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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | Charge Structure of a Summer Thunderstorm in North China:Simulation Using a Regional Atmospheric Model System显示文摘Electrification and simple discharge schemes are coupled into a 3D Regional Atmospheric Model System(RAMS) as microphysical parameterizations, in accordance with electrical experiment results. The dynamics, microphysics, and electrification components are fully integrated into the RAMS model, and the inductive and non-inductive electrification mechanisms are considered in the charging process. The results indicate that the thunderstorm mainly had a normal tripole charge structure.The simulated charge structure and lightning frequency are basically consistent with observations of the lightning radiation source distribution. The non-inductive charging mechanism contributed to the electrification during the whole lifetime of the thunderstorm, while the inductive electrification mechanism played a significant role in the development period and the mature stage when the electric field reached a large value. The charge structure in the convective region and the rearward region are analyzed, showing that the charge density in the convective region was double that in the rearward region. | LIU Dongxia QIE Xiushu PENG Liang LI Wanli | 2014 | Advances in Atmospheric Sciences2014，31，5： | 16 |
| 3 | Left atrial appendage morphology in patients with atrial fibrillation in China: implications for stroke risk assessment from a single center study显示文摘 | Kong Bin Liu Yu Hu He Wang Lei Fan Yang Mei Yang Liu Wanli Liao Jiafen Liu Dan Xing Dong Huang He | 2014 | Chinese Medical Journal2014，，24： | 12 |
| 4 | The synchronicity and difference in the change of suspended sediment concentration in the Yangtze River Estuary显示文摘从长江盆的沉积分泌物在最近的年里有一个逐步的减少趋势。扣押三座峡水库加重了这个减少的趋势并且通过传播效果在长江河口影响了推迟的沉积集中(SSC ) 的变化。长江河口的 SSC 数据在 19592012 期间显示出那:(1 ) 在南方的 SSC 在河口并且在长江分叉近海海区域显示了减少的趋势并且向海少些减少了。同时,在在 SSC 和沉积分泌物之间的减少的大小的差别向海变得更大。(2 ) 为北方布朗奇,优先的流动没很变化,但是 SSC 趋于减少,它被 SSC 的减少主要在南方布朗奇和中国东方海引起。( 3 )由于减少的流量和相对加强的潮,在在 20032012 的浅节移动了的酒吧中的 SSC 的山峰区域为在 19842002 与那相比联合起来的大约 1/6 经度里面,并且里面动人的距离在洪水季节的顺序>年度一般水准>旱季。(4 ) 在南方经过的入口,因为增加由暂停引起了,岸沟交换是, SSC 主要减少了不到减少在盆和海区域由锋利的 SSC 减少引起了。颠倒在中间的节是真的,在 SSC 显示出一个增加的趋势的地方。(5 ) 在北方经过的入口在减少的流动裂口和沉积裂口比率的联合影响下面,在盆和海区域和暂停的减少的数量的减少的 SSC, SSC 显示了一个减少的趋势。在中间的节,因为增加的数量由沉积引起了,温习塘是多于减少的数量由外部环境引起了,显著地, SSC 趋于增加。整体地,在沉积分泌物的锋利的减少在长江河口引起了同步 SSC 减少。但是在 SSC 从盆在沉积分泌物在对锋利的减少的 SSC 的反应显示了增加的趋势,显示的 synchronicity 和差别的地方,仍然有区域。 | YANG Yunping DENG Jinyun ZHANG Mingjin LI Yitian LIU Wanli | 2015 | Journal of Geographical Sciences2015，25，4： | 8 |
| 5 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 6 | Fluoxetine for poststroke depression A randomized placebo controlled clinical trial显示文摘BACKGROUND: Studies have demonstrated that poststroke depression(PSD) may be related with the disequilibrium between noradrenaline and 5-hydroxytryptamine (5-HT) caused by cerebral injury. The injured regions involve noradrenergic and 5-hydroxytryptaminergic neurons as well as conduction pathway. The levels of noradrenaline and 5-HT would be decreased. OBJECTIVE: To observe the effect of fluoxetine on preventing against PSD and recovery of neurologic function, and analyze the relationship of fluoxetine and the 5-HT level. DESIGN: A randomized controlled clinical trial. SETTING: Department of Neurology, First Hospital Affiliated to Soochow University. PARTICIPANTS: Ninety consecutive patients, 47 female and 43 male, were recruited who admitted to hospital for recent stroke in the Department of Neurology, First Affiliated Hospital of Soochow University between September 2003 and February 2005. Subjects were aged (64±7 ) years, ranging from 47 to 79 years old. They all met the diagnosis criteria of various cerebrovascular diseases formulated in the 4th National Cerebrovascular Disease Conference and confirmed as stroke by skull CT or MRI; The time from onset to tentative administration was less than 7 days; The patients had clear consciousness, without obvious language disorder. They were randomized into treatment group (n =48) and placebo group (n =42). METHODS: ①All the patients were given routine treatment according to treatment guideline of cerebrovascular disease after admission. Patients in the treatment group and placebo group received 20 mg/d fluoxetine and placebo (component: vitamin