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| 1 | Alveolar echinococcosis-spreading disease challenging clinicians: A case report and literature review显示文摘Human alveolar echinococcosis (AE) is a potentially deadly disease; recent studies have shown that the endemic area of Echinococcus multilocularis , its causative agent, is larger than previously known. This disease has low prevalence and remains underreported in Europe. Emerging clinical data show that diagnostic difficulties are still common. We report on a 76-year old patient suffering from AE lesions restricted to the left lobe of the liver who underwent a curative extended left hemihepatectomy. Prior to the resection a liver biopsy under the suspicion of an atypical malignancy was performed. After the intervention he developed a pseudoaneurysm of the hepatic artery that was successfully coiled. Surprisingly, during surgery, the macroscopic appearance of the tumour revealed a growth pattern that was rather typical for cystic echinococcosis (CE), i.e. , a gross tumour composed of multiple large vesicles with several centimeters in diameter. In addition, there were neither extensive adhesions nor infiltrations of the neighboring pancreas and diaphragm as was expected from previous imaging results. The unexpected diagnosis of AE was confirmed by definite histopathology, specific polymerase chain reaction and serology results. This is a rare case of unusual macroscopic presentation of AE that posed immense diagnostic challenges and had an eventful course. To our knowledge this is the first case of an autochthonous infection in this particular geographic area of Germany, the federal state of Saxony. This report may provide new hints for an expanding area of risk for AE and emphasizes the risk of complications in the scope of diagnostic procedures and the limitations of modern radiological imaging. | Georgi Atanasov Christoph Benckert Armin Thelen Dennis Tappe Matthias Frosch Dieter Teichmann Thomas FE Barth Christian Wittekind Stefan Schubert Sven Jonas | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 4 |
| 3 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 4 | Liver resection for hepatocellular carcinoma in patients without cirrhosis显示文摘 | A. Thelen C. Benckert H.‐M. Tautenhahn H.‐M. Hau M. Bartels J. Linnemann J. Bertolini M. Moche C. Wittekind S. Jonas | 2012 | Br J Surg2012，，1： | 2 |
| 5 | Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors显示文摘AIM:To investigate in vitro and in vivo treatment with histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589 in pancreatic cancer. METHODS:Cell-growth inhibition by NVP-LAQ824 and NVP-LBH589 was studied in vitro in 8 human pancreatic cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide(MTT) assay. In addition,the anti-tumoral effect of NVP-LBH589 was studied in a chimeric mouse model. Anti-tumoral activity of the drugs was assessed by immunoblotting for p21WAF-1,acH4,cell cycle analysis,TUNEL assay,and immunohistochemistry for MIB-1. RESULTS:In vitro treatment with both compounds significantly suppressed the growth of all cancer cell lines and was associated with hyperacetylation of nucleosomal histone H4,increased expression of p21WAF-1,cell cycle arrest at G2/M-checkpoint,and increased apoptosis. In vivo,NVP-LBH589 alone significantly reduced tumor mass and potentiated the efficacy of gemcitabine. Further analysis of the tumor specimens revealed slightly increased apoptosis and no significant reduction of cell proliferation.CONCLUSION:Our findings suggest that NVP-LBH589 and NVP-LAQ824 are active against human pancreatic cancer,although the precise mechanism of in vivo drug action is not yet completely understood. Therefore,further preclinical and clinical studies for the treatment of pancreatic cancer are recommended. | Martin Haefner Thilo Bluethner Manuel Niederhagen Christian Moebius Christian Wittekind Joachim Mossner Karel Caca Marcus Wiedmann | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 6 | Surgical treatment of hepatocellular carcinoma: Experience with liver resection and transplantation in 198 patients显示文摘 | Burckhardt Ringe M.D. Rudolf Pichlmayr M.D. Christian Wittekind M.D. Günter Tusch M.S | 1991 | World Journal of Surgery1991，，2： | 2 |
| 7 | Role of epigenetic alterations in cholangiocarcinoma显示文摘 | Iris Tischoff Christian Wittekind Andrea Tannapfel | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，4： | 2 |
| 8 | News of TNM and its use of classification of gastric cancer显示文摘 | Hermanek P Wittekind C | 1995 | World J Surg1995，19，4： | 1 |
| 9 | Role of epigenetic alterations in cholangiocarcinoma显示文摘 | Tischoff I Wittekind C Tannapfel A | 2006 | Hepatobil Pancrcat Surg2006，13，4： | 1 |
| 10 | Adjuvant vs neoadjuvant radiochemotherapy for locally advanced rectal cancer: The German trial CAO/ARO/AIO-94显示文摘 | Sauer R Fietkau R Wittekind C | 2003 | Colorectal Dis2003，5，： | 1 |
| 11 | TNM classification of malignant tumors显示文摘 | Sobin LH Wittekind C | 1997 | Sed Cancer1997，80，9： | 1 |
| 12 | Standarization of the Feulgen reaction:the influence of chromatin condensation on the kinetics of acid hydstoltsis显示文摘 | SCHULTE E WITTEKIND DH | 1990 | Anal Cell Pathol1990，2，3： | 1 |
| 13 | TNM Residual Tumor Classification Revisited 显示文摘 | Wittekind C Compton CC Greene FL | 2002 | Cancer2002，94，9： | 1 |
| 14 | Cancer Invasion and Metastasis显示文摘 | Wittekind C Neid M | 2005 | Oncolo-gy2005，69，1： | 1 |
| 15 | Multiple simultaneous gastric carcinomas显示文摘 | Wittekind C Klimpfinger M Hermanek P | 1997 | Br J Cancer1997，76，12： | 1 |
| 16 | The incidence of port-site metastases might be reduced显示文摘 | Reymond MA Wittekind C Jung A | 1997 | Surg Endosc1997，11，9： | 1 |
| 17 | Surgical treatment of hepatocellular carcinoma: Experience with liver resection and transplantation in 198 patients显示文摘 | Burckhardt Ringe M.D. Rudolf Pichlmayr M.D. Christian Wittekind M.D. Günter Tusch M.S | 1991 | World Journal of Surgery1991，，2： | 1 |
| 18 | Cancer invasion and metastasis显示文摘 | Wittekind C Neid M | 2005 | Oncology2005，69，1： | 1 |
| 19 | Mutations of p53 Tumor Suppressor Gene, Apoptosis, and Proliferation in Intrahepatic Cholangiocellular Carcinoma of the Liver显示文摘 | Andrea Tannapfel Lars Weinans Felix Gei?ler Alexander Sch?tz Alexander Katalinic Ferdinand K?ckerling Johann Hauss Christian Wittekind | 2000 | Digestive Diseases and Sciences2000，，2： | 1 |
| 20 | Standarization of the Feulgen reaction: influence of chromatin condensation on the kinetics of acid hydrolysis显示文摘 | Schulte E Wittekind D H | 1990 | Anal Cell Pathol1990，，2： | 1 |
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