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| 1 | PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13显示文摘脉管的光滑的肌肉房间(VSMC ) 被将生物的活组织移植于培养基中培养方法从男 SpragueDawley 老鼠的胸的主动脉准备经由 3 kinase (PI3K )/Akt 发信号 transduction 小径由 apelin-13 导致了的 phosphoinositide 观察 VSMC 增长。PI3K, phospho-PI3K, phospho-Akt, ERK1/2, phospho-ERK1/2 和 cyclin D1 的表示被西方的污点分析检测。结果证明 apelin-13 在剂量依赖者和时间依赖者举止支持了 phospho-PI3K 和 phospho-Akt 的表示。PI3K 禁止者 LY294002 显著地减少了 phospho-PI3K, phospho-Akt, phospho-ERK1/2,和 cyclin D1 的表示由 apelin-13 导致了。Akt 禁止者 1701-1 显著地减少了 phospho-Akt, phospho-ERK1/2,和 cyclin D1 的表示由 apelin-13 刺激了。MTT 试金结果证明 PI3K 禁止者 LY294002 和 Akt 禁止者 1701-1 显著地禁止了 apelin-13 导致的 VSMC 增长。Apelin-13 通过表明 transduction 小径的 PI3K/Akt 支持了 VSMC 增长。 | Changhui Liu Tao Su Fang Li Lanfang Li Xuping Qin Weinan Pan Fen Feng Feng Chen Duanfang Liao Linxi Chen | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 41 |
| 2 | The Deep Ritz Method: A Deep Learning-Based Numerical Algorithm for Solving Variational Problems显示文摘We propose a deep learning-based method,the Deep Ritz Method,for numerically solving variational problems,particularly the ones that arise from par-tial differential equations.The Deep Ritz Method is naturally nonlinear,naturally adaptive and has the potential to work in rather high dimensions.The framework is quite simple and fits well with the stochastic gradient descent method used in deep learning.We illustrate the method on several problems including some eigenvalue problems. | Weinan E Bing Yu | 2018 | Communications in Mathematics and Statistics2018，6，1： | 22 |
| 3 | Deep Learning-Based Numerical Methods for High-Dimensional Parabolic Partial Differential Equations and Backward Stochastic Differential Equations显示文摘We study a new algorithm for solvingparabolic partial differential equations(PDEs)and backward stochastic differential equations(BSDEs)in high dimension,which is based on an analogy between the BSDE and reinforcement learning with the gradient of the solution playing the role of the policy function,and the loss function given by the error between the prescribed terminal condition and the solution of the BSDE.The policy function is then approximated by a neural network,as is done in deep reinforcement learning.Numerical results using TensorFlow illustrate the efficiency and accuracy of the studied algorithm for several 100-dimensional nonlinear PDEs from physics and finance such as the Allen–Cahn equation,the Hamilton–Jacobi–Bellman equation,and a nonlinear pricing model for financial derivatives. | Weinan E Jiequn Han Arnulf Jentzen | 2017 | Communications in Mathematics and Statistics2017，5，4： | 20 |
| 4 | Boundary Layer Theory and the Zero-Viscosity Limit of the Navier-Stokes Equation | Weinan E Department of Mathematics and Program in Applied and Computational Mathematics,Princeton University,USA | 2000 | Acta Mathematica Sinica,English Series2000，16，2： | 10 |
| 5 | A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var.beijingensis显示文摘The protein synthesis inhibitor anisomycin features a unique benzylpyrrolidine system and exhibits potent selective activity against pathogenic protozoa and fungi.It is one of the important effective components in Agricultural Antibiotic120,which has been widely used as naturally-originated agents for treatment of crop decay in China.The chemical synthesis of anisomycin has recently been reported,but the complex process with low productivity made the biosynthesis still to be a vital mainstay in efforts.The biosynthetic gene cluster(BGC)of anisomycin in Streptomyces hygrospinosus var.beijingensis has been identified in our previous work,while poor understanding of the regulatory mechanism limited the yield enhancement via regulation engineering of S.hygrospinosus var.beijingensis.In this study here,we characterized AniF as an indispensable LuxR family transcriptional regulator for the activation of anisomycin biosynthesis.The genetic manipulations of aniF and the real-time quantitative PCR(RT-qPCR)revealed that it positively regulated the transcription of the anisomycin BGC.Moreover,the overexpression of aniF contributed to the improvement of the production of anisomycin and its derivatives.Dissection of the mechanism underlying the function of AniF revealed that it directly activated the transcription of the genes aniR-G involved in anisomycin biosynthesis.Especially,one AniF-binding site in the promoter region of aniR was identified by DNase I footprinting assay and an inverted repeat sequence(5′-GGGC-3′)composed of two 4-nt half sites in the protected region was found.Taken together,our systematic study confirmed the positive regulatory role of AniF and might facilitate the future construction of engineering strains with high productivity of anisomycin and its derivatives. | Jufang Shen Lingxin Kong Yan Li Xiaoqing Zheng Qing Wang Weinan Yang Zixin Deng Delin You | 2019 | Synthetic and Systems Biotechnology2019，4，1： | 10 |
