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| 1 | Somatic Embryogenesis Receptor Kinases Control Root Development Mainly via Brassinosteroid-Independent Actions in Arabidopsis thaliana显示文摘Brassinosteroids(BRs),a group of plant steroidal hormones,play critical roles in many aspects of plant growth and development.Previous studies showed that BRI1-mediated BR signaling regulates cell division and differentiation during Arabidopsis root development via interplaying with auxin and other phytohormones.Arabidopsis somatic embryogenesis receptor-like kinases(SERKs),as co-receptors of BRI1,were found to play a fundamental role in an early activation step of BR signaling pathway.Here we report a novel function of SERKs in regulating Arabidopsis root development.Genetic analyses indicated that SERKs control root growth mainly via a BR-independent pathway.Although BR signaling pathway is completely disrupted in the serk1 bak1 bkk1 triple mutant,the root growth of the triple mutant is much severely damaged than the BR deficiency or signaling null mutants.More detailed analyses indicated that the triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport,cell cycle,endodermis development and root meristem differentiation,which were not observed in null BR biosynthesis mutant cpd and null BR signaling mutant bri1-701. | Junbo Du Hongju Yin Shasha Zhang Zhuoyun Wei Baolin Zhao Jinghua Zhang Xiaoping Gou Honghui Lin Jia Li | 2012 | Journal of Integrative Plant Biology2012，54，6： | 22 |
| 2 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 3 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 4 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 5 | Flexible self-charging power units for portable electronics based on folded carbon paper显示文摘对便携式的电子学的迫切要求支持了高效率、持续、甚至可拉长的自我控告的力量来源的发展。在这个工作,我们建议为从人的运动和力量便携式计算机电子学收获机械精力基于合拢的碳(FC ) 统一纸的灵活自我控告的力量。现在的单位主要由摩擦电 nanogenerator (FC-TENG ) 和 supercapacitor (FC-SC ) 组成,基于合拢的复写纸精力 harvester 和存储设备分别地。这个有利几何图案向高幼仔模量复写纸提供优秀 stretchability 并且使力量单位能甚至在严重变丑下面工作,扭动,并且滚动,例如弯曲。另外,张力的紧张能被调节合拢三角的复写纸的合拢的角度最大化。而且,包装设备的防水性质使它可洗,保护它免受人的汗的伤害,并且使它能在严厉环境工作。最后,同样准备的自我控告的力量单位被把它放在人的身体上从手拍,踩的脚,并且手臂接触成功地驱动一块电子手表收获机械精力测试。这个工作表明可拉长的自我控告的力量单位的出色的潜力,它将进一步为便携 / 便携式的电子学支持高幼仔模量材料的发展。 | Changjie Zhou Yanqin Yang Na Sun Zhen Wen Ping Cheng Xinkai Xie Huiyun Shao Qingqing Shen Xiaoping Chen Yina Liu Zhong Lin Wang Xuhui Sun | 2018 | Nano Research2018，11，8： | 9 |
| 6 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 7 | Fe5C2 nanoparticles as low-cost HER electrocatalyst:the importance of Co substitution显示文摘Constructing and understanding the doping effect of secondary metal in transition metal carbide(TMC)catalysts is pivotal for the design of low-cost hydrogen evolution reaction(HER) electrocatalysts. In this work, we developed a wet-chemistry strategy for synthesizing Co-modified Fe_5C_2 nanoparticles((Fe_(1-x)Cox)_5C_2 NPs) as highly active HER electrocatalysts in basic solution. The structure of(Fe_(1-x)Cox)_5C_2 NPs was characterized by X-ray diffraction(XRD), extended X-ray absorption fine structure spectra(EXAFS) and scanning/transmission electron microscopy(S/TEM), indicating that the isomorphous substitution of cobalt in the lattice of Fe_5C_2.(Fe_(0.75) Co_(0.25))_5C_2 exhibited the best HER activity(174 mV for j = -10 mA/cm^2). Computational calculation results indicate that Co provides the most active site for HER. X-ray adsorption spectra(XAS) studies further suggested that the electron transfer in Fe–C bonds are enhanced by the substitution of Co, which modulates the hydrogen adsorption on the adjacent electronic-enriched carbon, and therefore promotes HER activity. Our results affirm the design of lowcost bimetallic TMCs based HER catalysts. | Siwei Li Pengju Ren Ce Yang Xi Liu Zhen Yin Weizhen Li Hanjun Yang Jian Li Xiaoping Wang Yi Wang Ruochen Cao Lili Lin Siyu Yao Xiaodong Wen Ding Ma | 2018 | Science Bulletin2018，63，20： | 6 |
