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| 1 | 核磁共振法表征硫黄用量对天然橡胶交联密度及结构的影响显示文摘用核磁共振(NMR)法测定了硫黄用量及硫化温度对天然橡胶(NR)硫化胶交联结构的影响,并与传统的平衡溶胀法进行了对比。结果表明,用NMR法可以测定硫化胶的总交联密度、未硫化胶的物理交联密度和由于交联反应产生的化学交联密度;NR硫化胶的总交联密度和化学交联密度随硫黄用量的增加而呈线性增加;随着硫黄用量的增加,交联密度增加,NR硫化胶的纵向弛豫时间和横向弛豫时间下降;NR硫化胶的交联密度越大,弛豫时间对温度的依赖性越小;NMR法可以清晰展示NR/硫黄/促进剂NS硫化体系的硫化过程中橡胶交联点间的相对分子质量、化学交联密度及橡胶大分子连到橡胶交联网络上的演变过程。 | 赵菲 张萍 赵树高 Winfried Kuhn 于建 | 2008 | 合成橡胶工业2008，31，2： | 38 |
| 2 | 用核磁共振法研究促进剂对硫黄硫化天然橡胶结构的影响显示文摘用核磁共振交联密度仪研究了次磺酰胺类促进剂NS、DZ和CZ对天然橡胶硫化胶结构的影响,考察了相同用量下促进剂种类与天然橡胶硫化胶交联密度的关系。结果表明,在基本配方和硫化条件相同的情况下,促进剂的相对分子质量越低,天然橡胶硫化胶的交联密度越高。硫化胶的交联密度不仅对核磁共振的横向弛豫时间有影响,而且影响其纵向弛豫时间。随着交联密度的增加,硫化胶的核磁共振弛豫时间缩短,弛豫时间对温度的依赖性减弱。 | 赵菲 毕薇娜 张萍 于建 Winfried Kuhn | 2008 | 合成橡胶工业2008，31，1： | 33 |
| 3 | 不同肝病患者抗肝抗原自身抗体的研究显示文摘目的 观察我国不同类型肝病患者中几种抗肝抗原自身抗体的存在状况 ;探讨自身免疫性肝脏疾病的自身抗体特征。方法 由 14 12例标本中选择 2 30例肝功能异常患者分为 5组 :①自身免疫性肝病组 4 2例 :自身免疫性肝炎 (AIH) 18例、原发性胆汁性肝硬化 (PBC) 2 1例、原发性硬化性胆管炎 (PSC) 3例。②HAV组 2 3例 ;③HBV组 70例 ;④HCV组 35例 ;⑤非甲~戊型肝炎组 6 0例。用间接免疫荧光、Westernblot、酶免疫条带技术等分别检测抗核抗体 (ANA)、抗线粒体抗体(AMA)、平滑肌抗体 (SMA)、肝肾微粒抗体Ⅰ型 (LKM 1)、肝细胞胞溶质抗原Ⅰ型 (LC 1)、可溶性肝抗原 (SLA) 肝胰抗原 (LP)和AMA M2亚型 ,以及SS A、SS B、dsDNA等多种抗体。结果 14 12例中诊断AIH、PBC和PSC者分别为送检标本的 1.2 7% ,1.4 9%和 0 .2 1%。 2 30例血清中 2例LKM 1阳性和 2例SLA LP阳性 ,分别见于AIH和HCV感染者。PBC患者AMA和M2全部阳性 ;其ANA以核膜型为主 (7 14 ) ;AIH患者ANA抗体未见特定的荧光类型 ,而抗 Actin仅见于AIH者。非甲~戊组 4例AMA和M2阳性 ,3例SMA高滴度阳性 ,4例出现SS A、SS B或dsDNA等抗体。结论 肝抗原抗体和ANA及AMA分型的检测有助于自身免疫性肝病和重叠多种免疫性肝病的诊断 ;非甲~戊型肝炎诊断时应? | 阎惠平 Winfried Stcker 贺立香 张世斌 李秀惠 黄德庄 赵春惠 | 2002 | 中华微生物学和免疫学杂志2002，22，5： | 30 |
| 4 | Interpolation of Morrey-Campanato and related smoothness spaces显示文摘We study the interpolation of Morrey-Campanato spaces and some smoothness spaces based on Morrey spaces, e. g., Besov-type and Triebel-Lizorkin-type spaces. Various interpolation methods, including the complex method, the ±-method and the Peetre-Gagliardo method, are studied in such a framework. Special emphasis is given to the quasi-Banach case and to the interpolation property. | YUAN Wen SICKEL Winfried YANG DaChun | 2015 | Science China Mathematics2015，58，9： | 19 |
| 5 | 肝病患者自身抗体特征性的研究显示文摘目的 :观察抗肝抗原自身抗体在我国不同类型肝病患者中的存在状况 ;探讨自身免疫性肝脏疾病的自身抗体特征。方法 :间接免疫荧光法初筛 14 12例肝功能异常血清 ,从中选择 2 2 8例 :①自身免疫性肝病组 4 2例 :初步诊断为AIH 18例、PBC 2 1例、PSC 3例。②HAV组 2 3例 ;③HBV组 70例 ;④HCV组 33例 ;⑤非甲~非戊型肝炎组 6 0例。结合Westernblot、酶免疫条带技术等分别检测ANA、AMA、SMA、LKM 1、LC 1、SLA LP和AMA M2亚型、dsDNA及ENA类多种抗体。结果 :14 12例中诊断AIH、PBC和PSC者分别为送检标本的 12 7‰ ,14 9‰和 2 1‰。 2 2 8例血清中 2例LKM 1阳性和 2例SLA LP阳性 ;按AIH的分型标准 ,自身免疫性肝病组属于I型AIH者 14例 (78% ) ,II型 2例 (11% ) ,III型 2例 (11% ) ;AIH患者ANA抗体未见特定的荧光类型。PBC患者AMA和M2全部阳性 ;其ANA以核膜型为主 (7 14 )。NonA~E组 4例AMA和M2阳性 ,3例SMA高滴度阳性 ,4例出现SS A、SS B或dsDNA等抗体。结论 :三型自身免疫性肝炎在中国都存在 ,肝抗原自身抗体和ANA及AMA的分型检测有助于自身免疫性肝病的诊断与治疗 ;少数非甲~非戊型肝炎应考虑自身免疫性肝病诊断。 | 阎惠平 Winfried Stecker 贺立香 张世斌 孔淑玲 于红卫 闵福援 | 2003 | 中国免疫学杂志2003，19，4： | 19 |
