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| 1 | Root-Specific Transcript Profiling of Contrasting Rice Genotypes in Response to Salinity Stress显示文摘提高的咸度强加渗透并且离子毒性在生活上强调房间并且要求大量的回答以便启用植物幸存。在在米饭( Oryza sativa )介绍抄本层次的更早的工作上造 FL478 射击,盐容忍的 indica recombinant 生来的线,和 IR29 ,盐敏感的栽培变种,抄本层次在这二就职的根以及在二另外的盐容忍的 indica 遗传型的根被比较, landrace Pokkali 和 recombinant 生来的线 IR63731 。这研究的目的是比较抄本在敏感并且容忍的线以便多半识别基因涉及工厂咸度忍耐,而非响应咸度本身。有到咸度忍耐的已知的连接的几个基因家庭的抄本侧面被描述(例如 HKT, NHX ) 。通过他们的盐应答,抄本层次,或 chromosomal 地点识别的一套基因的通常认为的功能(即在为咸度忍耐的 QTL 下面) 也被讨论。最后,在 FL478 的 Saltol 区域的父母起源进一步被调查。总的来说,介绍的数据集看起来柔韧,这个系统能为涉及咸度忍耐的新奇基因的发现提供可靠策略,似乎可能。 | Olivier Cotsaftis Darren Plett Alexander A.T. Johnson Harkamal Walia Clyde Wilson Abdelbagi M. Ismail Timothy J. Close Mark Tester Ute Baumann | 2011 | Molecular Plant2011，4，1： | 14 |
| 2 | Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages显示文摘Background: Acute lung injury(ALI) is a major component of multiple organ dysfunction syndrome(MODS) following pulmonary and systemic infection. Alveolar macrophages(AMφ) are at the center of ALI pathogenesis. Emerging evidence has shown that cell-cell interactions in the lungs play an important regulatory role in the development of acute lung inflammation. However, the underneath mechanisms remain poorly addressed. In this study, we explore a novel function of lung epithelial cells(LEPCs) in regulating the release of exosomes from AMφ following LPS stimulation.Methods: For the in vivo experiments, C57 BL/6 wildtype(WT) mice were treated with lipopolysaccharide(LPS)(2 mg/kg) in 0.2 ml of saline via intratracheal aerosol administration. Bronchoalveolar lavage fluid was collected at 0–24 h after LPS treatment, and exosomes derived from AMφ were measured. For the in vitro studies, LEPCs and bone marrowderived Mφ(BMDM) were isolated from WT or TLR4-/-mice and were then cocultured in the Transwell? system. After coculture for 0–24 h, the BMDM and supernatant were harvested for the measurement of exosomes and cytokines.Results: We demonstrate that LPS induces macrophages(Mφ) to release exosomes, which are then internalized by neighboring Mφ to promote TNF-α expression. The secreted interleukin(IL)-25 from LEPCs downregulates Rab27 a and Rab27 b expression in Mφ, resulting in suppressed exosome release and thereby attenuating exosome-induced TNF-α expression and secretion.Conclusion: These findings reveal a previously unidentified crosstalk pathway between LEPCs and Mφ that negatively regulates the inflammatory responses of Mφ to LPS. Modulating IL-25 signaling and targeting exosome release may present a new therapeutic strategy for the treatment of ALI. | Zhi-Gang Li Melanie J. Scott Tomasz Brzóska Prithu Sundd Yue-Hua Li Timothy R. Billiar Mark A. Wilson Ping Wang Jie Fan | 2018 | Military Medical Research2018，5，4： | 5 |
| 3 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 4 | Magnetic resonance imaging and multi-detector computed tomography assessment of extracellular compartment in ischemic and non-ischemic myocardial pathologies显示文摘Myocardial pathologies are major causes of morbidity and mortality worldwide. Early detection of loss of cellular integrity and expansion in extracellular volume(ECV) in myocardium is critical to initiate effective treatment. The three compartments in healthy myocardium are: