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| 1 | Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood,bone marrow and peritoneal lavage of pancreatic carcinoma patients显示文摘AIM: To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas. METHODS: Sixty-eight patients with pancreatic cancer (n = 37), chronic pancreatitis (n = 16), and non-pan- creatic benign surgical diseases (n = 15, control group) were included in the study. Venous blood was taken preoperatively, intraoperatively and at postoperative d 1 and 10. Preoperative bone marrow aspirates and peritoneal lavage taken before mobilization of the tumor were analyzed. All samples were evaluated for disseminated tumor cells by CK-19-specific nested-PCR and quantitative fluorogenic RT-PCR. RESULTS: CK-19 mRNA expression was increased in 24 (64%) blood samples and 11 (30%) of the peritoneal lavage samples in the patients with pancreatic cancer. In 15 (40%) of the patients with pancreatic cancer, disseminated tumor cells were detected in venous blood and bone marrow and/or peritoneal lavage. In the peritoneal lavage, the detection rates were correlated with the tumor size and the tumor differentiation. CK-19 levels were increased in pT3/T4 and moderately/poorly differentiated tumors (G2/G3). Pancreatic cancer patients with at least one CK-19 mRNA-positive sample showed a trend towards shorter survival. Pancreatic cancerpatients showed significantly increased detection rates of disseminated tumor cells in blood and peritoneal lavage compared to the controls and the patients with chronic pancreatitis. CONCLUSION: Disseminated tumor cells can be detected in patients with pancreatic ductal adenocar- cinoma by CK-19 fluorogenic RT-PCR. In peritoneal lavage, detection rate is correlated with tumor stage and differentiation. In the clinical use, CK-19 is suitable for the distinction between malignant and benign pancreatic disease in combination with other tumor-specific markers. | Katrin Hoffmann Christiane Kerner Wolfgang Wilfert Marc Mueller Joachim Thiery Johann Hauss Helmut Witzigmann | 2007 | World Journal of Gastroenterology2007，13，2： | 20 |
| 2 | Complicated small-bowel diverticulosis: A case report and review of the literature显示文摘当 jejunoileal 憩室稀罕、经常无征状时,他们可以导致长期的非特定或尖锐的症状。与类似于阑尾炎,胆汁或结肠的憩室炎而是他们的急腹症在场的复杂并发症的大多数可以也与不正常的症状出现。作为结果,复杂 jejunoileal 憩室形成的诊断能是相当困难的,并且可以完全取决于外科的探索的结果。当禁止徵候不在时,诊断腹腔镜检查有腹的内容和帮助的彻底的检查的利益到达绝对诊断。有主要吻合的深奥小肠的片断的外科的切除术是在有征兆的复杂 jejunoileal 的病人的比较喜欢的治疗憩室的疾病。与与腹腔镜检查诊断并且与外科的切除术对待的 S 字形的憩室炎一起的复杂空肠憩室炎的一个不正常的演讲被介绍。 | Woubet T Kassahun Josef Fangmann Jens Harms Michael Bartels Johann Hauss | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 3 | Transplantation einer Spenderleber auf zwei Empf?nger (Splitting-Transplantation) - Eine neue Methode in der Weiterentwicklung der Lebersegmenttransplantation显示文摘 | R. Pichlmayr B. Ringe G. Gubernatis J. Hauss H. Bunzendahl | 1988 | Langenbecks Archiv für Chirurgie1988，，2： | 2 |
| 4 | Idebenone and reduced cardiac hypertrophy in Friedreieh's ataxia显示文摘 | Aggoun Y Bonnet D | 2002 | Heart2002，87，： | 1 |
