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| 1 | Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD显示文摘We characterized a unique group of patients with neuromyelitis optica spectrum disorder(NMOSD) who carried autoantibodies of aquaporin-4(AQP4) and myelin-oligodendrocyte glycoprotein(MOG). Among the 125 NMOSD patients, 10(8.0%) were AQP4- and MOG-ab double positive, and 14(11.2%) were MOG-ab single positive. The double-positive patients had a multiphase disease course with a high annual relapse rate(P=0.0431), and severe residual disability(P<0.0001). Of the double-positive patients, 70% had MS-like brain lesions, more severe edematous, multifocal regions on spinal magnetic resonance imaging(MRI), pronounced decreases of retinal nerve fiber layer thickness and atrophy of optic nerves. In contrast, patients with only MOG-ab had a higher ratio of monophasic disease course and mild residual disability. Spinal cord MRI illustrated multifocal cord lesions with mild edema, and brain MRIs showed more lesions around lateral ventricles. NMOSD patients carrying both autoantibodies to AQP4 and MOG existed and exhibited combined features of prototypic NMO and relapsing-remitting form of MS, whereas NMOSD with antibodies to MOG only exhibited an 'intermediate' phenotype between NMOSD and MS. Our study suggests that antibodies against MOG might be pathogenic in NMOSD patients and that determination of anti-MOG antibodies maybe instructive for management of NMOSD patients. | Yaping Yan Yujing Li Ying Fu Li Yang Lei Su Kaibin Shi Minshu Li Qiang Liu Aimee Borazanci Yaou Liu Yong He Jeffrey L Bennett Timothy L Vollmer Fu-Dong Shi | 2016 | Science China(Life Sciences)2016，59，12： | 20 |
| 2 | Autophagy in Atherosclerosis: A Phenomenon Found in Human Carotid Atherosclerotic Plaques显示文摘 | Huihui Liu Yongjun Gag Tong Tong Jijun Shi Yanlin Zhang Yaping Yang Chunfeng Liu | 2015 | Chinese Medical Journal2015，，1： | 16 |
| 3 | Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhage显示文摘Intracerebral hemorrhage(ICH) leads to high rates of death and disability. The pronounced infl ammatory reactions that rapidly follow ICH contribute to disease progression. Our recent clinical trial demonstrated that oral administration of an immune modulator fingolimod restrained secondary injury derived from initial hematoma,but the mechanisms remain unknown. In this study,we aim to investigate the effects of fingolimod on inflammatory mediators and vascular permeability in the clinical trial of oral fingolimod for intracerebral hemorrhage(ICH). The results showed that fingolimod decreased the numbers of circulating CD4^+ T,CD8^+ T,CD(19)^+B,NK,and NKT cells and they recovered quickly after the drug was stopped. The plasma ICAM level was decreased and IL-10 was increased by fingolimod. Interestingly,fingolimod protected vascular permeability as indicated by a decreased plasma level of MMP9 and the reduced r T1%. In conclusion,modulation of systemic inflammation by fingolimod demonstrates that it is an effective therapeutic agent for ICH. Fingolimod may prevent perihematomal edema enlargement by protecting vascular permeability. | Yu-Jing Li Guo-Qiang Chang Yuanchu Liu Ye Gong Chunsheng Yang Kristofer Wood Fu-Dong Shi Ying Fu Yaping Yan | 2015 | Neuroscience Bulletin2015，31，6： | 12 |
| 4 | The impact of climate change and human activities on streamflow and sediment load in the Pearl River basin显示文摘This paper uses monthly streamflow, suspended sediment concentration, and meteorological data to examine the impact of human activity and climate change on streamflow and sediment load in the Pearl River basin from the 1950s to the 2000s. The influences of climate change and human activities on hydrological processes were quantitatively evaluated using the Mann–Kendall abrupt change test and power rating curves. The results showed that:(1) abrupt changes and turning points in streamflow occurred in 1963, 1983, and 1991 which were found to be consistent with global ENSO events and volcanic eruptions. However, abrupt changes in sediment load showed significant spatial differences across the Pearl River basin. For the Xijiang River, an abrupt change in sediment load occurred in 2002, and after 2007 the change becomes significant at the 95% confidence level. At Beijiang and Dongjiang, abrupt changes in sediment load occurred in 1998 and 1988, respectively.