C) for 8 weeks, respectively. ② Neurologic deficit was assessed according to 24-item Hamilton Rating Scale for Depression (HAMD) and Activity of Daily Living Scale (ADL) before and at 2,4 and 8 weeks after test, separately; Meanwhile, the levels of platelet 5-HT and plasma 5-HT were determined. Grading criteria of HAMD intergral depression: non-depression < 8 points; mild depression 8–20 points; moderate depression 21–35 points; severe depression > 35 points. ADL was assessed with Barthel index score (full mark 100 points). Higher points indicated better incidence and smaller dependence. Neurologic deficit score was made according to scoring criteria of neurologic deficit formulated in 1995 4th National Cerebrovascular Disease Conference: a score of 0–15 indicated a mild focal neurologic deficit, a score of 16–30 a moderate focal neurologic deficit, and a score of 31–45 a severe focal deficit. MAIN OUTCOME MEASURES: Scores of HAMD, ADL and neurologic deficit, and levels of plasma and platelet 5-HT of patients from 2 groups before, 2,4 and 8 weeks after test. RESULRS: Seventy-three of 90 randomized patients participated in the final analysis. In the treatment group, 11 patients dropped out due to insufficient clinical response (n =4), somatic side effects (n =2), intervening medical illness (n =1), hypomania (n =3), and other reasons (n =2). In the placebo group, 6 patients existed due to insufficient clinical response (n =2), somatic side effects (n =1) and other reasons (n =3). ① Before treatment, there were no significant differences in scores of HAMD, DAL and neurologic deficit in patients between two groups (P > 0.05). After 8 weeks of treatment, the scores of HAMD, DAL and neurologic deficit in the treatment group were significantly different from those in the placebo group (12.6±5.3 vs. 16.3 ±3.7; 8.6±6.4 vs. 11.2±6.4; 60.4±12.5 vs. 52.3±13.5, P < 0.01). ② After 8 weeks of treatment, platelet 5-HT level of patients in the treatment group was significantly lower than that in the placebo group [(325.3± 110.5) mg/L vs. (653.6±138.4) mg/L, P < 0.05], while there were no significant differences in plasma 5-HT between two groups (P > 0.05). CONCLUSION: Early fluoxetine treatment obviously retards PSD. The increase of platelet 5-HT level promotes the recovery of neurologic function. | Yan Kong Wanli Dong Chunfeng Liu | 2007 | Neural Regeneration Research2007，2，3： | 5 |
| 7 | No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory显示文摘获得的免疫学的记忆是惹人注目的现象。致命的流行病通过 naï 扫; ve 人口,许多死但是幸存的那些从来不是 “攻击了 ― 两次;从未至少 fatally”,在 430 BCE 观察的历史学家修西得底斯。抗体记忆为对许多人的传染疾病的保护是批评的并且是的基础将近所有当前的人的疫苗。部分地,抗体记忆被编码为切换适应于不同地区生活的动物的免疫球蛋白(Ig ) 在对抗原的主要反应被产生并且产生的表示 G 记忆 B 房间快速,高亲密关系并且在有一样的抗原的挑战之上的 high-titered 抗体回答。IgG-B-cell 受体(BCR ) 并且导致抗原的 IgG-BCR 发信号怎么贡献记忆抗体回答,充分没被理解。在这评论,我们总结在抗体记忆在玩正在揭示细胞、分子的机制并且讨论怎么用不同试验性的途径学习的令人激动的新进展帮助将阐明 B 房间记忆的复杂现象。 | Yinsheng Xu Liling Xu Meng Zhao ChenGuang Xu Yilin Fan Susan K Pierce Wanli Liu | 2014 | Cell Research2014，24，6： | 4 |
| 8 | Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling显示文摘The B7-family inducible costimulator(ICOS)activates phosphoinositide-3 kinase(PI3K)and augments calcium mobilization triggered by the T-cell receptor(TCR).We surprisingly found that the entire cytoplasmic domain of ICOS is dispensable for its costimulation of calcium mobilization.This costimulatory function relies on the unique transmembrane domain(TMD)of ICOS,which promotes association with the tyrosine kinase Lck.TMD-enabled Lck association is also required for p85 recruitment to ICOS and subsequent PI3K activation,and Lck underlies both the bystander and costimulatory signaling activity of ICOS.TMD-replaced ICOS,even with an intact cytoplasmic domain,fails to support T FH development or GC formation in vivo.When transplanted onto a chimeric antigen receptor(CAR),the ICOS TMD enhances interactions between T cells and antigen-presenting target cells.Therefore,by revealing an unexpected function of the ICOS TMD,our study offers a new perspective for the understanding and potential application of costimulation biology. | Zurong Wan Xingxing Shao Xingyu Ji Lihui Dong Jiacheng Wei Zhuqing Xiong Wanli Liu Hai Qi | 2020 | Cellular & Molecular Immunology2020，17，2： | 4 |
