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| 1 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 2 | Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival显示文摘哺乳动物的胰腺的房间通过胰岛素的生产和分泌物在开发和葡萄糖动态平衡起一个枢轴的作用。在房间数字的功能的失败或减少导致类型 2 糖尿病(T2D ) 。尽管有 -cells, 的生理的重要性,房间的生存能力经常主要由于它适应他们的变化微型环境的差的能力被质问。否定地影响房间生存能力的因素之一是象 palmitate 那样的免费的丰满的酸(船边交货) 的高集中。在这个工作,我们证明当房间与 palmitate 被对待时,那联系是的蛋白质(Yap1 ) 被激活。我们用啮齿类动物 insulinoma 房间线的 loss-of-function 和 gain-of-function 分析表明没有调整他们的增长, Yap1 在房间压制导致 palmitate 的 apoptosis。我们也发现在 palmitate 处理之上, F 肌动朊的重新整理调停 Yap1 激活。Yap1 目标基因之一的 Palmitate 处理增加表示,结缔组织生长因素(CTGF ) 。我们有 CTGF 的 gain-of-function 分析建议 CTGF 可以是在对导致船边交货的 apoptosis 的保护的机制的 Yap1 的下游的因素。 | Yaoting Deng Yurika Matsui Wenfei Pan Qiu Li Zhi-Chun Lai | 2016 | Protein & Cell2016，7，5： | 7 |
| 3 | High performance of a unique mesoporous polystyrene-based adsorbent for blood purification显示文摘A multi-functional polystyrene based adsorbent(NKU-9)with a unique mesoporous and a high surface area was prepared by suspension polymerization for removal of therapeutic toxins in blood purification.The adsorbent produced had an almost equal amount of mesopore distribution in the range from 2 to 50 nm.The adsorption of serum toxins with different molecular weights were examined by in vitro adsorption assays and compared with some clinical currently used adsorbents such as HA-330,Cytosorb and BL-300 which are produced by China,America and Japan,respectively.Test results indicated that the adsorption rate for pentobarbital by NKU-9 was 81.24%which is nearly as high as HA-330(81.44%).The latter adsorbent is currently used for acute detoxification treatment in China.To reach adsorption equilibrium,NKU-9 was faster than HA-330,which implies short treatment time.For the removal of middle molecular toxins such as b2-microglobulin(98.88%),NKU-9 performed better adsorptive selectivity than Cytosorb(92.80%).In addition,NKU-9 showed high performance for the removal of albumin-bound toxins(e.g.,bilirubin),and its adsorption rate for total bilirubin(80.79%)in plasma was 8.4%higher than that of anion exchange resin BL-300 which is currently used to eliminate bilirubin in clinic.Therefore,our results indicate that the newly developed adsorbent with a wide distribution and almost equal amount of mesopores is a multifunctional adsorbent for high efficient removal of serum toxins with different molecular weights which might be an excellent blood purification adsorbent especially to treat diseases that conventional medical methods are low or not efficient. | Jian Chen Wenyan Han Jie Chen Wenhui Zong Weichao Wang Yue Wang Guanghui Cheng Chunran Li Lailiang Ou Yaoting Yu | 2017 | Regenerative Biomaterials2017，4，1： | 3 |
| 4 | Structure and magnetism of a porous three-dimensional metal-organic framework based on planar tetranuclear copper(Ⅱ) cluster units显示文摘A porous three-dimensional copper(Ⅱ) metal-organic framework (MOF) {[Cu2(tci)(OH)(pip)0.5(H2O)]·6H2O}n (1) [tci = tris (2-carboxyethyl)isocyanurate, pip = piperazine] has been generated under hydrothermal conditions at 120 °C. Single crystal X-ray diffraction reveals that the polymer exhibits a novel three-dimensional framework based on planar tetranuclear copper(Ⅱ) cluster units. The variable temperature magnetic susceptibility data in the range 2-280 K show antiferromagnetic spin-spin coupling in the tetranuclear unit in complex 1. A theoretical fitting of the magnetic data gives J values of -31.3 cm-1, -30.8 cm-1, and 13.5 cm-1. | LI HuiJun, ZHANG ErPeng, GUO QianQian, HOU HongWei & FAN YaoTing Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China | 2010 | Science China Chemistry2010，53，10： | 2 |
| 5 | Optimization of initial substrate and pH levels for germination of sporing hydrogen-producing anaerobes in cow dung compost显示文摘 | Fan Yaoting Li Chenlin Lay Jiunn Jyi | 2004 | Bioresour Technol2004，91，2： | 1 |
| 6 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 7 | Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study显示文摘 | Song Wu Peide Huang Chong Li Yi Huang Xianxin Li Yongqiang Wang Chao Chen Zhaojie Lv Aifa Tang Xiaojuan Sun Jingxiao Lu Weiping Li Jie Zhou Yaoting Gui Fangjian Zhou Daping Wang Zhiming Cai | 2013 | European Urology2013，，： | 1 |
| 8 | Optimization of initial substrate and pH levels for germination of sporting hydrogen-producing anaerobes in cow dung compost显示文摘 | Fan Yaoting Li Chenlin Lay JiunnJyi | | 0，，02： | 1 |