(2) The time series of sediment load data was divided into four periods according to abrupt changes. The contribution of climate change and human activities is different in the different rivers. For the Xijiang River, compared with the first period, climate change and human activities contributed 83% and 17%, respectively, to the increasing sediment load during the second period. In the third period, the variation of sediment load followed a decreasing trend. The contribution from climate change and human activities also changed to t236% and -136%, respectively. In the fourth period, climate change and human activities contributed -32% and t132%, respectively. Meanwhile, For the Beijiang River, climate change and human activities contributed 90% and 10% in the second period, the contribution of climate change increased to t115% and human activities decreased to -15% in the third period. In the fourth period, the value for climate change decreased to t36% and human activities increased to t64%. For the Dongjiang River, the contribution of human activities was from 74.5% to 90%, and the values for climate change were from 11% to 25%. Therefore, the effect of human activity showed both spatial and temporal differences, and it seems likely that the decreased sediment load will continue to be controlled mainly by human activities in the future. | Chuangshou Wu Changchen Ji Benwei Shi Yaping Wang Jianhua Gao Yang Yang Jinbin Mu | 2019 | International Journal of Sediment Research2019，34，4： | 12 |
| 5 | Tolerance to low phosphorus in rice varieties is conferred by regulation of root growth显示文摘Phosphorus use efficiency(PUE)can be improved through cultivation techniques and breeding.However,little is known about rice(Oryza sativa L.)agronomic and physiological traits associated with high PUE.We characterized the agronomic and physiological traits of rice varieties with different tolerances to low phosphorus in nutrient solution.Two varieties with strong tolerance to low phosphorus(STVs)and two with weak tolerance(WTVs)were grown at normal(NP,control)and low phosphorus(LP,1/20 of NP)concentrations.Plants grown at LP produced significantly lower grain yield than those grown at NP.WTVs yields were lower than STVs yields.Compared to NP,LP significantly increased phosphorus translocation efficiency(PTE),internal phosphorus efficiency(IPE)and phosphorus harvest index(PHI).Under the LP condition,PTE and IPE were higher for STVs than for WTVs.LP also reduced tiller number,shoot biomass,leaf area index(LAI),leaf photosynthetic rate,and mean root diameter of both kinds of varieties at the main growth stages,but to a lower extent in STVs.LP significantly increased the number of productive tillers,root biomass,root-shoot ratio,root bleeding rate,and root acid phosphatase(RAP)activity.Total root length,root oxidation activity(ROA),and root total and active absorbing surface areas for STVs were significantly increased under LP,whereas the opposite responses were observed for WTVs.Total root length,ROA,root bleeding rate,root active absorbing surface area,and RAP activity were positively and significantly correlated with grain yield,PTE,and IPE.These results suggest that the tolerance of rice varieties to a low-phosphorus growth condition is closely associated with root growth with higher biomass and activity. | Yaping Deng Chuanbao Men Shengfeng Qiao Wenjie Wang Junfei Gu Lijun Liu Zujian Zhang Hao Zhang Zhiqin Wang Jianchang Yang | 2020 | The Crop Journal2020，8，4： | 8 |