| 8 | High-temperature oxidation behavior of modified 4Al alumina-forming austenitic steel: Effect of cold rolling显示文摘The oxidation behavior and mechanism of as-received and 30 % cold-rolled alumina-forming austenitic(AFA) steel were investigated in dry air at 700℃.The results show that the mass gain per unit area curves of as-received and 30 % cold-rolled steels subject to near-parabolic law before 100 h oxidation time.Two samples both show higher high-temperature oxidation resistance due to the formation of dense Al_(2)O_(3) oxide scale.Gradual spallation of outer scale results in the formation of continuous and dense alumina scale.Dislocations can act as short-circuit diffusion channel for the diffusion of Al from alloy matrix to surface,and also provide nucleation sites for B2-NiAl phase,which ensure the continuous formation of Al_(2)O_(3) scale. | Qiuzhi Gao Ziyun Liu Huijun Li Hailian Zhang Chenchen Jiang Aimin Hao Fu Qu Xiaoping Lin | 2021 | Journal of Materials Science & Technology2021，，9： | 5 |
| 9 | Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice显示文摘Oxysophoridine, a new alkaloid extracted from Sophora alopecuroides L., has been shown to have a protective effect against ischemic brain damage. In this study, a focal cerebral ischemia/reperfusion injury model was established using middle cerebral artery occlusion in mice. Both 62.5, 125, and 250 mg/kg oxysophoridine, via intraperitoneal injection, and 6 mg/kg nimodipine, via intragastric administration, were administered daily for 7 days before modeling. After 24 hours of reperfusion, mice were tested for neurological deficit, cerebral infarct size was assessed and brain tissue was collected. Results showed that oxysophoridine at 125, 250 mg/kg and 6 mg/kg nimodipine could reduce neurological deficit scores, cerebral infarct size and brain water content in mice. These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. In addition, oxysophoridine at 62.5, 125, and 250 mg/kg and 6 mg/kg nimodipine increased adenosine-triphosphate content, and decreased malondialdehyde and nitric oxide content. These compounds enhanced the activities of glutathione-peroxidase, superoxide dismutase, catalase, and lactate dehydrogenase, and decreased the activity of nitric oxide synthase. Protein and mRNA expression levels of N-methyl-D-aspartate receptor subunit NR1 were markedly inhibited in the presence of 250 mg/kg oxysophoridine and 6 mg/kg nimodipine. Our experimental findings indicated that oxysophoridine has a neuroprotective effect against cerebral ischemia/reperfusion injury in mice, and that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1. | Hongbo Wang Yuxiang Li Ning Jiang Xiaoping Chen Yi Zhang Kuai Zhang Tengfei Wang Yinju Hao Lin Ma Chengjun Zhao Yanrong Wang Tao Sun Jianqiang Yu | 2013 | Neural Regeneration Research2013，8，15： | 5 |
| 10 | AFM quantitative analysis and determination of shear angle of {259}_f martensitic surface relief显示文摘An attentive observation and quantitative analysis of {259}f martensitic surface relief in an Fe-23Ni-0.55C alloy are made by means of an atomic force microscope (AFM), and different martensitic variants' shear angles are determined in this paper. The experiments show that {259}f martensitic surface relief exhibits regular shape in many cases, which is in agreement with the prediction of invariant plane strain (IPS). Generally, {259}f martensitic surface relief appears to be 'N'-shaped, but it is tent-shaped in the case of zigzag-shaped martensite. The compressed deformation of parent phase diminishes the surface relief in size but with little change of its relief angle. {259}f martensitic surface relief, large or small, has approximately the same relief angles, exhibiting a good 'self-similar fractal'. The determined values of different {259}f martensitic variants' shear angles are in fine agreement with the prediction of Wechsler-Liberman-Read (W-L-R) theory, with only a slight difference of less than 3.65°. | LIN Xiaoping, GU Nanju, ZHANG Yong, MENG Zhaowei and MA Xiaoli(Department of Materials Science and Technology, Hebei University of Technology, Tianjin 300130, China) | 2002 | Progress in Natural Science:Materials International2002，12，10： | 5 |
