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| 1 | Spatial Distribution of Large-scale Landslides Induced by the 5.12 Wenchuan Earthquake显示文摘The 5.12 Wenchuan Earthquake in 2008 induced hundreds of large-scale landslides. This paper systematically analyzes 112 large-scale landslides (surface area > 50000 m2), which were identified by interpretation of remote sensing imagery and field investigations. The analysis suggests that the distribution of large-scale landslides is affected by the following four factors: (a) distance effect: 80% of studied large-scale landslides are located within a distance of 5 km from the seismic faults. The farther the distance to the faults, the lower the number of large-scale landslides; (b) locked segment effect: the large-scale landslides are mainly located in five concentration zones closely related with the crossing, staggering and transfer sections between one seismic fault section and the next one, as well as the end of the NE fault section. The zone with the highest concentration was the Hongbai-Chaping segment, where a great number of large-scale landslides including the two largest landslides were located. The second highest concentration of large-scale landslides was observed in the Nanba-Donghekou segment at the end of NE fault, where the Donghekou landslide and the Woqian landslide occurred; (c) Hanging wall effect: about 70% of the large-scale landslides occurred on the hanging wall of the seismic faults; and (d) direction effect: in valleys perpendicular to the seismic faults, the density of large-scale landslides on the slopes facing the seismic wave is obviously higher than that on the slopes dipping in the same direction as the direction of propagation of the seismic wave. Meanwhile, it is found that the sliding and moving directions of large-scale landslides are related to the staggering direction of the faults in each section. In Qingchuan County where the main fault activity was horizontal twisting and staggering, a considerable number of landslides showed the feature of sliding and moving in NE direction which coincides with the staggering direction of the seismic faults. | XU Qiang ZHANG Shuai LI Weile | 2011 | Journal of Mountain Science2011，8，2： | 21 |
| 2 | Safety and Efficacy of Physical Thermal Ablation Combined Sorafenib for Hepatocellular Carcinoma:A Meta-analysis显示文摘Background and Aims:To compare the efficacy and safety of physical thermal ablation(PTA),including radiofrequency ablation(RFA)and microwave ablation(MWA),combined with sorafenib and physical thermal ablation alone for the control and treatment of hepatocellular carcinoma(HCC)according to the available literature.Methods:Comprehensive searches were performed on PubMed,Embase,CNKI,the Cochrane Library,China Biomedical Literature Database(known as CBM),Weipu Journal,and Wanfang Database.Meta-analysis was performed using Revman 5.3 software.Results:A total of 15 studies,consisting of 2,227 HCC patients,were selected and included in this meta-analysis.Compared with the RFA-alone group,the patients in the RFA+sorafenib group had longer 1-,2-,and 3-year overall survival(all p<0.05),better overall efficacy(p<0.0001),longer radiofrequency interval(p<0.001),and lower 2-year recurrence rate(p=0.02).The 1-year overall survival(p=0.003)and overall efficacy(p=0.002)of the MWA+sorafenib group were also higher than those of the MWA-alone group.The incidences of adverse reactions in the RFA+sorafenib group,such as hand-foot skin reactions(p<0.001),diarrhea and constipation(p=0.0001),hypertension(p=0.009),and alopecia(p<0.001),were significantly higher than those in the RFA-alone group.Conclusions:RFA or MWA combined with sorafenib has produced a better therapeutic effect on HCC than physical thermal ablation alone;however,adverse reactions have been obvious.It is necessary to evaluate the safety of combination therapy,and pay close attention to the adverse reactions that develop in patients. | Mengdi Jin Qiong Yu Yahui Liu Weiling Xu Xueqi Fu Bai Ji | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 6 |
| 3 | Geohazard Recognition and Inventory Mapping Using Airborne LiDAR Data in Complex Mountainous Areas显示文摘Geohazard recognition and inventory mapping are absolutely the keys to the establishment of reliable susceptibility and hazard maps. However, it has been challenging to implement geohazards recognition and inventory mapping in mountainous areas with complex topography and vegetation cover. Progress in the light detection and ranging(Li DAR) technology provides a new possibility for geohazard recognition in such areas. Specifically, this study aims to evaluate the performances of the Li DAR technology in recognizing geohazard in the mountainous areas of Southwest China through visually analyzing airborne Li DAR DEM derivatives. Quasi-3 D relief image maps are generated based on the sky-view factor(SVF), which makes it feasible to interpret precisely the features of geohazard. A total of 146 geohazards are remotely mapped in the entire 135 km^(2) study area in Danba County, Southwest China, and classified as landslide, rock fall, debris flow based on morphologic characteristics interpreted from SVF visualization maps. Field validation indicate the success rate of Li DAR-derived DEM in recognition and mapping geohazard with higher precision and