| 6 | Accumulation and Output of Heavy Metals by the Invasive Plant Spartina alterniflora in a Coastal Salt Marsh显示文摘Spartina alterniflora is a foreign introduced species and has far-reaching effects on salt marsh ecosystems, particularly on the biogeochemical cycle of heavy metals. To ascertain whether the invasive plant Spartina alterniflora Loisel is a source of metals in the environment, we determined the bimonthly concentrations of heavy metals, chromium(Cr), lead(Pb), copper(Cu), zinc(Zn),and manganese(Mn), in the roots, stems, and leaves of S. alterniflora from a typical semidiurnal tidal zone in the coastal area of northern Jiangsu Province, China. Based on the measurements, we calculated annual metal primary accumulation and output. To calculate the annual output of heavy metals from S. alterniflora, a new method that calculates the annual rate of biomass loss and decomposition was developed. The annual primary accumulation of Cr, Pb, Cu, Zn, and Mn was 19.08, 84.19, 63.74, 442.58, and774.66 mg m^(-2), respectively, and the annual output from S. alterniflora to the surrounding environment was 4.01, 18.09, 14.00, 97.11,and 164.28 mg m^(-2), respectively. Spartina alterniflora only provides temporary storage, and its absorption of heavy metals could be used to remediate contaminated soil and for phytomining. The heavy metals released by S. alterniflora to the environment cannot be ignored; thus, S. alterniflora should be considered a source of metal contamination. Therefore, when we evaluate the remarkable ability of certain plant species to concentrate metals in their tissues, the balance between heavy metal accumulation and output should be considered. | CHEN Lian GAO Jianhua ZHU Qingguang WANG Yaping YANG Yang | 2018 | Pedosphere2018，28，6： | 7 |
| 7 | Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species/JUN Pathway显示文摘Oleic acid(OA),a monounsaturated fatty acid(MUFA),has previously been shown to reverse saturated fatty acid palmitic acid(PA)-induced hepatic insulin resistance(IR).However,its underlying molecular mechanism is unclear.In addition,previous studies have shown that eicosapentaenoic acid(EPA),aω-3 polyunsaturated fatty acid(PUFA),reverses PA-induced muscle IR,but whether EPA plays the same role in hepatic IR and its possible mechanism involved need to be further clarified.Here,we confirmed that EPA reversed PA-induced IR in HepG2 cells and compared the proteomic changes in HepG2 cells after treatment with different free fatty acids(FFAs).A total of 234 proteins were determined to be differentially expressed after PA+OA treatment.Their functions were mainly related to responses to stress and endogenous stimuli,lipid metabolic process,and protein binding.For PA+EPA treatment,the PA-induced expression changes of 1326 proteins could be reversed by EPA,415 of which were mitochondrial proteins,with most of the functional proteins involved in oxidative phosphorylation(OXPHOS)and tricarboxylic acid(TCA)cycle.Mechanistic studies revealed that the protein encoded by JUN and reactive oxygen species(ROS)play a role in OA-and EPA-reversed PA-induced IR,respectively.EPA and OA alleviated PA-induced abnormal adenosine triphosphate(ATP)production,ROS generation,and calcium(Ca^(2+))content.Importantly,H_(2)O_(2)-activated production of ROS increased the protein expression of JUN,further resulting in IR in HepG2 cells.Taken together,we demonstrate that ROS/JUN is a common response pathway employed by HepG2 cells toward FFA-regulated IR. | Yaping Sun Jifeng Wang Xiaojing Guo Nali Zhu Lili Niu Xiang Ding Zhensheng Xie Xiulan Chen Fuquan Yang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 6 |
| 8 | Dolomitization by Penesaline Sea Water in Early Cambrian Longwangmiao Formation, Central Sichuan Basin, China显示文摘The Lower Cambrian Longwangmiao Formation shoal dolostone reservoir in Sichuan Basin is currently an exploration and research highlight in China. Reservoir rocks mainly consist of crystalline dolomite with residual grain texture, and dolarenite of which the arene is mainly composed of muddy to micritic dolomite with some crystalline grain directionally aligned. The trace element indicates that the dolomites of Longwangmiao Formation may be related to the high salinity of sea water. The oxygen isotope values of crystalline dolomite and dolarenite are both similar to that of the Early Cambrian marine dolomites, and the carbon isotope values of every kind of dolomites