| 9 | Influence of Annealing Temperature on the Microstructure and Electrical Properties of Indium Tin Oxide Thin Films显示文摘Indium tin oxide(ITO) thin films were prepared on alumina ceramic substrates by radio frequency magnetron sputtering.The samples were subsequently annealed in air at temperatures ranging from 500 to 1,100 °C for 1 h.The influences of the annealing temperature on the microstructure and electrical properties of the ITO thin films were investigated,and the results indicate that the as-deposited ITO thin films are amorphous in nature.All samples were crystallized by annealing at 500 °C.As the annealing temperature increases,the predominant orientation shifts from(222)to(400).The carrier concentration decreases initially and then increases when the annealing temperature rises beyond1,000 °C.The resistivity of the ITO thin films increases smoothly as the annealing temperature increases to just below900 °C.Beyond 900 °C,however,the resistivity of the films increases sharply.The annealing temperature has a significant effect on the stability of the ITO/Pt thin film thermocouples(TFTCs).TFTCs annealed at 1,000 °C show improved hightemperature stability and Seebeck coefficients of up to 77.73 μV/°C. | Yinzhi Chen Hongchuan Jiang Shuwen Jiang Xingzhao Liu Wanli Zhang Qinyong Zhang | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，2： | 4 |
| 10 | Bloodletting at Jing-well points decreases interstitial fluid flow in the thalamus of rats显示文摘OBJECTIVE: To investigate the changes in the neuronal microenvironment of the middle cerebral artery(MCA) territory induced by Jing-well points bloodletting acupuncture(WPBA) and to explore the neuroprotective mechanism of WPBA in stroke.METHODS: Adult male Sprague Dawley(n = 32)rats were randomly divided into four groups of eight animals each: WPBA-thalamus group(WT),WPBA-caudate nucleus group(WC), sham-control thalamus group(ST) and sham-control caudate nucleus group(SC). Animals in the WT and WC groups received 2 μL of the extracellular tracer gadolinium-diethylene triamine pentaacetic acid(Gd-DTPA)injected into the thalamus or caudate nucleus, respectively, and 12 Jing-well points in the distal ends of the rats' digits were used for WPBA. Although 2 μL of Gd-DTPA was injected into the thalamus or caudate nucleus, respectively, for animals in the two sham groups(ST and SC), no acupuncture or bloodletting was performed. Brain extracellular space and interstitial fluid flow parameters were measured using Gd-DTPA-enhanced magnetic resonance imaging.RESULTS: The brain interstitial fluid flow speed was decreased in the thalamus after WPBA, with a significantly lower Gd-DTPA clearance rate and longer half-life of Gd-DTPA in the thalamus of treated rats than those in sham-control rats [WPBA-treated rats' clearance rate,(7.47 ± 3.15) × 10^(-5)/s(P = 0.009);half-life,(1.52 ± 0.13) h, P = 0.000]. By contrast, no significant changes in brain extracellular space and interstitial fluid flow parameters were detected in the caudate nucleus after WPBA(P = 0.649). In addition, no differences in the morphology of the brain extracellular space or the final distribution of the traced brain interstitial fluid were demonstrated between the WT and WC groups(P = 0.631, P = 0.970,respectively).CONCLUSION: The WPBA decreased the speed of the local thalamic ISF flow in rats, which is assumed to be a beneficial protection by down-modulated the metabolic rate of the attacked neurons under stroke. | FuYu LiYuliang GuoJia Liu Bin Liu Huipo Zhang Weibo Sun Wanli GaoYajuan Ren Qiushi Han Haojun | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 3 |
| 11 | Therapeutic effects of human amniotic epithelial cell transplantation on double-transgenic mice co-expressing APPswe and PS1ΔE9-deleted genes显示文摘Human amniotic epithelial cells (HAECs), which exhibit characteristics of embryonic and pluripotent stem cells, could be utilized for cell therapy without legal or ethical problems. Double-transgenic (TG) mice (n=20) and wild-type (WT) mice (n=20) were randomly assigned to two groups, respectively. The transplantation group was treated with HAECs and the control group with PBS. A six-radial arm water maze was used to assess spatial memory. Immunofluorescence was utilized to track HAEC survival. Immunohistochemistry was used to determine octamer-binding protein 4 (oct-4) and nanog expression in the HAECs. High-performance liquid chromatography (HPLC) was used to measure acetylcholine levels in the hippocampus. The density of cholinergic neurons in the basal forebrain and nerve fibers in the hippocampus was measured following