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| 1 | Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes显示文摘The objective was to investigate the effect of kinsenoside(Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis(OA) progression.RAW264.7 macrophages were polarized to M1/M2 subtypes then administered with different concentrations of Kin. The polarization transitions were evaluated with quantitative real-time polymerase chain reaction(q RT-PCR), confocal observation and flow cytometry analysis. The mechanism of Kin repolarizing M1 macrophages was evaluated by Western blot. Further, macrophage conditioned medium(CM) and IL-1β were administered to chondrocytes. Micro-CT scanning and histological observations were conducted in vivo on anterior cruciate ligament transection(ACLT) mice with or without Kin treatment. We found that Kin repolarized M1 macrophages to the M2 phenotype. Mechanistically, Kin inhibited the phosphorylation of IκBα, which further reduced the downstream phosphorylation of P65 in nuclear factor-κB(NF-κB) signaling. Moreover, Kin inhibited mitogen-activated protein kinases(MAPK) signaling molecules p-JNK, p-ERK and p-P38. Additionally, Kin attenuated macrophage CM and IL-1β-induced chondrocyte damage. In vivo, Kin reduced the infiltration of M1 macrophages,promoted M2 macrophages in the synovium, inhibited subchondral bone destruction and reduced articular cartilage damage induced by ACLT. All the results indicated that Kin is an effective therapeutic candidate for OA treatment. | Feng Zhou Jingtian Mei Xiuguo Han Hanjun Li Shengbing Yang Minqi Wang Linyang Chu Han Qiao Tingting Tang | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 35 |
| 2 | Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis显示文摘Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment. | Yiqi Yang Yixuan Lin Minqi Wang Kai Yuan Qishan Wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang Kai Huang Yugang Wang Hanjun Li Tingting Tang | 2022 | Bone Research2022，10，3： | 19 |
| 3 | Wet-chemistry synthesis of cobalt carbide nanoparticles as highly active and stable electrocatalyst for hydrogen evolution reaction显示文摘转变金属碳化物(TMC ) nanomaterials 正在答应选择到磅,并且广泛地为电气化学的氢进化反应被用作异构的 electrocatalysts (她的) 。在这个工作,综合的导致溴化物的湿化学的策略公司 2 C nanoparticles (NP ) 被开发。如此的 NP 展出了高 electrocatalytic 活动(= 为 j = 的 181 mV 10 | Siwei Li Ce Yang Zhen Yin Hanjun Yang Yifu Chen Lili Lin Mengzhu Li Weizhen Li Gang HU Ding Ma | 2017 | Nano Research2017，10，4： | 7 |
| 4 | Fe5C2 nanoparticles as low-cost HER electrocatalyst:the importance of Co substitution显示文摘Constructing and understanding the doping effect of secondary metal in transition metal carbide(TMC)catalysts is pivotal for the design of low-cost hydrogen evolution reaction(HER) electrocatalysts. In this work, we developed a wet-chemistry strategy for synthesizing Co-modified Fe_5C_2 nanoparticles((Fe_(1-x)Cox)_5C_2 NPs) as highly active HER electrocatalysts in basic solution. The structure of(Fe_(1-x)Cox)_5C_2 NPs was characterized by X-ray diffraction(XRD), extended X-ray absorption fine structure spectra(EXAFS) and scanning/transmission electron microscopy(S/TEM), indicating that the isomorphous substitution of cobalt in the lattice of Fe_5C_2.(Fe_(0.75) Co_(0.25))_5C_2 exhibited the best HER activity(174 mV for j = -10 mA/cm^2). Computational calculation results indicate that Co provides the most active site for HER. X-ray adsorption spectra(XAS) studies further suggested that the electron transfer in Fe–C bonds are enhanced by the substitution of Co, which modulates the hydrogen adsorption on the adjacent electronic-enriched carbon, and therefore promotes HER activity. Our results affirm the design of lowcost bimetallic TMCs based HER catalysts. | Siwei Li Pengju Ren Ce Yang Xi Liu Zhen Yin Weizhen Li Hanjun Yang Jian Li Xiaoping Wang Yi Wang Ruochen Cao Lili Lin Siyu Yao Xiaodong Wen Ding Ma | 2018 | Science Bulletin2018，63，20： | 6 |
