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| 1 | Hydrothermal synthesis of calcium sulfate whisker from flue gas desulfurization gypsum显示文摘Plenty of flue gas desulfurization(FGD) gypsum generated from coal-fired power plants for sulfur dioxide sequestration caused many environmental issues. Preparing calcium sulfate whisker(CSW) from FGD gypsum by hydrothermal synthesis is considered to be a promising approach to solve this troublesome problem and utilize calcium sulfate in a high-value-added way. The effects of particle size of FGD gypsum, slurry concentration,and additives on CSW were investigated in this work. The results indicated that fine particle size of FGD gypsum and moderately high slurry concentration were beneficial for crystal nucleation and growth. Three additives of magnesium chloride, citric acid, and sodium dodecyl benzene sulfonate(SDBS) were employed in this study. It was found that mean length and aspect ratio of CSW were both decreased by the usage of magnesium chloride,while a small quantity of citric acid or SDBS could improve the CSW morphology. When multi-additives of citric acid-SDBS were employed, the mean length and aspect ratio increased more than 20%. Moreover, surface morphology of CSW went better, and the particle size and crystal shape became more uniform. | Chengjun Liu Qing Zhao Yeguang Wang Peiyang Shi Maofa Jiang | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 15 |
| 2 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 3 | Clinical features and outcomes of 210 patients with idiopathic pulmonary fibrosis显示文摘 | Cai Miaotian Zhu Min Ban Chengjun Su Jin Ye Qiao Liu Yan Zhao Wen Wang Chen Dai Huaping | 2014 | Chinese Medical Journal2014，，10： | 8 |
| 4 | Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice显示文摘Oxysophoridine, a new alkaloid extracted from Sophora alopecuroides L., has been shown to have a protective effect against ischemic brain damage. In this study, a focal cerebral ischemia/reperfusion injury model was established using middle cerebral artery occlusion in mice. Both 62.5, 125, and 250 mg/kg oxysophoridine, via intraperitoneal injection, and 6 mg/kg nimodipine, via intragastric administration, were administered daily for 7 days before modeling. After 24 hours of reperfusion, mice were tested for neurological deficit, cerebral infarct size was assessed and brain tissue was collected. Results showed that oxysophoridine at 125, 250 mg/kg and 6 mg/kg nimodipine could reduce neurological deficit scores, cerebral infarct size and brain water content in mice. These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. In addition, oxysophoridine at 62.5, 125, and 250 mg/kg and 6 mg/kg nimodipine increased adenosine-triphosphate content, and decreased malondialdehyde and nitric oxide content. These compounds enhanced the activities of glutathione-peroxidase, superoxide dismutase, catalase, and lactate dehydrogenase, and decreased the activity of nitric oxide synthase. Protein and mRNA expression levels of N-methyl-D-aspartate receptor subunit NR1 were markedly inhibited in the presence of 250 mg/kg oxysophoridine and 6 mg/kg nimodipine. Our experimental findings indicated that oxysophoridine has a neuroprotective effect against cerebral ischemia/reperfusion injury in mice, and that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1. | Hongbo Wang Yuxiang Li Ning Jiang Xiaoping Chen Yi Zhang Kuai Zhang Tengfei Wang Yinju Hao Lin Ma Chengjun Zhao Yanrong Wang Tao Sun Jianqiang Yu | 2013 | Neural Regeneration Research2013，8，15： | 5 |
| 5 | Group VB transition metal dichalcogenides for oxygen reduction reaction and strain-enhanced activity governed by p-orbital electrons of chalcogen显示文摘Developi ng alter native oxyge n reducti on reactio n (ORR) catalysts to replace precious Pt-based metals with abundant materials is the key challe nge of commercial application of fuel cells. Owing to their various compositi ons and tun able electronic properties, transition metal dichalcogenides (TMDs) have the great potential to realize high-efficiency catalysts for ORR. Here, various 3R-phase dichalcogenides of group VB and VIB transition metals (MX2, M = Nb, Ta, Mo, W;X = S, Se, Te) are investigated for ORR catalysts