acetylcholinesterase staining. Results showed that transplanted HAECs survived for at least eight weeks and migrated to the third ventricle without immune rejection. Graft HAECs also expressed the specific stem cell markers oct-4 and nanog. Compared with the control group, HAEC transplantation significantly ameliorated spatial memory deficits in TG mice, as well as increased acetylcholine levels and the number of hippocampal cholinergic neurites. Intracerebroventricular HAEC transplantation improved spatial memory in double-TG mice, and results suggested that increased acetylcholine levels in the hippocampus, released by surviving cholinergic neurites, were responsible for this improvement. | XUE ShouRu CHEN ChongFang DONG WanLi HUI GuoZhen LIU TianJun GUO Lille | 2012 | Science China(Life Sciences)2012，55，2： | 3 |
| 12 | Late Cretaceous Transpressional Fault System: A Case Study of the Yishu Fault Belt, Shandong Province, Eastern China显示文摘On the basis of field observations of the structures of three profiles from the Linshu region, deformation characteristics and the tectonic background of the Yishu fault belt in the Late Cretaceous–Early Cenozoic have been discussed in detail.Three structural profiles, whose deformations consist mainly of earlier transpressional faults and later normal faults, were developed for the Mengtuan Formation of the Lower Cretaceous Dasheng Group.Typical positive flower structures, duplex structures, and break-through faults were found in these profiles.On the basis of analyses of the structural deformation and previous geochronological studies, it was concluded that the earlier transpressional faults of the profiles were triggered by the sinistral transpression of the Yishu fault belt in the Late Cretaceous–Early Paleogene, and that the later normal faults, formed during the Late Paleogene–Neogene extension, truncated the earlier transpressional faults.With consideration of the tectonic evolution of the Tan-Lu fault belt and the different drift directions of the Pacific plate since the Cretaceous, we suggest that the major tectonic events of the Late Cretaceous–Neogene in eastern China were mainly controlled by the subduction of the Pacific plate. | LI Chunlin WANG Zongxiu WU Qingzi LIU Yongqing GAO Wanli TAN Yuanlong KUANG Hongwei LI Huijun | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 3 |
| 13 | Quality of information disclosure, property rights, and bank loans: A bank heterogeneity perspective显示文摘Using the context of the financial reform and the development of the non-state sector in China in the past decade, we examine the roles that the quality of information disclosure and property rights play in the allocation of different types of bank credit. We find that foreign banks and policy banks exercise ‘‘financial discrimination,' and that local commercial banks, large state- owned commercial banks, national joint-stock banks, local city commercial banks, and rural commercial banks not only exercise financial discrimination but also provide significant ‘‘financial support' to non-state-owned enterprises by providing more lending opportunities and larger loans. However, when enterprises commit information disclosure violations, the local commercial banks, national joint-stock banks, local city commercial banks, and rural commercial banks reverse their credit decisions and begin to exercise financial dis- crimination against non-state-owned enterprises. At the same time, large stateowned commercial banks continue to provide financial support to non-state-owned enterprises. We also find that the quality of the information disclosed by enterprises has a moderating effect rather than an intermediary effect on the relationship between property rights and bank loans. Overall, the results of this paper shine new light on the market-oriented reform of the banking industry, and provide new empirical evidence for the presence of financial discrimination in the supply of bank credit. Our findings also have practical implications for solving the financing difficulties of non-state-owned enterprises. | Xichan Chen Wanli Li Shiyang Hu Xing Liu | 2019 | China Journal of Accounting Research2019，，1： | 2 |