| 11 | Microstructure and properties of novel Al-Ce-Sc,Al-Ce-Y,Al-Ce-Zr and Al-Ce-Sc-Y alloy conductors processed by die casting,hot extrusion and cold drawing显示文摘In order to overcome the trade-off between the strength and electrical conductivity of aluminum alloy conductors,the new Al-Ce-Sc,Al-Ce-Y,Al-Ce-Zr and Al-Ce-Sc-Y alloys were prepared by die casting,high temperature homogenization treatment,hot extrusion and cold drawing.Adding Sc and Y eliminated the dendrite segregation of the as-cast Al-0.2 Ce alloy and promoted the formation of equiaxed grains with the average grain size of 142.5μm.The Al-0.2 Ce-0.2 Sc-0.1 Y alloy inherited the great tensile properties of Al-0.2 Ce-0.2 Sc alloy and the high electrical conductivity of Al-0.2 Ce-0.1 Y alloy simultaneously.After cold drawing and annealing at 200℃for 5 h,the ultimate tensile strength of Al-0.2 Ce-0.2 Sc-0.1 Y alloy reached 200 MPa and 198 MPa,the elongation reached 6.8%and 8.5%,and the electrical conductivity reached 61.01%and 61.77%,respectively.The main second phase of Al-0.2 Ce-0.2 Sc-0.1 Y alloy after hot extrusion were Al_(13)Fe_3 Ce containing a few Y and Si atoms.The larger size and proportion of the second phase greatly reduced the concentration of solute Fe and Si atoms and the addition of Y significantly decreased the density of defects after cold drawing compared to Al-0.2 Ce-0.2 Sc alloy,which improved electrical conductivity of the alloy.Furthermore,the dispersed and coherent nano-size Al_3 Sc precipitions of Al-0.2 Ce-0.2 Sc-0.1 Y alloy greatly improved strength,elongation and heat resistance.Compared with Al-0.2 Ce-0.2 Sc alloy,the lower density of dislocation,stacking fault and subgrain boundary and the larger size of Al_3 Sc precipitions with enrichment of Y atoms enable the Al-0.2 Ce-0.2 Sc-0.1 Y alloy to maintain high strength,elongation and electrical conductivity after annealing. | Weiyi Wang Qinglin Pan Geng Lin Xiaoping Wang Yuqiao Sun Xiangdong Wang Ji Ye Yuanwei Sun Yi Yu Fuqing Jiang Jun Li Yaru Liu | 2020 | Journal of Materials Science & Technology2020，58，23： | 4 |
| 12 | Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy显示文摘Extensive studies have demonstrated that mesenchymal stem cells(MSCs)are multipotent mesoderm-derived stromal cells that can differentiate into a variety of cell types,including adipocytes,osteoblasts,chondrocytes,myocytes and neuronal cells.1 MSCs are found in numerous organs and tissues,including bone marrow,heart,lung,muscle,peripheral blood,adipose tissue,cartilage,synovium,dental pulp,tonsil,umbilical cord,placenta,thymus and olfactory mucosa.1 MSCs have been shown to possess potent immunosuppressive functions and tissue repair capacities,which have facilitated the clinical applications of MSCs in treating a diverse range of disorders involving angiogenesis and fibrosis,including rheumatic diseases and graft-versus-host diseases.2,3 Here,we provide a brief commentary on newly emerging evidence of the immunoregulatory function and potential application of ecto-mesenchymal stem cells. | Ke Rui Xiang Lin Jie Tian Xiaohui Wang Lingyun Sun Xiaoping Hong Dongzhou Liu Shengjun Wang Liwei Lu | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 13 | Validation of the Nanjing Criteria for Diagnosing Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstruction Syndrome显示文摘Background and Aims:Hepatic sinusoidal obstruction