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| 1 | Discrete element modeling of ice loads on ship hulls in broken ice fields显示文摘Ice loads on a ship hull affect the safety of the hull structure and the ship maneuvering performance in ice-covered regions.A discrete element method(DEM)is used to simulate the interaction between drifting ice floes and a moving ship.The pancake ice floes are modelled with three-dimensional(3-D)dilated disk elements considering the buoyancy,drag force and additional mass induced by the current.The ship hull is modelled with 3D disks with overlaps.Ice loads on the ship hull are determined through the contact detection between ice floe element and ship hull element and the contact force calculation.The influences of different ice conditions(current velocities and directions,ice thicknesses,concentrations and ice floe sizes)and ship speeds are also examined on the dynamic ice force.The simulated results are compared qualitatively well with the existing field data and other numerical results.This work can be helpful in the ship structure design and the navigation security in ice-covered fields. | JI Shunying LI Zilin LI Chunhua SHANG Jie | 2013 | Acta Oceanologica Sinica2013，32，11： | 12 |
| 2 | 上海市闸北区学龄前儿童注意缺陷多动障碍患病率及症状分布特征的研究显示文摘目的了解上海市闸北区学龄前儿童注意缺陷多动障碍(ADHD)的症状阳性率和影响因素。方法使用一般情况调查表和注意缺陷多动症状调查表,采取整群-分层抽样的方法对上海市闸北区3~6岁学龄前儿童进行调查。针对注意缺陷多动症状调查表中症状阳性率的总体情况、年龄分布、及其与性别、户籍、家庭情况的关系,进行了比较和分析。结果学龄前儿童ADHD患病率为3.9%,男、女患病率分别为2.5%和1.3%,男、女比例为2:1。大部分症状阳性率大致随年龄增长而递减;阳性率最高年龄段分布于4~5岁;男性阳性率显著高于女性;外地户籍的儿童阳性率高于上海市户籍的儿童;按父母文化程度比较,症状阳性率有显著差异。结论学龄前儿童的注意缺陷症状的阳性率普遍高于多动症状,父母文化程度的高低与儿童ADHD症状严重程度有关。 | 阿依奴尔 吾买尔 杜亚松 金文岚 钟向阳 David Coghill Shunying Au | 2012 | 中国医疗设备2012，27，4： | 10 |
| 3 | A viscoelastic-plastic constitutive model with Mohr-Coulomb yielding criterion for sea ice dynamics显示文摘A new viscoelastic-plastic (VEP) constitutive model for sea ice dynamics was developed based on continuum mechanics. This modelconsists of four components: Kelvin-Vogit viscoelastic model, Mohr-Coulomb yielding criterion, associated normality flow rule forplastic rehololgy, and hydrostatic pressure. The numerical simulations for ice motion in an idealized rectangular basin were made usingsmoothed particle hydrodynamics (SPH) method, and compared with the analytical solution as well as those based on the modified vis-cous plastic(VP) model and static ice jam theory. These simulations show that the new VEP model can simulate ice dynamics accu-rately. The new constitutive model was further applied to simulate ice dynamics of the Bohai Sea and compared with the traditionalVP, and modified VP models. The results of the VEP model are compared better with the satellite remote images, and the simulated iceconditions in the JZ20-2 oil platform area were more reasonable. | JI Shunying SHEN Hung Tao WANG Zhilian SHEN H Hayley YUE Qianjin | 2005 | Acta Oceanologica Sinica2005，24，4： | 9 |
| 4 | Chemical Composition and Antimicrobial Activity of Essential Oil of Asarum caulescene显示文摘Both essential oils of fresh and air-dried Asarum caulescene (Maxim.) were analyzed by GC-MS in three different polarities. The results show that thirty-four components were identified in the oils, and main compounds of both oils were β-pinene (7.63% vs. 20.72%), 2-carene (8.94% vs. 7.99%), β-phellandrene (7.80% vs. 14.39%), 1,8-cineole (8.91% vs. 13.29%) and germacrone (46.64% vs. 6.64% ), however, the content of monoterpene hydrocarbons(30.29% vs. 52.30% ) and oxygenated sesquiterpenes( 47.69% vs. 10.65%) of both oils was different. The antimicrobial activity of the oil was evaluated against 3 fungi and 11 bacteria including 7 clinical isolated strains. Our results showed that both oils presented a broad antimicrobial spectrum, and compared with the essential oil from fresh herb, the extracted oil from dried herb had better antimicrobial activity, its minimum inhibitory concentration(c_ mi ) values of dried herb were 0.16-2.5 g/L and lowest minimum bactericidal concentration(c_ mb ) value was 0.31 g/L. | ZHU Shunying YANG Yang YU Huaidong YING Yue LONG Dong Zou Guolin | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 7 |