accuracy. These mapped geohazards lie along both sides of the river, and their spatial distributions are related highly to human engineering activities, such as road excavation and slope cutting. The minimum geohazard that can be recognized in the 0.5 m resolution DEM is about 900 m^(2). Meanwhile, the SVF visualization method is demonstrated to be a great alternative to the classical hillshaded DEM method when it comes to the determination of geomorphological properties of geohazard. Results of this study highlight the importance of Li DAR data for creating complete and accurate geohazard inventories, which can then be used for the production of reliable susceptibility and hazard maps and thus contribute to a better understanding of the movement processes and reducing related losses. | Chen Guo Qiang Xu Xiujun Dong Weile Li Kuanyao Zhao Huiyan Lu Yuanzhen Ju | 2021 | Journal of Earth Science2021，32，5： | 6 |
| 4 | Effect of CeO_2 preparation method and Cu loading on CuO/CeO_2 catalysts for methane combustion显示文摘CeO2 was synthesized by sol-gel,hydrothermal,nitrate thermal decomposition methods,respectively,and used as support to prepare CuO/CeO2 catalysts. According to characterization and reaction results,preparation method of CeO2 had a great influence on the physicochemical properties and activities of CuO/CeO2 catalysts. CuO with high dispersion and strong interaction with CeO2 was highly active in methane combustion,while CuO particles less associated with CeO2 showed less activity. The CuO catalyst supported on CeO2 which was prepared via nitrate thermal decomposition method showed the largest area,the smallest particle size,the highest dispersion of copper species and strong support metal interactions. Therefore,it presented the highest redox ability and activity for methane combustion. Activities of the catalysts with different copper content kept increasing until 5% Cu loading and from then on kept constant. Moreover,methane conversion decreased as methane space velocities increased on CuO/CeO2 catalyst. Addition of CO2 to the feed did not produce a significant effect on the catalytic activity,but the presence of H2O provoked a remarkable decrease on the activity of CuO/CeO2 catalyst. | Weiling Yang Dao Li Dongmei Xu Xingyi Wang | 2009 | Journal of Natural Gas Chemistry2009，18，4： | 6 |
| 5 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 6 | Active Landslide Detection Based on Sentinel-1 Data and InSAR Technology in Zhouqu County, Gansu Province, Northwest China显示文摘Zhouqu County in Gansu Province, Northwest China, is typically highly prone to landslides. On July 12, 2018, a landslide blocked the Bailong River near Zhouqu County, posing a serious threat to the life and property of local residents and the safety of infrastructure. Small baseline subset interferometry synthetic aperture radar technology(SBAS-In SAR) was adopted to identify the potential active landslides in the surrounding area of Zhouqu County, using ascending and descending orbit Sentinel-1 satellite images taken from October 2017 to December 2018. The surface deformation areas detected by SBAS-In SAR were verified by optical remote sensing image interpretation and field investigation, and a total of 23 active landslides were identified finally. The deformation characteristics of four typical landslides are analysed in detail using deformation velocity and rainfall data. It is found that the deformation velocity of landslides in this area is mainly affected by rainfall and there is a lag effect. The results can provide a reference for the prevention and control of landslide risk in Zhouqu County. | Cong Dai Weile Li Dong Wang Huiyan Lu Qiang Xu Ji Jian | 2021 | Journal of Earth Science2021，32，5： | 3 |
| 7 | Significance of the lymph nodes in the 7th station in rational dissection for metastasis of distal gastric cancer with different T categories显示文摘Objective: To determine the clinicopathological characteristics, and evaluate the appropriate extent of lymph node dissection in distal gastric cancer patients with comparable T category.Methods: A retrospective study was conducted on 570 distal gastric cancer patients, who underwent gastric resection with D2 nodal dissection, which was performed by the same surgical team from January 1997 to January 2011. We compared the differences in lymph node metastasis rates and metastatic lymph node ratios between different T categories. Additionally, we investigated the impact of lymph node metastasis in the 7th station on survival rate of distal gastric cancer patients with the same TNM staging.Results: Among the 570 patients, the overall lymph node metastasis rate of advanced distal gastric cancer was 78.1%, and the metastatic lymph node ratio was 27%. The lymph node metastasis rate in the 7th station was similar to that of perigastric lymph nodes. There was no statistical significance in patients with the same TNM stage(stage II and III), irrespective of the metastatic status in the 7th station.Conclusions: Our results suggest that to a certain extent, it is reasonable to include lymph nodes in the 7th station in the D1 lymph node dissection. | Wu Song Yulong He Shaochuan Wang Weiling He Jianbo Xu | 2014 | Chinese Journal of Cancer Research2014，26，4： | 3 |