| 5 | Synthesis and transformation of zero-dimensional Cs3BiX6(X=Cl,Br)perovskite-analogue nanocrystals显示文摘The unique structure of zero-dimensional(0D)perovskite-analogues has attracted a great amount of research interest in recent years.To date,the current compositional library of 0D perovskites is largely limited to the lead-based Cs4PbX6(X=Cl,Br,and I)systems.In this work,we report a new synthesis of lead-free 0D Cs3BiX6(X=Cl,Br)perovskite-analogue nanocrystals(NCs)with a uniform cubic shape.We observe a broad photoluminescence peak centered at 390 nm for the 0D Cs3BiCl6 NCs at low temperatures.This feature originates from a self-trapped exciton mechanism.In situ thermal stability studies show that Cs3BiX6 NCs remain stable upon heating up to 200°C without crystal structural degradation.Moreover,we demonstrate that the Cs3BiX6 NCs can transform into other bismuth-based perovskite-analogues via facile anion exchange or metal ion insertion reactions.Our study presented here offers the opportunity for further understanding of the structure-property relationship of 0D perovskite-analogue materials,leading toward their future optoelectronic applications. | Hanjun Yang Tong Cai Exian Liu Katie Hills-Kimball Jianbo Gao Ou Chen | 2020 | Nano Research2020，13，1： | 4 |
| 6 | A 3D-bioprinted scaffold with doxycycline-controlled BMP2-expressing cells for inducing bone regeneration and inhibiting bacterial infection显示文摘Large bone defects face a high risk of pathogen exposure due to open wounds,which leads to high infection rates and delayed bone union.To promote successful repair of infectious bone defects,fabrication of a scaffold with dual functions of osteo-induction and bacterial inhibition is required.This study describes creation of an engineered progenitor cell line(C3H10T1/2)capable of doxycycline(DOX)-mediated release of bone morphogenetic protein-2(BMP2).Three-dimensional bioprinting technology enabled creation of scaffolds,comprising polycaprolactone/mesoporous bioactive glass/DOX and bioink,containing these engineered cells.In vivo and in vitro experiments confirmed that the scaffold could actively secrete BMP2 to significantly promote osteoblast differentiation and induce ectopic bone formation.Additionally,the scaffold exhibited broad-spectrum antibacterial capacity,thereby ensuring the survival of embedded engineered cells when facing high risk of infection.These findings demonstrated the efficacy of this bioprinted scaffold to release BMP2 in a controlled manner and prevent the occurrence of infection;thus,showing its potential for repairing infectious bone defects. | Minqi Wang Hanjun Li Yiqi Yang Kai Yuan Feng Zhou Haibei Liu Qinghui Zhou Shengbing Yang Tingting Tang | 2021 | Bioactive Materials2021，6，5： | 3 |
| 7 | Effects of High Hydrostatic Pressure Treated Mung Bean Starch on Characteristics of Batters and Crusts from Deep-Fried Pork Nuggets显示文摘 | Lingwen Zhang Hongfang Ji Mingduo Yang Hanjun Ma | 2014 | International Journal of Food Engineering2014，，2： | 1 |
| 8 | Lifetime tracing of cardiopulmonary sounds with low-power sound sen- sor stick connected to wireless Mobile network 显示文摘 | YANG Kai JIANG Hanjun YANG Wendi | 2014 | Analog Integr Circuits Signal Process2014，81，3： | 1 |
| 9 | Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures显示文摘Objective and Impact Statement.Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases.Introduction.Traditional thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body cavities.Evaluations at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the patient.Also,surgical extraction procedures after a period of need can introduce additional risks and costs.Methods.Here,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body processes.Results.The designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical simulations.Studies with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo measurements.Conclusion.The results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare. | Wubin Bai Masahiro Irie Zhonghe Liu Haiwen Luan Daniel Franklin Khizar Nandoliya Hexia Guo Hao Zang Yang Weng Di Lu Di Wu Yixin Wu Joseph Song Mengdi Han Enming Song Yiyuan Yang Xuexian Chen Hangbo Zhao Wei Lu Giuditta Monti Iwona Stepien Irawati Kandela Chad R.Haney Changsheng Wu Sang Min Won Hanjun Ryu Alina Rwei Haixu Shen Jihye Kim Hong-Joon Yoon Wei Ouyang Yihan Liu Emily Suen Huang-yu Chen Jerry Okina Jushen Liang Yonggang Huang Guillermo A.Ameer Weidong Zhou John A.Rogers | 2021 | Biomedical Engineering Frontiers2021，2，1： | 0 |
