes had a BSCVA of 1.0 in DALK and 5.3% in PK group(P=0.644). Mean spherical equivalent was-2.94 D in DALK and-3.09 D in PK group.Mean topographic astigmatism was 4.62 D and 4.18 D respectively. Regular topographic patterns were observed in 31(81.6%)of DALK and 29(76.3%)of PK(P=0.574). The most frequent topographic pattern was oblate asymmetric bow tie,seen in 39.5% in DALK and 23.7% in PK. CONCLUSION:Big bubble DALK provides an earlier visual improvement compare to PK. However,visual and topographic outcomes are similar to those in PK at 1y. Postoperative complications including rejection and intraocular pressure elevation are more frequent in PK. DALK is a safer alternative to PK for KC. However,intraoperativeperforation of the Descemet's membrane is a significant complication. | Bora Yüksel Baran Kandemir Umut Duygu Uzunel Ozan Celik Sezgin Ceylan Tuncay Küsbeci | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 5 |
| 7 | Balanced scorecard-based analysis of customer expectations for cosmetology services:a hybrid decision modeling approach显示文摘The goal of this study is to analyze and characterize customer expectations in the cosmetics sector.Within this framework,first,the extant literature is reviewed,and 12 most prominent performance measurement criteria are identified.Then,these criteria are organized along the four different balanced scorecard dimensions.By employing an Interval Type-2 Fuzzy DEMATEL methodology,the weighted importance of these dimensions and criteria are identified.Additionally,with the Interval Type-2 Fuzzy TOPSIS approach,13 leading cosmetic service providers in Ukraine are ranked based on their relative scores.The findings of the study indicate that consumer is the most significant dimension while learning and growth seem to have the least importance.Similarly,it is also concluded that all consumerfocused criteria(i.e.diversification of services,feedback on the product and services,and customer loyalty)have the highest priorities in the complete criterion set. | Dursun Delen Oleksandr Dorokhov Liudmyla Dorokhova Hasan Dincer Serhat Yüksel | 2020 | Journal of Management Analytics2020，7，4： | 3 |
| 8 | Serum beta 2-microglobulin as a biomarker in inflammatory bowel disease显示文摘AIM: To investigate the diagnostic utility of beta 2 microglobulin(B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease(IBD).METHODS: Overall, 78 IBD patients and 30 healthy controls were enrolled in the study. We examined B2-M serum levels in 43 ulcerative colitis(UC) patients, 35 with Crohn's disease(CD) and 30 control subjects, using an enzymatic method. Patients were divided into two groups according to two disease types: active and in remission. Subjects were also divided into two subgroups according to extent of the disease: left-side and pancolitis for UC and ileitis and ileocolitis for CD. All groups were compared for mean serum B2-M levels and also examined to see whether there was a correlation between serum B2-M levels and other inflammatory markers.RESULTS: The mean serum B2-M levels in the control group, UC and CD were 1.71, 2.41 and 2.24 respectively. B2-M values ≥ 1.96 mg/L had a 62% sensitivity, 76% specificity, a 79% positive predictive value, and a 58% negative predictive value for UC patients. B2-Mvalues ≥ 1.70 mg/L had 80% sensitivity, 53% specificity, 66% positive predictive value, and 69% negative predictive value for CD patients. Mean B2-M values were significantly higher in ulcerative colitis and Crohn's disease patients than in healthy controls(UC 2.41 ± 0.87 vs 1.71 ± 0.44, P = 0.002; CD 2.24 ± 1.01 vs 1.71 ± 0.44, P = 0.033). Also, mean B2-M values were significantly higher in active disease when compared to patients in remission(UC 2.66 ± 0.92 vs 1.88 ± 0.41, P = 0.004; CD 2.50 ± 1.15 vs 1.73 ± 0.31, P = 0.033). The difference between groups(UC and CD) in terms of serum B2-M levels was statistically insignificant(2.41 ± 0.87 vs 2.24 ± 1.01, P > 0.05 respectively).CONCLUSION: Serum B2-M levels may be used as an activity parameter in IBD. | Bülent Y|lmaz Seyfettin Kklü Osman Yüksel Serap Arslan | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 9 | Primary sclerosing cholangitis in Turkish patients:characteristic features and prognosis显示文摘BACKGROUND:Primary sclerosing cholangitis(PSC)is a chronic cholestatic liver disease characterized by destruction and fibrosis of the bile ducts.This study aimed to demonstrate the hepatic and extrahepatic characteristic findings and prognostic outcomes of Turkish patients with PSC. METHODS:The medical records of 35 consecutive patients with PSC from January 1988 to June 2007 were recorded prospectively.From the time of diagnosis,clinical features and laboratory data were collected. RESULTS:The mean age of the 35 patients was 41.69 years (range 15-80 years)at the time of diagnosis;14(40%)were female,and 21(60%)were male.The mean duration of follow-up was 58.86 months(1-180 months).Twenty(57.1%) of the patients with PSC were asymptomatic and 22(62.9%) had inflammatory bowel disease.At the time of diagnosis, 20(57.1%)of the patients had both intra-and extra-hepatic PSC.Twenty-one(60%)of the patients,who had undergone ERCP for stent placement,had dominant bile duct stenosis. Cholangiocarcinoma was found in 2(5.7%)of the patients and cirrhosis was detected in 7(20%);5(14.3%)underwent liver transplantation.The median follow-up time after liver transplantation was 23 months and all are still alive.Six (17.1%)patients died. CONCLUSIONS:PSC has a clinical course varied from advanced liver disease requiring liver transplantation within a short time to being asymptomatic for decades. The prognosis of Turkish patients with PSC is also disappointing as described in other studies. | Hilmi Ataseven Erkan Parlak lhami Yüksel mer Ba■ar brahim Ertu■rul Nurgül ■a■maz Burhan ■ahin | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，3： | 3 |
| 10 | The effects on prognosis of surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular approach显示文摘 | R. Alper Kaya Osman Türkmeno?lu Ibrahim M Ziyal Türker Dalkili? Yüksel ?ahin Yunus Aydin | 2003 | Surgical Neurology2003，，3： | 2 |
| 11 | Synthesis and characterization of salt-impregnated anodic aluminum oxide composites for low-grade heat storage显示文摘Thermochemical heat storage(THS)systems have recently attracted a lot of attention in research and development.In this study,an anodic aluminum oxide(AAO)template,fabricated by a two-step anodization method,was used for the first time as the matrix material for a THS system.Different salts were studied as thermochemical materials for their suitability in low-grade heat storage application driven by solar energy for an open system.Compositions were prepared by absorbing CaCl2,MgCl2,LiCl,LiNO3 and mixtures of these salts under a vacuum in an AAO matrix.Field Emission Scanning Electron Microscopy was used to examine the morphology of the produced AAO composites.Thermal energy storage capacities of the composites were characterized using a differential scanning calorimeter.Characterization analysis showed that anodized Al plates were suitable matrix materials for THS systems,and composite sorbent prepared with a 1:1 ratio LiCl/LiNO3 salt mixture had the highest energy value among all composites,with an energy density of 468.1 k J·kg-1. | Bengisu Yilmaz Behiye Yüksel Gökhan Orhan Devrim Aydin Zafer Utlu | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，1： | 2 |
| 12 | Postoperative pain after transvaginal cholecystectomy: single-center, double-blind, randomized controlled trial显示文摘 | Dietmar H. Borchert Matthias Federlein Frauke Fritze-Büttner Jens Burghardt Britta Liersch-L?hn Yüksel Atas Verena Müller Oskar Rückbeil Stefan Wagenpfeil Stefan Gr?ber Klaus Gellert | 2014 | Surgical Endoscopy2014，，6： | 2 |
