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| 1 | Spatial patterns and driving forces of land use change in China during the early 21st century显示文摘Land use and land cover change as the core of coupled human-environment systems has become a potential field of land change science (LCS) in the study of global environmental change. Based on remotely sensed data of land use change with a spatial resolution of 1 km × 1 km on national scale among every 5 years, this paper designed a new dynamic regionalization according to the comprehensive characteristics of land use change including regional differentiation, physical, economic, and macro-policy factors as well. Spatial pattern of land use change and its driving forces were investigated in China in the early 21st century. To sum up, land use change pattern of this period was characterized by rapid changes in the whole country. Over the agricultural zones, e.g., Huang-Huai-Hai Plain, the southeast coastal areas and Sichuan Basin, a great proportion of fine arable land were engrossed owing to considerable expansion of the built-up and residential areas, resulting in decrease of paddy land area in southern China. The development of oasis agriculture in Northwest China and the reclamation in Northeast China led to a slight increase in arable land area in northern China. Due to the 'Grain for Green' policy, forest area was significantly increased in the middle and western developing regions, where the vegetation coverage was substantially enlarged, likewise. This paper argued the main driving forces as the implementation of the strategy on land use and regional development, such as policies of 'Western Development', 'Revitalization of Northeast', coupled with rapidly economic development during this period. | LIU Jiyuan ZHANG Zengxiang XU Xinliang KUANG Wenhui ZHOU Wancun ZHANG Shuwen LI Rendong YAN Changzhen YU Dongsheng WU Shixin JIANG Nan | 2010 | Journal of Geographical Sciences2010，20，4： | 154 |
| 2 | Spatiotemporal characteristics, patterns, and causes of land-use changes in China since the late 1980s显示文摘Land-use/land-cover 变化(LUCC ) 有连接到人和自然相互作用。瓷器 Land-Use/cover 数据集(CLUD ) 从 1980 年代末在 5 年的间隔定期被更新到 2010,与基于 Landsat TMETM+ 图象的标准过程。陆地使用动态区域化方法被建议分析主要陆地使用变换。在国家规模的陆地使用变化的空间与时间的特征,差别,和原因然后被检验。主要调查结果如下被总结。越过中国的陆地使用变化(LUC ) 在最后 20 年(19902010 ) 里在空间、时间的特征显示了一个重要变化。农田变化的区域在南方减少了并且在北方,而是仍然是的全部的区域增加了几乎未改变。回收农田从东北被转移到西北。布满建筑物陆地很快膨胀了,主要在东方被散布,并且逐渐地展开到中央、西方的中国。树林首先减少了,然后增加但是荒芜的区域是反面。草地继续减少。在中国的 LUC 的不同空间模式被发现在之间迟了第 20 世纪并且早第 21 世纪。原版 13 个 LUC 地区在一些地区被边界的变化由 15 个单位代替。包括的这些变化(1 ) 的主要空间特征加速的扩大布满建筑物在 Huang-Huai-Hai 区域,东南的沿海的区域,长江的中流区域,和四川盆登陆;(2 ) 从东北中国和东方内部蒙古在北方转移了陆地开垦到绿洲在西北中国的农业区域;(3 ) 从在到稻的东北中国的喂雨的农田的连续转变回答;并且(4 ) 为在内部蒙古,黄土高原,和西南的多山的区域的南部的农业牧剧的交错群落的格林工程的谷物的有效性。在最后二十年,尽管在北方的气候变化在农田影响了变化,政策规定和经济驱动力仍然是越过中国的 LUC 的主要原因。在第 21 世纪的第一十年期间,在陆地使用模式驾驶了变化的人为的因素从单程的陆地开发转移了强调到开发和保存。动态区域化方法被用来在单位的 zoning 边界,地区的内部特征,和生长和减少的空间模式分析变化。结果揭示了变化过程的模式,也就是 LUC 的过程和在在不同阶段的特征的地区性的差别。地区的生长和减少在这动态 LUC zoning,在统一边界的变化,和在前者和后者十年之间的变化紧张的特征期间被检验。在为在不同类型和陆地使用的不同区域的变化的陆地使用和原因的模式和过程之间的其他的转变的模式被探索。 | LIU Jiyuan KUANG Wenhui ZHANG Zengxiang XU Xinliang QIN Yuanwei NING Jia ZHOU Wancun ZHANG Shuwen LI Rendong YAN Changzhe WU Shixin SHI Xuezheng JIANG Nan YU Dongsheng PAN Xianzhang CHI Wenfeng | 2014 | Journal of Geographical Sciences2014，24，2： | 245 |
| 3 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 4 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 5 | Third generation of vortex identification methods:Omega and Liutex/Rortex based systems显示文摘A vortex is intuitively recognized as the rotational/swirling motion of fluids,but a rigorous and universally-accepted definition is still not available.Vorticity tube/filament has been regarded equivalent to a vortex since Helmholtz proposed the concepts of vorticity tube/filament in 1858 and the vorticity-based methods can be categorized as the first generation of vortex identification methods.During the last three decades,a lot of vortex identification