| 5 | Characteristics of temporal-spatial parameters in quasi-solid-fluid phase transition of granular materials显示文摘The quasi-solid-fluid phase transition of granular materials is closely related to the shear rate and solid concentration in addition to their intrinsic properties. The contact duration and the coordination number are two important temporal-spatial parame-ters to describe the granular interaction in phase transition. In this study, characteristics of the contact duration and the coordination number associated with the transition processes are determined using a 3D discrete element model under different shear rates and concentrations. The resulting macroscopic stress and strain-rate relations are discussed. The temporal and spatial parameters provide a linkage between the macroscopic constitutive law and inter- particle micromechanics. | JI Shunying SHEN H Hayley | 2006 | Chinese Science Bulletin2006，51，6： | 5 |
| 6 | Unexpected catalytic activity of rhodium nanodendrites with nanosheet subunits for methanol electrooxidation in an alkaline medium显示文摘Rh 的 Nanocrystals,高贵金属催化剂家庭的一个重要成员,在异构的催化反应有宽应用。控制这些高贵金属 nanocrystals 的形态学为改进他们的催化活动和耐久性成为了有效策略。在这个工作,有很薄的三角形的分支的明确的 Rh nanodendrites 用一个灵巧的 diethylene 乙二醇减小方法作为子单元被综合,作为一个复杂形成的代理人和表面活化剂由 polyethyleneimine 帮助了。第一次,有明确的形态学的 Rh nanocrystals 上的甲醇氧化反应(粗腐殖质) 在碱的媒介用各种各样的电气化学的技术被调查。出人意料地,同样准备的 Rh nanodendrites 与 ultrathin nanosheet 子单元,在碱的媒介在 MOR 期间展出优异 electrocatalytic 活动和耐久性,与特定的形态学显示那 Rh nanocrystals 可以是在在碱的媒介的 MOR 的磅 electrocatalysts 的高度有希望的选择。 | Yongqiang Kang Fumin Li Shuni Li Pujun Jin Jinhui Zeng Jiaxing Jiang Yu Chen | 2016 | Nano Research2016，9，12： | 5 |
| 7 | Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors显示文摘CDK4/6 inhibitors are the standard treatment in advanced HR+/HER2-breast cancer patients.Nevertheless,the resistance to CDK4/6 inhibitors is inevitable and the strategies to overcome resistance are of great interest.Here,we show that the palbociclibresistant breast cancer cells expressed significantly higher levels of Cyclin D1 and CDK4 proteins because of upregulated protein synthesis.Silencing Cyclin D1 or CDK4 led to cell cycle arrest while silencing Cyclin E1 or CDK2 restored the sensitivity to palbociclib.Furthermore,PI3K/mTOR pathway was hyper-activated in palbociclib-resistant cells,leading to more phosphorylated 4E-BP1 and higher levels of Cyclin D1 and CDK4 translation.Targeting PI3K/mTOR pathway with a specific PI3Kαinhibitor(BYL719)or an mTOR inhibitor(everolimus)reduced the protein levels of Cyclin D1 and CDK4,and restored the sensitivity to palbociclib.The tumor samples expressed significantly higher levels of Cyclin D1,CDK4,p-AKT and p-4E-BP1 after progression on palbociclib treatment.In conclusion,our findings suggest that overexpressed Cyclin D1 and CDK4 proteins lead to the resistance to CDK4/6 inhibitor and PI3K/mTOR inhibitors are able to restore the sensitivity to CDK4/6 inhibitors,which provides the biomarker and rationale for the combinational use of CDK4/6 inhibitors and PI3K/mTOR inhibitors after CDK4/6 inhibitor resistance in breast cancer. | Zijie Cai Jingru Wang Yudong Li Qianfeng Shi Liang Jin Shunying Li Mengdi Zhu Qi Wang Lok Lam Wong Wang Yang Hongna Lai Chang Gong Yandan Yao Yujie Liu Jun Zhang Herui Yao Qiang Liu | 2023 | Science China(Life Sciences)2023，66，1： | 4 |
| 8 | A modified discrete element model for sea ice dynamics显示文摘Considering the discontinuous characteristics of sea ice on various scales,a modified discrete element model(DEM)for sea ice dynamics is developed based on the granular material rheology.In this modified DEM,a soft sea ice particle element is introduced as a self-adjustive particle size function.Each ice particle can be treated as an assembly of ice floes,with its concentration and thickness changing to variable sizes under the conservation of mass.In this model,the contact forces among ice particles are calculated using a viscous-elastic-plastic model,while the maximum shear forces are described with the Mohr-Coulomb friction law.With this modified DEM,the ice flow dynamics is simulated under the drags of wind and current in a channel of various widths.The thicknesses,concentrations and velocities of ice particles are obtained,and then reasonable dynamic process is analyzed.The sea ice dynamic process is also simulated in a vortex wind field.Taking the influence of thermodynamics into account,this modified DEM will be improved in the future work. | LI Baohui LI Hai LIU Yu WANG Anliang JI Shunying | 2014 | Acta Oceanologica Sinica2014，33，1： | 4 |
