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| 1 | Portal vein thrombosis:Prevalence,patient characteristics and lifetime risk:A population study based on 23796 consecutive autopsies显示文摘瞄准:估计一生在一般人口的门静脉血栓形成(PVT ) 的累积发生。方法:在 1970 和 1982 之间, 23,796 具尸体,在马尔摩城市人口代表 84% 所有在里面医院死亡,被执行,用包括门静脉的检查的一个 standardised 协议。PVT 病人被描述并且在尸体的 PVT 流行,一生的表情累积发生,在高风险的疾病范畴估计了并且以机会比率和 95% CI 表示了。结果:PVT 的人口流行是 1.0% 。有 PVT 28% 的 254 个病人有肝硬化, 23% 主要并且 44% 第二等的肝胆管恶意, 10% 主要腹的传染或煽动性的疾病并且 3% 有 myeloproliferative 混乱。有肝硬化和肝的癌的病人有最高的 PVT 风险,或 17.1 (95% CI 11.1-26.4 ) 。在 14% ,没有原因被发现;仅仅,少数他们开发了 portal-hypertension-related 复杂并发症。结论:在这基于人口的研究, PVT 比由以前的临床的系列显示被发现更普通。显著地,在肝硬化和肝的癌的过量风险应该在指导干预的未来的研究可能为被考虑的这些病人保证增加的了解。 | Mats gren David Bergqvist Martin Bjrck Stefan Acosta Henry Eriksson Nils H Sternby | 2006 | World Journal of Gastroenterology2006，12，13： | 66 |
| 2 | 细胞移植治疗脊髓损伤(英文)显示文摘Spinal cord injury can lead to severe motor,sensory and autonomic dysfunction.Currently,there is no effective treatment for the injured spinalcord.The transplantation of Schwann cells,neural stem cells or progenitor cells,olfactory ensheathing cells,oligodendrocyte precursor cells and mesenchymal stem cells has been investigated as potential therapies for spinal cord injury.However,little is known about the mechanisms through which these individual cell types promote repair and functional improvements.The five most commonly proposed mechanisms include neuroprotection,immunomodulation,axon regeneration,neuronal relay formation and myelin regeneration.A better understanding of the mechanisms whereby these cells promote functional improvements,as well as an appreciation of the obstacles in implementing these therapies and effectively modeling spinal cord injury,will be important to make cell transplantation a viable clinical option and may lead to the development of more targeted therapies. | Assinck P Duncan GJ Hilton BJ Plemel JR Tetzlaff W | 2017 | 中华神经外科疾病研究杂志2017，16，3： | 54 |
| 3 | 内蒙古温都尔庙群变质火山——沉积岩钐-钕同位素研究显示文摘温都尔庙群主要系指在集(宁)-二(连浩特)铁路线以东,朱日和及其北部出露的一套中-浅变质海相火山沉积岩系.该套岩层以产出有温都尔庙式铁矿,非层序性蛇绿岩和高压变质矿物组合为国内外地质学界所关注,并且一直作为早古生代海沟存在的重要标志.鉴于温都尔庙群岩层遭受到不同程度构造变动和变质作用以及缺失可信的古生物化石,其时代归属众说纷纭. | 聂凤军 裴荣富 吴良士 Arne Bjφrlykke | 1994 | 科学通报1994，39，13： | 27 |
| 4 | Ultrasonically activated scalpel versus monopolar electrocautery shovel in laparoscopic total mesorectal excision for rectal cancer显示文摘AIM: To investigate the feasibility and safety of monopolar electrocautery shovel (ES) in laparoscopic total mesorectal excision (TME) with anal sphincter preservation for rectal cancer in order to reduce the cost of the laparoscopic operation, and to compare ES with the ultrasonically activated scalpel (US). METHODS: Forty patients with rectal cancer, who underwent laparoscopic TME with anal sphincter preservation from June 2005 to June 2007, were randomly divided into ultrasonic scalpel group and monopolar ES group, prospectively. White