by using density functional theory calculations. The computed over-potentials of group VB TMDs are much less than those of group VIB TMDs. For group VB TMDs, a volcano-type plot of ORR catalytic activity is established on the adsorption energies of *OH, and NbS2 and TaTe2 exhibit best ORR activity with an oveepotential of 0.54 V. To achieve even better activity, strain engineering is performed to tune ORR catalytic activity, and the minimum over-potential of 0.43 V can be realized. We further dem on strate that the shift of p orbital center of surface chalcoge n elements under strain is responsible for tuning the catalytic activity of TMDs. | Shuyang Zhao Ke Wang Xiaolong Zou Lin Gan Hongda Du Chengjun Xu Feiyu Kang Wenhui Duan Jia Li | 2019 | Nano Research2019，12，4： | 4 |
| 6 | Effects of HMG on revascularization and follicular survival in heterotopic autotransplants of mouse ovarian tissue显示文摘 | Yanrong Wang Qing Chang Jing Sun Ling Dang Wenzhi Ma Changchun Hei Xinsheng Shen Chengjun Zhao Yufang Cai Xiuying Pei Xiaoguang Zhang Yin Wang Xiaohua Jiang | 2012 | Reproductive BioMedicine Online2012，，6： | 4 |
| 7 | TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2显示文摘Tripartite motif(TRIM)family proteins are important effectors of innate immunity against viral infections.Here we identified TRIM35 as a regulator of TRAF3 activation.Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon(IFN)in response to viral infection.777m35-deficient mice were more susceptible to influenza A virus(IAV)infection than were wild-type mice.TRIM35 promoted the RIG-Imediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 and the subsequent formation of a signaling complex with VISA and TBK1.IAV PB2 polymerase countered the innate antiviral immune response by impeding the Lys63-linked polyubiquitination and activation of TRAF3.TRIM35 mediated Lys48-linked polyubiquitination and proteasomal degradation of IAV PB2,thereby antagonizing its suppression of TRAF3 activation.Our in vitro and in vivo findings thus reveal novel roles of TRIM35,through catalyzing Lys63-or Lys48-linked polyubiquitination,in RIG-I antiviral immunity and mechanism of defense against IAV infection. | Nan Sun Li Jiang Miaomiao Ye Yihan Wang Guangwen Wang Xiaopeng Wan Yuhui Zhao Xia Wen Libin Liang Shujie Ma Liling Liu Zhigao Bu Hualan Chen Chengjun Li | 2020 | Protein & Cell2020，11，12： | 4 |
| 8 | Periurethral Injection of Autologous Adipose-Derived Stem Cells with Controlled-Release Nerve Growth Factor for the Treatment of Stress Urinary Incontinence in a Rat Model显示文摘 | Weiming Zhao Cheng Zhang Chengjun Jin Zijian Zhang Deling Kong Wanhai Xu Youcheng Xiu | 2010 | European Urology2010，，1： | 2 |
| 9 | The relationships among structure variables of larch forests in China显示文摘Background:Larch(Larix Mill.)forests are widely distributed in the upper parts of mountainous areas in China,playing vital roles in constructing mountain landscapes and maintaining mountain environments.Despite their importance,our knowledges on the large-scale patterns of structure characteristics and the relationships between different structure variables are unclear.In this paper,we investigated 155 plots from 11 natural larch forest types across the country to explore the biogeographic patterns of the structure characteristics and the allometric relationships between different structure variables for Chinese larch forests.Results:The structure characteristics were significantly different among larch forest types.For different larch forest types,the power function fits the relationships between tree height and diameter at breast height(DBH),average DBH and stem density,and taper and stem density well,but with different exponents among larch forest types.The power exponents of the allometric relationships between tree height and DBH for different larch forest types varied from 0.61 to 0.93(mean=0.86)by standard major axis regression(SMA),and from 0.51 to 0.78(mean=0.56)by ordinary least square regression(OLS).The 50%,75%and 95%quantile regression(QR)and OLS indicated that the average DBH and taper of the L.gmelinii forests,L.gmelinii var.principis-rupprechtii forests,and L.sibirica forests were significantly correlated with stem density.Conclusions:The relationship between tree height and DBH showed a power function relationship for all larch forest types in China,but with different exponents.Overall,stem density was negatively correlated with average DBH and taper.The Sect.Larix forests exhibited stand density effect.Our findings provide an important basis for recognizing the biogeographic patterns of structure factors and for the management of larch forests in China. | Wenjing Fang Qing Zhao Qiong Cai Anwar Eziz Guoping Chen Yuhao Feng Heng Zhang Jiangling Zhu Chengjun Ji Zhiyao Tang Jingyun Fang | 2020 | Forest Ecosystems2020，7，4： | 2 |