syndrome(HSOS)is caused by toxic injury to sinusoidal endothelial cells in the liver.The intake of pyrrolizidine alkaloids(PAs)in some Chinese herbal remedies/plants remains the major etiology for HSOS in China.Recently,new diagnostic criteria for PA-induced HSOS(i.e.PA-HSOS)have been developed;however,the efficacy has not been clinically validated.This study aimed to assess the performance of the Nanjing criteria for PA-HSOS.Methods:Data obtained from consecutive patients in multiple hospitals,which included 86 PA-HSOS patients and 327 patients with other liver diseases,were retrospectively analyzed.Then,the diagnostic performance of the Nanjing criteria and simplified Nanjing criteria were evaluated and validated.The study is registered in www.chictr.org.cn(ID:ChiCTR1900020784).Results:The Nanjing criteria have a sensitivity and specificity of 95.35%and 100%,respectively,while the simplified Nanjing criteria have a sensitivity and specificity of 96.51%and 96.33%,respectively,for the diagnosis of PA-HSOS.Notably,a proportion of patients with Budd-Chiari syndrome(11/49)was misdiagnosed as PA-HSOS on the basis of the simplified Nanjing criteria,and this was mainly due to the overlapping features in the enhanced computed tomography/magnetic resonance imaging examinations.Furthermore,most of these patients(10/11)had occlusion or thrombosis of the hepatic vein,and communicating vessels in the liver were found in 8/11 patients,which were absent in PA-HSOS patients.Conclusions:The Nanjing criteria and simplified Nanjing criteria exhibit excellent performance in diagnosing PA-HSOS.Thus,both could be valuable diagnostic tools in clinical practice. | Wei Zhang Lu Liu Ming Zhang Feng Zhang Chunyan Peng Bin Zhang Jun Chen Lin Li Jian He Jiangqiang Xiao Yanhong Feng Xunjiang Wang Aizhen Xiong Li Yang Xiaoping Zou Yuecheng Yu Yuzheng Zhuge | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 4 |
| 14 | Influence of nanoparticle concentrations on flow boiling heat transfer coefficients of Al_2O_3/R141b in micro heat exchanger by direct metal laser sintering显示文摘Al_2O_3/R141 b + Span-80 nanorefrigerant for 0.05 wt.% to 0.4 wt.% is prepared by ultrasonic vibration to investigate the influence of nanoparticle concentrations on flow boiling heat transfer of Al_2O_3/R141 b + Span-80 in micro heat exchanger by direct metal laser sintering. Experimental results show that nanoparticle concentrations have significantly impact on heat transfer coefficients by homogeneity test of variances according to mathematical statistics. The heat transfer performance of Al_2O_3/R141 b+ Span-80 nanorefrigerant is enhanced after adding nanoparticles in the pure refrigerant R141 b. The heat transfer coefficients of 0.05 wt.%, 0.1 wt.%, 0.2 wt.%, 0.3 wt.%and 0.4 wt.% Al_2O_3/R141 b + Span-80 nanorefrigerant respectively increase by 55.0%, 72.0%, 53.0%, 42.3% and 39.9% compared with the pure refrigerant R141 b. The particle fluxes from viscosity gradient, non-uniform shear rate and Brownian motion cause particles to migrate in fluid especially in the process of flow boiling. This migration motion enhances heat transfer between nanoparticles and fluid. Therefore, the heat transfer performance of nanofluid is enhanced. It is important to note that the heat transfer coefficients nonlinearly increase with nanoparticle concentrations increasing. The heat transfer coefficients reach its maximum value at the mass concentration of 0.1% and then it decreases slightly. There exists an optimal mass concentration corresponding to the best heat transfer enhancement. The reason for the above phenomenon is attributed to nanoparticles deposition on the minichannel wall by Scanning Electron Microscopy observation. The channel surface wettability increases during the flow boiling experiment in the mass concentration range from 0.2 wt.