are completely overlapped with that of the seawater in Early Cambrian, indicating the dolomitization fluid is originated from the Early Cambrian sea water. The restricted marine biological communities and a small amount of gypsum pseudonodule seen in muddy to micritic dolomite indicate that the sea water in Early Cambrian was restricted and evaporated. However, the general lack of massive evaporite mineral and gypsum karst breccia indicates that the salinity of sea water during dolomitization was lower than the value of gypsum's precipitation. The Longwangmiao Formation consists of several high-frequency sedimentary cycles, indicating frequent sea level changes. This study indicates that massive dolomitization may also occur in underwater palaeohigh in carbonate platform through the reflux of penesaline sea water driven by a combination of high-and low-frequency sea-level changes. This kind of dolomitization can explain the generation of massive dolomites in the absence of evaporite precipitation, and further indicates that replacement dolomites can be produced by sea water with a wide range of salinity(normal, penesaline to hypersaline). | Xuefei Yang Hao Tang Xingzhi Wang Yaping Wang Yueming Yang | 2017 | Journal of Earth Science2017，28，2： | 6 |
| 9 | Variations of Stable Carbon Isotopes of CH4 Emission from Three Typical Rice Fields in China显示文摘Little is known about the stable carbon isotopes of methane(CH4) emitted(δ^(13)CH_(4emitted)) from permanently flooded rice fields and double rice-cropping fields.The CH4 emission and corresponding δ^(13)CH_(4emitted) under various field managements(mulching,water regime,tillage,and nitrogen(N) fertilization) were simultaneously measured in three typical Chinese rice fields,a permanently flooded rice field in Ziyang City,Sichuan Province,Southwest China,a double-rice cropping field in Yingtan City,Jiangxi Province,Southeast China,and a rice-wheat rotation field in Jurong City,Jiangsu Province,East China,from 2010 to 2012.Results showed different seasonal variations of δ^(13)CH_(4emitted) among the three fields during the rice-growing season.The values of δ^(13)CH_(4emitted) were negatively correlated with corresponding CH4 emissions in seasonal variation and mean,indicating the importance of CH_4 production,oxidation,and transport associated with isotopic fractionation effects to the δ^(13)CH_(4emitted).Seasonal variations of δ^(13)CH_(4emitted) were slightly impacted by mulching cultivation,tillage,and N application,but highly controlled by drainage.Meanwhile,tillage,N application,and especially mulching cultivation had important effects on seasonal mean CH4 emissions and corresponding δ^(13)CH_(4emitted) with low emissions accompanied by high values of δ^(13)CH_(4emitted).Seasonal mean values of δ^(13)CH_(4emitted) from the three fields were similar,mostly ranging from —60‰ to — 50‰,which are well in agreement with previously published data.These demonstrated that seasonal variations of δ^(13)CH_(4emitted) mainly depended on the changes in CH4 emission from rice fields and further indicated the important effects of methanogenic pathways,CH4 oxidation,and CH4 transport associated with isotope fractionation effects influenced by field managements on δ^(13)CH_(4emitted). | ZHANG Guangbin MA Jing YANG Yuting YU Haiyang SHI Yaping XU Hua | 2017 | Pedosphere2017，27，1： | 6 |
| 10 | Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats显示文摘Chronic stress models,established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone,once per day,were given a daily oral feeding of 50 mg/kg baicalin.The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed rats.Results showed that subcutaneous injection of corticosterone significantly decreased the total number of doublecortin-positive neurons in the hippocampus.The reduced cell Ⅰ number caused by corticosterone was mainly due to the decrease of class Ⅱ doublecortin-positive neurons,but the class doublecortin-positive neurons were unaffected.Baicalin treatment increased the number of both class Ⅰ and class Ⅱ doublecortin-positive neurons.In addition,doublecortin-positive neurons showed less complexity in dendritic morphology after corticosterone injection,and this change was totally reversed by baicalin treatment.These findings suggest that baicalin exhibits a beneficial effect on adult neurogenesis. | Xinghua Jiang Junmei Xu Dingquan Zou Lin Yang Yaping Wang | 2013 | Neural Regeneration Research2013，8，6： | 6 |