| 6 | Psychosocial issues in evidence-based guidelines on inflammatory bowel diseases: A review显示文摘AIM:To study statements and recommendations on psychosocial issues as presented in international evidence-based guidelines on the management of inflammatory bowel diseases(IBD).METHODS:MEDLINE,guidelines International Network,National Guideline Clearing House and National Institute for Health and Care Excellence were searched from January 2006 to June 30,2013 for evidencebased guidelines on the management of IBD.RESULTS:The search yielded 364 hits.Thirteen guidelines were included in the review,of which three wereprepared in Asia,eight in Europe and two in the United States.Eleven guidelines made statements and recommendations on psychosocial issues.The guidelines were concordant in that mental health disorders and stress do not contribute to the aetiology of IBD,but that they can influence its course.It was recommended that IBD-patients should be screened for psychological distress.If indicated,psychotherapy and/or psychopharmacological therapy should be recommended.IBDcentres should collaborate with mental health care specialists.Tobacco smoking patients with Crohn’s disease should be advised to quit.CONCLUSION:Patients and mental health specialists should be able to participate in future guideline groups to contribute to establishing recommendations on psychosocial issues in IBD.Future guidelines should acknowledge the presence of psychosocial problems in IBD-patients and encourage screening for psychological distress. | Winfried Huser Gabriele Moser Petra Klose Antonina Mikocka-Walus | 2014 | World Journal of Gastroenterology2014，20，13： | 14 |
| 7 | 不锈钢在烟气脱硫装置中长时间使用经验显示文摘 | Bernd Beckers 孙长庆 Winfried Heimann Malin Snis | 2004 | 化工设备与防腐蚀2004，7，3： | 5 |
| 8 | FSPM-P: towards a general functional-structural plant model for robust and comprehensive model development显示文摘在最后十年,功能结构的植物建模(FSPM ) 在庄稼和树生产成为了一个更广泛地接受的范例,当为最重要的庄稼的 3D 模型被建议了。给可得到的模型的更宽的公事包,在 FSPM 开发进入下一水平现在是适当的,由为模型开发介绍更有效的方法。这包括模型复用的考虑(由 modularisation ) ,联合和比较,和存在的改进当模特儿。便于这个过程,为设计的标准和要定义并且建立的通讯需要。我们在场第一步向一有效、一般,即,不是 speciesspecific FSPM,目前限制了为年度或每年两次的植物,但是与为扩展和进一步的归纳的潜力。模型结构是层次、面向对象的,与是的植物机关底级的目标和植物个人和华盖高度级的目标。,为生理的过程的多数的模块在有一个类似的目的另外的平台被合并(例如,光合作用,器官形成和生长) 。有从文学采用的几个一般参数集合的模拟跑证明能复制嘴巧的产量的现在的 prototypewas 为不同庄稼变化(油菜籽,大麦,等等)以动力学和最后的值(在收获时间)模型状态变量例如吸收生产,机关生物资源,叶区域和体系结构。 | Michael HENKE Winfried KURTH Gerhard H. BUCK-SORLIN | 2016 | Frontiers of Computer Science2016，10，6： | 5 |
| 9 | Identification of Tissue-Specific MicroRNAs from Mouse显示文摘 | Mariana Lagos-Quintana Reinhard Rauhut Abdullah Yalcin Jutta Meyer Winfried Lendeckel Thomas Tuschl | 2002 | Current Biology2002，，9： | 4 |