% to 0.4 wt.%. The channel surface with wettability increasing needs more energy to produce a bubble. Therefore, the heat transfer coefficients decrease with nanoparticle concentrations in the range from 0.2 wt.% to 0.4 wt.%. In addition, a new correlation has been proposed by fitting the experimental data considering the influence of mass concentrations on the heat transfer performance. The new correlation can effectively predict the heat transfer coefficient. | Jianyang Zhou Xiaoping Luo Cong Deng Mingyu Xie Lin Zhang Di Wu Feng Guo | 2017 | Chinese Journal of Chemical Engineering2017，25，12： | 4 |
| 15 | Estrogenic effect of the extract of Renshen(Radix Ginseng) on reproductive tissues in immature mice显示文摘OBJECTIVE: To evaluate the estrogenic efficacy of Renshen(Radix Ginseng)(GS) on reproductive target tissues in immature mice.METHODS: One hundred and ten female immature Kunming(KM) mice, 21-day-old, were randomly assigned to eleven groups, 10 for each; one served as control group treated with 0.154 mg/kg estradiol valerate(EV,n = 10), the rest were treated respectively with GS intragastrically at a daily dose of 0.5,1.0, 1.5, 3.0, 6.0, 12.0, 18.0, 24.0 and 30.0 g/kg(n =10 in per group) for 7 days. The estrous cycle, uterine weight, hormone levels in circulation and histomorphology changes of uterus and vagina were scrupulously examined. The estrogen receptor(ER)α and ERβ expressions in the uterus and vagina were detected by immunohistochemistry and western blotting.RESULTS: Treatment with GS at the dose of 12.0,18.0 and 24.0 g/kg resulted significant estrogenic activity in the mice, as indicated by advanced and prolonged estrous stage and increased uterine weight(all P < 0.05). GS treatment substantially promoted development of reproductive tissue by thickening the uterine endometrium and increasing vaginal epithelial layers. In addition, treatment with GS induced significant up-regulation of ERαand ERβ expressions in reproductive tissues, and ERα up-regulation was stronger than that of ERβ.GS could raise levels of circulating estrogen, simultaneously decrease levels of luteinizing hormone and follicle-stimulating hormone(all P < 0.001)compared with the control group.CONCLUSION: Our findings suggest that GS had estrogenic effect on reproductive tissues in immature mice by stimulating biosynthesis of estrogen in circulation and up-regulating ERs. | Ding Jie Xu Ying Ma Xiaoping An Jinna Yang Xiudong Liu Zhiqiang Lin Na | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 3 |
| 16 | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization显示文摘NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectively. Although p100 responds to noncanonical NF-κB stimuli for processing, it does not undergo degradation, but rather becomes accumulated, along with canonical NF-κB activation. We show here that the stability of p100 is tightly controlled by a deubiquitinase, Otub1. Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-κB activation but also causes steady-state p100 degradation, leading to aberrant NF-κB activation in the canonical pathway. B-cell-conditional deletion of Otub1 results in B-cell hyperplasia, antibody hyper-production, and lupus-like autoimmunity. Otub1-deficient B cells display aberrantly activated phenotypes and overproduce the cytokine IL-6, contributing to autoimmunity induction. Thus, maintenance of p100 stability by Otub1 serves as an unusual mechanism of NF-κB regulation that prevents autoimmunity. | Yanchuan Li Jin-Young Yang Xiaoping Xie Zuliang Jie Lingyun Zhang Jianhong Shi Daniel Lin Meidi Gu Xiaofei Zhou Haiyan S. Li Stephanie S. Watowich Antrix Jain Sung Yun Jung Jun Qin Xuhong Cheng Shao-Cong Sun | 2019 | Cell Research2019，29，6： | 3 |