methods,including 0,A,and Aci criteria,have been proposed to overcome the problems associated with the vorticity-based methods.Most of these criteria are based on the Cauchy-Stokes decomposition and/or eigenvalues of the velocity gradient tensor and can be considered as the second generation of vortex identification methods.Starting from 2014,the Vortex and Turbulence Research Team at the University of Texas at Arlington(the UTA team)focus on the development of a new generation of vortex identification methods.The first fruit of this effort,a new Omega(/2)vortex identification method,which defined a vortex as a connected region where the vorticity overtakes the deformation,was published in 2016.In 2017 and 2018,a Liutex(previously called Rortex)vector was proposed to provide a mathematical definition of the local rigid rotation part of the fluid motion,including both the local rotational axis and the rotational strength.Liutex/Rortex is a new physical quantity with scalar,vector and tensor forms exactly representing the local rigid rotation of fluids.Meanwhile,a decomposition of the vorticity to a rotational part namely Liutex/Rortex and an anti-symmetric shear part(RS decomposition)was introduced in 2018,and a universal decomposition of the velocity gradient tensor to a rotation part(7?)and a non-rotation part(NR、was also given in 2018 as a counterpart of the traditional Cauchy-Stokes decomposition.Later in early 2019,a Liutex/Rortex based Omega method called Omega-Liutex,which combines the respective advantages of both Liutex/Rortex and Omega methods,was developed.And a latest objective Omega method,which is still under development,is also briefly introduced.These advances are classified as the third generation of vortex identification methods in the current paper.To elaborate the advantages of the third-generation methods,six core issues for vortex definition and identification have been raised,including:(1)the absolute strength,(2)the relative strength,(3)the rotational axis,(4)the vortex core center location,(5)the vortex core size,(6)the vortex boundary.The new third generation of vortex identification methods can provide reasonable answers to these questions,while other vortex identification methods fail to answer all questions except for the approximation of vortex boundaries.The purpose of the current paper is to summarize the main ideas and methods of the third generation of vortex identification methods rather than to conduct a comprehensive review on the historical development of vortex identification methods. | Chaoqun Liu Yi-sheng Gao Xiang-rui Dong Yi-qian Wang Jian-ming Liu Yu-ning Zhang Xiao-shu Cai Nan Gui | 2019 | Journal of Hydrodynamics2019，31，2： | 82 |
| 6 | Mechanism of the December 2015 Catastrophic Landslide at the Shenzhen Landfill and Controlling Geotechnical Risks of Urbanization显示文摘 | Yueping Yin Bin Li Wenpei Wang Liangtong Zhan Qiang Xue Yang Gao Nan Zhang Hongqi Chen Tiankui Liu Aiguo Li | 2016 | Engineering2016，2，2： | 64 |
| 7 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 8 | Influences of blood lipids on the occurrence and prognosis of hemorrhagic transformation after acute cerebral infarction: a case-control study of 732 patients显示文摘Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including intravenous recombinant human tissue plasminogen activator(r TPA), intensive lipid-lowering statins and anti-platelets, were not significantly related to either HT or long-term, post-ACI poor prognosis.Conclusions: For patients with large infarct sizes, especially those with cortex involvement, AF, or lower levels of TC, the risk of HT might increase after ACI. The risk of a long-term unfavorable outcome in these patients might increase with a reduction in LDL-C. | Gang Lv Guo-Qiang Wang Zhen-Xi Xia Hai-Xia Wang Nan Liu Wei Wei Yong-Hua Huang Wei-Wei Zhang | 2019 | Military Medical Research2019，6，3： | 60 |
