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| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | Development on Micro Precision Truing Method for Metal Bonded Diamond Grinding Wheel on ELID -- Grinding显示文摘 | Yin Shaohui Ohmori H Lin Weimin | 2005 | Key Engineering Materials2005，，： | 1 |
| 3 | Study on Ultrapresion Synergistic Finishing Process of ELID-- grinding and MRF显示文摘 | Yin Shaohui Ohmori H Lin Weimin | 2006 | JSAT2006，50，6： | 1 |
| 4 | Loading-Balance Relay-Selective Strategy Based on Stochastic Dynamic Program显示文摘A Relay-Assisted(RA) network with relay selection is considered as a type of effective technology to improve the spectrum and energy efficiency of a cellular network. However, loading balance of the assisted relay node becomes an inevitable bottleneck in RA network development because users do not follow uniform distribution. Furthermore, the time-varying channel condition of wireless communication is also a major challenge for the RA network with relay selection. To solve these problems and improve the practicability of the RA network, a Loading Balance-Relay Selective(LBRS) strategy is proposed for the RA network in this paper. The proposed LBRS strategy formulates the relay selection of the RA network under imperfect channel state information assumption as a Multistage Decision(MD) problem. An optimal algorithm is also investigated to solve the proposed MD problem based on stochastic dynamic program. Numerical results show that the performance of the LBRS strategy is better than that of traditional greedy algorithm and the former is effective as an exhaustive search-based method. | Wei Zhao Lin Zhao Weidong Wu Sigen Chen Shaohui Sun Yong Cao | 2018 | Tsinghua Science and Technology2018，23，4： | 1 |
| 5 | Using hydrochemical signatures to characterize the long-period evolution of groundwater information in the Dagu River Basin,China显示文摘The evolution of hydrochemical compositions influenced by long-period interactions between groundwater and the geo-environment is a fundamental issue for exploring groundwater quality and vulnerability.This study systematically investigated the hydrochemical processes and anthropogenic interference occurring in the river basin by bivariate plots,Gibbs diagrams,saturation index,and the major ions ratios.Apparent changes in groundwater hydrochemistry have been observed in the study area,illustrating the origins of major ions are affected by various internal and external factors.Results highlighted that TDS varied from freshwater to brackish water,ranging between 187.90 and 2294.81 mg/L.Ca^(2+)and HCO_(3)^(−)are the dominant ions in the studied samples.The results gained by Gibbs diagrams,bivariate plots,saturation index,and the major ions ratios demonstrated that minerals dissolution/precipitation,cation exchange,and human inputs play crucial roles in the unconfined aquifers.Moreover,the overuse of nitrogen fertilizer,livestock manure,and industrial/domestic sewage led to nitrate and nitrite contamination and brought significant challenges to the surrounding hydrogeo-environment.The present study could make an unambiguous identification of natural processes and anthropogenic interventions influencing groundwater hydrochemistry’s long-period evolution and create a preliminary strategy for groundwater resources management. | Ziyue Yin Qing Lin Shaohui Xu | 2021 | Frontiers of Environmental Science & Engineering2021，15，5： | 1 |
| 6 | Evaluation of the Wound Healing Potential of Resina Draconis(Dracaena cochinchinensis)in Animal Models显示文摘 | LIU Huihui LIN Shaohui XIAO Dan | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，70： | 1 |
| 7 | Synergetic roadmap of carbon neutrality and clean air for China显示文摘It is well recognized that carbon dioxide and air pollutants share similar emission sources so that synergetic policies on climate change mitigation and air pollution control can lead to remarkable co-benefits on greenhouse gas reduction,air quality improvement,and improved health.In the context of carbon peak,carbon neutrality,and clean air policies,this perspective tracks and analyzes the process of the synergetic governance of air pollution and climate change in China by developing and monitoring 18 indicators.The 18 indicators cover the following five aspects:air pollution and associated weather-climate