| 10 | The Soft-Strain Effect Enabled High-Performance Flexible Pressure Sensor and Its Application in Monitoring Pulse Waves显示文摘Flexible and wearable pressure sensors attached to human skin are effective and convenient in accurate and real-time tracking of various physiological signals for disease diagnosis and health assessment.Conventional flexible pressure sensors are constructed using compressible dielectric or conductive layers,which are electrically sensitive to external mechanical stimulation.However,saturated deformation under large compression significantly restrains the detection range and sensitivity of such sensors.Here,we report a novel type of flexible pressure sensor to overcome the compression saturation of the sensing layer by softstrain ffect,enabling an utra-high sensitivity of~636 kPa^(-1) and a wide detection range from 0.1 kPa to 56 kPa.In addition,the cyclic loading-unloading test reveals the excellent stability of the sensor,which maintains its signal detection after 10.000 cycles of 10 kPa compression.The sensor is capable of monitoring arterial pulse waves from both deep tissue and distal parts,such as digital arteries and dorsal pedal arteries,which can be used for blood pressure estimation by pulse transit time at the same artery branch. | Yue Li Yuan Wei Yabao Yang Lu heng Lei Luo Jiuwei Gao Hanjun Jiang Juncai Song Manzhang Xu Xuewen Wang Wei Huang | 2023 | Research2023，，1： | 0 |
| 11 | Chinese Compilation of Physical Activities in healthy adults aged 18-64:Categories and metabolic intensities显示文摘A Chinese Compilation of Physical Activities was compiled to estimate the energy costs of physical activities(PAs)using data on adults aged 18–64.Data were obtained from published articles and laboratory measurements.Databases,including PubMed,Embase,Scopus,Ebsco,Web of Science,Chinese National Knowledge Infrastructure,Wan Fang Data,National Science and Technology Report Service,Public Health Scientific Data were searched to collect data from inception to January 2022,on energy expenditure associated with PA in the healthy Chinese population.Two reviewers independently screened the literature and extracted,classified,and summarized data.Data were measured for 36 PAs using indirect calorimetry.Detailed descriptions of specific activities and metabolic equivalent values were provided by summarizing 241 physical activities in 13 categories.The first edition of the Chinese Compilation of PAs in Healthy Adults Aged 18–64(CCPA)was created.It provides valuable resources for people who regularly engage in physical exercise,researchers,educators,fitness professionals,and health or commercial sectors to quickly obtain various PA MET intensities.In the future,the energy expenditure of various PAs of different ages within the Chinese population can be measured based on the CCPA. | Junqiang Qiu Junchao Yang Mingyue Lu Yuyang Chen Yanping Yang Wei Cao Kun Meng Yan Chen Jun Zhang Chunyan Xu Longyan Yi Xian Guo Yang Wang Xiaolei Liu Yi Yan Hanjun Li Qin Zhuo Wenhua Zhao Lianshi Feng Barbara E.Ainsworth | 2022 | Sports Medicine and Health Science2022，4，3： | 0 |
| 12 | Multi-omics analysis based on 3D-bioprinted models innovates therapeutic target discovery of osteosarcoma显示文摘Current in vitro models for osteosarcoma investigation and drug screening,including two-dimensional(2D)cell culture and tumour spheroids(i.e.cancer stem-like cells),lack extracellular matrix(ECM).Therefore,results from traditional models may not reflect real pathological processes in genuine osteosarcoma histological structures.Here,we report a three-dimensional(3D)bioprinted osteosarcoma model(3DBPO)that contains osteosarcoma cells and shrouding ECM analogue in a 3D frame.Photo-crosslinkable bioinks composed of gelatine methacrylamide and hyaluronic acid methacrylate mimicked tumour ECM.We performed multi-omics analysis,including transcriptomics and DNA methylomics,to determine differences between the 3DBPO model and traditional models.Compared with 2D models and tumour spheroids,our 3DBPO model showed significant changes in cell cycle,metabolism,adherens junctions,and other pathways associated with epigenetic regulation.The 3DBPO model was more sensitive to therapies targeted to the autophagy pathway.We showed that simulating ECM yielded different osteosarcoma cell metabolic characteristics and drug sensitivity in the 3DBPO model compared with classical models.We suggest 3D printed osteosarcoma models can be used in osteosarcoma fundamental and translational research,which may contribute to novel therapeutic strategy discovery. | Yixuan Lin Yiqi Yang Kai Yuan Shengbing Yang Shuhong Zhang Hanjun Li Tingting Tang | 2022 | Bioactive Materials2022，7，12： | 0 |