| 6 | The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families显示文摘We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes. | ZHAO Jinying WANG Heng XIONG Momiao HUANG Wei ZUO Jin CHEN Zhu QIANG Boqin SUN Qi LI Yuxiu LIU Qiuying DU Weinan CHEN Jialun DING Wei YUAN Wentao ZHAO Yang XU Hongyan JIN Li FANG Fude | 2000 | Chinese Science Bulletin2000，45，19： | 8 |
| 7 | Highly luminescent and stable CsPbBr3 perovskite quantum dots modified by phosphine ligands显示文摘All-inorganic cesium lead halide perovskite quantum dots (QDs) have been a promising candidate for optoelectronic devices in recent years,such as light-emitting diodes,photodetectors and solar cells,owing to their superb optoelectronic properties.Still,the stability issue of nanocrystals is a bottleneck for their practical application.Herein,we report a facile method for the synthesis of a series of phosphine ligand modified CsPbBr3 QDs with high PL intensity.By introducing organic phosphine ligands,the tolerance of CsPbBr3 QDs to ethanol,water and UV light was dramatically improved.Moreover,the phosphine ligand modified QD films deposited on the glass subtracts exhibit superior PL intensity and optical stability to those of pristine QD based films. | Yan Li Xiaoyan Wang Weinan Xue Wei Wang Wei Zhu Lianjing Zhao | 2019 | Nano Research2019，12，4： | 7 |
| 8 | Distributed Adaptive Fault-Tolerant Output Regulation of Heterogeneous Multi-Agent Systems With Coupling Uncertainties and Actuator Faults显示文摘In this paper, we consider the distributed adaptive fault-tolerant output regulation problem for heterogeneous multiagent systems with matched system uncertainties and mismatched coupling uncertainties among subsystems under the influence of actuator faults. First, distributed finite-time observers are proposed for all subsystems to observe the state of the exosystem. Then, a novel fault-tolerant controller is designed to compensate for the influence of matched system uncertainties and actuator faults. By using the linear matrix inequality technique, a sufficient condition is provided to guarantee the solvability of the considered problem in the presence of mismatched coupling uncertainties. Moreover, it is shown that the system in closed-loop with the developed controller can achieve output regulation by using the Lyapunov stability theory and cyclic-small-gain theory.Finally, a numerical example is given to illustrate the effectiveness of the obtained result. | Chao Deng Weinan Gao Weiwei Che | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，4： | 6 |
| 9 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 10 | Dedicated to Professor Chi-Wang Shu on the occasion of his 60th birthday A Proposal on Machine Learning via Dynamical Systems显示文摘Wediscuss the idea of using continuous dynamicalsystemstomodel generalhigh-dimensional nonlinear functions used in machine learning.We also discuss theconnection with deep learning. | Weinan E | 2017 | Communications in Mathematics and Statistics2017，5，1： | 4 |
| 11 | A comparative analysis of optimization and generalization properties of two-layer neural network and random feature models under gradient descent dynamics显示文摘A fairly comprehensive analysis is presented for the gradient descent dynamics for training two-layer neural network models in the situation when the parameters in both layers are updated.General initialization schemes as well as general regimes for the network width and training data size are considered.In the overparametrized regime,it is shown that gradient descent dynamics can achieve zero training loss exponentially fast regardless of the quality of the labels.In addition,it is proved that throughout the training process the functions represented by the neural network model are uniformly close to those of a kernel method.For general values of the network width and training data size,sharp estimates of the generalization error are established for target functions in the appropriate reproducing kernel Hilbert space. | Weinan E Chao Ma Lei Wu | 2020 | Science China Mathematics2020，63，7： | 4 |