| 13 | 原发性房角关闭眼激光虹膜切除术后UBM测量参数比较(英文)显示文摘目的:比较激光虹膜切开术前后原发性房角关闭(primary angle closure,PAC)眼超声生物显微镜(ultrasound biomicroscopy,UBM)参数。方法:对46例74眼PAC患者进行了一项前瞻性临床试验。平均年龄58,04±11.33(24.0-82.0)岁。所有病例行完整的眼科检查,前房角镜A超生物测量和超声生物显微镜检查(Vu-max,SonomedInc.,NY,USA)及24-2标准无色差视野检查(SAP,Humphrey Visual Field Analyzer-II i,Carl Zeiss Meditec Inc.,Dublin,CA,USA)。使用配对t检验评估基准和随访的平均值之间的变化。结果:激光周边虹膜切除术(laser peripheral iridotomy,LPI)术后,平均房角从8.02±4.61(0.10-19.60)度增加到17.66±6.39(0.10-32.70)度(P=0.000),房角开放距离500(angle opening distance 500,AOD500)从0.11±0.06(0.01-0.30)mm增加到0.23±0.07(0.13-0.50)mm(P=0.000),平均虹膜厚度(iris thickness,IT)从0.58±0.11(0.33-0.99)mm下降到0.52±0.10(0.25-0.77)mm(P=0.000)。小梁睫状突距离,虹膜睫状突距离和睫状体厚度均未发现显著统计学差异。结论:LPI术后PAC的白种人眼睛的AOD500,虹膜晶体距离和前房角增加,IT和虹膜晶体高度减少。这说明LPI解除了瞳孔阻滞,加深了前房,扩大了房角,减少了虹膜前凸和增厚。 | Bora Yüksel Tümay (O)rsel Memed Acar Sevgi Onat | 2012 | 国际眼科杂志2012，12，1： | 2 |
| 14 | Weibull analysis of fluidity and hardness of ultrasonical y degassed secondary Al7Si0.3Mg aluminum alloy显示文摘The influence of ultrasonic degassing process on fluidity and hardness of secondary Al7Si0.3Mg alloy castings was studied by Weibull analysis. This work makes a contribution about fluidity and hardness distribution of secondary aluminum alloys with ultrasonic degassing phenomena using a two-parameter form of Weibull analysis. Results show that both hardness and fluidity of alloy are improved after the ultrasonic degassing process. Average efficiency of ultrasonic degassing on fluidity measurements is 31.71%, whereas on hardness values is 8.48%. The Brinell hardness of 45.7 and fluidity of 19.5 of Weibull modulus were achieved as the most reliable and reproducible after 45 s ultrasonic degassing process against 15 s and 30 s ultrasonic degassing processes. The value of 70.08 HB is obtained from ultrosonic degassing, which is equivalent to sand casting of primary Al7Si0.3Mg aluminum alloy, and the highest value of 56.4 cm for 45 s after ultrasonic degassing of fluidity was measured. | ?a?lar Yüksel | 2019 | China Foundry2019，16，5： | 2 |
| 15 | Liquid-Liquid Equilibria of Water + Butyric Acid + Nonanol Ternary System显示文摘Liquid-liquid equilibrium (LLE) data for the water + butyric acid + nonanol system have been determined experimentally at the temperatures of 298.15 K, 308.15 K and 318.15 K. Tie-line compositions were correlated by Othmer-Tobias method. The universal quasichemical functional group activity coefficient (UNIFAC) and modified UNIFAC methods were used to predict the phase equilibrium in the system using the interaction parameters between CH3, CH2, COOH, OH and H2O functional groups. Distribution coefficients and separation factors were evaluated for the immiscibility region. | S.Ismail Kirbaslar Sema Yüksel Erol Ince Ismail Boz | 2004 | Chinese Journal of Chemical Engineering2004，12，5： | 2 |
| 16 | Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome and associated extrahepatic autoimmune diseases显示文摘 | Cumali Efe Staffan Wahlin Ersan Ozaslan Alexandra Heurgue Berlot Tugrul Purnak Luigi Muratori Chiara Quarneti Osman Yüksel Gérard Thiéfin Paolo Muratori | 2012 | European Journal of Gastroenterology & Hepatology2012，，5： | 2 |
| 17 | Report of 24 1eft-sided portal hypertension cases:a single-center prospective cohort study显示文摘 | K(o)klü S Yüksel O Arhan M | 2005 | Dig Dis Sci2005，50，5： | 1 |
| 18 | Medical image segmentation with transform and moment based features and incremental supervised neural network显示文摘 | Zafer Iscan Ayhan Yüksel Zümray Dokur | | 0，，05： | 1 |
| 19 | Homocysteine and nitric oxide levels in plasma of patients with pseudoexfoliation syndrome,pseudoexfoliation glaucoma,and primary open-angle glaucoma显示文摘 | Altinta(s) O Maral H Yüksel N | 2005 | Graefe''s Arch Clin Exp Ophthalmo12005，243，： | 1 |
| 20 | Report of 24 left-sided portal hypertension cases:A single-center prospective cohort study显示文摘 | Koklü S Yüksel O Arhan M | 2005 | Dig Dis Sei2005，50，5： | 1 |
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