conditions,progress in structural transition,sources,inks,and mitigation pathway of atmospheric composition,health impacts and benefits of coordinated control,and synergetic governance system and practices.By tracking the progress in each indicator,this perspective presents the major accomplishment of coordinated control,identifies the emerging challenges toward the synergetic governance,and provides policy recommendations for designing a synergetic roadmap of Carbon Neutrality and Clean Air for China. | Qiang Zhang Zhicong Yin Xi Lu Jicheng Gong Yu Lei Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Hancheng Dai Zhanfeng Dong Guannan Geng Dabo Guan Jianlin Hu Cunrui Huang Jianing Kang Tiantian Li Wei Li Yongsheng Lin Jun Liu Xin Liu Zhu Liu Jinghui Ma Guofeng Shen Dan Tong Xuhui Wang Xuying Wang Zhili Wang Yang Xie Honglei Xu Tao Xue Bing Zhang Da Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Bo Zheng Yixuan Zheng Tong Zhu Jinnan Wang Kebin He | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
| 8 | Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response显示文摘Understanding changes in pathogen behavior(e.g.increased virulence,a shift in transmission channel)is critical for the public health management of emerging infectious diseases.Genome degradation via gene depletion or inactivation is recognized as a pathoadaptive feature of the pathogen evolving with the host.However,little is known about the exact role of genome degradation in affecting pathogenic behavior,and the underlying molecular detail has yet to be examined.Using large-scale global avian-restricted Salmonella genomes spanning more than a century,we projected the genetic diversity of Salmonella Pullorum(bvSP)by showing increasingly antimicrobial-resistant ST92 prevalent in Chinese flocks.The phylogenomic analysis identified three lineages in bvSP,with an enhancement of virulence in the two recently emerged lineages(L2/L3),as evidenced in chicken and embryo infection assays.Notably,the ancestor L1 lineage resembles the Salmonella serovars with higher metabolic flexibilities and more robust environmental tolerance,indicating stepwise evolutionary trajectories towards avian-restricted lineages.Pan-genome analysis pinpointed fimbrial degradation from a virulent lineage.The later engineeredfim-deletion mutant,and all other five fimbrial systems,revealed behavior switching that restricted horizontal fecal-oral transmission but boosted virulence in chicks.By depleting fimbrial appendages,bvSP established persistent replication with less proinflammation in chick macrophages and adopted vertical transovarial transmission,accompanied by ever-increasing intensification in the poultry industry.Together,we uncovered a previously unseen paradigm for remodeling bacterial surface appendages that supplements virulence-enhanced evolution with increased vertical transmission. | Xiao Zhou Xiamei Kang Jiaqi Chen Yan Song Chenghao Jia Lin Teng Yanting Tang Zhijie Jiang Xianqi Peng Xiaoxi Tao Yiwei Xu Linlin Huang Xuebin Xu Yaohui Xu Tengfei Zhang Shenye Yu Jiansen Gong Shaohui Wang Yuqing Liu Guoqiang Zhu Corinna Kehrenberg Franois-Xavier Weill Paul Barrow Yan Li Guoping Zhao Min Yue | 2023 | National Science Review2023，10，10： | 0 |
| 9 | Study on Litter Water Interception Capacity of Phyllostachys edulis Plantations with Different Densities显示文摘The litter amount and the water holding characteristic parameters,such as the maximum water holding capacity and rate,the water absorption rate and the modified interception amount of Phyllostachys edulis plantations with four densities were studied in Huangshan district.The results are as follows:The total amount,thickness and natural water content of litters under all the four stands tested were different.The total litter amount in different stands ranged between 3.98 t·ha-1 to 6.00 t·ha-1, which in the stand with the density of 3 000 stems·ha-1 was the most.The ratio of maximum water-holding capacity of litter in various stands ranged from 317.09%to 347.58%.The maximum water holding capacity of litter in the stand with the density of 3 000 stems·ha-1 was 20.70 t·ha-1. By analyzing,the relationship between the water holding capacity of litter and the immersion time followed the equation of:S = alnt + b(a is the coefficient;b is the constant term).The relationship