| 10 | Highly transmitted silver nanowires-SWCNTs conductive flexible film by nested density structure and aluminum-doped zinc oxide capping layer for flexible amorphous silicon solar cells显示文摘Indium tin oxide(ITO)is widely used in transparent conductive films(TCFs);however,several disadvan-tages,such as high cost and toxicity of indium,limit its applications.Therefore,it is necessary to develop other materials that can replace ITO.Silver nanowires or single walled carbon nanotubes(SWCNTs)have attracted considerable interest owing to their unique electrical,optical,and thermal stabilities,and thus,they are ideal for transparent electrodes for flexible or stretchable devices.In this study,we develop a novel architecture of composite TCFs on a polyethylene naphthalate(PEN)flexible substrate.Herein,the silver nanowires-SWCNTs films with nested density structure were fabricated through ultrasonic spraying technology by varying the spraying width.For achieving enhanced transmittance,we combined the larger irregular grids and holes with fewer nanowires stacked in the longitudinal direction,more optical chan-nels,and good carrier transport.Thereafter,aluminum-doped zinc oxide(AZO)was used as capping to the structure for enhancing the optical properties of the TCFs.The silver nanowires-SWCNTs/AZO(ASA)bilayer was obtained in the optimized architecture,which showed superior optoelectronic performance to that shown by commercial ITO with a high optical transmittance of 92%at the wavelength of 550 nm and low sheet resistance of 17/sq.In the specially structured conductive film,the significant improvement in the transmittance and uniformity of the sheet resistance was attributed to the effective nanowire junc-tion contact compared to that in ordinary structure of silver nanowires,which reduced the mean density of small clusters of nanowires.Compared with the silver nanowires-SWCNTs films,the ASA bilayer film exhibited excellent resistance to boiling,mechanical bending(10,000 cycles),and CO_(2)plasma.Moreover,the sheet resistance of ASA changed slightly after the tape tests,thereby illustrating a strong adhesion to the PEN substrate after the enclosure of AZO.Meanwhile,the AZO capping layer can enhance the op-tical transmittance between 600 and 1500 nm.In addition,the amorphous silicon photovoltaic devices with flexible ASA TCFs exhibited a power conversion efficiency(PCE)of 8.67%.After bending for 3000 times,the PCE was decreased to 8.20%,thereby demonstrating the potential of developed films to replace traditional ITO. | Shunliang Gao Xiaohui Zhao Qi Fu Tianchi Zhang Jun Zhu Fuhua Hou Jian Ni Chengjun Zhu Tiantian Li Yanlai Wang Vignesh Murugadoss Gaber A.M.Mersal Mohamed M.Ibrahim Zeinhom M.El-Bahy Mina Huang Zhanhu Guo | 2022 | Journal of Materials Science & Technology2022，，31： | 2 |
| 11 | Differentiated super-enhancers in lung cancer cells显示文摘Super-enhancers(SEs) are regulatory elements with enriched accumulation of key transcription factors.Few studies were done investigating SEs in lung cancers.Here we analyzed epigenetic profiling data to identify SEs in lung cancer cell lines.Enhancers were classified as SEs and typical enhancers(TEs).Most of the TEs were overlapped between normal cell and cancer cells.A great portion of SEs were differentiated comparing these cells.Analysis of GO terms associated with SEs revealed SE remodeling(lost on some sites while gain on others) between normal and lung cancer cells.By comparing the average number of SEs in each GO term in cancer cells with the number in control cells,surprisingly,no GO terms with significantly increased SE number in