blood cells (WBC) were measured before and after operation, operative time, blood loss, pelvic volume of drainage, time of anal exhaust, visual analogue scales (VAS) and surgery-related complications were recorded. RESULTS: All the operations were successful; no one was converted to open procedure. No significant differences were observed in terms of preoperative and postoperative d 1 and d 3 WBC counts (P = 0.493, P = 0.375, P = 0.559), operation time (P = 0.235), blood loss (P = 0.296), anal exhaust time (P = 0.431), pelvicdrainage volume and VAS in postoperative d 1 (P = 0.431, P = 0.426) and d 3 (P = 0.844, P = 0.617) between ES group and US group. The occurrence of surgery-related complications such as anastomotic leakage and wound infection was the same in the two groups. CONCLUSION: ES is a safe and feasible tool as same as US used in laparoscopic TME with anal sphincter preservation for rectal cancer on the basis of the skillful laparoscopic technique and the complete understanding of laparoscopic pelvic anatomy. Application of ES can not only reduce the operation costs but also benef it the popularization of laparoscopic operation for rectal cancer patients. | Bao-Jun Zhou, Wei-Qing Song, Qing-Hui Yan, Jian-Hui Cai, Feng-An Wang, Jin Liu, Guo-Jian Zhang, Guo-Qiang Duan, Zhan-Xue Zhang, Department of Gastrointestinal Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China Author contributions: Zhou BJ, Song WQ, Yan QH, Cai JH, Wang FA, Liu J, Zhang GJ, Duan GQ and Zhang ZX contributed equally to this work Zhou BJ, Song WQ, Yan QH, Cai JH and Wang FA designed the research Zhou BJ, Liu J and Zhang GJ performed the research Duan GQ and Zhang ZX analyzed the data and Zhou BJ, Song WQ and Yan QH wrote the paper. | 2008 | World Journal of Gastroenterology2008，14，25： | 25 |
| 5 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 6 | 初中留守儿童社会支持特点与情绪行为问题的关系显示文摘目的探讨福建省初中留守儿童社会支持的特点及其与情绪行为问题的关系,为制定有效的干预措施提供依据。方法采用社会支持问卷及长处和困难问卷(学生版),对福建省乡镇中学的963名留守儿童和1 520名非留守儿童进行调查分析。结果留守儿童与非留守儿童总体社会支持得分分别为(34.98±6.01),(35.94±5.78)分,差异无统计学意义(t=3.959,P>0.05)。非留守儿童和仅父亲外出务工的留守儿童得到的社会支持高于其他类型的留守儿童(F=8.699,P<0.05)。社会支持水平与留守儿童的情绪行为呈负相关,主观支持、支持利用度对于初中留守儿童的情绪行为问题均具有负向预测作用。高社会支持水平下的留守儿童比低社会支持水平下的留守儿童具有较少的情绪行为问题,低社会支持水平的留守女生较男生存在更多的情绪问题(P值均<0.01)。结论为减少情绪行为问题的发生,在给留守儿童提供客观社会支持的同时,应特别重视其对支持的主观感受和培养利用社会支持的能力。 | 江琴 Bj?rn Albin | 2014 | 中国学校卫生2014，35，3： | 23 |
| 7 | 身体功能恢复的脑卒中患者仍存在认知障碍、抑郁症状和重返社会障碍显示文摘脑卒中后的功能预后往往通过改良的Rankin量表进行评估,仅对主要日常生活活动能力进行评估。但脑卒中患者可能在重新融入社会生活的时候遇到困难,心理上感觉孤立,生活质量差,即便是身体功能完全恢复的患者也存在上述问题。 | Kapoor A Lanctt KL Bayley M Kiss A Herrmann N Murray BJ Swartz RH 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 16 |
| 8 | Study on the risk factors of lymphatic metastasis and the indications of less invasive operations in early gastric cancer显示文摘INTRODUCTIONThe principle of surgical treatment for gastric cancer is theradical resectioning although the suitable resetting range fordifferent cases of gastric cancer is still being arguedupon.However,the diagnostic accuracy of | Jiang BJ Sun RX Lin H Gao YF | 2000 | World Journal of Gastroenterology2000，6，4： | 15 |