| 14 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 15 | NOVEL METHOD FOR ERROR ANALYSIS AND SELF-CALIBRATION OF LASER TRACKING MIRROR MECHANISM显示文摘Laser tracking system(LTS)is an advanced device for large size 3D coordinates measuring with the advantages of broad range, high speed and high accuracy. However, its measuring accuracy is highly dominated by the geometric errors of the tracking mirror mechanism. Proper calibration of LTS is essential prior to the use of it for metrology. A kinematics model that describes not only the motion but also the geometric variations of LTS is developed. Through error analysis of the proposed model, it is claimed that gimbals axis misalignments and tracking mirror center off-set are the key contributors to measuring errors of LTS. A self-calibration method is presented of calibrating LTS with planar constraints. Various calibration strategies utilizing single-plane and multiple-plane constraints are proposed for different situations. For each calibration strategy, issues about the error parameter estimation of LTS are exploded to fred out in which conditions these parameters can be uniquely estimated. Moreover, these conditions reveal the applicability of the planar constraints to LTS self-calibration. Intensive studies have been made to check validity of the theoretical results. The results show that the measuring accuracy of LTS has increased by 5 times since this technique for calibration is used. | OUYANG Jianfei LIU Wanli QU Xinghua YAN Yonggang WANG Zhankui | 2008 | Chinese Journal of Mechanical Engineering2008，21，4： | 2 |
| 16 | CLM3-simulated soil moisture in East Asia and its possible response to global warming during 1979 through 2003显示文摘Hydrological processes related to soil moisture play an important role in determining regional and global climate. In this study, using a state-of-art Community Land Model (CLM) developed by the National Center for Atmospheric Research (NCAR), we simulated soil moisture in East Asia and its possible response to global warming through a long off-line experiment under 0.5° (longitude) × 0.5° (latitude) resolution and real atmospheric forcing of the National Center for Environmental Protection/ Department of Energy (NCEP/DOE) reanalysis during 1979 through 2003. The 25-year simulation is examined and compared with limited observations. The results can be summarized as follows: (1) Soil moisture takes time in response to the atmospheric forcing. The equilibration time depends on the depth of the soil and is as much as 20 years in deep layers (>1.5 m); (2) In comparison with observations, the CLM reasonably reproduces the seasonal and inter-annual variability, spatial structure, and vertical pattern of soil moisture in East Asia; (3) The soil tends to be drier in the past 25 years in northeastern Asia-including northern China north of 30°N-while wetter in the southern China and the Tibetan Plateau, especially in summer. Our analysis shows that the regional drying is attributed to increase of the land-surface evaporation induced by global warming. | ChuanLi Du 1,2*, XiaoDong Liu 1, WanLi Wu 31. State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment,Chinese Academy of Sciences, Xi’an, Shaanxi 710075, China.2. Shaanxi Provincial Meteorological Institute, Xi’an, Shaanxi 710014, China.3. National Center for Atmospheric Research, Boulder, Colorado 80307, USA. | 2009 | Research in Cold and Arid Regions2009，1，1： | 2 |
| 17 | Adsorption isotherms and kinetic characteristics of methane on block anthracite over a wide pressure range显示文摘It is important to quantitatively understand the methane adsorption and transport mechanism in coal for an evaluation of the reserves and for its production forecast. In this work, a block coal sample was chosen to perform the CH4 adsorption experiments using the gravimetric method at temperatures of 293.60 K, 311.26 K, 332.98 K and 352.55 K and pressures up to 19 MPa. The excess adsorption capacity of CH4 in dry block anthracite increased, followed by a sequence decrease with the increasing pressure. High temperature restrained the growth of the excess adsorption due to that the adsorption is an intrinsically physical and exothermic process. The excess adsorption peak decreased slowly with the increase of temperature and intersected at a pressure of more than 18 MPa; meanwhile, the pressure at the excess adsorption peak increased.The existing correlations were examined in terms of density rather than pressure. The DR+k correlation, with an average relative deviation of ±0.51%, fitted our data better than the others, with an average relative deviation of up