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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Necklace-like Si@C nano?bers as robust anode materials for high performance lithium ion batteries显示文摘Silicon is believed to be a promising anode material for lithium ion batteries because of its highest theoretical capacity and low discharge potential. However, severe pulverization and capacity fading caused by huge volume change during cycling limits its practical application. In this work, necklace-like N-doped carbon wrapped mesoporous Si nanofibers(NL-Si@C) network has been synthesized via electrospinning method followed by magnesiothermic reduction reaction process to suppress these issues. The mesoporous Si nanospheres are wrapped with N-doped carbon shells network to form yolk-shell structure.Interestingly, the distance of adjacent Si@C nanospheres can be controllably adjusted by different addition amounts of SiO_2 nanospheres. When used as an anode material for lithium ion batteries, the NL-Si@C-0.5 exhibits best cycling stability and rate capability. The excellent electrochemical performances can be ascribed to the necklace-like network structure and N-doped carbon layers, which can ensure fast ions and electrons transportation, facilitate the electrolyte penetration and provide finite voids to allow large volume expansion of inner Si nanoparticles. Moreover, the protective carbon layers are also beneficial to the formation of stable solid electrolyte interface film. | Xiangzhong Kong Yuchao Zheng Yaping Wang Shuquan Liang Guozhong Cao Anqiang Pan | 2019 | Science Bulletin2019，64，4： | 13 |
| 3 | Characteristics of strike-slip inversion structures of the Karatau fault and their petroleum geological significances in the South Turgay Basin,Kazakhstan显示文摘The Karatau fault is one of the important strike-slip faults in central Asia,and the South Turgay Basin is located towards its northern end.Detailed seismic interpretation indicated that the strikeslip tectonism of the Karatau fault weakened gradually from west to east in the South Turgay Basin.Typical flower structures developed on the section,and strike-slip faults showed an echelon pattern on planar view.The Karatau strike-slip fault affected the South Turgay Basin in two periods:(1) The South Turgay strike-slip pull-apart rift basin formed as a result of regional extensive stress in the Early-Middle Jurassic,characterized by the juxtaposition of horsts and grabens.The formation of horsts provided favorable reservoir spaces for later hydrocarbon accumulation,and different filling stages of grabens controlled different reservoir-forming factors in grabens.(2) Two stages of tectonic inversion occurred in the Late Jurassic and Late Cretaceous and played a crucial role in the final shape of the structure in the South Turgay Basin.The oil and gas migrated to form reservoirs and mainly concentrated in the horsts,graben slopes and in both sides of the strike-slip fault zone.In the case of the degree of accumulation of petroleum,the factor explaining why horsts are better than grabens is the strike-slip pull-apart of the South Turgay Basin,and the structure inversion of the South Turgay Basin explains why the west graben is better than the east one.Overall,the Karatau strike-slip fault played a very important role in the formation of the South Turgay Basin and its hydrocarbon accumulations. | Yin Wei Fan Zifei Zheng Junzhang Yin Jiquan Zhang Mingjun Sheng Xiaofeng Guo Jianjun Li Qiyan Lin yaping | 2012 | Petroleum Science2012，9，4： | 11 |
| 4 | Studies of key technologies for CdTe solar modules显示文摘In this paper, CdS thin films, which act as the window layer and n-type partner to the p-type CdTe layer, were prepared by chemical bath deposition (CBD). CdTe thin films were deposited by the close-spaced sublimation (CSS) method. To obtain high-quality back contacts, a Te-rich layer was created with chemical etching and back contact materials were applied after CdTe annealing. The results indicate that the ZnTe/ZnTe:Cu complex layers show superior performance over other back contacts. Finally, by using laser scribing and mechanical scribing, the CdTe mini-modules were fabricated, in which a glass/SnO2:F/CdS/CdTe/ZnTe/ZnTe:Cu/Ni solar module with a PWQC-confirmed total-area efficiency of 7.03% (54 cm2) was achieved. | LI Wei FENG LiangHuan ZHANG JingQuan WU LiLi CAI YaPing ZHENG JiaGui CAI Wei LI Bing LEI Zhi | 2008 | Science China(Technological Sciences)2008，51，1： | 5 |