| 9 | Gut bless you:The microbiota-gut-brain axis in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS. | Eline Margrete Randulff Hillestad Aina van der Meeren Bharat Halandur Nagaraja Ben RenéBjørsvik Noman Haleem Alfonso Benitez-Paez Yolanda Sanz Trygve Hausken Gülen Arslan Lied Arvid Lundervold Birgitte Berentsen | 2022 | World Journal of Gastroenterology2022，28，4： | 15 |
| 10 | 虎斑夜鳽分布与亚群态势研究显示文摘本世纪以来对虎斑夜鳽分布地点的新发现,表明该种从滨海到内陆漫布于中国长江以南广大地区,并向北渗透直逼东洋界北限秦岭-淮河一线;作者据此将各地的虎斑夜鳽初划为11个亚群,提出目前该种存有3个相对健康而稳定的亚群,即黄山-天目山亚群、南岭亚群和广西亚群,且每个亚群的分布范围均至少不会小于5000km2,其中以黄山-天目山亚群的记录由历史至现今相对最为长久而完整,进而提出今后在上述诸亚群范围之外还会有新的发现。文中指出,尽管近期对虎斑夜分布状况有了新认识,目前仍可视该种的受胁等级为濒危。 | 何芬奇 周放 杨晓君 杨岚 邓学建 胡鸿兴 林剑声 江航东 林植 李立 朱开明 Bjrn Anderson 张浩辉 董江天 | 2007 | 动物分类学报2007，32，4： | 14 |
| 11 | 为什么中国农村人口贫富不同?显示文摘本文提出的问题是“在90年代中期的中国农村,哪些特征因素影响了一个人的贫困状况?”我们使用了一项在1996年1至3月间进行的大型调查,以1995年为参照年份,覆盖了全国19个省的8000个家庭。我们将贫困线设定在每人每年908元的收入水平上,并得到了149%的贫困率。不同的logistic回归模型得出的结果表明,一个家庭的贫困状况高度依赖于其所在位置。在分析少数民族比汉族有更高的贫困概率方面,空间差异是主要的解释变量。此外,中国农村的贫困还与人口因素有关,并依赖于家庭从事的活动、拥有的资产和控制的资源。 | BjrnGustafsson 魏众 吴桂英 | 2002 | 世界经济文汇2002，，3： | 13 |
| 12 | NAFLD fibrosis score:A prognostic predictor for mortality and liver complications among NAFLD patients显示文摘AIM:To study whether the severity of liver fibrosis estimated by the nonalcoholic fatty liver disease(NAFLD) fibrosis score can predict all-cause mortality,cardiac complications,and/or liver complications of patients with NAFLD over long-term follow-up.METHODS:A cohort of well-characterized patients with NAFLD diagnosed during the period of 1980-2000 was identified through the Rochester Epidemiology Project.The NAFLD fibrosis score(NFS) was used to separate NAFLD patients with and without advanced liver fibrosis.We used the NFS score to classify the probability of fibrosis as <-1.5 for low probability,>-1.5 to < 0.67 for intermediate probability,and > 0.67 for high probability.Primary endpoints included allcause death and cardiovascular-and/or liver-related mortality.From the 479 patients with NAFLD assessed,302 patients(63%) greater than 18 years old were included.All patients were followed,and medical charts were reviewed until August 31,2009 or the date when the first primary endpoint occurred.By using a standardized case record form,we recorded a detailed history and physical examination and the use of statins and metformin during the follow-up period.RESULTS:A total of 302/479(63%) NAFLD patients(mean age:47 ± 13 year) were included with a followup period of 12.0 ± 3.9 year.A low probability of advanced fibrosis(NFS <-1.5 at baseline) was found in 181 patients(60%),while an intermediate or high probability of advanced fibrosis(NSF >-1.5) was found in 121 patients(40%).At the end of the follow-up