intravascular(approximately 10% of tissue volume), interstitium(approximately 15%) and intracellular(approximately 75%). Myocardial cells, fibroblasts and vascular endothelial/smooth muscle cells represent intracellular compartment and the main proteins in the interstitium are types Ⅰ/Ⅲ collagens. Microscopic studies have shown that expansion of ECV is an important feature of diffuse physiologic fibrosis(e.g., aging and obesity) and pathologic fibrosis [heart failure, aortic valve disease, hypertrophic cardiomyopathy, myocarditis, dilated cardiomyopathy, amyloidosis, congenital heart disease, aortic stenosis, restrictive cardiomyopathy(hypereosinophilic and idiopathic types), arrythmogenic right ventricular dysplasia and hypertension]. This review addresses recent advances in measuring of ECV in ischemic and non-ischemic myocardial pathologies. Magnetic resonance imaging(MRI) has the ability to characterize tissue proton relaxation times(T1, T2, and T2*). Proton relaxation times reflect the physical and chemical environments of water protons in myocardium. Delayed contrast enhanced-MRI(DE-MRI) and multi-detector computed tomography(DE-MDCT) demonstrated hyper-enhanced infarct, hypo-enhanced microvascular obstruction zone and moderately enhanced peri-infarct zone, but are limited for visualizing diffuse fibrosis and patchy microinfarct despite the increase in ECV. ECV can be measured on equilibrium contrast enhanced MRI/MDCT and MRI longitudinal relaxation time mapping. Equilibrium contrast enhanced MRI/MDCT and MRI T1 mapping is currently used, but at a lower scale, as an alternative to invasive sub-endomyocardial biopsies to eliminate the need for anesthesia, coronary catheterization and possibility of tissue sampling error. Similar to delayed contrast enhancement, equilibrium contrast enhanced MRI/MDCT and T1 mapping is completely noninvasive and may play a specialized role in diagnosis of subclinical and other myocardial pathologies. DE-MRI and when T1-mapping demonstrated sub-epicardium, sub-endocardial and patchy mid-myocardial enhancement in myocarditis, Behcet's disease and sarcoidosis, respectively. Furthermore, recent studies showed that the combined technique of cine, T2-weighted and DE-MRI technique has high diagnostic accuracy for detecting myocarditis. When the tomographic techniques are coupled with myocardial perfusion and left ventricular function they can provide valuable information on the progression of myocardial pathologies and effectiveness of new therapies. | Maythem Saeed Steven W Hetts Robert Jablonowski Mark W Wilson | 2014 | World Journal of Cardiology2014，6，11： | 4 |
| 5 | 卒中一级预防指南美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议,包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外,本指南还提供了针对遗传和药理学检测以及在其他特殊情况下(包括镰状细胞疾病和卵圆孔未闭)进行卒中预防的建议。 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Edward C. Jauch Wesley S. Moore John A. Wilson 李迪 高一鹭 陈政弘 霍晓川 孙海欣 孙冬玲 茹小娟 江滨 | 2015 | 国际脑血管病杂志2015，23，6： | 4 |
