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| 1 | Toosendanin-induced change of dopamine level detected by microdialysis in vivo at rat striatum显示文摘To investigate the effect on central nervous transmission of toosendanin (TSN), a presynaptic blocker, rat striatum was perfused in vivo with a TSN-containing artificial cere-brospinal fluid (ACSF) and the level of dopamine (DA) as well as related metabolites in the collected dialysates has been determined by a microbore HPLC with electrochemical detection (mi-crobore HPLC-ECD). The results are as follows: ( i ) TSN induced a biphasic change of DA from its basal level;( ii ) the basal contents of two metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) increased in turn and stayed at a higher level than basal control for a long period. The basal level of 5-hydroxyindoleacetic acid (5-HIAA), a metabolite of 5-hydroxytryptamine(5-HT), had a change similar to that of HVA; (iii) after per-fusion with TSN-containing ACSF, high K+-evoked DA release was inhibited. These results show that TSN does not selectively affect acetylcholine (ACh) release, but probably acts on a common | Wenyan Chen Pingbo Yin Weiling Ye Yuliang Shi | 1999 | Chinese Science Bulletin1999，44，12： | 10 |
| 2 | Radio interferometric localization of WSNs based on Doppler effect显示文摘A novel distributed localization method based on the Doppler effect for wireless sensor networks is proposed in this paper, which only relies on radio transceivers without the need of other auxiliary measurement equipments. Based on radio interference, each sensor node can obtain a multi-group of distance variations from itself to a mobile anchor through the measurement of the cumulative phase variations caused by Doppler effect, by which its position can be determined. The proposed method has the following advantages: the sensor node conducts localization in a completely distributed manner without information exchange or centralized processing, and the measurement result equals the actual distance without modulus operation, which is in reality measuring the distance with a ruler of radio wavelength, and will significantly reduce the system complexity and achieve high location accuracy. Analysis and simulation results demonstrate the effectiveness of our proposed method. | ZHANG WeiLe, YIN QinYe, HAN Wei & WANG WenJie School of Electronic and Information Engineering, Xi’an Jiaotong University, Xi’an 710049, China | 2010 | Science China(Information Sciences)2010，53，1： | 4 |
| 3 | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy显示文摘Polyetheretherketone(PEEK)has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance.However,its biological inertness,poor osteoinduction,and weak antibacterial activity make the clinical applications in a dilemma.Inspired by the mussel adhesion mechanism,here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins(Mfps)-mimic peptide with clickable azido terminal.The peptide enables mussel-like adhesion on PEEK biomaterial surfaces,leaving azido groups for the further steps of biofunctionalizations.In this study,antimicrobial peptide(AMP)and osteogenic growth peptide(OGP)were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair.Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios,an optimal PEEK surface was finally obtained in this research,which could long-term inhibit bacterial growth,stabilize bone homeostasis and facilitate interfacial bone regeneration.In a word,this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants,in particular,achieving rational integration of multiple biofunctions to match clinical requirements. | Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng | 2022 | Bioactive Materials2022，7，2： | 2 |
| 4 | StRAP2.3, an ERF-Ⅶ transcription factor, directly activates StInvInh2 to enhance cold-induced sweetening resistance in potato显示文摘Potato invertase inhibitor(StInvInh2)positively regulates cold-induced sweetening(CIS)resistance by inhibiting the activity of vacuolar invertase.The distinct expression patterns of StInvInh2 have been thoroughly characterized in different potato genotypes,but the related CIS ability has not been characterized.The understanding of the regulatory mechanisms that control StInvInh2 transcription is unclear.In this study,we identified an ERF‐Ⅶ transcription factor,StRAP2.3,that directly regulates StInvInh2 to positively modulate CIS resistance.Acting as a nuclear-localized transcriptional activator,StRAP2.3 directly binds the ACCGAC cis-element in the promoter region of StInvInh2,enabling promoter activity.Overexpression of StRAP2.3 in CIS-sensitive potato tubers induced StInvInh2 mRNA abundance and increased CIS resistance.In contrast,silencing StRAP2.3 in CIS-resistant potato tubers repressed the expression of StInvInh2 and decreased CIS resistance.We conclude that cold-responsive StInvInh2 is due to the binding of StRAP2.3 to the ACCGAC cis-element in the promoter region of StInvInh2.Overall,these findings indicate that StRAP2.3 directly regulates StInvInh2 to positively modulate CIS resistance,which may provide a strategy to improve the processing quality of potatoes. | Weiling Shi Yuhao Song Tiantian Liu Qiuqin Ma Wang Yin Yuchen Shen Tengfei Liu Chunyan Jiang Kai Zhang Dianqiu Lv Botao Song Jichun Wang Xun Liu | 2021 | Horticulture Research2021，8，1： | 1 |