period,55 patients(18%) developed primary endpoints.A total of 39 patients(13%) died during the follow-up.The leading causes of death were non-hepatic malignancy(n = 13/39;33.3%),coronary heart disease(CHD)(n = 8/39;20.5%),and liver-related mortality(n = 5/39;12.8%).Thirty patients had new-onset CHD,whereas 8 of 30 patients(27%) died from CHD-related causes during the follow-up.In a multivariate analysis,a higher NFS at baseline and the presence of new-onset CHD were significantly predictive of death(OR = 2.6 and 9.2,respectively;P < 0.0001).Our study showed a significant,graded relationship between the NFS,as classified into 3 subgroups(low,intermediate and high probability of liver fibrosis),and the occurrence of primary endpoints.The use of metformin or simvastatin for at least 3 mo during the follow-up was associated with fewer deaths in patients with NAFLD(OR = 0.2 and 0.03,respectively;P < 0.05).Additionally,the rate of annual NFS change in patients with an intermediate or high probability of advanced liver fibrosis was significantly lower than those patients with a low probability of advanced liver fibrosis(0.06 vs 0.09,P = 0.004).The annual NFS change in patients who died was significantly higher than those in patients who survived(0.14 vs 0.07,P = 0.03).At the end of the follow-up,we classified the patients into 3 subgroups according to the progression pattern of liver fibrosis by comparing the NFS at baseline to the NFS at the end of the followup period.Most patients were in the stable-fibrosis(60%) and progressive-fibrosis(37%) groups,whereas only 3% were in the regressive fibrosis.CONCLUSION:A higher NAFLD fibrosis score at baseline and a new onset of CHD were significantly predictive of death in patients with NAFLD. | Sombat Treeprasertsuk Einar Bjrnsson Felicity Enders Sompongse Suwanwalaikorn Keith D Lindor | 2013 | World Journal of Gastroenterology2013，19，8： | 13 |
| 13 | Effects of soil moisture and plant interactions on the soil microbial community structure显示文摘 | Chen MM Zhu YG Su YH Chen BD Fu BJ Marschner P | 2007 | 中国生物学文摘2007，21，6： | 13 |
| 14 | New insights into the role of PML in tumour suppression显示文摘PML 基因涉及 t (15; 17 ) 尖锐 promyelocytic 白血球过多症(APL ) 的 translocation,它产生 oncogenic 熔化蛋白质 PML (promyelocytic 白血球过多症蛋白质)-retinoic 酸受体高山哈。PML 蛋白质本地化称为 PML 原子领域(PML-ND ) 的原子结构到一个代用品,哪个 PML 是必要结构的部件。在 APL, PML-NDs 被破坏,因此含有在这白血球过多症的致病的这些结构。出人意料地,最近的研究显示 PML 和 PML-ND 玩一个瘤在除了 APL 的人的瘤的几种不同类型的镇压角色。因为 PML 在多重细胞的小径的极端通用性和参与,理解位于它的功能下面的机制,并且因此在瘤抑制的角色,是一项挑战性的任务。在这评论,我们试图非常在这个领域里估价更最近的进展并且建议调查的新大街。 | P Salomoni BJ Ferguson AH Wyllie T Rich | 2008 | Cell Research2008，18，6： | 12 |