| 12 | Signal pathways of melanoma and targeted therapy显示文摘Melanoma is the most lethal skin cancer that originates from the malignant transformation of melanocytes.Although melanoma has long bee n regarded as a cancerous malig nancy with few therapeutic opti ons,in creased biological understandi ng and unprecedented innovations in therapies targeting mutated driver genes and immune checkpoints have substantially improved the prog nosis of patients.However,the low response rate and inevitable occurre nee of resistance to curre ntly available targeted therapies have posed the obstacle in the path of melanoma management to obtain further amelioration.Therefore,it is necessary to understand the mechanisms underlying melanoma pathogenesis more comprehensively,which might lead to more substantial progress in therapeutic approaches and expand clinical options for melanoma therapy.In this review,we firstly make a brief introduction to melanoma epidemiology,clinical subtypes,risk factors,and current therapies.Then,the signal pathways orchestrati ng mela noma pathogenesis,in eluding gen etic mutatio ns,key tran scripti onal regulators,epige netic dysregulati ons,metabolic reprogramming,crucial metastasis-related signals,tumor-promoting inflammatory pathways,and pro-angiogenic factors,have been systemically reviewed and discussed.Subsequently,we outline current progresses in therapies targeting mutated driver genes and immune checkpoi nts,as well as the mecha nisms underlying the treatment resista nee.Finally,the prospects and challe nges in the developme nt of mela noma therapy,especially immu no therapy and related ongoing din ical trials,are summarized and discussed. | Weinan Guo Huina Wan Chunying Li | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 4 |
| 13 | High thermal stability Cu_(2)O@OZrP micro-nano hybrids for melt-spun excellent antibacterial activity polyester fibers显示文摘Public safety incidents caused by bacterial infections have attracted widespread attention towards antibacterial textiles(fibers,fabrics,etc.).Nevertheless,it is still challenging to efficiently load inorganic nano-antibacterial materials in polymer fibers.In this work,zirconium phosphate(ZrP,layered micro-nano materials)was utilized as a micro-nano carrier.The octadecyl triphenyl phosphonium bromide(OTP)was intercalated between the ZrP sheets by the ion exchange method to improve the carrier-polymer compatibility and the antibacterial performance.Through in-situ chemical reduction,the ultra-small nano-sized cuprous oxide(Cu_(2)O<5 nm)was loaded on the outer surface of ZrP to realize the uniform and stable dispersion of the Cu_(2)O on the carrier and improve the antibacterial performance.The ZrP nanosheets loaded with Cu_(2)O and OTP(Cu_(2)O@OZrP)had excellent antibacterial properties,and the antibacterial rate against E.coli,S.aureus and C.albicans was more than 99%.The intercalation amount of OTP in Cu_(2)O@OZrP can reach 16%,and the thermal stability was excellent and a significant increase in the Zeta potential.Indeed,the decomposition temperature was greater than 350℃,which was suitable for high-temperature melt processing of polymers.Consequently,we prepared PET/Cu_(2)O@OZrP fibers using polyethylene glycol terephthalate(PET),which accounts for 70%of the total chemical fibers,as the fiber matrix.PET/Cu_(2)O@OZrP fibers exhibited excellent mechanical property and antibacterial performance when the content of Cu_(2)O@OZrP was only 0.2%.The antibacterial rate against five types of bacteria including super bacteria(MRSA,VRE)was more than 99%. | Jialiang Zhou Yaping Wang Weinan Pan Hengxue Xiang Peng Li Zhe Zhou Meifang Zhu | 2021 | Journal of Materials Science & Technology2021，，22： | 4 |
| 14 | Heterogeneous Multiscale Methods: A Review显示文摘This paper gives a systematic introduction to HMM,the heterogeneous multiscale methods,including the fundamental design principles behind the HMM philosophy and the main obstacles that have to be overcome when using HMM for a particular problem.This is illustrated by examples from several application areas,including complex fluids,micro-fluidics,solids,interface problems,stochastic problems,and statistically self-similar problems.Emphasis is given to the technical tools,such as the various constrained molecular dynamics,that have been developed,in order to apply HMM to these problems.Examples of mathematical results on the error analysis of HMM are presented.The review ends with a discussion on some of the problems that have to be solved in order to make HMM a more powerful tool. | Weinan E Bjorn Engquist Xiantao Li Weiqing Ren Eric Vanden-Eijnden | 2007 | Communications in Computational Physics2007，2，3： | 4 |