| 9 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 10 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 11 | Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer显示文摘AIM:To investigate the impact of prognostic nutritional index(PNI)on the postoperative complications and long-term outcomes in gastric cancer patients undergoing total gastrectomy.METHODS:The data for 386 patients with gastric cancer were extracted and analyzed between January2003 and December 2008 in our center.The patients were divided into two groups according to the cutoff value of the PNI:those with a PNI≥46 and those with a PNI<46.Clinicopathological features were compared between the two groups and potential prognostic factors were analyzed.The relationship between postoperative complications and PNI was analyzed by logistic regression.The univariate and multivariate hazard ratios were calculated using the Cox proportional hazard model.RESULTS:The optimal cutoff value of the PNI was set at 46,and patients with a PNI≥46 and those with a PNI<46 were classified into PNI-high and PNI-low groups,respectively.Patients in the PNI-low group were more likely to have advanced tumor(T),node(N),and TNM stages than patients in the PNI-high group.The low PNI is an independent risk factor for the incidence of postoperative complications(OR=2.223).The 5-year overall survival(OS)rates were 54.1%and21.1%for patients with a PNI≥46 and those with a PNI<46,respectively.The OS rates were significantly lower in the PNI-low group than in the PNI-high group among patients with stagesⅡ(P=0.001)andⅢ(P<0.001)disease.CONCLUSION:The PNI is a simple and useful marker not only to identify patients at increased risk for postoperative complications,but also to predict long-term survival after total gastrectomy.The PNI should be included in the routine assessment of advanced gastric cancer patients. | Nan Jiang Jing-Yu Deng Xue-Wei Ding Bin Ke Ning Liu Ru-Peng Zhang Han Liang | 2014 | World Journal of Gastroenterology2014，20，30： | 41 |
| 12 | Expression of IL-10 and TNF-α in Rats with Cerebral Infarction after Transplantation with Mesenchymal Stem Cells显示文摘我们调查了骨头的效果在老鼠的 MCAO (中间的服的动脉吸藏) 的神经病学的功能的恢复上的导出髓的间充质的干细胞(MSC ) 移植模型和它的 mechanism.MSCs 从男 Sprague Dawley (SD ) 老鼠的骨头髓被孤立。女成年 SD 老鼠随机被分配进 4 个组:假冒操作组, MCAO 组,车辆组和 MCAO +对待 MSCs 的组。MSC 在对待 MSCs 的组被注入老鼠的侧面的室, PBS 的一样的体积被给车辆组。IL-10 和 TNF- 的表情在 MCAO 以后是由在白天 1 和 4 点的 RT-PCR 和 ELISA 察觉的 assayed。梗塞体积被染色 TTC 测量。老鼠经历了的所有行为的测试在前,以及在 MCAO 以后的 1, 4,和 14 天。MSC 显著地在在移植以后的白天 14 点与控制相比改进了功能的恢复。与 MCAO 组和车辆相比,组, IL-10 mRNA 的表示和它的蛋白质显著地在 MSC 组铺平 upregulated。然而, TNF 的表示 -- 4 显著地在在 MSC 的 MCAO 以后组织的一 at 天与 MCAO 组和车辆组的相比减少了。作为结果,有 MSC 的移植显著地减少了在白天 1 和 4 点的梗塞体积。这研究强烈建议有 MSC 的移植能减少 neuronal 损害由在大脑调整 IL-10 和 TNF- 的表达式部分在老鼠张贴焦点的服的局部缺血。细胞与分子的免疫学。2009; 6 (3 ): 207-213。 | Nan Liu Ronghua Chen Houwei Du Jiehua Wang Yixian Zhang Jinsen Wen | 2009 | Cellular & Molecular Immunology2009，6，3： | 40 |
| 13 | Oceanic plate subduction history in the western Pacific Ocean:Constraint from late Mesozoic evolution of the Tan-Lu Fault Zone显示文摘The NE-to NNE-striking Tan-Lu Fault Zone(TLFZ) is the largest fault zone in East China, and a typical representative for the circum-Pacific tectonics. Its late Mesozoic evolution resulted from subduction of the Paleo-Pacific Plate,and can be used for indication to the subduction history. The TLFZ reactivated at the end of Middle Jurassic since its origination in Middle Triassic. This phase of sinistral motion can only be recognized along the eastern edge of the Dabie-Sulu orogenis,and indicates initiation of the Paleo-Pacific(Izanagi) Plate subduction beneath the East China continent. After the Late Jurassic standstill, the fault zone experienced intense sinistral faulting again at the beginning of Early Cretaceous under N-S compression that resulted from the NNW-ward, low-angle, high-speed subduction of the Izanagi Plate. It turned into normal faulting in the rest of Early Cretaceous, which was simultaneous with the peak destruction of the North China Craton caused by backarc extension that resulted from rollback