| 15 | Validation of Fujinon intelligent chromoendoscopy with high definition endoscopes in colonoscopy显示文摘AIM:To validate high definition endoscopes with Fujinon intelligent chromoendoscopy(FICE) in colonoscopy.METHODS:The image quality of normal white light endoscopy(WLE),that of the 10 available FICE filters and that of a gold standard(0.2% indigo carmine dye) were compared.RESULTS:FICE-filter 4 [red,green,and blue(RGB) wavelengths of 520,500,and 405 nm,respectively] provided the best images for evaluating the vascular pattern compared to white light.The mucosal surface was best assessed using filter 4.However,the views obtained were not rated significantly better than those observed with white light.The 'gold standard',indigo carmine(IC) dye,was found to be superior to both white light and filter 4.Filter 6(RGB wavelengths of 580,520,and 460 nm,respectively) allowed for exploration of the IC-stained mucosa.When assessing mucosal polyps,both FICE with magnification,and magnification following dye spraying were superior to the same techniques without magnification and to white light imaging.In the presence of suboptimal bowel preparation,observation with the FICE mode was possible,and endoscopists considered it to be superior to observation with white light.CONCLUSION:FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE. | Adolfo Parra-Blanco Alejandro Jiménez Bjrn Rembacken Nicolás González David Nicolás-Pérez Antonio Z Gimeno-García Marta Carrillo-Palau Takahisa Matsuda Enrique Quintero | 2009 | World Journal of Gastroenterology2009，15，42： | 12 |
| 16 | Identification of tumor associated single-chain Fv by panning and screening antibody phage library using tumor cells显示文摘AIM:To study the feasibility of panning and screeningphage-displaying recombinant single-chain variablefragment (ScFv) of anti-tumor monoclonal antibodiesfor fixed whole cells as the carriers of mAb-bindingantigens.ME,ODS: The recombinant phage displaying librariesfor anti-colorectal tumor mAb MC3Ab, MC5Ab andanti-gastric tumor mAb MGD1 was constructed.Panning and screening were carried outby means ofmodified fixation of colorectal and gastric tumor cellsexpressed the mAb-binding antigens. Concordance ofbinding specificity to tumor cells between phageclones and parent antibodies was analyzed. Thephage of positive clones was identified withcompetitive ELISA, and infected by E.coli HB2151 toexpress soluble ScFv.RESULTS:The ratio of positive clones to MC3-ScF-MC5-ScFv and MGD1-ScFv were 60 %, 24 % and 30 %. MC3-ScFv had Mr 32 000 confirmed by Western blot. Thespecificity to antigen had no difference between 4positive recombinant phage antibodies and MC3Ab.CONCLUSION:The modified process of fixing wholetumor cells is efficient, convenient and feasible to panand screen the phage-displaying ScFv of anti-tumormonoclonal antibodies. | Nie, YZ He, FT Li, ZK Wu, KC Cao, YX Chen, BJ Fan, DM | 2002 | World Journal of Gastroenterology2002，8，4： | 12 |