| 5 | Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer显示文摘Efficient tumor-targeting drug delivery systems are urgently needed for treating metastatic breast cancer.In this work, a docetaxel(DTX)-loaded micelle(pDM) as the tumor-microenvironment-responsive delivery platform is developed. The micelle is composed of a pH-sensitive amphiphilic copolymer,poly((1,4-butanediol)-diacrylate-b-N,N-diisopropylethylenediamine)-polyethyleneimine(BD-PEI), and a matrix metalloproteinase(MMP)-responsive polymer, poly((1,4-butanediol)-diacrylate-b-N,N-diisopropy lethylenediamine)-peptide-polyethylene glycol(PEG)(BD-peptide-PEG). The PEG block of BD-peptidePEG will be split by MMPs at the tumor microenvironment, which leads to the change of the surface charge and particle size of the micelle to more positive and smaller one. Owing to this transformation and enhanced permeability and retention(EPR) effect, pDM delivers more DTX into tumor tissues and is internalized more efficiently by tumor cells than the non-MMP-sensitive micelles in the 4 T1 tumorbearing mice model. In addition, DTX is released in acidic endo/lysosomes due to the dissociation of the micelle, triggered by the protonation of the hydrophobic block of BD-PEI. As a result, the DTX-loaded micelle inhibits primary tumor growth and pulmonary metastasis effectively. Thus, this pH/MMP-dual-sensitive drug delivery system, which simultaneously attains three keypoints: prolonged circulation time, directional and efficient uptake into tumor cells, and speedy intracellular drug release, is a promising strategy for metastatic breast cancer therapy. | Tianqun Lang Xinyue Dong Zhong Zheng Yiran Liu Guanru Wang Qi Yin Yaping Li | 2019 | Science Bulletin2019，64，2： | 5 |
| 6 | Effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on excisional wound healing in a rat's model显示文摘OBJEVTIVE: To investigate the effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on the excisional wound healing in a rat's model.METHODS: Rats were performed a surgical lesion with a 2.0 cm resected tissue in the dorsal fascia.Following, animals were randomly divided into model group, YNB group and APE group those were respectively treated with saline, 1 mg/mL of Yunnan Baiyao and 1 mg/mL of Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) extracts. Wound contractions in days 0, 3, 7, 14 and 21 were calculated by an image analyzer. Histological analysis was analyzed using hematoxilin and eosin.Levels of tumor necrosis factor-2(IL-2), IL-4, IL-10, transformαin(TNF-g growα), interleukinth factor-1(TGF-nd basic fibroblast growth factor(bFββ1) a-GF) were determined by real-time quantitative PCR.RESULTS: Compared with that of YNB group and APE gtoup, the skin of rats showed poor re-modeling and re-epithelization characterized by a significant decrease of neovascularization, epithelialization and fibroblast in the model group. In the APE group, levels of TNF-α-and IL-2 were significantly down-regulated and IL4 and IL-10 significantly upregulated in contrasted with that of model group.In addition, levels of TGF-roup were significantly iβ1 and bFGF in the APE gnduced compared with that of model group.CONCLUSION: The results suggest that the extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) promote wound healing in the rats, which is associated with enhancing antiinflammatory ability and inducing fibroblast formation. | Xia Xichao Ma Yuhong Wang Fuan Zheng Xinhua Liu Yang Zhang Junfeng Cui Juan Shi Bingqin Li Hongwen Liu Rongzhi Zhang Yaping Cheng Zhaofei Han Xiaolong | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 7 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 8 | Topotactic reduction of layered double hydroxides for atomically thick two-dimensional non-noble-metal alloy显示文摘Layered double hydroxides (LDHs) have been widely used as catalysts owingto their tunable structure and atomic dispersion of high-valence metal ions;however, limited tunability of electronic structure and valence states havehindered further improvement in their