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| 1 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 2 | Pattern Scan Laser Photocoagulator on Retinopathy: an annual clinical application summary显示文摘Purpose:To evaluate the clinical efficacy of Pattern Scan Laser Photocoagulator (PASCAL) by observing the efficacy of PASCAL on retinopathy.Methods:A total of 92 patients with retinopathy (121 eyes) who underwent PASCAL between December 2008 and February 2009 in our center were retrospectively analyzed to evaluate the visual acuity changes and recovery conditions of the patients from baseline to posterior to the treatment.The retinopathy included:diabetic retinopathy,ischemic retinal vein occlusion.(IRVO),central serous chorioretinopathy (CSC),retinal periphlebitis (Eales disease) and retinal degeneration /holes.Results:The patients were subject to a 12-month follow up after PASCAL.The visual acuity findings were stated as below:for diabetic retinopathy.(73 eyes),10 eyes had improved visual acuity;55 eyes were stabilized and 8 eyes progressed;for IRVO (13 eyes),4 eyes showed improvement,6 eyes were stabilized and 3 eyes progressed;for CSC (9 eyes),6 eyes were alleviated and 3 eyes progressed;for retinal periphlebitis (5 eyes),2 eyes had enhanced visual acuity and 3 eyes showed stable visual acuity;for retinal degeneration /holes (21 eyes),5 eyes presented improved visu-al acuity,16 eyes were stabilized and no eye progressed.Indirect ophthalmoscopic reexamination confirmed secured blockage by laser spots and favorable absorption of the retinal edema and newborn capillaries.No obvious leakage was observed during fundus fluorescein angiography and no laser-related ocular adverse effect was reported.Conclusion:PASCAL is accurate,effective and well-tolerated.The duration of short laser pulse falls within the safety range,ensuring the stabilization and improvement in the pa-tient's visual acuity.The parameters,long-term efficacy and complications of PASCAL should be further demonstrated by performing long-term clinical trials with larger sample size. | Haiyun Ye Chenjin Jin Xiaoqing Zhong Zhen Tian Wanyi Lin | 2011 | Eye Science2011，26，2： | 3 |
| 3 | HomocyclotirucalIane and Two Dihydrophenanthrenes from Spiranthes sinensis 显示文摘 | Lin YunLian Wang WanYi Kuo YuehHsiung | 2001 | Chem Pharm Bull2001，49，9： | 1 |
| 4 | Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents显示文摘 | Wanyi Zhao Xiue Feng Shurong Ban Wenhan Lin Qingshan Li | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，14： | 1 |
| 5 | Homocyclotirucallane and Two Dihydrophenanthrenes from Spiranthes sinensis显示文摘 | YunLian Lin WanYi Wang YuehHsiung Kuo | 2001 | Chem Pharm Bull2001，49，9： | 1 |
| 6 | Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents显示文摘 | Wanyi Zhao Xiue Feng Shurong Ban Wenhan Lin Qingshan Li | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，14： | 1 |
| 7 | Homocy-clotirucallane and Two Dihydrophenanthrenes from Spiranthe sinensis显示文摘 | YunLian Lin WanYi Wang YuehHsiung Kuo | 2001 | Chem Pharm Bull2001，49，9： | 1 |
| 8 | Homocyclotirucallane and TwoDihy drophenanth - renesfrom Spiranthes sinensis显示文摘 | Yun Lian Lin WanYi Wang YuehHsiung Kuo | 2001 | Chem Pharm Bull2001，49，9： | 1 |
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