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| 1 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 2 | Cellulose-hydrogen production from corn stalk biomass by anaerobic fermentation显示文摘Cellulose-hydrogen production from corn stalk by lesser panda manure was carried out in batch tests and a 5 L scale-up continuously stirred anaerobic bioreactor(CSABR),respectively.The bio-pretreatment of corn stalk was found most effective at 25℃ using microbe additive of 7.5 g/kg,in which the yields of soluble saccharides(SS) and lactic acid were 212 mg/g-TS and 21 mg/g-TS,respectively.The maximum cumulative H2 yield(176 ml/g-TS) and H2 production rate(14.5 ml/g-TS h-1) were obtained at pH 5.5,36℃ by treating a substrate of 15 g/L.The hydrogen content in biogas was 57.2% and there was no significant methane gas observed.During the optimal period of H2 production,the ORP values stayed in the lower level ranging from -445 mV to -455 mV.The results show that the bio-pretreatment of the raw materials played a vital role in the effective conversion of corn stalk into cellulose-hydrogen by mixed culture. | XING Yan MA HongCui FAN YaoTing HOU HongWei CHEN JingRun | 2009 | Chinese Science Bulletin2009，54，8： | 3 |
| 3 | Structure and magnetism of a porous three-dimensional metal-organic framework based on planar tetranuclear copper(Ⅱ) cluster units显示文摘A porous three-dimensional copper(Ⅱ) metal-organic framework (MOF) {[Cu2(tci)(OH)(pip)0.5(H2O)]·6H2O}n (1) [tci = tris (2-carboxyethyl)isocyanurate, pip = piperazine] has been generated under hydrothermal conditions at 120 °C. Single crystal X-ray diffraction reveals that the polymer exhibits a novel three-dimensional framework based on planar tetranuclear copper(Ⅱ) cluster units. The variable temperature magnetic susceptibility data in the range 2-280 K show antiferromagnetic spin-spin coupling in the tetranuclear unit in complex 1. A theoretical fitting of the magnetic data gives J values of -31.3 cm-1, -30.8 cm-1, and 13.5 cm-1. | LI HuiJun, ZHANG ErPeng, GUO QianQian, HOU HongWei & FAN YaoTing Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China | 2010 | Science China Chemistry2010，53，10： | 2 |
| 4 | Five novel transition metal coordination polymers with 2D/3D framework structure based on flexible H2 tzda and ancillary ligand bpe显示文摘 | Wang Yuting Xu Yan Fan Yaoting | 2009 | J Solid State Chem2009，182，10： | 1 |
| 5 | Metal-organic coordination polymers assembled from divalent transition salts with a flexible spacer ligand: hydrothermal syntheses, crystal structures, and luminescent and magnetic properties显示文摘 | Wang Yuting Shen Xiaoqing Fan Yaoting | 2008 | Supramol Chem2008，20，5： | 1 |
| 6 | Optimization of initial substrate and pH levels for germination of sporing hydrogen-producing anaerobes in cow dung compost显示文摘 | Fan Yaoting Li Chenlin Lay Jiunn Jyi | 2004 | Bioresour Technol2004，91，2： | 1 |
| 7 | Biohydrogen-production from beer lees biomass by cow dung compost显示文摘 | Fan Yaoting Zhang Gaosheng Gao Xinyang | 2006 | Biomass and Bioenergy2006，30，： | 1 |
| 8 | Effcient conversion of wheat straw wastes into biohydrogen gas by bow dung compost显示文摘 | Fan Yaoting Zhang Yahui Zhang Shufang | 2006 | Bioresource Technology2006，97，： | 1 |
| 9 | Bioconversion of corncob to hydrogen using anaerobic mixed microflora显示文摘 | Pan Chunmei Zhang Shufang Fan Yaoting | 2010 | International Journal of Hydrogen Energy2010，35，17： | 1 |
| 10 | Bioaugmented cellulosic hydrogen production from cornstalk by integrating dilute acid-enzyme hydrolysis and dark fermentation显示文摘 | Pan Chunmei Ma Hongcui Fan Yaoting | 2011 | International Journal of Hydrogen Energy2011，36，8： | 1 |
