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| 1 | Bile acid receptors and nonalcoholic fatty liver disease显示文摘With the high prevalence of obesity, diabetes, and otherfeatures of the metabolic syndrome in United States, nonalcoholic fatty liver disease(NAFLD) has inevitably become a very prevalent chronic liver disease and is now emerging as one of the leading indications for liver transplantation. Insulin resistance and derangement of lipid metabolism, accompanied by activation of the pro-inflammatory response and fibrogenesis, are essential pathways in the development of the more clinically significant form of NAFLD, known as nonalcoholic steatohepatitis(NASH). Recent advances in the functional characterization of bile acid receptors, such as farnesoid X receptor(FXR) and transmembrane G protein-coupled receptor(TGR) 5, have provided further insight in the pathophysiology of NASH and have led to the development of potential therapeutic targets for NAFLD and NASH. Beyond maintaining bile acid metabolism, FXR and TGR5 also regulate lipid metabolism, maintain glucose homeostasis, increase energy expenditure, and ameliorate hepatic inflammation. These intriguing features have been exploited to develop bile acid analogues to target pathways in NAFLD and NASH pathogenesis. This review provides a brief overview of the pathogenesis of NAFLD and NASH, and then delves into the biological functions of bile acid receptors, particularly with respect to NASH pathogenesis, with a description of the associated experimental data, and, finally, we discuss the prospects of bile acid analogues in the treatment of NAFLD and NASH. | Liyun Yuan Kiran Bambha | 2015 | World Journal of Hepatology2015，7，28： | 15 |
| 2 | Ethnicity and nonalcoholic fatty liver disease显示文摘 | Kiran Bambha Patricia Belt Maria Abraham Laura A. Wilson Mark Pabst Linda Ferrell Aynur Unalp‐Arida Nathan Bass | 2012 | Hepatology2012，，： | 2 |
| 3 | Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation显示文摘 | Scott W. Biggins James Trotter Jane Gralla James R. Burton Kiran M. Bambha Jennifer Dodge Megan Brocato Linling Cheng Matt McQueen Lisa Forman Michael Chang Igal Kam Gregory Everson Richard A. Spritz Goran Klintmalm Hugo R. Rosen | 2013 | Journal of Hepatology2013，，5： | 2 |
| 4 | Incidence,clinical spectrum,and outcomes of primary sclerosing cholangitis in a United States community显示文摘 | BAMBHA K KIM WR TALWALKAR J | 2003 | Gastroenterology2003，125，5： | 1 |
| 5 | Predicting survival among patients listed for liver transplantation:an assessment of serial MELD measurements显示文摘 | Bambha K Kim WR Kremers WK | 2004 | Am J Transplant2004，4，： | 1 |
| 6 | Predictors of early rebleed-ing and mortality after acute variceal haemorrhage in patients withcirrhosis显示文摘 | Bambha K Kim WR Pedersen R | 2008 | Gut2008，57，6： | 1 |
| 7 | Assessing mortality in women withhepatitis C virus and HIV using indirect markers of fibrosis 显示文摘 | Bambha K Pierce C Cox C | 2012 | AIDS2012，26，5： | 1 |
| 8 | Incidence,clinical spectrum,and outcomes of primary sclerosing cholangitis in a United States community显示文摘 | Bambha K Kim WR Talwalkar J | 2004 | Gastroenterology2004，126，7： | 1 |
| 9 | MELD-based liver allocation: Who is underserved?显示文摘 | Biggins SW Bambha K | 2006 | Semin Liver Dis2006，26，3： | 1 |
| 10 | MELD-based liver allocation: who is un-derserved? 显示文摘 | Biggins SW Bambha K | 2006 | Seminars in Liver Disease2006，26，3： | 1 |
| 11 | Predictor of earlyrebleeding and mortality after acute variceal haemorrhage in patients with cirrhosis显示文摘 | BAMBHA K KIM WR PEDERSEN R | 2008 | Gut2008，57，6： | 1 |
| 12 | Incidence,clinical spectrum,and outcomes of primary sclerosing cholangitis in a United States community显示文摘 | Bambha K Kim WR Talwalkar J | 2003 | Gastroenterology2003，125，： | 1 |
| 13 | Intermediate representations for design automation of multiprocessor DSP sys- tems显示文摘 | BAMBHA N KIANZAD V KHANDELIA M | 2002 | Design Automation for Embedded Systems2002，7，4： | 1 |
| 14 | Predictors of early re- bleeding and mortality after acute variceal haemorrhage in patientswith cirrhosis显示文摘 | Bambha K Kim WR Pedersen R | 2008 | Gut2008，57，6： | 1 |
| 15 | Predictors of early re-bleed- ing andmortality after acute variceal haemorrhage in patients with cir- rhosis显示文摘 | K Bambha WR Kim R Pedersen | 2008 | Gut2008，57，6： | 1 |
| 16 | Predictors of early rebleeding and mortality after acute variceal haemorrhage in patients with cirrhosis显示文摘 | Bambha K Kim W R Pedersen R | 2008 | Gut2008，57，6： | 1 |
| 17 | Fatty liver:think globally显示文摘 | Everhart J E Bambha K M | 2010 | Hepatology2010，51，5： | 1 |
| 18 | Predictors of rebleeding and mortality following acute variceal hemorrhage in patients with cirrhosis显示文摘 | Bambha K Kim WR Pedersen RA | 2008 | Gut2008，57，： | 1 |
| 19 | Predictors of early re-bleeding and mortality after acute variceal haemorrhage in patients with cirrhosis 显示文摘 | Bambha K Kim W R Pedersen R | 2008 | Gut2008，57，6： | 1 |
| 20 | Predictors of early rebleeding and mortality after acute variceal haemorrhage in patients with cirrhosis显示文摘 | BAMBHA K KIM WR PEDERSEN R | 2008 | Gut2008，57，： | 1 |
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