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| 1 | Short-term effectiveness of golimumab for ulcerative colitis: Observational multicenter study显示文摘AIM To evaluate the real-world effectiveness of golimumab in ulcerative colitis(UC) and to identify predictors of response.METHODS We conducted an observational, prospective and multi-center study in UC patients treated with golimumab, from September 2014 to September 2015. Clinical activity was assessed at wk 0 and 14 with the physician's global clinical assessment(PGA) and the partial Mayo score. Colonoscopies and blood tests were performed, following daily-practice clinical criteria, and the results were recorded in an SPSS database.RESULTS Thirty-three consecutive patients with moderately to severely active UC were included. Among them, 54.5% were female and 42 years was the average age. Thirty percent had left-sided UC(E2) and 70% had extensive UC(E3). All patients had an endoscopic Mayo score of 2 or 3 at baseline. Twenty-seven point three percent were anti-tumor necrosis factor(TNF) treatment na?ve, whereas 72.7% had previously received infliximab and/or adalimumab. Sixty-nine point seven percent showed clinical response and were steroid-free at wk 14(a decrease from baseline in the partial Mayo score of at least 3 points). Based on PGA, the clinical remission and clinical response rates were 24% and 55% respectively. Withdrawal of corticosteroids was observed in 70.8% of steroid-dependent patients at the end of the study. Three out of 10 clinical non-responders needed a colectomy. Mean fecal calprotectin value at baseline was 300 μg/g, and 170.5 μg/g at wk 14. Being anti-TNF treatment na?ve was a protection factor, which was related to better chances of reaching clinical remission. Twenty-seven point three percent of the patients required treatment intensification at 14 wk of followup. Only three adverse effects(AEs) were observed during the study; all were mild and golimumab was not interrupted.CONCLUSION This real-life practice study endorses golimumab's promising results, demonstrating its short-term effectiveness and confirming it as a safe drug during the induction phase. | Marta Maia Bosca-Watts Xavier Cortes Marisa Iborra Jose Maria Huguet Laura Sempere Gloria Garcia Rafa Gil Mari Fe Garcia Marga Munoz Pedro Almela Nuria Maroto Jose Maria Paredes | 2016 | World Journal of Gastroenterology2016，22，47： | 5 |
| 2 | Brownian Motion and the Temperament of Living Cells显示文摘The migration of living cells usually obeys the laws of Brownian motion.While the latter is due to the thermal motion of the surrounding matter,the locomotion of cells is generally associated with their vitality.We study what drives cell migration and how to model memory effects in the Brownian motion of cells.The concept of temperament is introduced as an effective biophysical parameter driving the motion of living biological entities in analogy with the physical parameter of temperature,which dictates the movement of lifeless physical objects.The locomemory of cells is also studied via the generalized Langevin equation.We explore the possibility of describing cell locomemory via the Brownian self-similarity concept.An heuristic expression for the diffusion coefficient of cells on structured surfaces is derived. | Roumen Tsekov Marga C.Lensen | 2013 | Chinese Physics Letters2013，30，7： | 3 |
| 3 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 4 | Incidence of post- abortion intra- uterine adhesions evaluated by h ysteroscopy- a prospective study显示文摘 | Friedler S Marga~ioth EJ Kafka I | 1993 | Hum Reprod1993，8，3： | 1 |
| 5 | Differentiation of phylogenetically related slowly growing mycobacteria based on 16S - 23S rRNA gene internal transcribed spacer sequences 显示文摘 | Andreas Marga Mohamed | 1998 | J Clin Microbiol1998，36，： | 1 |
| 6 | The effect of repeated treatment with pramipexole on the central dopamine D3 system显示文摘 | J. Maj Z. Rogó? W. Margas M. Kata M. Dziedzicka-Wasylewska | 2000 | Journal of Neural Transmission2000，，12： | 1 |
| 7 | A biologic risk model for stage I lung cancer显示文摘 | Thomas A Marga M James E | 1999 | J Thorac Cardiovasc Surg1999，117，4： | 1 |
| 8 | Classification of hypertension Cardiomyopathy显示文摘 | Iriarte M Marga N Sagastagoitia D et ol | 2001 | Eur Heart J2001，14，： | 1 |
| 9 | Global Spread of Vancomycinresistant Enterococcus faecium from Distinct Nosoeomial Genetic Complex显示文摘 | Rob JLW Janetta T Marga VS | 2005 | Emerging Infectious Diseases2005，11，6： | 1 |
| 10 | Genetic diversity and phylogenetic analysis of glycoprotein 5 of European-type porcine reproductive and respiratory virus strains in Spain 显示文摘 | Enric M Marga M Dolors V | 2003 | J Gen Virol2003，84，： | 1 |
| 11 | Improved production of mannanase by Streptomyces lividans 显示文摘 | Marga F Ghakis C Dupont C | 1996 | Appl and Envir Micro1996，62，12： | 1 |
| 12 | Wettstein/Salmon Debate 显示文摘 | Reimer Marga | 1997 | Pacific Philosophical Quarterly1997，79，： | 1 |
| 13 | Donnellan's Distinction / Kripke's Test 显示文摘 | Reimer Marga | 1998 | Analysis1998，58，2： | 1 |
| 14 | UV curable PSAs augment exiting adhesive technologies显示文摘 | Tom K Jim C Marga A | 1998 | Adhesivesage1998，，7： | 1 |
| 15 | Dynamic modeling of planar parallel robots considering passive joint sensor data显示文摘 | Asier Z Itziar C Marga M | 2010 | Robotica2010，28，5： | 1 |
| 16 | UV curab|e PSAs aug- ment exiting adhesive technologies显示文摘 | TOM K JIM C MARGA A MARK M | 1998 | Adhesives age1998，，7： | 1 |
| 17 | The tributary valley systems of the Almeria Canyon (Alboran Sea, SW Mediterranean) = Sedimentary architecture 显示文摘 | Marga Garcia Belen Alonso Gemma Ercilla | 2006 | Marine Geology2006，226，34： | 1 |
| 18 | Muscarinic acetylcholine receptor modulation of mu(mu)opoid re-ceptors in adult rat sphenopalatine ganglion neurons显示文摘 | Margas W Mahmoud S Ruiz-Vleasco V | 2010 | J Neurophysiol2010，103，1： | 1 |
| 19 | Altered dopamine D2 receptor function and binding in obese OLETF rat 显示文摘 | HAJNAL A MARGAS W M COVASA M | 2008 | Brain Res Bull2008，75，1： | 1 |
| 20 | Influence of occupational low-level lead exposure on renal parameters 显示文摘 | Marga V Anton W Robert H | 1987 | Am J Ind Med1987，12，3： | 1 |
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