between the water absorption speed of the litter and the immerse time followed the equation of: V = ctd(c is the coefficient;d is the exponential term).The litter water capacity increased rapidly within the first four hours,and then increased slowly.The results also showed that the hydrological character of litter was positively related to density in Ph.Edulis forest.Therefore, it is important to choose appropriate density for enhancing the eco-hydrological benefits of litter layer in Ph.edulis forest. | Yu Lin Fan Shaohui Su Wenhui LiuWeiyi Feng Huanying | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 10 | Principles of fluorescence correlation spectroscopy applied to studies of biomolecular liquid–liquid phase separation显示文摘Fluorescence correlation spectroscopy (FCS) investigates the temporal relationship of fluctuating fluorescence signals reflecting underlying molecular processes occurring in a solution sample or a single live cell. This review article introduces the principles of two basic and most used FCS techniques: fluorescence auto-correlation spectroscopy (FACS) and fluorescence cross-correlation spectroscopy (FCCS). Combined, FACS and FCCS techniques can quantitatively analyze multiple properties of molecule or nanoparticle samples, including molar concentration, diffusion coefficient and hydrodynamic radius, homo- or hetero-interaction, fluorescence brightness, etc. Not surprisingly, FCS techniques have long been used to investigate molecular mechanisms of biomolecular phase separation, first in the lipid bilayer and more recently in cell cytosol and nucleoplasm. The latter applications are especially exciting since a whole new class of membraneless cellular organelles have been discovered, which are proposed to be results of biomolecule liquid-liquid phase separation (LLPS). LLPS research can benefit significantly from the multifunctionality and single-molecule sensitivity of a variety of FCS techniques, particularly for live-cell studies. This review illustrates how FACS and FCCS techniques can be used to investigate multiple aspects of the molecular mechanisms of LLPS, and summarizes FCS applications to LLPS research in vivo and in vitro. | Zhulou Wang Huizhi Zhang Lin Jian Bo Ding Keying Huang Wolun Zhang Qian Xiao Shaohui Huang | 2022 | Biophysics Reports2022，8，2： | 0 |
| 11 | Coupled effects of pH and kaolinite colloids on antibiotic transport in porous media显示文摘Antibiotics can interact with natural colloids and the surrounding media upon entry into soil and groundwater systems,which significantly alters their dynamic behavior and complicates our understanding of antibiotic fate and transport in porous media.In this study,co-transport of antibiotics and kaolinite colloids was systematically investigated using combined column experiments and numerical simulation under different pH conditions.Sulfadiazine(SDZ)transport was enhanced by kaolinite colloids under neutral and alkaline conditions,which was attributed to the higher mobility of colloids as SDZ carriers,as well as competitive sorption.However,most injected SDZ was transported in a dissolved form owing to the low sorption capacity of SDZ to kaolinite colloids and quartz sand.The colloid-facilitated transport model provided a good description of total SDZ transport,but underestimated colloidal SDZ transport using parameters from kinetic sorption experiments.Kaolinite colloids significantly promoted ciprofloxacin(CIP)transport at pH 4.0,but inhibited it at pH 7.0 and9.0.Interestingly,enhanced CIP transport was due to the decreased number of effective sorption sites on quartz sand and the increased desorption of CIP from kaolinite colloids.Under neutral and alkaline conditions,deposited colloids provided additional sorption sites for CIP,which contributed to CIP retention.Moreover,CIP significantly inhibited the transport of kaolinite colloids owing to the increases in colloidal aggregate size and zeta potential.Overall,our results highlighted the different effects of mobile and immobile colloids on antibiotic transport,in addition to the implications of antibiotic speciation and clay colloids when predicting the transport behavior of these compounds. | Shuhua JI Xiaowen LIU Xiu MENG Shaohui XU Qing LIN | 2023 | Pedosphere2023，33，5： | 0 |
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