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| 1 | Genetics of hepatocellular carcinoma显示文摘The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC). Moreover, since an efficient treatment for this disease is lacking, further understanding of the genetic background of HCC will be crucial in order to develop new therapies aimed at selected targets. We report on the current status and recent developments in HCC genetics. Special emphasis is given to the genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt- signalling, TGFβ, Ras, and Rb pathways. Furthermore, we describe the influence of chromosomal aberrations as well as of DNA methylation. Finally, we report on the rapidly developing field of genomic expression profiling in HCC, mainly by microarray analysis. | Andreas Teufel Frank Staib Stephan Kanzler Arndt Weinmann Henning Schulze-Bergkamen Peter R Galle | 2007 | World Journal of Gastroenterology2007，13，16： | 21 |
| 2 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 3 | 巨獭(Pteronura brasiliensis)处境危险吗?秘鲁鱼体和水獭粪便中总汞和甲基汞水平显示文摘本文对秘鲁马努国家公园(Manu National Park)及其邻近的一个金矿区内的鱼的肌肉和巨獭(Pteronura brasiliensis)粪便中的汞和甲基汞水平进行了分析。68%的鱼肌肉中,总汞水平超过了规定的欧洲水獭(Lutra lutra)最大忍受水平(0.1mg/kg鱼鲜重),17.6%超过了最一般的人类消费标准0.5mg/kg鱼鲜重。鱼肌肉中甲基汞与总汞的比值在61.3%~96.9%之间。水獭粪便中没有检出甲基汞而只有微量的无机汞。目前还没有巨獭组织汞浓度的有关数据,但鱼体汞水平大比例超过欧洲水獭的可忍受值,根据过去对欧洲和北美自由生活的水獭的汞中毒的描述,可以设想巨獭体内汞中毒的危险可能存在。 | Arno Christian Gutleb Christof Schenck Elke Staib 张国梁 | 1997 | 人类环境杂志1997，26，8： | 2 |
| 4 | Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53 显示文摘 | Pesch J Brehm U Staib C | 1996 | J Interferon Cytokine Res1996，16，8： | 1 |
| 5 | Surgery of colorectal cancer: surgical morbidity and five-and ten year results in 2 400 patients monoinstitutional experience显示文摘 | Staib L Link KH Blatz A etal | 2002 | World J Surg2002，126，1： | 1 |
| 6 | Neural Correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder:a positron emission tomography study显示文摘 | Staib LH Kaloupek D | 1999 | Biol Psychiatry1999，45，7： | 1 |
| 7 | TP53 and liver carcino- genesis 显示文摘 | Staib F Hussain SP Hofseth LJ | 2003 | Hum Mutat2003，21，3： | 1 |
| 8 | Deformable boundary finding in medical image by integrating gradient and region information显示文摘 | Chakraborty A Staib L Duncan J | 1996 | IEEE Transactions on Medical Imaging1996，15，： | 1 |
| 9 | Deformable boundary finding in medical images by integrating gradient and region information显示文摘 | Chakraborty A Staib H Duncan J | 1996 | IEEE Transactions on Medical Imaging1996，15，6： | 1 |
| 10 | Boundary fitting with parametrically deformable models显示文摘 | Staib L H Duncan J S | 1992 | IEEE Transactions on Pattern Analysis and Machine Intelligence1992，14，11： | 1 |
| 11 | TP53 mutations and hepatocellular carcinoma: insights into the etiology and patho- genesis of liver cancer 显示文摘 | Hussain SP Schwank J Staib F | 2007 | Oncogene2007，26，15： | 1 |
| 12 | Deformable boundary finding in medical images by integrating gradient and region information显示文摘 | Chakraborthy A Staib L H Duncan J S | 1996 | IEEE Transactions on Medical Imaging1996，15，6： | 1 |
| 13 | Small molecule inhibitors of Wnt signaling effectively induce apoptosis in acute myeloid leukemia cells 显示文摘 | Minke KS Staib P Puetter A | 2009 | Eur J Haematol2009，82，3： | 1 |
| 14 | Exercise,antioxidants,and HSP72:protection against myocardial ischemia/reperfusion显示文摘 | Hamilton K L Staib J L Phillips T | 2003 | Free Radic Biol Med2003，34，7： | 1 |
| 15 | Deformable boundary finding in medical images by integrating gradient and region information显示文摘 | Chakraborty A Staib L H Duncan J S | 1996 | IEEE Transactions on Medical Imaging1996，15，6： | 1 |
| 16 | Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice 显示文摘 | Kretschmar M Felk A Staib P | 2002 | Mierob Pathog2002，32，2： | 1 |
| 17 | Deformable boundary finding in medical images by integrating gradient and region infor- mation显示文摘 | Chakraborty A Staib L H Duncan J S | 1996 | IEEE Transaction on Medical Imaging1996，15，6： | 1 |
| 18 | Vaccinia vectors as candidate vaccines: the development of modified vaccinia virus Ankara for antigen de- livery显示文摘 | Sutter G Staib C | 2003 | Curt Drug Targets Infect Disord2003，3，3： | 1 |
| 19 | Surgery of colorectal cancer: surgical morbidity and five - and ten - year results in 2400 patients - monoinstitutional experience 显示文摘 | STAIB L LINK K H BLATZ A et ai | 2002 | World jour- nal of surgery2002，26，1： | 1 |
| 20 | Boundary finding with parametrically deformable contour models显示文摘 | Staib L Duncan J | 1992 | IEEE Trans on Pattern Anal Machine Intell1992，14，： | 1 |
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