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| 1 | Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses显示文摘Ferritin,an iron-storage protein,regulates cellular iron metabolism and oxidative stress.The ferritin structure is characterized as a spherical cage,inside which large amounts of iron are deposited in a safe,compact and bioavailable form.All ferritins readily catalyze Fe(II)oxidation by peroxides at the ferroxidase center to prevent free Fe(II)from participating in oxygen free radical formation via Fenton chemistry.Thus,ferritin is generally recognized as a cytoprotective stratagem against intracellular oxidative damage.The expression of cytosolic ferritins is usually regulated by iron status and oxidative stress at both the transcriptional and post-transcriptional levels.The mechanism of ferritin-mediated iron recycling is far from clarified,though nuclear receptor co-activator 4(NCOA4)was recently identified as a cargo receptor for ferritin-based lysosomal degradation.Cytosolic ferritins are heteropolymers assembled by H-and L-chains in different proportions.The mitochondrial ferritins are homopolymers and distributed in restricted tissues.They play protective roles in mitochondria where heme-and Fe/S-enzymes are synthesized and high levels of ROS are produced.Genetic ferritin disorders are mainly related to the L-chain mutations,which generally cause severe movement diseases.This review is focused on the biochemistry and function of mammalian intracellular ferritin as the major iron-storage and anti-oxidation protein. | Jianlin Zhang Xuehui Chen Juanji Hong Aifa Tang Yang Liu Ni Xie Guohui Nie Xiyun Yan Minmin Liang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 2 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 3 | Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study显示文摘 | Song Wu Peide Huang Chong Li Yi Huang Xianxin Li Yongqiang Wang Chao Chen Zhaojie Lv Aifa Tang Xiaojuan Sun Jingxiao Lu Weiping Li Jie Zhou Yaoting Gui Fangjian Zhou Daping Wang Zhiming Cai | 2013 | European Urology2013，，： | 1 |
| 4 | Topical treatment with a new matrix therapy agent (RGTA)for the treatment of corneal neurotrophic ulcers显示文摘 | Aifa A Gueudry J Portmann A | 2012 | Invest Ophthalmol Vis Sci2012，53，13： | 1 |
| 5 | Suspected microbial mat-related crack-like sedimentary structures in the Palaeo- Proterozoic Magaliesberg Formation sandstones, South Africa 显示文摘 | Parizot M Eriksson P G Aifa T | 2005 | Precambrian Research2005，138，： | 1 |
| 6 | Heterologous expression of lignin peroxidase of Phanerochaete chrysosporium in Alspergil-lusniger显示文摘 | Aifa M S Sayadi S Gargouri A | 1999 | Biotechnolog Letters1999，21，10： | 1 |
| 7 | A TLR4 polymorphism is associated with asthma and re- duced lipopolysaccharide-induced interleukin-12 (p70) responses in Swedish children 显示文摘 | Fageras Bottcher M Hmani Aifa M Lindstr3m A | 2004 | J Allergy Clin Immunol2004，114，3： | 1 |
| 8 | Inhospital evaluation of orthopthaladehyde as a high level disinfectant for flexible endoscopes显示文摘 | Aifa MJ Sitter DL | 1994 | Hosp Infect1994，26，： | 1 |
| 9 | Heterologous expression of lignin peroxidase of Phanerochaete chrysosporium in Aspergillus niger显示文摘 | Mohamed Sami Aifa Sami Sayadi Ali Gargouri | 1999 | Biotechnology Letters1999，，10： | 1 |
| 10 | A basic peptide within the juxtamembrane region is required for EGF receptor dimerization显示文摘 | AIFA S AYDIN J G NORDVALL G | 2005 | Exp Cell Res2005，302，1： | 1 |
| 11 | A basic peptide within the juxtamembrane region is required for EGF receptor dimerization显示文摘 | AIFAS AYDINJ NORDVALLG | 2005 | Exp Cell Res2005，302，1： | 1 |
| 12 | Phosphorylation of Thr654 but not Thr669 within the juxtamembrane domain of the EGF receptor inhibits calmodulin binding显示文摘 | Aifa S Frikha F Miled N | | 0，，： | 1 |
| 13 | A Basic Peptide Within the Juxtamembrane Region is Required for EGF Receptor Dimerization 显示文摘 | AIFA S AYDIN J NORDVALL G | 2005 | Experimental Cell Research2005，302，： | 1 |
| 14 | Prodigiosin from Serratia:Synthesis and potential applications显示文摘Prodigiosin is a red pigment with a pyrrolylpyrromethane skeleton.It is mainly produced by bacterial strains belonging to the Serratia genus,but also by some other genera,including Streptomyces and Vibrio.Within the genus Serratia,the pigment is generally produced as a virulence factor.However,it also has many important beneficial biological activities such as immunosuppressive and anti-proliferative activities.Moreover,the pigment has many industrial applications in textile and cosmetics.In this mini-review,we discuss the genetic and molecular mechanisms supporting prodigiosin synthesis and production from the Serratia genus,as well as its potential applications. | Sami Mnif Marwa Jardak Brahim Bouizgarne Sami Aifa | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，6： | 1 |
| 15 | A natural nanozyme in life is found:the iron core within ferritin shows superoxide dismutase catalytic activity显示文摘Nanozymes are nanomaterials exhibiting intrinsic enzymatic properties,which suggests that inorganic nanoparticles could be bioactive.It’s in 2007,when we introduced the biological methodologies for natural enzymes to systematically study the enzymatic properties of iron oxide nanoparticles,we discovered nanozymes.We found that nanozymes,just as natural enzymes,are able to catalyze biochemical reactions under the physiological conditions,following the similar enzymatic kinetics and catalytic mechanisms(Gao et al.,2007).Since then,the developments of nanozymes bloomed,and lots of nanomaterials were found exhibiting various enzymatic activities(Huang et ah,2019). | Jianlin Zhang Shimin Li Ni Xie Guohui Nie Aifa Tang Xian-En Zhang Minmin Liang Xiyun Yan | 2021 | Science China(Life Sciences)2021，64，8： | 0 |
| 16 | 省电又安全 VIA C7-M技术详解显示文摘笔记本电脑市场突然爆发是最近两年IT厂商最希望看到的情景,目前主流笔记本向着更轻、更快、更薄、更省电的方向发展。与台式机发展不同的是,高频低能的台式核心已经成为过去。自从Intel发布了迅驰平台之后,笔记本处理器就进入了革新时代,Intel的Pentium-M处理器与AMD的Turion64都是低频高能的代表产品。我们不能否认这两款处理器的成功之处,不过在这两款处理器之外,VIA的C7-M处理器同样特点鲜明,值得关注。对于笔记本平台来说,性能并不是全部,更好的移动性和更低的功耗才是人们更希望出现在笔记本上的技术。在这一点上,VIA的C7-M为我们更好地诠释了移动的定义。 | Aifa | 2006 | 大众硬件2006，，8： | 0 |
| 17 | Evidence for GAL3ST4 mutation as the potential cause of Dectus excavatum显示文摘 | Song Wu Xiaojuan Sun Weimin Zhu Yi Huang Lisha Mou Mingming Liu Xia Li Feiyang Li Xianxin Li Yong Zhang Zheng Wang Wencui Li Zesong Li Aifa Tang Yaoting Gui Rongfu Wang Weiping Li Zhiming Cai Daping Wang | 2012 | Cell Research2012，22，12： | 0 |
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