of the subducting Izanagi Plate. The TLFZ was subjected to sinistral, transpressive displacement again at the end of Early Cretaceous. This shortening event led to termination of the North China Craton destruction. The fault zone suffered local normal faulting in Late Cretaceous due to the far-field, weak backarc extension. The late Mesozoic evolution of the TLFZ show repeated alternation between the transpressive strike-slip motion and normal faulting. Each of the sinistral faulting event took place in a relatively short period whereas every normal faulting event lasted in a longer period, which are related to the subduction way and history of the Paleo-Pacific Plates. | Guang ZHU Cheng LIU Chengchuan GU Shuai ZHANG Yunjian LI Nan SU Shiye XIAO | 2018 | Science China Earth Sciences2018，61，4： | 38 |
| 14 | Vision,Requirements and Network Architecture of 6G Mobile Network beyond 2030显示文摘With the 5th Generation(5G)Mobile network being rolled out gradually in 2019,the research for the next generation mobile network has been started and targeted for 2030.To pave the way for the development of the 6th Generation(6G)mobile network,the vision and requirements should be identified first for the potential key technology identification and comprehensive system design.This article first identifies the vision of the society development towards 2030 and the new application scenarios for mobile communication,and then the key performance requirements are derived from the service and application perspective.Taken into account the convergence of information technology,communication technology and big data technology,a logical mobile network architecture is proposed to resolve the lessons from 5G network design.To compromise among the cost,capability and flexibility of the network,the features of the 6G mobile network are proposed based on the latest progress and applications of the relevant fields,namely,on-demand fulfillment,lite network,soft network,native AI and native security.Ultimately,the intent of this article is to serve as a basis for stimulating more promising research on 6G. | Guangyi Liu Yuhong Huang Na Li Jing Dong Jing Jin Qixing Wang Nan Li | 2020 | China Communications2020，17，9： | 37 |
| 15 | Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways显示文摘Acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) is a severe, lifethreatening medical condition characterized by widespread inflammation in the lungs, and is a significant source of morbidity and mortality in the patient population. New therapies for the treatment of ALI are desperately needed. In the present study, we examined the effect of andrographolide sulfonate, a water-soluble form of andrographolide(trade name: Xi-Yan-Ping Injection), on lipopolysaccharide(LPS)-induced ALI and inflammation. Andrographolide sulfonate was administered by intraperitoneal injection to mice with LPS-induced ALI. LPS-induced airway inflammatory cell recruitment and lung histological alterations were significantly ameliorated by andrographolide sulfonate. Protein levels of pro-inflammatory cytokines in bronchoalveolar lavage fluid(BALF) and serum were reduced by andrographolide sulfonate administration. m RNA levels of pro-inflammatory cytokines in lung tissue were also suppressed. Moreover, andrographolide sulfonate markedly suppressed the activation of mitogen-activated protein kinase(MAPK) as well as p65 subunit of nuclear factor-κB(NF-κB). In summary, these results suggest that andrographolide sulfonate ameliorated LPS-induced ALI in mice by inhibiting NF-κB and MAPK-mediated inflammatory responses. Our study shows that water-soluble andrographolide sulfonate may represent a new therapeutic approach for treating inflammatory lung disorders. | Shuang Peng Nan Hang Wen Liu Wenjie Guo Chunhong Jiang Xiaoling Yang Qiang Xu Yang Sun | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 38 |