catalytic performance. Herein, we reducedultrathin LDH precursors in situ and topotactically converted them to atomicallythick (N2 nm) two-dimensional (2D) multi-metallic, single crystalline alloynanosheets with highly tunable metallic compositions. The as-obtained alloynanosheets not only maintained the vertically aligned ultrathin 2D structure,but also inherited the atomic dispersion of the minor metallic compositions ofthe LDH precursors, even though the atomic percentage was higher than 20%,which is far beyond the reported percentages for single-atom dispersions (usuallyless than 0.1%). Besides, surface engineering of the alloy nanosheets can finely tunethe surface electronic structure for catalytic applications. Such in situ topotacticconversion strategy has introduced a novel approach for atomically dispersedalloy nanostructures and reinforced the synthetic methodology for ultrathin 2Dmetal-based catalysts. | Pengsong Li Qixian Xie Lirong Zheng Guang Feng Yingjie Li Zhao Cai Yongmin Bi Yaping Li Yun Kuang Xiaoming Sun Xue Duan | 2017 | Nano Research2017，10，9： | 4 |
| 9 | Ultrathin lanthanide oxides nanomaterials: synthesis, properties and applications显示文摘Over the past decade, ultrathin lanthanide oxides(Ln_2O_3, Ln = La to Lu) nanomaterials have been intensively studied in the fields of rare earth materials science. This unique class of nanomaterials has shown many unprecedented properties(big surface area, high surface effect, physical and chemical activities) and is thus being explored for numerous promising applications. In this review, a brief introduction of ultrathin Ln_2O_3 nanomaterials was given and their unique advantages were highlighted. Then, the typical synthetic methodologies were summarized and compared(thermal decomposition, solvothermal, soft template, co-precipition and microwave etc.). Due to the high surface effect, some promising applications of ultrathin Ln_2O_3 nanomaterials, such as drug delivery and catalysis of CO oxidation, were reviewed. Finally, on the basis of current achievements on ultrathin Ln_2O_3 nanomaterials, personal perspectives and challenges on future research directions were proposed. | Xinyu Zhang Yongwei Wang Fenghua Cheng Zhiping Zheng Yaping Du | 2016 | Science Bulletin2016，61，18： | 3 |
| 10 | Detailed resume of RNA m^(6)A demethylases显示文摘N6-Methyladenosine(m^(6)A) is the most abundant internal modification in eukaryotic mRNA,playing critical role in various bioprocesses. Like other epigenetic modifications, m^(6)A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m^(6)A demethylases have been reported, fat mass and obesity-associated protein(FTO)and alkylation protein AlkB homolog 5(ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5. | Dandan Shen Bo Wang Ya Gao Lijuan Zhao Yaping Bi Jinge Zhang Ning Wang Huiqin Kang Jingru Pang Ying Liu Luping Pang Zhe-Sheng Chen Yi-Chao Zheng Hong-Min Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 3 |
| 11 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 12 | Controlling the Properties of Solvent-free Fe_3O_4 Nanofluids by Corona Structure显示文摘We studied the relationship between corona structure and properties of solvent-free Fe3O4 nanofluids. We proposed a series of corona structures with different branched chains and synthesize different solvent-free nanofluids in order to show the effect of corona structure on the phase behavior, dispersion, as well as rheology properties. Results demonstrate novel liquid-like behaviors without solvent at room temperature. Fe3O4 magnetic nanoparticles content is bigger than 8% and its size is about 23 nm. For the solvent-free nanofluids,the long chain corona has the internal plasticization, which can decrease the loss modulus of system, while the short chain of corona results in the high viscosity of nanofluids. Long alkyl chains of modifiers lead to lower viscosity and better flowability of nanofluids. The rheology and viscosity of the nanofluids are correlated to the microscopic structure of the corona, which provide an in-depth insight into the preparing nanofluids with promising applications based on their tunable and controllable physical properties. | Yumo Tan Yaping Zheng Nan Wang Aibo Zhang | 2012 | Nano-Micro Letters2012，4，4： | 2 |