| 9 | Interaction between sea ice/iceberg and ship structures: A review显示文摘For ship structural design and good maneuverability in an ice-covered sea, the local and global load of ice cover on ships should be well understood. This paper reviews the extensive work done on ice loads on ships, including: (a) Ice pressure and local load determination based on field and model tests; (b) Global ice loads on ships from full-scale field observations, model tests and numerical models under different ice conditions (level ice and pack ice) and ship operations (maneuvering and mooring). Special attention is paid to the discrete element simulation of global ice loads on ships; and (c) Analytical solutions and numerical models of impact loads of icebergs on ships for polar navigation. Finally, research potential in these areas is discussed. | JI Shunying LIU Shewen | 2012 | Advances in Polar Science2012，23，4： | 4 |
| 10 | Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker and implicates potential therapeutic targets显示文摘Macrolide and corticosteroid resistance has been reported in patients with Mycoplasma pneumoniae(MP)pneumonia(MPP).MP clearance is difficult to achieve through antibiotic treatment in sensitive patients with severe MPP(SMPP).SMPP in children might progress to airway remodeling and even bronchiolitis/bronchitis obliterans.Therefore,identifying serum biomarkers that indicate MPP progression and exploring new targeted drugs for SMPP treatment require urgency.In this study,serum samples were collected from patients with general MPP(GMPP)and SMPP to conduct proteomics profiling.The Fc fragment of the IgG-binding protein(FCGBP)was identified as the most promising indicator of SMPP.Biological enrichment analysis indicated uncontrolled inflammation in SMPP.ELISA results proved that the FCGBP level in patients with SMPP was substantially higher than that in patients with GMPP.Furthermore,the FCGBP levels showed a decreasing trend in patients with GMPP but the opposite trend in patients with SMPP during disease progression.Connectivity map analyses identified 25 possible targeted drugs for SMPP treatment.Among them,a mechanistic target of rapamycin kinase(mTOR)inhibitor,which is a macrolide compound and a cell proliferation inhibitor,was the most promising candidate for targeting SMPP.To our knowledge,this study was the first proteomics-based characterization of patients with SMPP and GMPP. | Jinrong Liu Rongfang Shen Lin Feng Shujun Cheng Jun Chen Ting Xiao Shunying Zhao | 2022 | Frontiers of Medicine2022，16，3： | 3 |
| 11 | Probability analysis of contact forces in quasi-solid-liquid phase transition of granular shear flow显示文摘The quasi-solid-liquid phase transition exists widely in different fields,and attracts more attention due to its instinctive mechanism.The structure of force chains is an important factor to describe the phase transition properties.In this study,the discrete element model(DEM) is adopted to simulate a simple granular shear flow with period boundary condition on micro scale.The quasi-solid-liquid phase transition is obtained under various volume fractions and shear rates.Based on the DEM results,the probability distribution functions of the inter-particle contact force are obtained in different shear flow phases.The normal,tangential and total contact forces have the same distributions.The distribution can be fitted as the exponential function for the liquid-like phase,and as the Weibull function for the solid-like phase.To describe the progressive evolution of the force