| 11 | Multi-Residual Module Stacked Hourglass Networks for Human Pose Estimation显示文摘A multi-residual module stacked hourglass network(MRSH)was proposed to improve the accuracy and robustness of human body pose estimation.The network uses multiple hourglass sub-networks and three new residual modules.In the hourglass sub-network,the large receptive field residual module(LRFRM)and the multi-scale residual module(MSRM)are first used to learn the spatial relationship between features and body parts at various scales.Only the improved residual module(IRM)is used when the resolution is minimized.The final network uses four stacked hourglass sub-networks,with intermediate supervision at the end of each hourglass,repeating high-low(from high resolution to low resolution)and low-high(from low resolution to high resolution)learning.The network was tested on the public datasets of Leeds sports poses(LSP)and MPII human pose.The experimental results show that the proposed network has better performance in human pose estimation. | Wenxia Bao Yaping Yang Dong Liang Ming Zhu | 2020 | Journal of Beijing Institute of Technology2020，29，1： | 6 |
| 12 | Improved dissolution and bioavailability of silymarin delivered by a solid dispersion prepared using supercritical fluids显示文摘The objective of this study was to improve the dissolution and bioavailability of silymarin(SM).Solid dispersions(SDs)were prepared using solution-enhanced dispersion by supercritical fluids(SEDS)and evaluated in vitro and in vivo,compared with pure SM powder.The particle sizes,stability,and contents of residual solvent of the prepared SM-SDs with SEDS and solvent evaporation(SE)were investigated.Four polymer matrix materials were evaluated for the preparation of SM-SD-SEDS,and the hydrophilic polymer,polyvinyl pyrrolidone K17,was selected with a ratio of 1:5 between SM and the polymer.Physicochemical analyses using X-ray diffraction and differential scanning calorimetry indicated that SM was dispersed in SD in an amorphous state.The optimized SM-SD-SEDS showed no loss of SM after storage for 6 months and negligible residual solvent(ethanol)was detected using gas chromatography.In vitro drug release was increased from the SM-SDSEDS,as compared with pure SM powder or SM-SD-SE.In vivo,the area under the rat plasma SM concentration-time curve and the maximum plasma SM concentration were 2.4-fold and 1.9-fold higher,respectively,after oral administration of SM-SD-SEDS as compared with an aqueous SM suspension.These results illustrated the potential of using SEDS to prepare SM-SD,further improving the biopharmaceutical properties of this compound. | Gang Yang Yaping Zhao Nianping Feng Yongtai Zhang Ying Liu Beilei Dang | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，3： | 6 |
| 13 | Quantitative Proteomics Using Isobaric Labeling:A Practical Guide显示文摘In the past decade,relative proteomic quantification using isobaric labeling technology has developed into a key tool for comparing the expression of proteins in biological samples.Although its multiplexing capacity and flexibility make this a valuable technology for addressing various biological questions,its quantitative accuracy and precision still pose significant challenges to the reliability of its quantification results.Here,we give a detailed overview of the different kinds of isobaric mass tags and the advantages and disadvantages of the isobaric labeling method.We also discuss which precautions should be taken at each step of the isobaric labeling workflow,to obtain reliable quantification results in large-scale quantitative proteomics experiments.In the last section,we discuss the broad applications of the isobaric labeling technology in biological and clinical studies,with an emphasis on thermal proteome profiling and proteogenomics. | Xiulan Chen Yaping Sun Tingting Zhang Lian Shu Peter Roepstorff Fuquan Yang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 5 |