| 13 | An efficient route towards R-2-phenoxypropionic acid synthesis for biotransformative production of R-2-(4-hydroxyphenoxy)propionic acid显示文摘R2(4hydroxyphenoxy)propionic acid(RHPPA)is a key intermediate for the synthesis of classic herbicides with high selectivity against grassy weed.The main route for RHPPA biosynthesis is to hydroxylate the substrate R2phenoxypropionic acid(RPPA)at C4 position with microbes.In order to provide sufficient RPPA for the industrial production of RHPPA,an effective RPPA synthesis method was established and optimized in this work.The synthesis process mainly consisted of two steps:(1)synthesis of S2chloropropionic acid from Lalanine via diazotization and chlorination reactions;and(2)synthesis of RPPA from S2chloropropionic acid and phenol via etherification reaction.The optimal reaction conditions were as follows:HCl:NaNO_(2):KI:LAla=2.0:1.2:0.7:1.0(in molar),125℃reflux for 1.5 h,with KI as catalyst,and KI:S2chloropropionic acid:phenol=0.075:1.2:1.0(in molar).Under these conditions,an improved molar conversion rate(74.9%,calculated in phenol)was achieved.After extraction using anionic exchange resin Amberlite IRA400(CI),RPPA product with a purity of 95.08%was obtained.The purified RPPA was identified and evaluated in the application of the biotransformative production of RHPPA.The results indicated that the synthesized RPPA supported the RHPPA biosynthesis with a comparable yield as that of the standard RPPA.The RPPA synthesis method provided herein exhibited the advantages of low price and easy availability of raw materials,less toxicity of reagents,simple manipulations,and low equipment/instrument requirements. | Haiyan Zhou Yizuo Li Rui Jiang Xianlin Wang Yuanshan Wang Yaping Xue Yuguo Zheng | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 2 |
| 14 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 15 | OsSRK1,an Atypical S-Receptor-Like Kinase Positively Regulates Leaf Width and Salt Tolerance in Rice显示文摘Receptor-like kinases(RLKs)are important for plant growth,development and defense responses.The S-receptor protein kinases(SRKs),which represent an RLK subfamily,control the selfincompatibility among Brassica species.However,little information is available regarding SRK functions in rice.We identified a gene OsSRK1 encoding an atypical SRK.The transcript of OsSRK1 was induced by abscisic acid(ABA),salt and polyethylene glycol.OsSRK1 localized to the plasma membrane and cytoplasm.Leaf width was increased in OsSRK1-overexpression(OsSRK1-OX)transgenic rice plants,likely because of an increase in cell number per leaf.Furthermore,the expression levels of OsCYCA3-1 and OsCYCD2-1,which encode positive regulators of cell division,were up-regulated in leaf primordium of OsSRK1-OX rice plants relative to those in wild type.Meanwhile,the expression level of OsKRP1,which encodes cell cycle inhibitor,was down-regulated in the OsSRK1-OX plants.Therefore,it is deduced that OsSRK1 regulates leaf width by promoting cell division in the leaf primordium.Additionally,OsSRK1-OX plants exhibited enhanced ABA sensitivity and salt tolerance compared with wild type.These results suggest that OsSRK1 plays important roles in leaf development and salt responses in rice. | ZHOU Jinjun JU Peina ZHANG Fang ZHENG Chongke BAI Bo LI Yaping WANG Haifeng CHEN Fan XIE Xianzhi | 2020 | Rice science2020，27，2： | 2 |
| 16 | Thermal properties of glass frit and effects on Si solar cells显示文摘 | Zhang Yaping Yang Yunxia Zheng Jianhua | 2009 | Mater Chem Phys2009，114，1： | 1 |
| 17 | Effects of Nanoparticles SiO2 on the Performance of Nanocomposites显示文摘 | Zheng Yaping Zheng Y Ning Rongchang | | 0，，19： | 1 |
| 18 | Effects of nanoparticles SiO2 on the performance of the nanecomposites 显示文摘 | Zheng yaping Zheng ying Ning Rongchang | 2003 | Materials Letters2003，，57： | 1 |
| 19 | Studies on the enhancement of flue gas desulfurization with oxidation reaction 显示文摘 | Zhi Yongting Zheng Juanjuan Zhou Yaping Sun Yan Su Wei Zhou Li | 2011 | Energy& Fuels2011，25，： | 1 |
| 20 | Effect of surface decoration of CNTs on the interracial interac- tion and microstructure of epoxy/MWNT nanocompos- ites显示文摘 | Zhou Wei Wang Bo Zheng Yaping | 2008 | Chem Phys Chem2008，9，： | 1 |
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