|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nutrient availability and leaching in an archaeological Anthrosol and a Ferralsol of the Central Amazon basin: fertilizer, manure and charcoal amendments显示文摘 | Johannes Lehmann Jose Pereira da Silva Christoph Steiner Thomas Nehls Wolfgang Zech Bruno Glaser | 2003 | Plant and Soil2003，，2： | 8 |
| 2 | Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time PCR analysis显示文摘AIM: To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling. METHODS: Oligonucleotide arrays (Affymetrix U133A) were used to establish a specific gene expression profile of intrahepatic CCC in comparison to corresponding non- malignant liver tissue. To validate the expression values of the most overexpressed genes, RT-PCR experiments were performed. RESULTS: Five hundred and fifty-two statistically differentially expressed genes/ESTs (221 probes significantly up-regulated, 331 probes down-regulated; P < 0.05; fold change > 2; ≥ 70%) were identified. Using these data and two-dimensional cluster analysis,a specific gene expression profile was obtained allowing fast and reproducible differentiation of CCC, which was confirmed by supervised neuronal network modelling. The most consistently overexpressed gene (median fold change 33.5, significantly overexpressed in 100%) encoded osteopontin. Furthermore, an association of various genes with the histopathological grading could be demonstrated. CONCLUSION: A highly specific gene expression profile for intrahepatic CCC was identified, allowing for its fast and reproducible discrimination against non- malignant liver tissue and other liver masses. The most overexpressed gene in intrahepatic CCC was the gene encoding osteopontin. These data may lead to a better understanding of human cholangiocarcinogenesis. | Holger G Hass Oliver Nehls Juergen Jobst Andrea Frilling Ulrich Vogel Stephan Kaiser | 2008 | World Journal of Gastroenterology2008，14，16： | 4 |
| 3 | siRNA介导的ERA1表达下调对拟南芥抗旱性的影响显示文摘ERA1是控制植物气孔开闭的一个重要基因,根据其保守域构建RNA干扰(RNAi)载体并转化拟南芥,考察转基因植株的生长、气孔导度、离体叶片失水率以及ERA1和相关基因表达,探讨siRNA介导的ERA1表达下调对拟南芥抗旱性的影响。结果表明:转基因拟南芥株系中ERA1的表达受到明显抑制,其离体叶片失水率低于野生型,但并未出现ERA1缺失突变体的负面生长表型;转基因株系对ABA处理比野生型更敏感,其ABA处理株的根长显著变短,气孔孔径更小;转基因株ABI1、ABI2、ATHB6的表达量降低,而RAB18、RD29B、ADH1的表达量升高,siRNA介导的ERA1表达下调可能会激活RAB18、RD29B等逆境响应元件。研究发现,采用RNAi技术可以有效下调ERA1表达,在没有过多负面生长表型的前提下提高拟南芥的抗旱性,且ERA1表达下调可能通过ABA途径正面影响拟南芥的抗旱性。 | 史金凤 刘志学 祝建 REINHARD Nehls 王泓 | 2012 | 西北植物学报2012，32，11： | 3 |
| 4 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil显示文摘 | Christoph Steiner Wenceslau G. Teixeira Johannes Lehmann Thomas Nehls Jeferson Luis Vasconcelos Macêdo Winfried E. H. Blum Wolfgang Zech | 2007 | Plant and Soil2007，，1： | 2 |
| 5 | Long term effects of manure, charcoal and mineral fertilization on crop production and fertility on a highly weathered Central Amazonian upland soil显示文摘 | Christoph Steiner Wenceslau G. Teixeira Johannes Lehmann Thomas Nehls Jeferson Luis Vasconcelos Macêdo Winfried E. H. Blum Wolfgang Zech | 2007 | Plant and Soil (-)2007，，1： | 2 |
| 6 | Nutrient availability and leaching in an archaeological Anthrosol and a Ferralsol of the Central Amazon basin: fertilizer, manure and charcoal amendments显示文摘 | Johannes Lehmann Jose Pereira da Silva Christoph Steiner Thomas Nehls Wolfgang Zech Bruno Glaser | 2003 | Plant and Soil2003，，2： | 2 |
| 7 | Contact-dependent inhibition of angiogenesis by cardiac fibroblasts in three- dimensional fibrin gels in vitro:Implications for mierovascular network remodeling and coronary eoolateral formation显示文摘 | Nehls V Herrmann R Hnken M | 1998 | Cell Tissue Res1998，293，3： | 1 |
| 8 | Deleterious rhizosphere bacteria:An integrating perspectice显示文摘 | Nehl D B Allen S J Brown J F | 1996 | Applied Soil Ecology1996，5，： | 1 |
| 9 | Capecitabine plus oxaliplatin as first-line treatment in patients with advanced biliary system adenocareinoma: a prospective multicentre phase II trial显示文摘 | Nehls O Oettle H Hartmann J T | 2010 | Br J cancer2010，98，2： | 1 |
| 10 | Keeping cool while saving space and money:A semi-integrated,sensorless PM brushless drive for a 42-V automotive HVAC compressor显示文摘 | NAIDU M NEHL T W GOPALAKRISHNAN S | | 0，，： | 1 |
| 11 | Optical properties of star- shaped gold nanoparticles显示文摘 | Nehl C L Liao H W Hafner J H | 2006 | Nano Letters2006，6，4： | 1 |
| 12 | Capecitabine plus oxaliplatin as first-line treatment in patients with advanced biliary system adenocarcinoma: A prospective multicentre phase Ⅱ trial显示文摘 | Nehls O Oettle H Hartmann JT | 2008 | Br J Cancer2008，98，： | 1 |
| 13 | Experimental intercerebral hemorrhage progression of hemodynamic changes after production of a spontaneous mass lesion显示文摘 | Nehls DG Mendelow AD Graham DI | 1988 | Neurosurgery1988，23，4： | 1 |
| 14 | Mithramycin se lectively inhibits collagen-alpha 1 (I) gene expression in human fibroblast显示文摘 | Nehls MC Brenner DA Oruss HJ | 1993 | J Clin Vest1993，93，： | 1 |
| 15 | Capecitabine plus oxaliplat- in as first-line treatment in patients with advanced biliary system adenocarcinoma: a prospective multicentre phase Ⅱ trial显示文摘 | Nehls O Oetde H HartmannJT | 2008 | Br J Cancer2008，98，2： | 1 |
| 16 | Fungal carbohydrate support in the eetomycorrhizal symbiosis: a review 显示文摘 | Nehls U Gohringer F Wittulsky S | 2010 | Plant Biol2010，12，2： | 1 |
| 17 | Eddy-current machines with permanent magnets and solid rotors显示文摘 | Lequesne Bruno Liu Buyun Nehl Thomas w | 1997 | IEEE Transactions on Industry Applications1997，33，05： | 1 |
| 18 | Experimental intracerebral hemorrhage progression of hemodynamic changes after production of a spontaneons mass lesion显示文摘 | Nehls DG | 1988 | Neurosurgery1988，23，： | 1 |
| 19 | Three dimensional finite element vector potential formulation of magnetic fields in electrical apparatus显示文摘 | Demerdash N A Nehl T W Fouad F A | 1981 | IEEE Transactions on Power Apparatus and Systems1981，100，10： | 1 |
| 20 | Characterization of cellulose and cellulose derivatives in solution by high resolution ^13C NMR spectroscopy 显示文摘 | NEHLS I WAGENKNECHT W PHILIPP B | 1994 | Progress in Polymer Science1994，19，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员