| 6 | Bio-inspired carbon electro-catalysts for the oxygen reduction reaction显示文摘We report the synthesis, characterisation and catalytic performance of two nature-inspired biomassderived electro-catalysts for the oxygen reduction reaction in fuel cells. The catalysts were prepared via pyrolysis of a real food waste(lobster shells) or by mimicking the composition of lobster shells using chitin and CaCO_3 particles followed by acid washing. The simplified model of artificial lobster was prepared for better reproducibility. The calcium carbonate in both samples acts as a pore agent, creating increased surface area and pore volume, though considerably higher in artificial lobster samples due to the better homogeneity of the components. Various characterisation techniques revealed the presence of a considerable amount of hydroxyapatite left in the real lobster samples after acid washing and a low content of carbon(23%), nitrogen and sulphur(<1%), limiting the surface area to 23 m^2/g, and consequently resulting in rather poor catalytic activity. However, artificial lobster samples, with a surface area of ≈200 m^2/g and a nitrogen doping of 2%, showed a promising onset potential, very similar to a commercially available platinum catalyst, with better methanol tolerance, though with lower stability in long time testing over 10,000 s. | Kathrin Preuss Vasanth Kumar Kannuchamy Adam Marinovic Mark Isaacs Karen Wilson Isaac Abrahams Maria-Magdalena Titirici | 2016 | Journal of Energy Chemistry2016，25，2： | 3 |
| 7 | 金龙鱼(Scleropages:Osteoglossomorpha)化石的首次发现(英文)显示文摘金龙鱼化石的鳞片和骨骼碎片在过去时有报道,但鉴定并非十分可靠,因为在骨舌鱼科鱼类中这些鳞片和骨骼十分相似。首次记述了保存完美的金龙鱼化石,标本产于湖南湘乡下湾铺组和湖北松滋洋溪组,确立为骨舌鱼科金龙鱼属一新种:中华金龙鱼Scleropages sinensis sp.nov.。新种与现生金龙鱼(Scleropages)在头部骨骼、尾骨骼、各鳍的形状和位置以及具有网状鳞片等方面极为相似,因而归入该属。然而,新种在以下特征上不同于金龙鱼的现生种:鼻骨无纹饰,鼻骨上的感觉管显露于沟内,感觉管联合不经过顶骨,翼耳骨侧向加厚,眶前骨上的感觉孔大,眼眶后的眶下骨不完全覆盖前鳃盖骨上支,其宽高比例为0.75而非现生种的1–1.2,前鳃盖骨后下角变尖,鳃盖骨后下缘凹形、下端变尖,匙骨背突长大,脊椎46–48,椎体横突短小,胸鳍十分长大,上下两端的尾鳍条和内部鳍条等长。亚洲的现生种发现于各种河流和小溪中,比较喜欢水草茂盛的静水环境,一般游弋于表层水中,以鱼虾、昆虫等为食,新种中华金龙鱼也应该有相似的生长环境和食性。新种似具有性二形性,雄鱼体形略纤细,头部略大,口裂更深。中华金龙鱼化石的发现,说明金龙鱼属(Scleropages)和骨舌鱼属(Osteoglossum)在早始新世以前就已经分化,这对解释骨舌鱼类的跨洋分布具有十分重要的意义。 | 张江永 Mark V H WILSON | 2017 | 古脊椎动物学报2017，55，1： | 3 |
| 8 | Ethnicity and nonalcoholic fatty liver disease显示文摘 | Kiran Bambha Patricia Belt Maria Abraham Laura A. Wilson Mark Pabst Linda Ferrell Aynur Unalp‐Arida Nathan Bass | 2012 | Hepatology2012，，： | 2 |
| 9 | 在指导图象的身体干预的先生对比媒介的价值显示文摘 In the past few years,there have been multiple advances in magnetic resonance (MR) instrumentation,in vivo devices,real-time imaging sequences and interventional procedures with new therapies.More recently,interventionists have started to use minimally invasive image-guided procedures and local therapies,which reduce the pain from conventional surgery and increase drug effectiveness,respectively.Local therapy also reduces the systemic dose and eliminates the toxic side effects of some drugs to other organs.The success of MR-guided procedures depends on visualization of the targets in 3D and precise deployment of ablation catheters,local therapies and devices.MR contrast media provide a wealth of tissue contrast and allows 3D and 4D image acquisitions.After the development of fast imaging sequences,the clinical applications of MR contrast media have been substantially expanded to include pre-during-and post-interventions.Prior to intervention,MR contrast media have the potential to localize and delineate pathologic tissues of vital organs,such as the brain,heart,breast,kidney,prostate,liver and uterus.They also offer other options such as labeling therapeutic agents or cells.During intervention,these agents have the