to 2.29%. The transportation characteristics of CH4 adsorption was also investigated in this study, including the adsorption rate and diffusion in block coal. The kinetic data could be described by a modified unipore model. The adsorption rates were found to exhibit dependence on pressure and temperature at low pressures, while the calculated diffusivities exhibited little temperature dependence. In addition, the kinetic characteristics were compared between CH4 and CO2 adsorption on the block coal. The excess adsorption ratios of CO2 to CH4obtained from the DR+k model decreased with the increasing pressure. | Wanli Xing Yongchen Song Yi Zhang Weiguo Liu Lanlan Jiang Yanghui Li Yuechao Zhao | 2015 | Journal of Energy Chemistry2015，24，2： | 2 |
| 18 | Regio- and (E)-Stereoselective Triborylation of Propargylic Carbonates显示文摘 | Zheng Yang Tao Cao Yulin Han Weilong Lin Qi Liu Yang Tang Yizhan Zhai Minqiang Jia Wanli Zhang Tonghao Zhu Shengming Ma | 2017 | Chinese Journal of Chemistry2017，35，8： | 2 |
| 19 | The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis显示文摘The endoplasmic reticulum(ER) membrane protein complex(EMC) regulates the synthesis and quality control of membrane proteins with multiple transmembrane domains. One of the membrane spanning subunits, EMC3, is a core member of the EMC complex that provides essential hydrophilic vestibule for substrate insertion. Here, we show that the EMC subunit Emc3 plays critical roles in the retinal vascular angiogenesis by regulating Norrin/Wnt signaling. Postnatal endothelial cell(EC)-specific deletion of Emc3 led to retarded retinal vascular development with a hyperpruned vascular network, the appearance of bluntended, aneurysm-like tip endothelial cells(ECs) with reduced numbers of filopodia and leakage of erythrocytes at the vascular front. Diminished tube formation and cell proliferation were also observed in EMC3 depleted human retinal endothelial cells(HRECs). We then discovered a critical role for EMC3 in expression of FZD4 receptor of β-catenin signaling using RNA sequencing, real-time quantitative PCR(RT-q PCR) and luciferase reporter assay. Moreover, augmentation of Wnt activity via lithium chloride(Li Cl) treatment remarkably enhanced β-catenin signaling and cell proliferation of HRECs. Additionally, Li Cl partially reversed the angiogenesis defects in Emc3-c KO mice. Our data reveal that Emc3 plays essential roles in angiogenesis through direct control of FZD4 expression and Norrin/β-catenin signaling. | Mu Yang Shujin Li Wenjing Liu† Xiao Li Yunqi He Yeming Yang Kuanxiang Sun Lin Zhang Wanli Tian Lixin Duan Huafu Chen Dezhong Yao Zhenglin Yang Xianjun Zhu | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 20 | A general and simple method for evaluating the electrical transport performance of graphene by the van der Pauw–Hall measurement显示文摘Expected for many promising applications in the field of electronics and optoelectronics, a reliable method for the characterization of graphene electrical transport properties is desired to predict its device performance or provide feedback for its synthesis.However, the commonly used methods of extracting carrier mobility from graphene field effect transistor or Hall-bar is time consuming, expensive, and significantly affected by the device fabrication process other than graphene itself.Here we reported a general and simple method to evaluate the electrical transport performance of graphene by the van der Pauw–Hall measurement.By annealing graphene in vacuum to remove the adsorbed dopants and then exposing it in ambient surroundings, carrier mobility as a function of density can be measured with the increase of carrier density due to the dopant re-adsorption from the surroundings.Further, the relationship between the carrier mobility and density can be simply fitted with a power equation to the first level approximation, with which any pair of measured carrier mobility and density can be normalized to an arbitrary carrier density for comparison.We experimentally demonstrated the reliability of the method, which is much simpler than making devices and may promote the standard making for graphene characterization. | Fangzhu Qing Yang Shu Linsen Qing Yuting Niu He Guo Shuyi Zhang Chunlin Liu Changqing Shen Wanli Zhang Samuel S.Mao Wenjuan Zhu Xuesong Li | 2018 | Science Bulletin2018，63，22： | 2 |
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