| 16 | 2000–2020年中国氮氧化物排放清单及排放趋势(英文)显示文摘研究目的:建立2000–2020年中国氮氧化物排放清单,了解中国主要行业和省份氮氧化物的排放情况,为评估氮氧化物的环境影响和制定相关减排政策提供依据。创新要点:分析了中国主要省份产业结构对氮氧化物排放量的影响;根据不同情景分析,预测2020年中国氮氧化物的排放量。研究方法:1.基于自底向上法,根据不同类型化石燃料的氮氧化物排放因子,结合化石燃料消耗量,建立中国2000–2010年氮氧化物排放清单;2.基于IPAT方程,并以中国2000–2010年的国内生产总值增长数据和氮氧化物排放量为依据,分三种情景,分析2011–2020年中国能源消耗和氮氧化物排放趋势。重要结论:2010年中国氮氧化物的排放量约是2000年的两倍;自2009年起,中国氮氧化物总排放量超过了二氧化硫总排放量;主要由于产业结构和地区生产总值的不同,中国东部和西部氮氧化物排放量有明显差异;制造业、电力行业和交通运输业是中国氮氧化物的主要排放源,其中交通运输业氮氧化物排放量呈现逐年增长趋势;预计2020年中国氮氧化物排放量为19.7 Mt。 | Yun SHI Yin-feng XIA Bi-hong LU Nan LIU Lei ZHANG Su-jing LI Wei LI | 2014 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2014，15，6： | 34 |
| 17 | Distribution and assessment of heavy metals in the surface sediment of Yellow River, China显示文摘Large amounts of heavy metals discharged by industrial cities that are located along the middle reach of Yellow River, China have detrimental impacts on both the ecological environment and human health. In this study, fourteen surface sediment samples were taken in the middle reach of the Yellow River. Contents of Zn, Pb, Ni, Cu, Cr, Cd, As were measured, and the pollution status was assessed using three widely used pollution assessment methods, including the single factor index method, Nemerow pollution index method and potential ecological risk index. The concentrations of the studied heavy metals followed the order: Zn > Cr > Cu > Ni > Pb > As > Cd. Nearly 50% of sites had Cu and Cr accumulation. The concentration of Cu at the Yiluo River exceeded the secondary standard value of the Environmental quality standard for soils. Comparison of heavy metal concentrations between this study and other selected rivers indicated that Cu and Cr may be the major pollutants in our case. The single factor index indicated that many samples were at high levels of pollution for Cu and Cd; the Nemerow pollution index indicated that the Yihe River, Luohe River, Yiluo River and Huayuankou were polluted. According to the results of potential ecological risk assessment, Cd in the tributaries of Luo River, Yihe River,and Yiluo River showed high risk toward the ecosystem and human health, Cd in Huanyuankou and Cu in Yiluo River showed a middle level of risk and other samples were at a low level of risk. | Nan Yan Wenbin Liu Huiting Xie Lirong Gao Ying Han Mengjing Wang Haifeng Li | 2016 | Journal of Environmental Sciences2016，28，1： | 33 |
| 18 | New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions显示文摘Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent years.Zhuangguguanjiewan pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)model.This present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS model.Liver function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated rats.Moreover,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated rats.Furthermore,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic hepatotoxicity.Thus,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 inflammasome.In addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic pathways.Therefore,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions. | Yuan Gao Zhilei Wang Jinfa Tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan Wang Yu Pang Ruisheng Li Yaming Zhang Jiabo Wang Ming Niu Zhaofang Bai Xiaohe Xiao | 2020 | Frontiers of Medicine2020，14，1： | 32 |
| 19 | Clinical observations on the treatment of prolapsing hemorrhoids with tissue selecting therapy显示文摘AIM:To compare the effects and postoperative complications between tissue selecting therapy stapler(TST)and Milligan-Morgan hemorrhoidectomy(M-M).METHODS:Four hundred and eighty patients with severe prolapsing hemorrhoids,who were admitted to the Shenyang Coloproctology Hospital between 2009and 2012,were randomly divided into observation(n=240)and control(n=240)groups.Hemorrhoidectomies were performed with TST in the observation group and with the M-M technique in the control group.The therapeutic effects,operation security,and postoperative complications in the two groups were compared.The immediate and long-term complications