| 15 | Characterization of the positive SARP family regulator PieR for improving piericidin A1 production in Streptomyces piomogeues var.Hangzhouwanensis显示文摘Piericidin A1,a member ofɑ-pyridone antibiotic,exhibits various biological activities such as antimicrobial,antifungal,and antitumor properties and possesses potent respiration-inhibitory activity against insects due to its competitive binding capacity to mitochondrial complex I.The biosynthetic pathway of piericidin A1 has been reported in Streptomyces piomogeues var.Hangzhouwanensis,while the regulatory mechanism remains poorly understood.In this study,a Streptomyces antibiotic regulatory protein(SARP)family transcriptional regulator PieR was characterized.Genetic disruption and complementation manipulations revealed that PieR positively regulated the production of piericidin A1.Moreover,the overexpression of pieR contributed to the improvement of piericidin A1 productivity.The real-time quantitative PCR(RT-qPCR)was carried out and the data showed that pieR stimulated the transcription of all the biosynthesis-related genes for piericidin A1.In order to explore the regulatory mechanism,electrophoresis mobility shift assays(EMSA)and DNase I footprinting experiments have been conducted.A protected region covering 50 nucleotides within the upstream region of pieR was identified and two 5-nt direct repeat sequences(5′-CCGGA-3′)in the protected region were found.These findings,taken together,set stage for transcriptional control engineering in the view of optimizing piericidin A1 production and thus provide a viable potent route for the construction of strains with high productivity. | Yan Li Lingxin Kong Jufang Shen Qing Wang Qian Liu Weinan Yang Zixin Deng Delin You | 2019 | Synthetic and Systems Biotechnology2019，4，1： | 4 |
| 16 | On the Struggle for International Power of Discourse on Climate Change显示文摘With climate change developing into one of the global focal issues,the struggle for the international power of discourse on climate change tends to be intensified,The struggle is in essence the contest for national interest revolving around economic and development interest,The weight of international power of discourse acquired by each country is determined by its national strength and its relevant policies as well. | Wang Weinan is PhD at the Institute of Asia and Pacific Studies,Shanghai Academy of Social Sciences | 2010 | China International Studies2010，30，4： | 3 |
| 17 | Spatial Structure,Hierarchy and Formation Mechanisms of Scientific Collaboration Networks:Evidence of the Belt and Road Regions显示文摘Scientific collaboration has become an important part of the people-to-people exchanges in the Belt and Road initiative,and remarkable progress has been made since 2013.Taking the 65 countries along the Belt and Road(BRI countries)as the research areas and using collaborated Web of Science(WOS)core collection papers to construct an international scientific collaboration matrix,the paper explores the spatial structure,hierarchy and formation mechanisms of scientific collaboration networks of 65 countries along the Belt and Road.The results show that:1)Beyond the Belt and Road regions(BRI regions),Central&Eastern Europe,China and West Asia&North Africa have formed a situation in which they all have the most external links with other countries beyond BRI regions.China has the dominant role over other BRI countries in generating scientific links.The overall spatial structure has changed to a skeleton structure consisting of many dense regions,such as Europe,North America,East Asia and Oceania.2)Within the Belt and Road regions,Central&Eastern Europe has become the largest collaboration partner with other sub-regions in BRI countries.The spatial structure of scientific collaboration networks has transformed from the‘dual core’composed of China and the Central&Eastern Europe region,to the‘multi-polarization’composed of‘one zone and multi-points’.3)The hierarchical structure of scientific collaboration networks presents a typical‘core-periphery’structure,and changes from‘single core’to‘double cores’.4)Among the formation mechanisms of scientific collaboration networks,scientific research strength and social proximity play the most important roles,while geographical distance gradually weakens the hindrance to scientific collaboration. | GU Weinan LIU Hui | 2020 | Chinese Geographical Science2020，30，6： | 3 |