| 5 | Dynamic Colloidal Photonic Crystal Hydrogels with Self-Recovery and Injectability显示文摘Simulation of self-recovery and diversity of natural photonic crystal(PC)structures remain great challenges for artificial PC materials.Motivated by the dynamic characteristics of PC nanostructures,here,we present a new strategy for the design of hydrogel-based artificial PC materials with reversible interactions in the periodic nanostructures.The dynamic PC hydrogels,derived from self-assembled microgel colloidal crystals,were tactfully constructed by reversible crosslinking of adjacent microgels in the ordered structure via phenylboronate covalent chemistry.As proof of concept,three types of dynamic colloidal PC hydrogels with different structural colors were prepared.All the hydrogels showed perfect self-healing ability against physical damage.Moreover,dynamic crosslinking within the microgel crystals enabled shear-thinning injection of the PC hydrogels through a syringe(indicating injectability or printability),followed by rapid recovery of the structural colors.In short,in addition to the great significance in biomimicry of self-healing function of natural PC materials,our work provides a facile strategy for the construction of diversified artificial PC materials for different applications such as chem-/biosensing,counterfeit prevention,optical display,and energy conversion. | Yue Ma Peiyan He Wanli Xie Qiang Zhang Weiling Yin Jianming Pan Miao Wang Xin Zhao Guoqing Pan | 2021 | Research2021，，1： | 1 |
| 6 | Adsorption characteristics of Pb(Ⅱ) adsorption by Al2O3 nanoparticles显示文摘 | SUN Weiling YIN Kun YU Xiangquan | 2013 | Chemical Engineering Journal2013，225，： | 1 |
| 7 | A strategy for improving the sensitivity of molecularly imprinted electrochemical sensors based on catalytic copper deposition显示文摘 | Jianping Li Yijuan Shao Weiling Yin Yun Zhang | 2014 | Analytica Chimica Acta2014，，： | 1 |
| 8 | Anti-tumor pharmacology of natural products targeting mitosis显示文摘Cancer has been an insurmountable problem in the history of medical science.The uncontrollable proliferation of cancer cells is one of cancers main characteristics,which is closely associated with abn ormal mitosis.Targeting mitosis is an effective method for cancer treatment.This review summarizes several natural products with anti-tumor effects related to mitosis,focusing on targeting microtubulin,inducing DNA damage,and modulating mitosis-associated kinases.Furthermore,the main disadvantages of several typical compounds,including drug resistance,toxicity to non-tumor tissues,and poor aqueous solubility and pharmacokinetic properties,are also discussed,together with strategies to address them.Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer. | Manru Huang Caiyan Liu Yingying Shao Shiyue Zhou Gaoyong Hu Shuangshuang Yin Weiling Pu Haiyang Yu | 2022 | Cancer Biology & Medicine2022，19，6： | 1 |
| 9 | Autumn NDVI contributes more and more to vegetation improvement in the growing season across the Tibetan Platea显示文摘Detecting changes in vegetation,distinguishing the persistence of changes,and seeking their causes during multiple periods are important to gaining a deeper understanding of vegetation dynamics.Using the Global Inventory Modeling and Mapping Studies Normalized Difference Vegetation Index(NDVI)version NDVI_(3g) dataset in the Tibetan Plateau,the trends in the seasonal components of NDVI and their linkage with climatic factors were analyzed over 14 asymptotic periods of 18–31 years since 1982.Dynamic trends in vegetation experienced an obvious increase at regional scale,but the increases of vegetation activity mostly tended to stall or slow down as the studied time period was extended.At pixel scale,areas with significant browning significantly expanded over 14 periods for all seasons,but for significant greening significantly increased only in autumn.The changes of vegetation activity in spring were the most drastic among three seasons.Increased increments of NDVI in summer,spring,and autumn took turns being the main reason for the enhanced vegetation activity in the growing season in the nested 14 periods.Vegetation activity was mainly regulated by a thermal factor,and the dominant climatic drivers of vegetation growth varied across different seasons and regions.We speculate that the increase of NDVI will continue but the increments will decline in all seasons except autumn. | Jiaqiang Du Ping He Shifeng Fang Weiling Liu Xinjie Yuan Junqi Yin | 2017 | International Journal of Digital Earth2017，10，11： | 0 |
| 10 | Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba显示文摘Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of death.Ginkgo biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for centuries.Preclinical studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease models.Of clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia stroke.Here,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and therapy.We highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and others.Finally,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis. | Weile Ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
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