distribution in phase transition,we use the Weibull function and Corwin-Ngan function,respectively.Both of them can determine the probability distributions in different phases and the Weibull function shows more reasonable results.Finally,the force distributions are discussed to explain the characteristics of the force chain in the phase transition of granular shear flow.The distribution of the contact force is an indicator to determine the flow phase of granular materials.With the discussions on the statistical properties of the force chain,the phase transition of granular matter can be well understood. | JI ShunYing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 3 |
| 12 | Progress and development on multi-parameters remote sensing application in earthquake monitoring in China显示文摘In this paper,the progress and development on remote sensing technology applied in earthquake monitoring research are summarized,such as differential interference synthetic aperture radar(D-InSAR),infrared remote sensing,and seismo-ionospheric detecting.Many new monitoring data in this domain have been used,and new data processing methods have been developed to obtain high-precision images about crustal deformation,outgoing longwave radiation(OLR),surface latent heat flux(SLHF),and ionospheric parameters.The development in monitoring technology and data processing technique largely enriches earthquake research information and provides new tools for earthquake stereoscope monitoring system,especially on the space part.Finally,new developing trend in this area was introduced,and some key problems in future work were pointed out. | Xuhui Shen Xuemin Zhang Shunying Hong Feng Jing Shufan Zhao | 2013 | Earthquake Science2013，26，6： | 3 |
| 13 | A hybrid Lagrangian-Eulerian numerical model for sea-ice dynamics显示文摘A hybrid Lagrangian-Eulerian(HLE) method is developed for sea ice dynamics,which combines the high computational efficiency of finite difference method(FDM) with the high numerical accuracy of smoothed particle hydrodynamics(SPH).In this HLE model,the sea ice cover is represented by a group of Lagrangian ice particles with their own thicknesses and concentrations.These ice variables are interpolated to the Eularian gird nodes using the Gaussian interpolation function.The FDM is used to determine the ice velocities at Eulerian grid nodes,and the velocities of Lagrangian ice particles are interpolated from these grid velocities with the Gaussian function also.The thicknesses and concentrations of ice particles are determined based on their new locations.With the HLE numerical model,the ice ridging process in a rectangular basin is simulated,and the simulated results are validated with the analytical solution.This method is also applied to the simulation of sea ice dynamics in a vortex wind field.At last,this HLE model is applied to the Bohai Sea,and the simulated concentration,thickness and velocity match the satellite images and the field observed data well. | JI Shunying LI Hai SHEN Hung Tao WANG Ruixue YUE Qianjin | 2007 | Acta Oceanologica Sinica2007，26，5： | 3 |
| 14 | ON THE EFFECTIVENESS OF TEACHER TALK IN THE ELT CLASSROOM显示文摘Teacher talk is of crucial significance to the ELT classroom.However,little research hasbeen carried out on teacher talk.This paper discusses the types of teacher talk,analyzes the vari-ous factors affecting teacher talk,and puts forward some suggestions to make teacher talk moreeffective and efficient.Teacher talk (TT) is of crucial significance for all classrooms,particularly the ELT class-room,because in the ELT classroom,language is not only the objective of the course,but also themedia to achieve the objective.Both the organization of the classroom and the process of acquisi-tion are achieved through TT.Whether an ELT class is successful or not depends to a large degreeon the effectiveness of TT.However,not many professionals in China have realized the impor-tance of TT.Little research has been carried out on TT.(Wang Yinquan,1999:54) The papercasts away a brick to attract jade. | Li Shunying Chong Qing Medical University | 1999 | Chinese Journal of Applied Linguistics1999，22，4： | 2 |