were assessed according to corresponding criteria.Pain was assessed on a visual analogue scale.The efficacy was assessed by specialized criteria.The follow-up was conducted one year after the operation.RESULTS:The total effective rates of the observation and control groups were 99.5%(217/218)and 98.6%(218/221)respectively;the difference was not statistically significant(P=0.322).Their were significant differences between observation and control groups in intraoperative blood loss(5.07±1.14 vs 2.45±0.57,P=0.000),pain(12 h after the surgery:5.08±1.62 vs 7.19±2.01,P=0.000;at first dressing change:2.64±0.87 vs 4.34±1.15,P=0.000;first defecation:3.91±1.47 vs 5.63±1.98,P=0.001),urine retention(n=22 vs n=47,P=0.001),anal pendant expansion after the surgery(2.35±0.56 vs 5.16±1.42,P=0.000),operation time(18.3±5.6 min vs 29.5±8.2 min,P=0.000),and the length of hospital stay(5.3±0.6 d vs 11.4±1.8 d,P=0.000).Moreover TST showed significant reductions compared to M-M in the rates of long-term complications such as fecal incontinence(n=3 vs n=16,P=0.003),difficult bowel movement(n=1 vs n=9,P=0.011),intractable pain(n=2 vs n=12,P=0.007),and anal discharge(n=3 vs n=23,P=0.000).CONCLUSION:TST for severe prolapsing hemorrhoids is a satisfactory technique for more rapid recovery,lower complication rates,and higher operation security. | Zhi-Gang Wang Yong Zhang Xian-Dong Zeng Tie-Hui Zhang Qi-Dong Zhu De-Long Liu Yun-Yu Qiao Nan Mu Zhi-Tao Yin | 2015 | World Journal of Gastroenterology2015，21，8： | 33 |
| 20 | Correlation of matrix metalloproteinase suppressor genes RECK,VEGF,and CD105 with angiogenesis and biological behavior in esophageal squamous cell carcinoma显示文摘AIM: To explore the expression of reversion inducing cysteine-rich protein with Kazal motifs (RECK), vascular endothelial growth factor (VEGF) and endoglin (CD105) protein and its correlation with occurrence, development, invasion and metastasis in esophageal squamous cell carcinoma (ESCC). METHODS: Streptavidin-peroxidase (SP) immunohisto- chemistry was used to detect expression of RECK and VEGF in 62 cases of ESCC, 31 cases of adjacent atypical hyperplastic epithelium and 62 cases of normal esophageal epithelium. CD105 Mb was used to assess microvessel density (MVD). RESULTS: The expression of RECK was closely correlated with histological grade, infiltrative depth and lymphatic metastasis in ESCC (P < 0.05). The expression of RECK decreased during cancer development: normal esophageal epithelium (85.5%, 53/62), adjacent atypical hyperplastic epithelium (71.0%, 22/31), and carcinoma (59.7%, 37/62). There was a significant difference among the groups (P < 0.05). The expression of VEGF protein was closely correlated with infiltrative depth and lymphatic metastasis in ESCC (P < 0.05). The expression of VEGF protein increased during cancer development: normal esophageal epithelium (29.0%, 18/62), adjacent atypical hyperplastic epithelium (54.8%, 17/31), and carcinoma (67.7%, 42/62). There was a significant difference among the groups (P < 0.05). MVDCD105 increased in accordance with histological grade, butthere was no significant difference (grade Ⅰ, 36.92 ± 10.85; grade Ⅱ, 37.65 ± 9.50; and grade Ⅲ, 38.06 ± 12.19). The MVDCD105 was closely correlated with infiltration and lymphatic metastasis in ESCC (P < 0.05). The expression of RECK was inversely correlated with the expression of VEGF and CD105. CONCLUSION: RECK, VEGF and CD105 play important roles in the infiltration, metastasis and carcinogenesis in esophageal carcinoma. Angiogenesis in ESCC may be promoted by over-expression of CD105. | Sheng-Lei Li, Zhi-Hua Zhao, Dong-Ling Gao, Zong-Wen Liu, Qiu-Min Zhao, Jin-Xia Yu, Kui-Sheng Chen, Yun-Han Zhang, Department of Pathology, The First Affiliated Hospital Zhengzhou University He’nan Key Laboratory of Tumor Pathology, Zhengzhou 450052, He’nan Province, China | 2007 | World Journal of Gastroenterology2007，13，45： | 30 |
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