| 11 | The preparation and application of crude cellulase for cellulose-hydrogen production by anaerobic fermentation 显示文摘 | GUO Yiping FAN Shaoqun FAN Yaoting | 2010 | Int J Hydrogen Energy2010，35，： | 1 |
| 12 | Tri- pod - like Compounds : Syntheses of tris ( p - OR o - Amino Phe- noxymethyl) ,tris( p - OR o - Amino Phcnoxyethyl) Amine, and their Schiff Base or Salicyl Derivatives 显示文摘 | Huijie Lu Yaoting Fan Qinghuan Zhao and Yangjie Wu | 2001 | Synthetic Communica- tions2001，31，10： | 1 |
| 13 | Optimization of initial substrate and pH levels for germination of sporting hydrogen-producing anaerobes in cow dung compost显示文摘 | Fan Yaoting Li Chenlin Lay JiunnJyi | | 0，，02： | 1 |
| 14 | Optimization of initial substrate and pH levels for germination of sporing hydrogen-producing anaerobes in cow dung compost显示文摘 | Fan Yaoting Li Chenlin Hou Hongwei | 2004 | Bioresource Technology2004，91，： | 1 |
| 15 | Five novel transition metal coordination polymers with 2D/3D framework structure based on flexible H2tzda and ancillary ligand bpe显示文摘 | Wang Yuting Xu Yan Fan Yaoting | 2009 | J Solid State Chem2009，182，10： | 1 |
| 16 | Biohydrogen-production from beer lees biomass by cow dung compost显示文摘 | Fan Yaoting Zhang Gaosheng Guo Xinyong | 2006 | Biomass and Bioenergy2006，30，： | 1 |
| 17 | Synthesis,Crystal Structures,and Third-order Nonlinear Optical Properties of Two Novel Complexes of H4edbbp with Zn(Ⅱ),Cd(Ⅱ)显示文摘 | FAN Yaoting XUE Dongxu LI Gang | 2004 | Journal of Molecular Structure2004，707，： | 1 |
| 18 | Preparation of transparent iron oxide pigment显示文摘 | Fan Yaoting Fan Yulan Lu Bingling | 1996 | Modem Chemical Industry1996，，6： | 1 |
| 19 | 1 D helical Zn Ⅱ metal-organic polymers:syntheses,structures and fluorescent properties显示文摘 | Xiao Bo Hou Hongwei Fan Yaoting | | 0，，03： | 1 |
| 20 | Stiffness degradation-based damage model for RC members and structures using fiber-beam elements显示文摘To meet the demand for an accurate and highly efficient damage model with a distinct physical meaning for performance-based earthquake engineering applications, a stiffness degradation-based damage model for reinforced concrete(RC) members and structures was developed using fiber beam-column elements. In this model, damage indices for concrete and steel fibers were defined by the degradation of the initial reloading modulus and the low-cycle fatigue law. Then, section, member, story and structure damage was evaluated by the degradation of the sectional bending stiffness, rod-end bending stiffness, story lateral stiffness and structure lateral stiffness, respectively. The damage model was realized in Matlab by reading in the outputs of Open Sees. The application of the damage model to RC columns and a RC frame indicates that the damage model is capable of accurately predicting the magnitude, position, and evolutionary process of damage, and estimating story damage more precisely than inter-story drift. Additionally, the damage model establishes a close connection between damage indices at various levels without introducing weighting coefficients or force-displacement relationships. The development of the model has perfected the damage assessment function of Open Sees, laying a solid foundation for damage estimation at various levels of a large-scale structure subjected to seismic loading. | Guo Zongming Zhang Yaoting Lu Jiezhi Fan Jian | 2016 | Earthquake Engineering and Engineering Vibration2016，15，4： | 1 |
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