| 15 | LIN9 confers paclitaxel resistance in triple negative breast cancer cells by upregulating CCSAP显示文摘LIN9 functions to regulate cell mitotic process.Dysregulation of LIN9 expression is associated with development of human cancers.In this study we assessed the association of LIN9 expression with paclitaxel resistance and clarified the underlying mechanisms for the first time.LIN9 expression in breast cancer tissues was retrieved from publicly available online databases and statistically analyzed.Human TNBC cell lines MDA-MB-231 and MDA-MB-468 and their corresponding paclitaxelresistant sublines 231PTX and 468PTX were used to assess the expression of LIN9 by qRT-PCR and Western blot,cell growth by cell counting,cell viability by MTS assay,and cell apoptosis by flow cytometry.The data showed that high LIN9 expression in breast cancer patients receiving chemotherapy was related to poor overall survival(OS).LIN9 expression was upregulated in paclitaxel-resistant TNBC cells compared to their parental cells.Knockdown of LIN9 or treatment of paclitaxel-resistant TNBC cells with a bromo-and extra-terminal domain inhibitor(BETi)JQ1 which also decreased LIN9 expression enhanced the sensitivity of paclitaxel-resistant TNBC cells to paclitaxel.Mechanistically,decreased LIN9 in resistant cell lines reduced tumor cell viability,promoted multinucleated cells formation and induced tumor cell apoptosis,potentially by directly regulating microtubule-binding protein CCSAP.In conclusion,high LIN9 expression contributed to poor clinical outcomes and paclitaxel resistance in TNBC and BETi,targeting LIN9 expression,could be a reversible drug for PTX-resistant TNBC patients. | Hongna Lai Rui Wang Shunying Li Qianfeng Shi Zijie Cai Yudong Li Yujie Liu | 2020 | Science China(Life Sciences)2020，63，3： | 2 |
| 16 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 17 | Paleo-environmental study on the growth of magnetotactic bacteria and precipitation of magnetosomes in Chinese loess-paleosol sequences显示文摘405 samples were collected from L5-S5-L6 in consideration of obvious variations in susceptibility of the geological sections, which are section Xifeng in Gansu Province and section Duanjiapo in Shaanxi Province for study of magnetotactic bacteria (MB) and magnetosomes (MS) in Chinese loess-paleosol sequences. MB in each sample were observed by TEM after being cultured under 8-18℃, room temperature (RT), 25℃, 26℃ and 30℃ conditions. In general, MB are distributed widely in loess-paleosol sequences, fewer in loess layers with predomination of vibriod in shape. However, there are more MB in paleosol layers with morphological varieties such as roddish, vibriod and occasionally approximately coccus. The magnetosomes (MS) in MB of paleosol are usually arranged in chains along the cells. It was also found that MB growth and MS formation are associated with the environment in which MB live. It can be inferred from the distributions of MB and MS that the paleoclimates fluctuated during the formation of | PENG Xianzhi JIA Rongfen LI Rongsen DAI Shunying LIU Tungsheng | 2000 | Chinese Science Bulletin2000，45，S1： | 2 |
| 18 | Construction of irregular particles with superquadric equation in DEM显示文摘Non-spherical particles are widely present in industrial production,and significantly affect the macro and micro characteristics of granular materials.Although the superquadric equation can be used to construct non-spherical particles,its disadvantage is that the particle shape is geometrically symmetric and strictly convex.In this study,two composed approaches are used to describe geometrically asymmetric and concave particle shapes,including a multi-superquadric model and a poly-superquadric model.The multi-superquadric model is a combination of several superquadric elements,and can construct concave and geometrically asymmetric particle shapes.The poly-superquadric model is a combination of eight one-eighth superquadric elements,and can construct convex and geometrically asymmetric particle shapes.Both composed models are based on superquadric equations,and Newton’s iterative method is used to calculate the contact force between the elements.Furthermore,superquadric elements,multi-superquadric elements,and poly-superquadric elements are applied for the formation of complex granular beds,and the influences of particle shape on the packing fraction can be successfully captured by the proposed models. | Siqiang Wang Dzianis Marmysh Shunying Ji | 2020 | Theoretical & Applied Mechanics Letters2020，10，2： | 2 |