| 17 | 猪卵巢周期中卵泡刺激素和黄体生成素受体mRNA的定位及表达显示文摘以周期化的猪卵巢为标本,进行Northern和原位杂交,观察周期第0、4、7、12和16天猪卵泡刺激素(FSH)和黄体生成素(LH)受体mRNA的分布和表达。结果:FSH受体mRNA的转录模式在周期第0、4、7、12和16天中均为3个片段(4.2、3.5和2.4kb);LH受体mRNA表达多个共同片段(10.0、6.8、5.9、4.7、3.8、2.5和1.5kb)。FSH受体mRNA的表达在未成熟和成熟卵泡仅定位于卵巢颗粒细胞和卵丘细胞;促性腺激素峰值期,在未成熟卵泡颗粒细胞中的表达强于成熟卵泡;在卵泡退化过程中,闭锁卵泡中呈不同程度的减少而在黄体细胞则无表达。LH受体mRNA在成熟卵泡的颗粒细胞和卵泡膜细胞中均有表达,不成熟卵泡仅在卵泡膜细胞中表达,退化的卵泡表达逐渐减少;在峰值后的第4和第7天的少许黄体细胞中可见,在第12天达高峰,继而逐渐消失。表明在猪动情周期的不同阶段,FSH和LH受体mRNA在卵泡细胞中的表达呈多样性和细胞特异性。成熟黄体细胞仅表达LH受体mRNA而不表达FSH受体mRNA。 | 刘嘉茵 Aron.,BJ | 1998 | 生殖医学杂志1998，7，2： | 11 |
| 18 | Diagnosis and treatment of pancreatic exocrine insufficiency显示文摘Pancreatic exocrine insufficiency is an important cause of maldigestion and a major complication in chronic pancreatitis.Normal digestion requires adequate stimulation of pancreatic secretion,sufficient production of digestive enzymes by pancreatic acinar cells,a pancreatic duct system without significant outflow obstruction and adequate mixing of the pancreatic juice with ingested food.Failure in any of these steps may result in pancreatic exocrine insufficiency,which leads to steatorrhea,weight loss and malnutrition-related complications,such as osteoporosis.Methods evaluating digestion,such as fecal fat quantification and the13C-mixed triglycerides test,are the most accurate tests for pancreatic exocrine insufficiency,but the probability of the diagnosis can also be estimated based on symptoms,signs of malnutrition in blood tests,fecal elastase 1 levels and signs of morphologically severe chronic pancreatitis on imaging.Treatment for pancreatic exocrine insufficiency includes support to stop smoking and alcohol consumption,dietary consultation,enzyme replacement therapy and a structured follow-up of nutritional status and the effect of treatment.Pancreatic enzyme replacement therapy is administered in the form of enteric-coated minimicro-spheres during meals.The dose should be in proportion to the fat content of the meal,usually 40-50000 lipase units per main meal,and half the dose is required for a snack.In cases that do not respond to initial treatment,the doses can be doubled,and proton inhibitors can be added to the treatment.This review focuses on current concepts of the diagnosis and treatment of pancreatic exocrine insufficiency. | Bjrn Lindkvist | 2013 | World Journal of Gastroenterology2013，19，42： | 11 |
| 19 | 镉对生命活动的毒作用机制显示文摘镉是一种众所周知的环境毒物,对人体健康有重大危害。镉与众多疾病相关,例如癌症、神经退化性疾病和代谢综合征等。虽然疾病种类各异,但是都与镉的化学性质和毒作用机制有关。镉易与含硫氮功能基结合,从而取代金属酶内的必需元素锌。镉的促炎症效应伴随促炎因子[肿瘤坏死因子(TNF-α)、白介素(IL)-1、IL-6]的大量产生和抗炎因子(IL-1拮抗剂、IL-4、IL-6、IL-10、IL-13)的明显减少,并且镉的促炎症活性与其通过各种途径所诱导的氧化应激紧密相关。镉还能取代各种蛋白质内的铁铜原子,从而增加自由氧化还原反应的活性金属库,激活芬顿(Fenton)反应;反之,镉对电子传递链的抑制损害了对氧气的利用,增加了活性氧的产生。最后,镉对抗氧化酶的抑制加剧自由基对核酸等生物大分子的损伤,引起遗传毒性并改变基因调控。因此,干扰镉的毒作用机制是预防镉暴露不良健康效应的有效措施。 | Alexey A.TINKOV Olga P.AJSUVAKOVA Jan AASETH Yordanka G.GLUHCHEVA Juliana M.IVANOVA Geir BJФRKLUND Margarita G.SKALNAYA Oksana A.SKALNAYA 黄百粲 林雪 Anatoly V.SKALNY | 2018 | 环境与职业医学2018，35，5： | 11 |
| 20 | 骨原发Rosai-Dorfman病:15例临床病理分析显示文摘 | Demicco E G Rosenberg A E Bjrnsson J 郎志强 | 2010 | 临床与实验病理学杂志2010，26，5： | 10 |
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