| 8 | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy显示文摘Polyetheretherketone(PEEK)has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance.However,its biological inertness,poor osteoinduction,and weak antibacterial activity make the clinical applications in a dilemma.Inspired by the mussel adhesion mechanism,here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins(Mfps)-mimic peptide with clickable azido terminal.The peptide enables mussel-like adhesion on PEEK biomaterial surfaces,leaving azido groups for the further steps of biofunctionalizations.In this study,antimicrobial peptide(AMP)and osteogenic growth peptide(OGP)were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair.Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios,an optimal PEEK surface was finally obtained in this research,which could long-term inhibit bacterial growth,stabilize bone homeostasis and facilitate interfacial bone regeneration.In a word,this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants,in particular,achieving rational integration of multiple biofunctions to match clinical requirements. | Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng | 2022 | Bioactive Materials2022，7，2： | 2 |
| 9 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 10 | A Comparative Study of Supervised Classification Methods for Investigating Landslide Evolution in the Mianyuan River Basin,China显示文摘The Ms8.0 Wenchuan earthquake of 2008 dramatically changed the terrain surface and caused long-term increases in the scale and frequency of landslides and debris flows.The changing trend of landslides in the earthquake-affected area over the decade since the earthquake remains largely unknown.In this study,we were able to address this issue using supervised classification methods and multitemporal remote sensing images to study landslide evolution in the worst-affected area(Mianyuan River Basin)over a period of ten years.Satellite images were processed using the maximum likelihood method and random forest algorithm to automatically map landslide occurrence from 2007 to 2018.The principal findings are as follows:(1)when compared with visual image analysis,the random forest algorithm had a good average accuracy rate of 87%for landslide identification;(2)postevent landslide occurrence has generally decreased with time,but heavy monsoonal seasons have caused temporary spikes in activity;and(3)the postearthquake landslide activity in the Mianyuan River Basin can be divided into a strong activity period(2008 to 2011),medium activity period(2012 to 2016),and weak activity period(post 2017).Landslide activity remains above the prequake level,with damaging events being rare but continuing to occur.Long-term remote sensing and on-site monitoring are required to understand the evolution of landslide activity after strong earthquakes. | Yujie Long Weile Li Runqiu Huang Qiang Xu Bin Yu Gang Liu | 2023 | Journal of Earth Science2023，34，2： | 2 |
| 11 | Chemical equilibrium modeling of copper precipitation in hyper-concentrated solid-Liquid system 显示文摘 | Xu Nan Sun Weiling and Ni Jinren | 2003 | Hydrobiologia2003，494，13： | 1 |
| 12 | A distinct lineage of influenza A virus from bats显示文摘 | Tong S Li Y Rivailler P Conrardy C Castillo D A Chen L M Recuenco S Ellison J A Davis C T York I A Turmelle A S Moran D Rogers S Shi M Tao Y Weil M R Tang K Rowe L A Sammons S Xu X Frace M Lindblade K A Cox N J Anderson L J Rupprecht C E Donis R O | 2012 | PANS2012，109，11： | 1 |
| 13 | A Writable Polypeptide–DNA Hydrogel with Rationally Designed Multi‐modification Sites显示文摘 | Chuang Li Ping Chen Yu Shao Xu Zhou Yuzhou Wu Zhongqiang Yang Zhibo Li Tanja Weil Dongsheng Liu | 2015 | Small2015，，9： | 1 |
| 14 | Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrin- sic myeloid abnormalities显示文摘 | Samar Farha Kewal Asosingh Weiling Xu | 2011 | Blood2011，117，13： | 1 |
| 15 | Crystal structures of human IPP isomer- ase: new insights into the catalytic mechanism 显示文摘 | Cheng Zhang Lin Liu Hang Xu Zhiyi Weil Yanli Wang Ya- jing Lin Weimin Gong | 2007 | Journal of Molecular Biology2007，366，： | 1 |
| 16 | Effect of Tumor Subtype on Survival and the Graded Prognostic Assessment for Patients With Breast Cancer and Brain Metastases显示文摘 | Paul W. Sperduto Norbert Kased David Roberge Zhiyuan Xu Ryan Shanley Xianghua Luo Penny K. Sneed Samuel T. Chao Robert J. Weil John Suh Amit Bhatt Ashley W. Jensen Paul D. Brown Helen A. Shih John Kirkpatrick Laurie E. Gaspar John B. Fiveash Veronica Chia | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 1 |
| 17 | Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology 显示文摘 | Fonken LK Xu X Weil ZM | 2011 | Mol Psychiatry2011，16，： | 1 |
| 18 | Chemical equilibrium modeling of Copper precipitation in hyper-concentrated solid-Liquid system显示文摘 | Xu Nan Sun Weiling Ni Jinren | 2003 | Hydrobiologia2003，494，13： | 1 |
| 19 | Formation of hydropho- bic silica coatings on stones for conservation of historic sculptures显示文摘 | Xu Feigao I5 Dan Chen Weiling | 2010 | Chin J Chem2010，28，： | 1 |
| 20 | A distinct lineage of influenza A virus from bats 显示文摘 | Tong S Li Y Rivailler P Conrardy C Castillo DA Chen LM Recuenco S Ellison JA Davis CT York IA Turmelle AS Moran D Rogers S Shi M Tao Y Weil MR Tang K Rowe LA Sammons S Xu X France M Lindblade KA Cox NJ Anderson LJ Rupprecht CE Donis RO | 2012 | Proc Natl Acad Sci USA2012，109，11： | 1 |
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