cancer condition were observed.On the contrary,in aspects such as 'cell-cell adhesion','receptor activity' and'negative regulation of canonical Wnt signaling pathway',the related SEs were significantly reduced in cancer cells.These findings suggest that in lung cancer,cells may not gain decisive gene expression in the related aspect,instead,they may have lost control of the fateful genes.Taken together,our work with the usability of omics data identified SEs in lung cancer cells and further showed cancer-specific features of SE-related terms. | Xin Li Chengjun Lu Qijue Lu Chunguang Li Ji Zhu Tiejun Zhao Hezhong Chen Hai Jin | 2019 | Science China(Life Sciences)2019，62，9： | 1 |
| 12 | Si nanowire Bio-FET for electrical and label-free detection of cancer cell-derived exosomes显示文摘Exosomes are highly important in clinical diagnosis due to their high homology with their parental cells.However,conventional exosome detection methods still face the challenges of expensive equipment,low sensitivity,and complex procedures.Field effect transistors(FETs)are not only the most essential electronic component in the modern microelectronics industry but also show great potential for biomolecule detection owing to the advantages of rapid response,high sensitivity,and label-free detection.In this study,we proposed a Si nanowire field-effect transistor(Si-NW Bio-FET)device chemically modified with specific antibodies for the electrical and label-free detection of exosomes.The Si-NW FETs were fabricated by standard microelectronic processes with 45 nm width nanowires and packaged in a polydimethylsiloxane(PDMS)microfluidic channel.The nanowires were further modified with the specific CD63 antibody to form a Si-NW Bio-FET.The use of the developed Si-NW Bio-FET for the electrical and labelfree detection of exosomes was successfully demonstrated with a limit of detection(LOD)of 2159 particles/mL.In contrast to other technologies,in this study,Si-NW Bio-FET provides a unique strategy for directly quantifying and realtime detecting exosomes without labeling,indicating its potential as a tool for the early diagnosis of cancer. | Wenjie Zhao Jiawei Hu Jinlong Liu Xin Li Sheng Sun Xiaofeng Luan Yang Zhao Shuhua Wei Mingxiao Li Qingzhu Zhang Chengjun Huang | 2022 | Microsystems & Nanoengineering2022，8，3： | 1 |
| 13 | Nitrogen monoxide vector of ultrasonic atomizing inhalation improves vertebro-basilar artery insufficiency Hemodynamic changes are detected by transcranial Doppler test显示文摘BACKGROUND: Latest researches at home and abroad indicate that glycerol trinitrate plays its function because it can metabolize into nitrogen monoxide (NO) in vivo. OBJECTIVE: To study the therapeutic effects of NO vector of ultrasonic atomizing inhalation on vertebro-basilar artery insufficiency (VBI) through transcranial Doppler (TCD) detection and serum NO content and indirect effect of TCD on cerebral blood flow changes. DESIGN: Randomized grouping and controlled clinical study. SETTING: Department of Neurology, the Fourth People's Hospital of Jinan. PARTICIPANTS: A total of 130 patients who were diagnosed as VBI were selected from Department of Neurology, the Fourth People's Hospital of Jinan from December 2001 to December 2005. The involved inpatients were checked by CT and MRI, and met the VBI diagnostic standard enacted by the Fourth National Academic Meeting of Cerebrovascular Disease in 1995. All patients and their relatives provided the confirmed consent. They were randomly divided into low-dose treatment group (n =60), high-lose treatment group (n =30) and control group (n =40). METHODS: Patients in the low-dose and high-dose treatment groups were given ultrasonic atomizing inhalation of 3 mg and 5 mg glycerol trinitrate, respectively, for 20 minutes, once a day. In addition, ligustrazine and energy mixture were used once a day for three days in a course. Cases in the control group were only given ligustrazine and energy mixture. All selected cases accepted TCD, blood NO content was checked at the time of beginning, after the first time and after a period of treatment. According to the TCD test, VBI patients were divided into two groups (high-low flow velocity). The vertebral artery (VA) and basal artery (BA) of left or right sides were detected by 2 Hz detector via occipital window. MAIN OUTCOME MEASURES: ① Blood flow velocity of systolic phase, blood flow velocity of diastole phase and vascular resistance in left and right VA and BA detected by using TCD before treatment, after treatment for one course; ② content of serum NO indirectly measured by using nitric acid disoxidation technique. RESULTS: All 130 VBI patients were involved in the final analysis. ① Changes of hemodynamic indexes: Systolic phase of VA and diastole phase of BA were higher in low-dose treatment group than that in the control group after first treatment, and there was significant difference (P < 0.05); meanwhile, systolic phase and diastole phase of VA and systolic phase of BA were also higher in treatment group than that in the control group after one course (P < 0.05). However, both systolic phase and diastole phase of VA and BA were lower in high-dose treatment group than that in the control group after first treatment and one course, and there was significant difference (P < 0.05). ② Content of serum NO: After first treatment, there was no significant difference between low-dose treatment group and high-dose treatment group (P > 0.05); but both groups were higher than control group, and there was significant difference (P < 0.05, 0.01). CONCLUSION: NO vector of ultrasonic atomizing inhalation can improve VBI so as to improve cerebral blood-supply state. | Donghong Xu Jinfeng Liu Zhaohui Li Ailing Wang Chengjun Zhao | 2007 | Neural Regeneration Research2007，2，8： | 1 |
| 14 | Effect of Ca/Mg molar ratio on the calcium-based sorbents显示文摘Steelmaking industry faces urgent demands for both steel slag utilization and CO_(2)abatement.Ca and Mg of steel slag can be extracted by acid solution and used to prepare sorbents for CO_(2)capture.In this work,the calcium-based sorbents were prepared from stainless steel slag leachate by co-precipitation,and the initial CO_(2)chemisorption capacity of the calcium-based sorbent prepared from steel slag with the Ca and Mg molar ratio of 3.64:1 was 0.40 g/g.Moreover,the effect of Ca/Mg molar ratio on the morphology,structure,and CO_(2)chemisorption capacity of the calcium-based sorbents were investigated.The results show that the optimal Ca/Mg molar ratio of sorbent for CO_(2)capture was4.2:1,and the skeleton support effect of MgO in calcium-based sorbents was determined.Meanwhile,the chemisorption kinetics of the sorbents was studied using the Avrami-Erofeev model.There were two processes of CO_(2)chemisorption,and the activation energy of the first stage(reaction control)was found to be lower than that of the second stage(diffusion control). | Yumeng Li Qing Zhao Xiaohui Mei Chengjun Liu Henrik Saxén Ron Zevenhoven | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，11： | 1 |
| 15 | Photon-counting distributed free-space spectroscopy显示文摘Spectroscopy is a well-established nonintrusive tool that has played an important role in identifying and quantifying substances,from quantum descriptions to chemical and biomedical diagnostics.Challenges exist in accurate spectrum analysis in free space,which hinders us from understanding the composition of multiple gases and the chemical processes in the atmosphere.A photon-counting distributed free-space spectroscopy is proposed and demonstrated using lidar technique,incorporating a comb-referenced frequency-scanning laser and a superconducting nanowire single-photon detector.It is suitable for remote spectrum analysis with a range resolution over a wide band.As an example,a continuous field experiment is carried out over 72 h to obtain the spectra of carbon dioxide(CO_(2))and semi-heavy water(HDO,isotopic water vapor)in 6 km,with a range resolution of 60 m and a time resolution of 10 min.Compared to the methods that obtain only column-integrated spectra over kilometer-scale,the range resolution is improved by 2-3 orders of magnitude in this work.The CO_(2)and HDO concentrations are retrieved from the spectra acquired with uncertainties as low as±1.2%and±14.3%,respectively.This method holds much promise for increasing knowledge of atmospheric environment and chemistry researches,especially in terms of the evolution of complex molecular spectra in open areas. | Saifen Yu Zhen Zhang Haiyun Xia Xiankang Dou Tengfei Wu Yihua Hu Manyi Li Mingjia Shangguan Tianwen Wei Lijie Zhao Lu Wang Pu Jiang Chengjun Zhang Lixing You Leigang Tao Jiawei Qiu | 2021 | Light(Science & Applications)2021，10，11： | 1 |