| 5 | A neutron-diffraction study of the effect of hydration on stratum comeum structure 显示文摘 | CHARALAMBOPOULOU GC STER1OTIS TA HAUSS T | 2002 | Appl Phys A-Mater2002，74，1： | 1 |
| 6 | Technique and preliminary results of extracorporeal liver surgery (bench procedure) and of surgery on the in situ perfused liver显示文摘 | Pichlmayr R Grosse H Hauss J | 1990 | Br J Surg1990，77，1： | 1 |
| 7 | Technique and prelimina- ry results of extracorporeal liver surgery (bench procedure)and of surgery on the in situ perfused liver显示文摘 | Pichlmayr R Grosse H Hauss J | 1990 | Br J Surg1990，77，1： | 1 |
| 8 | Review of fluid slip over superhydrophobic surfaces显示文摘 | Steilz R Gutberlet T Hauss T | 2003 | Langmuir2003，19，6： | 1 |
| 9 | Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly wAter-soluble LTB4 inhibitor显示文摘 | Hauss DJ Fogal SE Ficorilli JV | 1998 | J Pharm Sci1998，87，2： | 1 |
| 10 | Overview of the MELD score and the UNOS adult liver allocation system显示文摘 | Martin A P Bartels M Hauss J | 2007 | Transplant Proc2007，39，10： | 1 |
| 11 | Dual bioa-ctivity of resveratrol fatty alcohols:differentiation of neural stem cells and modulation of neuroinflammation显示文摘 | HAUSS F LIU J MICHELUCCI A | 2007 | Bioorg Med Chem Letters2007，17，15： | 1 |
| 12 | Techniqueandpreliminaryresultsofextracorporealliversurgery(benchprocedure)andofsurgeryontheinsitupperfusedliver显示文摘 | Pichlmayr R Grosse H Hauss J | | 0，，01： | 1 |
| 13 | Management and outcome in patients with Klatskin-mimicking lesions of the biliary tree显示文摘 | Dirk Uhlmann M.D. Marcus Wiedmann M.D. Frank Schmidt M.D. Regine Kluge M.D. Andrea Tannapfel M.D. Frieder Berr M.D. Johann Hauss M.D. Helmut Witzigmann M.D | 2006 | Journal of Gastrointestinal Surgery2006，，8： | 1 |
| 14 | Oral lipid-based formulations 显示文摘 | Hauss DJ | 2007 | Adv Drug Deliv Rev2007，59，7： | 1 |
| 15 | Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor显示文摘 | Hauss DJ Fogal SE Ficorilli JV | 1998 | J pharm Sci1998，87，2： | 1 |
| 16 | Oral lipid-based formulations显示文摘 | Hauss DJ | 2007 | Advanced Drug Delivery Reviews2007，59，7： | 1 |
| 17 | Splenohepatic arterial steal syndrome in liver transplantation: clinical features and management显示文摘 | Ina Geissler Peter Lamesch Helmut Witzigmann Uwe Jost Johann Hauss Josef Fangmann | 2002 | Transplant International (-)2002，，2： | 1 |
| 18 | Validation and clinical impact of paediatric pressure ulcer risk assessment scales : A systemanc review显示文摘 | Kottner J Hauss A Schl~er AB | 2013 | IntJ Nuts Stud2013，50，6： | 1 |
| 19 | Mutations of p53 Tumor Suppressor Gene, Apoptosis, and Proliferation in Intrahepatic Cholangiocellular Carcinoma of the Liver显示文摘 | Andrea Tannapfel Lars Weinans Felix Gei?ler Alexander Sch?tz Alexander Katalinic Ferdinand K?ckerling Johann Hauss Christian Wittekind | 2000 | Digestive Diseases and Sciences2000，，2： | 1 |
| 20 | Ex situ Operation an der Leber Eine neue M?glichkeit in der Leberchirurgie显示文摘 | R. Pichlmayr H. J. Bretschneider E. Kirchner B. Ringe P. Lamesch G. Gubernatis J. Hauss K. J. Niehaus J. Kaukemüller | 1988 | Langenbecks Archiv für Chirurgie1988，，2： | 1 |
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