| 14 | A β-glucosidase-producing M-2 strain: Isolation from cow dung and fermentation parameter optimization for flaxseed cake显示文摘Flaxseed cake contains cyanogenic glucosides, which can be metabolized into hydrocyanic acid in an animal's body, leading to asphyxia poisoning in cells. Beta-glucosidase is highly efficient in degrading cyanogenic glucosides. The Cattle may have b-glucosidase-producing strains in the intestinal tract after eating small amounts of flaxseed cake for a long time. This study aimed to isolate of a strain from cow dung that produces b-glucosidase with high activity and can significantly reduce the amount of cyanogenic glucosides. We used cow dung as the microflora source and an esculin agar as the selective medium. After screening with 0.05% esculin and 0.01% ferric citrate, we isolated 5 strains producing high amounts of b-glucosidase. In vitro flaxseed cake fermentation was fermented by these 5 strains, in which the strain M-2 exerted the best effect(P < 0.05). The strain M-2 was identified as Lichtheimia ramosa and used as the fermentation strain to optimize the fermentation parameters by a single factor analysis and orthogonal experimental design. The optimum condition was as follows: inoculum size3%, water content 60%, time 144 h, and temperature 32℃. Under this condition, the removal rate of cyanogenic glucosides reached 89%, and crude protein increment reached 44%. These results provided a theoretical basis for the removal of cyanogenic glucosides in flaxseed and the comprehensive utilization of flaxseed cake. | Chenhui Li Junshu Wei Yaping Jing Baoxia Teng Pingrong Yang Xinjun Chen Haiying Huang Tang Zhao Tuanjie Che Chunjiang Zhang | 2019 | Animal Nutrition2019，，1： | 5 |
| 15 | Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders显示文摘Dear Editor,Autism spectrum disorders(ASD)are complex neurodevelopmental disorders characteristic of core behavioral traits like restricted,repetitive behaviors and deficiency in social interactions.1 The prevalence of ASD has rapidly increased worldwide,rising from 1/149 in 2000,1/68 in 2012,and to?1/40 in 2016 of children at the age of 3-17 in the United States.2 ASD prevalence was found to be associated with socioeconomic status(SES)as overpresented in high-income households,3 and to be significantly enriched in certain regions,e.g.,reaching up to 4.88%in Florida.2 In the last decades,advances in genetic studies have led to unprecedented understanding of the genetic factors that were associated with<50%of human ASD. | Zijian Hao Qionghui Wu Zhengwei Li Yali Li Qiu Li Xi Lai Huan Liu Menghuan Zhang Ting Yang Jie Chen Yaping Tang Jingkun Miao Huatai Xu Tingyu Li Ronggui Hu | 2019 | Cell Research2019，29，10： | 5 |
| 16 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 17 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 18 | A review of the interaction between the cryosphere and atmosphere显示文摘The interaction between the cryosphere and atmosphere is an essential and extremely sensitive mutual action process on the earth.Due to global warming and the cryospheric melting,more and more attention has been paid to the interaction process between the cryosphere and atmosphere,especially the feedback of the cryosphere change to the atmosphere.A comprehensive review of the studies on the interaction between the cryosphere and atmosphere is conducted from two aspects:(1)effects of climate change on the cryosphere or responses of the cryosphere to climate change;and(2)feedback of the cryosphere change to the climate.The response of the cryosphere to climate change is lagging.Such a lagging and cumulative effect of temperature rise within the cryosphere have resulted in a rapid change in the cryosphere in the 21st century,and its impacts have become more significant.The feedback from cryosphere change on the climate are omnifarious.Among them,the effects of sea ice loss and snow cover change,especially the