| 16 | Groundwater Nitrate Contamination and Driving Forces from Intensive Cropland in the North China Plain显示文摘High nitrate in groundwater is a serious problem especially in highly active agricultural areas.In this paper,the concentration and spatial distribution of groundwater nitrate in cropland area in the North China Plain were assessed by statistical and geostatistical techniques.Nitrate concentration in groundwater reached a maximum of 526.58 mg/L,and 47.2%,21.33%and 11.13%of samples had levels in excess of nitrate safety threshold concentration(50 mg/L)in shallow,middle-deep and deep groundwater,respectively.And NO-3 content significantly decreased with groundwater depth.Groundwater nitrate concentrations under vegetable area are significantly higher than ones under grain and orchard.And there are great differences in spatial distribution of nitrate in the North China Plain and pollution hotspot areas are mainly in Shandong Province.Based on both multiple regressions combined with principal component analysis(PCA),significant variables for nitrate variation in three types of ground water were found:population per unit area,percentage of vegetable area,percentage of grain crop area,livestock per unit area,annual precipitation and annual mean temperature for shallow groundwater;population per unit area and percentage of vegetable area for middle-deep groundwater;percentage of vegetable area,percentage of grain crop area and livestock per unit area for deep groundwater. | Jing LIU Chengjun ZHANG Peng LI Shunjiang LI Maoting MA Guoyin ZHANG Xianbiao GAO Changlin KOU Lihua JIANG Tongke ZHAO | 2019 | Asian Agricultural Research2019，11，9： | 1 |
| 17 | Generation and application of replication-competent Venus-expressing H5N1,H7N9,and H9N2 influenza A viruses显示文摘The generation and application of replication-competent influenza A virus(IAV) expressing a reporter gene represent a valuable tool to elucidate the mechanism of viral pathogenesis and establish new countermeasures to combat the threat of influenza. Here, replication-competent IAVs with a neuraminidase(NA) segment harboring a fluorescent reporter protein, Venus, were generated in the background of H5N1, H7N9, and H9N2 influenza viruses, the three subtypes of viruses with imminent pandemic potential. All three reporter viruses maintained virion morphology, replicated with similar or slightly reduced titers relative to their parental viruses, and stably expressed the fluorescent signal for at least two passages in embryonated chicken eggs. As a proof of concept, we demonstrated that these reporter viruses,used in combination with a high-content imaging system, can serve as a convenient and rapid tool for the screening of antivirals and host factors involved in the virus life cycle. Moreover, the reporter viruses demonstrated similar growth properties and tissue tropism as their parental viruses in mice, among which the H7N9 NA-Venus virus could potentially be used in ex vivo studies to better understand H7N9 pathogenesis or to develop novel therapeutics. | guangwen wang jie zhang fandi kong qibing li jinliang wang shujie ma yuhui zhao libin liang junping li nan sun lizheng guan yuan zhou chenchen zhou shanyu huang zhigao bu li jiang hualan chen chengjun li | 2018 | Science Bulletin2018，63，3： | 1 |
| 18 | Alkaline Phosphatase-Initiated Sensitive Responsiveness of Activatable Probes to Hydrogen Sulfide for Accurate Cancer Imaging and Differentiation显示文摘Optical imaging with molecular probes is becoming an essential tool for advancing biological research and clinical applications.However,most currently available molecular probes show limited sensitivity,specificity,and accuracy due to their typical responsiveness to a single stimulation for biomarker-based imaging.In this study,we develop a novel molecular probe that shows alkaline phosphatase(ALP)-instructed sensitive responsiveness to hydrogen sulfide for accurate cancer imaging and