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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Surgical treatment for liver cancer显示文摘Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a high risk,resource intensive procedure with limited application,to a safe and commonly performed operation with a range of indications. This article reviews the approach to surgical resection for malignancies such as hepatocellular cancer,metastatic liver de-posits and neuroendocrine tumors. Survival data after resection is also reviewed,as well as indications for curative resection. | Nicole C Tsim Adam E Frampton Nagy A Habib Long R Jiao | 2010 | World Journal of Gastroenterology2010，16，8： | 12 |
| 3 | Survival outcomes of cemented compared to uncemented stems in primary total hip replacement显示文摘Total hip replacement(THR) is a successful and reliable operation for both relieving pain and improving function in patients who are disabled with end stage arthritis.The ageing population is predicted to significantly increase the requirement for THR in patients who have a higher functional demand than those of the past. Uncemented THR was introduced to improve the long term results and in particular the results in younger, higher functioning patients. There has been controversy about the value of uncemented compared to cemented THR although there has been a world-wide trend towards uncemented fixation. Uncemented acetabular fixation has gained wide acceptance, as seen in the increasing number of hybrid THR in joint registries, but there remains debate about the best mode of femoral fixation.In this article we review the history and current worldwide registry data, with an in-depth analysis of the New Zealand Joint Registry, to determine the results of uncemented femoral fixation in an attempt to provide an evidence-based answer as to the value of this form of fixation. | Michael Wyatt Gary Hooper Christopher Frampton Alastair Rothwell | 2014 | World Journal of Orthopedics2014，5，5： | 4 |
| 4 | 王维仁的建筑显示文摘每隔一段时间,当一个新的建筑师走向世界舞台前沿,他的作品整体往往以一种超乎意料的方式,一步一步地逐渐呈现,宛如一种独特的建筑想象;作品里面所蕴涵特有的丰富和活力,甚至出乎建筑师本人的意料,而位于香港的王维仁正是这样一位建筑师。 | Kenneth Frampton | 2011 | 城市环境设计2011，，9： | 3 |
| 5 | Aberrant DNA methylation profile in cholangiocarcinoma显示文摘Cholangiocarcinoma(CCA)is a notoriously lethal epith-elial cancer originating from the biliary system.As radical resection offers a poor success rate and limited effective adjuvant modalities exist in its advanced stage,the disease leads to a fairly poor prognosis.As the incidence of CCA is increasing,although the mortality rate remains stable,and few other definite etiologies have yet to be established,renewing our knowledge of its fundamental carcinogenesis is advisable.The latest advances in molecular carcinogenesis have highlighted the roles of epigenetic perturbations and cancer-related inflammation in CCA.This review focuses on the reciprocal effects between aberrant DNA methylation and inflammatory microenvironment in CCA. | Gabriel Frampton Sharon DeMorrow | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 3 |
| 6 | Short-Term Outcomes of the Australasian Randomized Clinical Study Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The ALCCaS Trial显示文摘 | Peter J. Hewett Randall A. Allardyce Philip F. Bagshaw Christopher M. Frampton Francis A. Frizelle Nicholas A. Rieger J Shona Smith Michael J. Solomon Jacqueline H. Stephens Andrew R. L. Stevenson | 2008 | Annals of Surgery2008，，5： | 3 |
| 7 | Energy use associated with different travel choices显示文摘 | Susanne Becken David G Simmons Chris Frampton | 2002 | Tourism Management2002，，3： | 2 |
| 8 | 18F-fluorodeoxyglucose positron emission tomography in management of pancreatic cystic tumors显示文摘 | Yaojun Zhang Adam E. Frampton Jack L. Martin Charis Kyriakides Jan Jin Bong Nagy A. Habib Panagiotis Vlavianos Long R. Jiao | 2012 | Nuclear Medicine and Biology2012，，7： | 2 |
| 9 | Energy consumption patterns in the accommodation sector—the New Zealand case显示文摘 | Susanne Becken Chris Frampton David Simmons | 2001 | Ecological Economics2001，，3： | 2 |
| 10 | Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans 显示文摘 | FRAMPTON M W STEWART J C OBERDORSTER G | 2006 | Environ Health Perspect2006，114，1： | 1 |
| 11 | Improving risk stratifica-tion for heart failure a role for serial testing of B-type natriuretic peptides显示文摘 | Daly MG Frampton CM Troughton RW | 2010 | J Am Coll Cardiol2010，55，5： | 1 |
| 12 | Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptiole(N-BNP) concetrations显示文摘 | Troughtou RW Frampton CM Yandle TG | 2000 | Lancet2000，355，9210： | 1 |
| 13 | Solution- pro- cessable Red Phosphorescent Dendrimers for Light - Emitting Device Applications 显示文摘 | Anthopoulos T D Frampton M J Namdas E B | 2004 | Adv Mater2004，16，： | 1 |
| 14 | Brain natriuretic peptide and n-terminal brain natriuretic peptide in the diagnosis of heart failure in patients with acute shortness of breath显示文摘 | Lainchbury JG Campbell E Frampton CM | 2003 | J Am Coll Cardiol2003，42，4： | 1 |
| 15 | Polymorphism at the ovine β3-adrenergic receptor locus (ADRB3) and its association with lamb mortality 显示文摘 | Forrest RH Hickford JGH Frampton CM | 2007 | J Anim Sci2007，85，11： | 1 |
| 16 | Microfluidic systems: A new toolbox for pluripotent stem cells显示文摘 | Sasha Cai Lesher‐Perez John P. Frampton Shuichi Takayama | 2012 | Biotechnology Journal2012，，2： | 1 |
| 17 | Energy use associated with different travel choices 显示文摘 | Becken S Simmons D Frampton C | 2003 | Tourism Management2003，24，3： | 1 |
| 18 | Australasian Laparoscopic Colon Cancer Study shows that elderly patients may benefit from lower postoperative complication rates following laparoscopic versus open resection显示文摘 | Allardyce RA Bagshaw PF Frampton CM | | 0，，01： | 1 |
| 19 | Energy consumption patterns in the accommodation sector—the New Zealand case显示文摘 | Susanne Becken Chris Frampton David Simmons | 2001 | Ecological Economics2001，，3： | 1 |
| 20 | Prospective, multi-centretrial of mortality following general or spinal anaesthesia for hip fracturesurgery in the elderly 显示文摘 | Davis FM Woolner DF Frampton C | 1987 | Br J Anaesth1987，59，9： | 1 |
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