| 17 | A Novel Low Density Parity Check Coded Differential Amplitude and Pulse Position Modulation Free-Space Optical System for Turbulent Channel显示文摘Based on the proposed partly equidifferent mapping and its specific Differential Amplitude and Pulse Position Modulation(DAPPM) demodulation, a modified FSO scheme for turbulent channel is designed and analyzed. The novel Low Density Parity Check(LDPC) coded 4×4 and 4×8 DAPPM Free-Space Optical communication(FSO) system is constructed. The Monte Carlo simulation results show approximately 2d B transmit power reduction against classical LDPC-DAPPM at the identical Bit-Error-Rate in strong turbulent channel. The proposed partly equidifferent mapping is compatible with other modulations, so it enables widespread adoption in other coded FSO systems. | Yin Liang Hua Zhang Limin Chen Xiaoping Liu Xuehong Lin | 2017 | China Communications2017，14，3： | 3 |
| 18 | Effect of Residual Stress on Corrosion Sensitivity of Carbon Steel Studied by SECM显示文摘 | WANG Yujie HAN Xiaoping LIU Yu ZHANG Weiwei NIU Lin | 2014 | Chemical Research in Chinese Universities2014，30，6： | 3 |
| 19 | A stability condition for turbulence model:From EMMS model to EMMS-based turbulence model显示文摘The closure problem of turbulence is still a challenging issue in turbulence modeling.In this work,a stability condition is used to close turbulence.Specifically,we regard single-phase flow as a mixture of turbulent and non-turbulent fluids,separating the structure of turbulence.Subsequently,according to the picture of the turbulent eddy cascade,the energy contained in turbulent flow is decomposed into different parts and then quantified.A turbulence stability condition,similar to the principle of the energy-minimization multi-scale(EMMS) model for gas-solid systems,is formulated to close the dynamic constraint equations of turbulence,allowing the inhomogeneous structural parameters of turbulence to be optimized.We name this model as the 'EMMS-based turbulence model',and use it to construct the corresponding turbulent viscosity coefficient.To validate the EMMS-based turbulence model,it is used to simulate two classical benchmark problems,lid-driven cavity flow and turbulent flow with forced convection in an empty room.The numerical results show that the EMMS-based turbulence model improves the accuracy of turbulence modeling due to it considers the principle of compromise in competition between viscosity and inertia. | Lin Zhang Xiaoping Qiu Limin Wang Jinghai Li | 2014 | Particuology2014，12，5： | 3 |
| 20 | Electron back-scattering diffraction preliminary analysis of heterogeneous nuclei in magnesium alloy during solidification process under GPa high pressure显示文摘The effective heterogeneous nuclei in Mg-7.92 Zn-1.70 Y alloy during solidification process under high pressure was investigated by EBSD. It is found that the orientation relationship between Mg matrix and MgY phase, [111]_(MgY)//[1210]_(α-Mg) and(101)_(MgY)//(0001)_(α-Mg), exists between Mg matrix and MgY phase.The MgY phase is the potential heterogeneous nuclei substrate for a-Mg solidified under high pressure. It is calculated by Bramfitt mode that the mismatch between Mg matrix and MgY phase is greater than 12% under atmospheric pressure. When solidified under high pressure of 4 GPa, the solidification pressure can increase the number of the α-Mg nucleus by reducing the size of the nucleus, decreasing interfacial energy of MgY/a-Mg, and changing the wettability between MgY phase and α-Mg from non-wetting under atmospheric pressure to wetting under high pressure. The MgY phase becomes a powerful heterogeneous nuclei for α-Mg crystal. Increasing the number of valid heterogeneous nuclei substrate increases nucleus number and refines the grain of the alloy. | Zhibin Fan Xiaoping Lin Rui Xu Yun Dong Bin Wen Lin Wang Shengshi Zhao | 2018 | Journal of Rare Earths2018，36，2： | 3 |
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