Arctic sea ice loss and the Northern Hemisphere snow cover change,are the most prominent.The Arctic amplification(AA)associated with sea ice feedback is disturbing,and the feedback generated by the effect of temperature rise on snow properties in the Northern Hemisphere is also of great concern.There are growing evidence of the impact of the Arctic cryosphere melting on mid-latitude weather and climate.Weakened storm troughs,steered jet stream and amplified planetary waves associated with energy propagation become the key to explaining the links between Arctic cryosphere change and atmospheric circulation.There is still a great deal of uncertainty about how cryosphere change affects the weather and climate through different atmospheric circulation processes at different spatial and temporal scales due to observation and simulation problems. | YongJian Ding JianPing Yang ShengXia Wang YaPing Chang | 2020 | Research in Cold and Arid Regions2020，12，6： | 4 |
| 19 | Effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on excisional wound healing in a rat's model显示文摘OBJEVTIVE: To investigate the effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on the excisional wound healing in a rat's model.METHODS: Rats were performed a surgical lesion with a 2.0 cm resected tissue in the dorsal fascia.Following, animals were randomly divided into model group, YNB group and APE group those were respectively treated with saline, 1 mg/mL of Yunnan Baiyao and 1 mg/mL of Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) extracts. Wound contractions in days 0, 3, 7, 14 and 21 were calculated by an image analyzer. Histological analysis was analyzed using hematoxilin and eosin.Levels of tumor necrosis factor-2(IL-2), IL-4, IL-10, transformαin(TNF-g growα), interleukinth factor-1(TGF-nd basic fibroblast growth factor(bFββ1) a-GF) were determined by real-time quantitative PCR.RESULTS: Compared with that of YNB group and APE gtoup, the skin of rats showed poor re-modeling and re-epithelization characterized by a significant decrease of neovascularization, epithelialization and fibroblast in the model group. In the APE group, levels of TNF-α-and IL-2 were significantly down-regulated and IL4 and IL-10 significantly upregulated in contrasted with that of model group.In addition, levels of TGF-roup were significantly iβ1 and bFGF in the APE gnduced compared with that of model group.CONCLUSION: The results suggest that the extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) promote wound healing in the rats, which is associated with enhancing antiinflammatory ability and inducing fibroblast formation. | Xia Xichao Ma Yuhong Wang Fuan Zheng Xinhua Liu Yang Zhang Junfeng Cui Juan Shi Bingqin Li Hongwen Liu Rongzhi Zhang Yaping Cheng Zhaofei Han Xiaolong | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 20 | Joining of Zirconia and Ti-6Al-4V Using a Ti-based Amorphous Filler显示文摘Polycrystalline ZrO2-3 mol.%Y2O3 was brazed to Ti-6Al-4V by using a Ti47Zr28Cu14Ni11(at.%) amorphous ribbon at 1123-1273 K in a high vacuum. The influences of brazing temperature on the microstructure and shear strength of the joints were investigated. The interfacial microstructures can be described as ZrO2/TiO+TiO2+Cu2Ti4O+Ni2Ti4O/α-Ti+(Ti,Zr)2(Cu,Ni) eutectic/acicular Widmanst¨aten structure/Ti-6Al-4V alloy. With the increase in the brazing temperature, the thickness of the TiO+TiO2+Cu2Ti4O+Ni2Ti4O layer reduced, the content of the α-Ti+(Ti,Zr)2(Cu,Ni) eutectic phase decreased, while that of the coarse α-Ti phase gradually increased. The shear strength of the joints did not show a close relationship with the thickness of the TiO+TiO2+Cu2Ti4O+Ni2Ti4O layer. However, when the coarse (Ti,Zr)2(Cu,Ni) phase was non-uniformly distributed in the α-Ti phase, or when α-Ti solely situated at the center of the joint, forming a coarse block or even connecting into a continuous strip, the shear strength greatly decreased. | Yuhua Liu Jiandong Hu Yaping Zhang Zuoxing Guo Yue Yang | 2011 | Journal of Materials Science & Technology2011，27，7： | 3 |
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