| 10 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 11 | 宋代铁钱的中子衍射研究显示文摘利用飞行时间法中子衍射技术(time of flight neutron diffraction)对3枚陕西出土的宋代铁钱进行了无损的相分析,采用英国卢瑟福实验室的高分辨率中子衍射仪GEM(General Materials Diffractometer),定量地揭示了铁钱的相组成、合金成分与主要锈蚀产物的成分。分析结果表明铁钱的主要物相为铁素体、渗碳体(还含有Fe3P),主要锈蚀产物为棕黄色针铁矿(α-FeOOH),没有发现铁素体晶粒的织构化,表明铁钱系铸造而成。中子衍射这种完全无损且量化的物理实验技术在中国文化遗产的科学分析与保护研究中具有广阔的应用前景。 | 黄维 Winfried Kockelmann Evelyn Gordfrey David A Scott 吴小红 | 2010 | 北京大学学报(自然科学版)2010，46，2： | 3 |
| 12 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 13 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil显示文摘 | Christoph Steiner Wenceslau G. Teixeira Johannes Lehmann Thomas Nehls Jeferson Luis Vasconcelos Macêdo Winfried E. H. Blum Wolfgang Zech | 2007 | Plant and Soil2007，，1： | 2 |
| 14 | Hydroxyethylstarch revisited for acute brain injury treatment显示文摘Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss.In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients.Because of the serious risk for critically ill patients, the administration of hydroxyethylstarch was restricted for clinical use.Animal studies and recently published in vitro experiments showed that hydroxyethylstarch might exert protective effects on the blood-brain barrier.Since the prevention of blood-brain barrier disruption was shown to go along with the reduction of brain damage after several kinds of insults, we revisit the topic hydroxyethylstarch and discuss a possible niche for the application of hydroxyethylstarch in acute brain injury treatment. | Martin A.Schick Malgorzata Burek Carola Y.Forster Michiaki Nagai Christian Wunder Winfried Neuhaus | 2021 | Neural Regeneration Research2021，16，7： | 2 |
| 15 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil显示文摘 | Christoph Steiner Wenceslau G. Teixeira Johannes Lehmann Thomas Nehls Jeferson Luis Vasconcelos Macêdo Winfried E. H. Blum Wolfgang Zech | 2007 | Plant and Soil (-)2007，，1： | 2 |
| 16 | Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings显示文摘 | Andreas A. Schnitzbauer Sven A. Lang Holger Goessmann Silvio Nadalin Janine Baumgart Stefan A. Farkas Stefan Fichtner-Feigl Thomas Lorf Armin Goralcyk Rüdiger H?rbelt Alexander Kroemer Martin Loss Petra Rümmele Marcus N. Scherer Winfried Padberg Alfred K? | 2012 | Annals of Surgery2012，，3： | 2 |
| 17 | Nitrogen retention and plant uptake on a highly weathered central Amazonian Ferralsol amended with compost and charcoal显示文摘 | ChristophSteiner BrunoGlaser WenceslauGeraldes Teixeira JohannesLehmann Winfried E.H.Blum WolfgangZech | 2008 | 2008，，6： | 2 |
| 18 | Soil aggregation, aggregate stability, organic carbon and nitrogen in different soil aggregate fractions under forest and shrub vegetation on the Loess Plateau, China显示文摘 | Shaoshan An Axel Mentler Herwig Mayer Winfried E.H. Blum | 2010 | Catena2010，，3： | 2 |