capability to map blood vessels and enhance the contrast between the endovascular guidewire/catheters/devices,blood and tissues as well as direct therapies to the target.Furthermore,labeling therapeutic agents or cells aids in visualizing their delivery sites and tracking their tissue distribution.After intervention,MR contrast media have been used for assessing the efficacy of ablation and therapies.It should be noted that most image-guided procedures are under preclinical research and development.It can be concluded that MR contrast media have great value in preclinical and some clinical interventional procedures.Future applications of MR contrast media in image-guided procedures depend on their safety,tolerability,tissue specificity and effectiveness in demonstrating success of the interventions and therapies. | Maythem Saeed Mark Wilson | 2012 | World Journal of Radiology2012，4，1： | 2 |
| 10 | Earnings management and cross listing: Are reconciled earnings comparable to US earnings?显示文摘 | Mark Lang Jana Smith Raedy Wendy Wilson | 2006 | Journal of Accounting and Economics2006，，1： | 2 |
| 11 | Colitis and Intestinal Inflammation in IL10 ?/? Mice Results From IL-13Rα2–Mediated Attenuation of IL-13 Activity显示文摘 | Mark S. Wilson Thirumalai R. Ramalingam Aymeric Rivollier Kevin Shenderov Margaret M. Mentink–Kane Satish K. Madala Allen W. Cheever David Artis Brian L. Kelsall Thomas A. Wynn | 2011 | Gastroenterology2011，，1： | 2 |
| 12 | Evolution in the Management of Hepatic Trauma: A 25-Year Perspective显示文摘 | J. David Richardson Glen A. Franklin James K. Lukan Eddy H. Carrillo David A. Spain Frank B. Miller Mark A. Wilson Hiram C. Polk Lewis M. Flint | 2000 | Annals of Surgery2000，，3： | 2 |
| 13 | Predictors of Comprehension during Surgical Informed Consent显示文摘 | Aaron S. Fink Allan V. Prochazka William G. Henderson Debra Bartenfeld Carsie Nyirenda Alexandra Webb David H. Berger Kamal Itani Thomas Whitehill James Edwards Mark Wilson Cynthia Karsonovich Patricia Parmelee | 2010 | Journal of the American College of Surgeons2010，，6： | 1 |
| 14 | Real-time landslide warning during heavy rainfall显示文摘 | Keefer D K Wilson R C Mark R K | 1987 | Science1987，238，： | 1 |
| 15 | Real-time landslide warning during heavy rainfall显示文摘 | Keefer D K Wilson R C Mark RK | 1987 | Science1987，238，： | 1 |
| 16 | A Randomised Trial Comparing Holmium Laser Enucleation Versus Transurethral Resection in the Treatment of Prostates Larger Than 40Grams: Results at 2 Years显示文摘 | Liam C. Wilson Peter J. Gilling Andrew Williams Katie M. Kennett Chris M. Frampton Andre M. Westenberg Mark R. Fraundorfer | 2006 | European Urology2006，，： | 1 |
| 17 | Management of Portal Venous Complications After Liver Transplantation显示文摘 | David H. Woo Jeanne M. LaBerge Roy L. Gordon Mark W. Wilson Robert K. Kerlan | 2007 | Techniques in Vascular and Interventional Radiology2007，，3： | 1 |
| 18 | Real-time landslide warning during heavy rainfall显示文摘 | Keefer K D Wilson C R Mark K R | 1987 | Science1987，238，： | 1 |
| 19 | Real-time landslide warning during heavy rainfall显示文摘 | Keefer D K Wilson R C Mark R K | 1987 | Science1987，238，： | 1 |
| 20 | Real-time landslide warning during heavy rainfall 显示文摘 | Keefer D K Wilson R C Mark R K | 1987 | Science1987，238，： | 1 |
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