differentiation.This designed probe in an aggregated state under physiological conditions bears negatively charged surfaces,giving poor optical response to H_(2)S.The ALP-mediated dephosphorylation reaction yields an assembled product with a positively charged surface,affording significantly aggregation-enhanced responsiveness to H_(2)S with light-up NIR fluorescence at 755 nm.Such charge reversal of assembled probe from negative to positive plays a vital role in allowing precise visualization and differentiation of cancers based on differences in ALP upregulation and H_(2)S content.We envisage that our charge-reversal strategy for multiple-parameter-activated molecule probes will facilitate boosting the specificity and precision of cancer imaging. | Rongchen Wang Kai Yin Muye Ma Tianli Zhu Jinzhu Gao Jie Sun Xuemei Dong Chengjun Dong Xianfeng Gu He Tian Chunchang Zhao | 2022 | CCS Chemistry2022，4，12： | 0 |
| 19 | Efficient recovery of aromatic compounds from the wastewater of styrene monomer and propylene oxide co-production plant via hypercrosslinked aryl-rich starch-β-cyclodextrin polymeric sorbent显示文摘Adsorptive recovery of valuable components from industrial wastewater is highly desirable for avoiding resource wastage but remains a challenge.Herein,we develop an efficient continuous adsorption process for recovering aromatic compounds in wastewater from styrene monomer and propylene oxide coproduction(SMPO)plant.Based on our insight into the potential of bio-based porous materials for adsorption application,starch-graft-polystyrene(SPS)and aryl-modifiedβ-cyclodextrin(ACD)were prepared,and novel hypercrosslinked porous polymers combined SPS with ACD(HSPS-ACDs)were synthesized through external crosslinking approach.In a binary-component system,the best-performing one HSPS-ACD(H)with high ACD content and large specific surface area possessed superior capacities for the representative aromatic compounds,acetophenone(AP,2.81 mmol·g^(-1))and 1-phenylethanol(1-PE,1.35 mmol·g^(-1))compared with the previously reported materials.Further,the adsorption properties of aromatic compounds on HSPS-ACD(H)were investigated in batch mode.For practical application,continuous adsorption experiments were conducted in a HSPS-ACD(H)-packed fixed bed,where the target aromatic components in wastewater were effectively retained and further released by elution.Besides showing the reversible adsorption and efficient enrichment effect,the HSPS-ACD(H)-packed fixed bed also maintained great stability in multiple cycles.Moreover,quantum chemical calculations were performed to elucidate the potential mechanism of adsorption of AP and 1-PE onto HSPS-ACD(H). | Zhongwei Tan Xingguo Xu Yu Wan Chengjun Kang Zhaoqiang Zhang Zhenxia Zhao Fang Shen Kungang Chai Hongbing Ji | 2022 | Chinese Journal of Chemical Engineering2022，35，9： | 0 |
| 20 | A dual-modality hydrogen sulfide-specific probe integrating chemiluminescence with NIR fluorescence for targeted cancer imaging显示文摘Taking apart in numerous physiological and pathological activities,hydrogen sulfide(H_(2)S)has been selected as an excellent target spot for the early diagnosis of cancer.So far,there are many mature probes that apply single optical imaging to monitor endogenous H_(2)S.Nevertheless,a single modality is not an ideal method to afford accurate diagnostic information in comprehensive biological organisms.Herein,we developed a dual-modal imaging probe BWS.This designed probe showed a specific response to H_(2)S with both chemiluminescence and NIR fluorescence light-up.The concurrence of fluorescence and chemiluminescence signal provided“double insurances”for highly accurate monitoring of H_(2)S.Satisfactorily,this dual-modal imaging probe performed precise visualization of endogenous H_(2)S in living cells and in vivo.We envisaged that this chemiluminescence/fluorescence real-time dual-modality strategy for H_(2)S detection will expand and optimize the multimodal imaging methods for efficient diagnosis and treatment of cancer. | Xuemei Dong Lixin Sun Ziwen Zhang Tianli Zhu Jie Sun Jinzhu Gao Chengjun Dong Rongchen Wang Xianfeng Gu Chunchang Zhao | 2023 | Science China Chemistry2023，66，6： | 0 |
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