| 13 | A Randomized Controlled Trial of a Biodegradable Polymer,Microcrystalline Sirolimus-Eluting Stent(MiStent)versus Another Biodegradable Polymer Sirolimus-Eluting Stent(TIVOLI):The DESSOLVE-C Trial显示文摘Objective::Data comparing the outcomes of MiStent(Micell Technologies,Durham,North Carolina,USA)microcrystalline biodegradable polymer(BP)drug-eluting stent(DES)and those of another post-marketing BP-DES,TIVOLI(EssenTech,Beijing,China)are rare.This study sought to compare the angiographic efficacy and clinical outcomes of the microcrystalline BP sirolimus-eluting stent(SES)system MiStent and those of TIVOLI BP-SES.Methods::The DESSOLVE-C trial was a prospective,single-blinded,multicenter,randomized trial(NCT02448524),which randomly assigned patients with de novo coronary lesions to receive MiStent or TIVOLI BP-SES by a 1:1 ratio.The primary endpoint was a non-inferiority comparison of in-stent late lumen loss(LLL)by quantitative coronary angiography at 9 months.The secondary endpoint was device-related clinical cardiovascular composite events(target lesion failure(TLF),composite of cardiac death,target vessel myocardial infarction(MI),and clinically driven target lesion revascularization)and 1-year outcomes.Results::A total of 428 patients(216 patients in the MiStent group and 212 patients in the TIVOLI group)were enrolled and included in an intention-to-treat analysis.MiStent was not only non-inferior but superior to TIVOLI for in-stent LLL at 9 months((0.23±0.37)mm vs.(0.34±0.48)mm,P for non-inferiority<0.001,P for superiority=0.02).Although without significant difference,the rate of TLF in MiStent was quantitatively lower than that in TIVOLI(3.70%vs.6.60%;P=0.17).Conclusion::Compared with TIVOLI BP-SES,the MiStent system was superior in in-stent LLL at 9 months and had a comparable clinical benefit at 1 year in de novo coronary lesions. | Bin Wang Sicong Ma Zhiyong Wang Li Zhang Hanjun Pei Yang Zheng Yuejin Yang Zheng Zhang Xinqun Hu Ziwen Ren Feng Zhang Changqian Wang Renqiang Yang Zhiming Yang Yuexi Wang Guosheng Fu Yu Cao Zuyi Yuan Kai Xu Xin Zhao Bo Xu Miaohan Qiu Quanmin Jing | 2023 | Cardiology Discovery2023，3，1： | 0 |
| 14 | Achieving 20% photovoltaic efficiency by manganese doped methylammonium lead halide perovskites显示文摘We report a transition metal such as manganese doped methylammonium lead halide perovskite(MA(Pb:Mn)I_(3)) solar cell with an power conversion efficiency(PCE) over 20%. The rational design and fabrication of MA(Pb:Mn)I3 lead to the enhancements of all the photovoltaic parameters. To incorporate Mn can effectively eliminate the trap-assist and bi-molecular recombination. The photo-absorption ability at shorter wavelengths(i.e., less than 500 nm) and charge carrier lifetime can be elaborated. More importantly, the existence of the Mn^(2+)-I~--Mn^(3+)motif contributes for the double exchange effect, giving rise to the charge/spin transport. By a combination of linearly and circularly polarized photo-excitations, we have explicitly determined the role of intrinsic spin–orbit coupling(SOC) in MA(Pb:Mn)I_(3). More dark states are expected to be available for the photocurrent generation. This study may pave the way for deep understandings of transition metals doped hybrid perovskites for highly efficient solar cell applications. | Liangliang Deng Hanjun Yang Ruiheng Pan Haomiao Yu Jinpeng Li Ling Xu Kai Wang | 2021 | Journal of Energy Chemistry2021，30，9： | 0 |
| 15 | Counterbalancing of electron and hole transfer in quantum dots for enhanced photocatalytic H_(2)evolution显示文摘In-depth understandings of charge carrier transfer dynamics in any artificial catalytic system are of critical importance for the future design of highly efficient photocatalysts.Herein,we synthesized sub-monolayer ZnSe partial-shell coated CdSe/CdS core/shell quantum dots in a controlled fashion.The ZnSe decorated quantum dots were employed as a model catalyst for photogeneration of H_(2)under light illumination.Both theoretical calculations and experimental results unravel that the growth of ZnSe partial-shell would retard the photogenerated electron transfer,and meanwhile,accelerate the corresponding hole migration process during the H_(2)photogeneration reaction in the artificial photocatalytic system.As such,the performance of the relevant photocatalytic system can be modulated and optimized,and accordingly,a plausible underlying mechanism is rationalized. | Ping Wang Wenwu Shi Na Jin Zhenyang Liu Yongchen Wang Tong Cai Katie Hills-Kimball Hanjun Yang Xiaotian Yang Yongdong Jin Xinzhong Wang Jing Zhao Ou Chen | 2023 | Nano Research2023，16，2： | 0 |
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