| 18 | Different responses of soil respiration and its components to nitrogen and phosphorus addition in a subtropical secondary forest显示文摘Background:Nitrogen(N)and phosphorus(P)deposition have largely affected soil respiration(Rs)in forest ecosystems.However,few studies have explored how N and P individually or in combination to influence Rs and its components(autotrophic respiration,Ra;heterotrophic respiration,Rh),especially in highly P-limited subtropical forests.To address this question,we conducted a field manipulation experiment with N and/or P addition in a 50-year-old subtropical secondary forest.Results:We found that N addition on average reduced Rs,Ra,and Rh by 15.2%,15%,and 11.7%,respectively during 2-year field study.P addition had an inconsistent effect on Ra,with Ra increasing by 50.5%in the first year but reducing by 26.6%in the second year.Moreover,P addition on average decreased Rh by 8.9%–30.9%and Rs by 6.7%–15.6%across 2 years.In contrast,N and P co-addition on average increased Rs,Ra,and Rh by 1.9%,7.9%,and 2.1%during the experimental period.Though Rs and Rh were significantly correlated with soil temperature,their temperature sensitivities were not significantly changed by fertilization.Ra was predominantly regulated by soil nitrogen availability(NH4+and NO3−),soil dissolved organic carbon(DOC),and enzyme activities,while the variation in Rh was mainly attributable to changes in soil microbial community composition and soilβ-D-Cellubiosidase(CB)andβ-Xylosidase(XYL)activities.Conclusion:Our findings highlight the contrasting responses of Rs and its components to N or P addition against N and P co-addition,which should be differentially considered in biogeochemical models in order to improve prediction of forest carbon dynamics in the context of N and P enrichment in terrestrial ecosystems. | Junjun Zhang Yong Li Jinsong Wang Weinan Chen Dashuan Tian Shuli Niu | 2021 | Forest Ecosystems2021，8，3： | 3 |
| 19 | Research and application on multi-terminal and DC grids based on VSC-HVDC technology in China显示文摘Voltage source converter(VSC)-based high-voltage direct current(HVDC)and multi-terminal(MT)/DC grid technologies are the new HVDC transmission technologies after ultra-high voltage alternative current(UHVAC)and UHVDC transmission technologies which have been widely used in China.The application of the new technologies has resulted in a rapid increase in the number of schemes in construction and planning worldwide.This has been stimulated by the greater level of functionality available from the VSC technology,which makes it suitable for a wide variety of applications.These include the integration of off-shore wind farms,embedded links within AC networks and interconnectors,especially where the AC networks are relatively‘weak’.VSC technology has renewed interest in MT DC systems,which may ultimately lead to wide area DC grids.This study outlines the research and application on MT and DC grids in China with respect to VSC-HVDC key technologies and DC grid key technologies based on the presentation given in the International Workshop on Next Generation Power Equipment held on 23 September 2016 in Xian,China.The briefing details of the VSC-HVDC projects constructed and to be constructed in China are summarised in this study. | Ting An Guangfu Tang Weinan Wang | 2017 | High Voltage2017，2，1： | 3 |
| 20 | CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus显示文摘Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin–proteasome-mediated degradation of M1. However,the mechanism by which CypA regulates M1 ubiquitination remains unknown. In this study, we reported that E3 ubiquitin ligase AIP4 promoted K48-linked ubiquitination of M1 at K102 and K104, and accelerated ubiquitin–proteasome-mediated degradation of M1. The recombinant IAV with mutant M1 (K102 R/K104 R) could not be rescued, suggesting that the ubiquitination of M1 at K102/K104 was essential for IAV replication. Furthermore, CypA inhibited AIP4-mediated M1 ubiquitination by impairing the interaction between AIP4 and M1. More importantly, both the mutations of M1 (K102 R/K104 R) and CypA inhibited the nuclear export of M1, indicating that CypA regulates the cellular localization of M1 via inhibition of AIP4-mediated M1 ubiquitination at K102 and K104, which results in the reduced replication of IAV.Collectively, our findings reveal a novel ubiquitination-based mechanism by which CypA regulates the replication of IAV. | Madina Mahesutihan Weinan Zheng Liang Cui Yun Li Pengtao Jiao Wenxian Yang Wei Liu Jing Li Wenhui Fan Limin Yang Wenjun Liu Lei Sun | 2018 | Virologica Sinica2018，33，5： | 3 |
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