| 19 | A prospective two-center study comparing wireless capsule endoscopy with intraoperative enteroscopy in patients with obscure GI bleeding显示文摘 | Dirk Hartmann Harald Schmidt Georg Bolz Dieter Schilling Frank Kinzel Axel Eickhoff Winfried Huschner Kathleen M?ller Ralf Jakobs Peter Reitzig Uwe Weickert Klaus Gellert Harald Schultz Klaus Guenther Hartmut Hollerbuhl Klaus Schoenleben Hans-Joachim Schu | 2005 | Gastrointestinal Endoscopy2005，，7： | 2 |
| 20 | Microbiological screenings for infection control in unaccompanied minor refugees: the German Armed Forces Medical Service's experience显示文摘Background:The German Military Medical Service contributed to the medical screening of unaccompanied minor refugees(UMRs)coming to Germany in 2014 and 2015.In this study,a broad range of diagnostic procedures was applied to identify microorganisms with clinical or public health significance.Previously,those tests had only been used to screen soldiers returning from tropical deployments.This instance is the first time the approach has been studied in a humanitarian context.Methods:The offered screenings included blood cell counts,hepatitis B serology and microscopy of the stool to look for protozoa and worm eggs as well as PCR from stool samples targeting pathogenic bacteria,protozoa and helminths.If individuals refused certain assessments,their decision to do so was accepted.A total of 219 apparently healthy male UMRs coming from Afghanistan,Egypt,Somalia,Eritrea,Syria,Ghana,Guinea,Iran,Algeria,Iraq,Benin,Gambia,Libya,Morocco,Pakistan,and Palestine were assessed.All UMRs who were examined at the study department were included in the assessment.Results:We detected decreasing frequencies of pathogens that included diarrhoea-associated bacteria[Campylobacter(C.)jejuni,enteropathogenic Escherichia(E.)coli(EPEC),enterotoxic E.coli(ETEC),enteroaggregative E.coli(EAEC),enteroinvasive E.coli(EIEC)/Shigella spp.),Giardia(G.)duodenalis,helminths(comprising Schistosoma spp.,Hymenolepis(H.)nana,Strongyloides(S.)stercoralis]as well as hepatitis B virus.Pathogenic microorganisms dominated the samples by far.While G.duodenalis was detected in 11.4%of the assessed UMRs,the incidence of newly identified cases in the German population was 4.5 cases per 100,000 inhabitants.Conclusion:We conclude that the applied in-house PCR screening systems,which have proven to be useful for screening military returnees from tropical deployments,can also be used for health assessment of immigrants from the respective sites.Apparently healthy UMRs may be enterically colonized with a broad variety of pathogenic and apathogenic microorganisms.Increased colonization rates,as shown for G.duodenalis,can pose a hygiene problem in centralized homes for asylum seekers. | Winfried Maaβen Dorothea Wiemer Claudia Frey Christina Kreuzberg Egbert Tannich Rebecca Hinz Andreas Wille Andreas Fritsch Ralf Matthias Hagen Hagen Frickmann | 2018 | Military Medical Research2018，5，1： | 2 |
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