| 9 | Preparation and culture of hepatocyte on gelatin microcarriers显示文摘 | Xu Tao Li Shaolin Yu Yaoting | | 0，，： | 1 |
| 10 | Optimization of initial substrate and pH levels for germination of sporing hydrogen-producing anaerobes in cow dung compost显示文摘 | Fan Yaoting Li Chenlin Hou Hongwei | 2004 | Bioresource Technology2004，91，： | 1 |
| 11 | Removal of Lead from Aqueous Solution by Non- living Rhizopus Nigricans 显示文摘 | LI Zhao Yaoting Yu | 1998 | Water Research1998，32，： | 1 |
| 12 | Investigating urachal carcinoma for more than 15 years显示文摘 | Duqun Chen Yifan Li Zuhu Yu Zhengming Su Liangchao Ni Yaoting Gui Shangqi Yang Bentao Shi Yongqing Lai | 2014 | Oncology Letters2014，，5： | 1 |
| 13 | Synthesis,Crystal Structures,and Third-order Nonlinear Optical Properties of Two Novel Complexes of H4edbbp with Zn(Ⅱ),Cd(Ⅱ)显示文摘 | FAN Yaoting XUE Dongxu LI Gang | 2004 | Journal of Molecular Structure2004，707，： | 1 |
| 14 | Chaos and Lyapunov characteristic exponents显示文摘 | Li Yaoting | 1995 | Physics1995，25，2： | 1 |
| 15 | Local injury to the endometrium improves the pregnancy rate in patients undergoing in vitro fertilization显示文摘 | Rong Li Yaoting Gui Lihua Lu | 2004 | International Congress Series2004，，1271： | 1 |
| 16 | Local injury to the endometrium improves the pregnancy rate in patients undergoing in vitro fertilization显示文摘 | Rong Li Yaoting Gui Lihua Lu | 2004 | International Congress Series2004，，1271： | 1 |
| 17 | Optimization of initial substrate and pH levels for germination of sporing hydrogen-producing anaerobes in cow dung compost 显示文摘 | FAN Yaoting LI Chenlin LAY Jiunn-jyi | 2004 | Bioresource Technology2004，91，： | 1 |
| 18 | ERCP combined with colonoscopy in the treatment of biliary-colonic fistula:case report and literature review显示文摘Introduction Internal biliary fistula is a potentially serious complication of laparoscopic cholecystectomy[1].Biliary-colonic fistula is a rare type of internal biliary fistula.Formation of a biliary-colonic fistula can occur as the result of surgical injury,stone obstruction,and biliary hypertension.More infrequent causes include intestinal ulcer and malignant tumor.The formation of a fistula also has the effect of infection and inflammation.While very few cases of biliary-colonic fistulas have been reported,these cases typically present with the aforementioned clinical presentations[2,3].In the present case,a biliary-colonic fistula resulting from bile-duct injury after laparoscopic cholecystectomy was identified by endoscopic retrograde cholangiopancreatography(ERCP).We innovatively adopted ERCP combined with colonoscopy to clamp the sinus tract for the patient. | Hongfei He Tingting Yu Yaoting Li Senlin Hou Lichao Zhang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 19 | STRUCTURAL AND ADSORPTION RELATIONSHIP OF MACROPOROUS R ESIN IN HEMOPERFUSION显示文摘In order to achieve high adsorption capacity of adsorbents in hemoperfusion,macroporous resins were tailor made with appropriate pore sizes and specific area. This allows the toxin molecules to diffuse freely within the channels ofthe porous resins and rinally reach the adsorption sites.Macroporous resin NK - 107 having small pore size and large Surface area(1086cm2) were synthesized which showed a high adsorption capacity of 82 - 94%for small molecules such as hypnotic and sedative drugs. For the adsorption of middle molecules i. e. Vit B12 or cytochrome C adsorbents having large pore sizes weretailor made. In the case of the adsorption of unconjugated bilirubin which is a verybig molecule, the pore size of the adsorbent should be at least>160A. NK - 110 istailor made with a very big pore size,which have a high adsorption capacity of 87%for bilirubin. DNA immobilized on carbonized resins,which have a porous structurewith a large surface area of 1000m2/g,can adsorb DNA antibody effectively. Resultsfrom animal and clinical trials indicated that the above tailor - made adsorbentshave a high efficacy in the removal of endogenous and exogenous toxins in hemoperfusion. | Baoan Li Chunli Gao Changzhi Chen Yaoting Yu(Molecular Biology Institute,Bioactive MaterialsResearch Laboratory, Nankai University, Tianjin 300071,China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，1： | 0 |
| 20 | Exact Controllability and Stabilization of Networkswith an Interior Point Mass | WANG Yaoting LI Shengjia(Department of Mathematics, Shanxi University, Taiyuan 030006 P. R. China) | 1998 | Systems Science and Systems Engineering1998，8，4： | 0 |
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