| 19 | Flow characteristics of nonspherical granular materials simulated with multi-superquadric elements显示文摘The superquadric equation is typically used to mathematically describe nonspherical particles and construct particle shapes with different surface sharpness and aspect ratios.However,nonspherical elements constructed using the superquadric equation are strictly convex,limiting their engineering application.In this study,a multi-superquadric model based on a superquadric equation is developed.The model combines several superquadric elements that can be used to construct concave and convex particle shapes.Four tests are performed to examine the applicability of the multi-superquadric approach.The first involves a comparison of theoretical results for a single spherocylinder impacting a flat wall.The second involves the formation of a nonspherical granular bed.The third investigates the effects of the particle shape on the hopper discharge and angle of repose.The final test evaluates the mixing behaviors of granular materials within a horizontally rotating drum.These tests demonstrate the applicability of the multi-superquadric approach to nonspherical granular systems.Furthermore,the effects of particle shape on the packing density,discharge rate,angle of repose,and Lacey mixing index are discussed.Results indicate that concave particles have a lower packing density,flow rate,and mixing rate and higher angles of repose than convex particles.Interlocking of elements becomes more pronounced for concave particles and results in local cluster structures,thereby enhancing the stability of granular systems and limiting sliding or rotation between nonspherical particles. | Siqiang Wang Shunying Ji | 2021 | Particuology2021，19，1： | 2 |
| 20 | Clinical significance of interventional therapeutic bronchoscopy combined with bronchial arterial embolization in the treatment of hypervascular primary airway tumors in children显示文摘Importance Pediatric hypervascular primary airway tumors are progressive,fatal lesions with a low incidence,and the disease is often more serious than that in adults.Objective To evaluate the clinical efficacy and safety of interventional therapeutic bronchoscopy combined with conservative treatment and bronchial arterial embolization in children with primary airway tumors.Methods We retrospectively analyzed the clinical data of four pediatric patients with hypervascular primary airway tumor between 2017 and 2019 at Beijing Children’s Hospital.Results Two patients were low-grade bronchial mucoepidermoid carcinoma,one patient was pleomorphic adenoma,and one was bronchial leiomyoma.Interventional therapeutic bronchoscopy combined with bronchial arterial embolization was used for treatment(all four patients received general anesthesia).The tumors were safely resected in all patients via interventional bronchoscopy.There were no severe complications related to the procedures.All patients were followed up for 5–12 months,and one low-grade bronchial mucoepidermoid carcinoma recurred.Interpretation Interventional therapeutic bronchoscopy combined with bronchial arterial embolization appears to be a safe and efficient therapeutic method associated with less trauma and fewer complications,including no serious adverse events,in children with hypervascular primary airway tumors without bronchus wall infiltration. | Haiming Yang Jie Yin Xiaolei Tang Gan Li Huimin Li Shunying Zhao | 2021 | Pediatric Investigation2021，5，2： | 2 |
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