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| 1 | STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury显示文摘AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration. | Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 2 | Diabetic neph- ropathy: mechanisms of renal disease progression 显示文摘 | Kanwar Yashpal S Wada Jun Sun Lin | 2008 | Ex- perimental biology and medicine2008，233，1： | 1 |
| 3 | Association of anastomotic leakage with long-term oncologic outcomes of patients with esophagogastric junction cancer显示文摘BACKGROUND Despite improvements in surgical procedures and peri-operative patients management,the postoperative complications in esophagogastric junction(EGJ)cancer remain high because of technical aspects.Several studies have indicated the negative influence of postoperative infectious complications on long-term survival after gastrointestinal surgery.However,no study has shown the association between postoperative complications and long-term survival of patients with EGJ cancer.AIM To elucidate influence of postoperative complications on the long-term outcomes of patients with EGJ cancer.METHODS A total of 122 patients who underwent surgery for EGJ cancer at the Keio University were included in this study.We examined the association between complications and long-term oncologic outcomes.RESULTS In all patients,the 3-year overall survival(OS)rate was 71.9%,and the recurrencefree survival(RFS)rate was 67.5%.Compared with patients without anastomotic leakage,those with anastomotic leakage had poor median OS(8 mo vs not reached,P=0.028)and median RFS(5 mo vs not reached,P=0.055).Among patients with cervical anastomosis,there were not significant differences between patients with and without anastomotic leakage.However,among patients who underwent intrathoracic anastomosis,patients with anastomotic leakage had significantly worse OS(P=0.002)and RFS(P=0.005).CONCLUSION Anastomotic leakage was significantly associated with long-term oncologic outcomes of patients with EGJ cancer,especially those who underwent intrathoracic anastomosis.Cervical anastomosis with subtotal esophagectomy may be an option for the patients who are at high risk for anastomotic leakage. | Masashi Takeuchi Hirofumi Kawakubo Satoru Matsuda Shuhei Mayanagi Tomoyuki Irino Jun Okui Kazumasa Fukuda Rieko Nakamura Norihito Wada Hiroya Takeuchi Yuko Kitagawa | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 1 |
| 4 | The contribution of phospholipase A2 to the cochlear dysfunction induced by transient ischemia显示文摘 | Keiji Tabuchi Zenya Ito Shigeki Tsuji Tetsuro Wada Kazuhiko Takahashi Akira Hara Tetsuro Wada KazuhikoTakahashi Akira Hara Jun Kusakari | | Hearing Research0，20，： | 1 |
| 5 | Genetic relationship among Japanese sentinel crabs (Decapoda: Ocypodidae: genus Macrophthalmus )显示文摘 | Toru Horii Jun Kitaura Keiji Wada Mutsumi Nishida | 2001 | Comparative Biochemistry and Physiology Part B2001，，1： | 1 |
| 6 | Flow properties of microcrystalline cellulose suspension prepared by acid treatment of native cellulose显示文摘 | Jun Araki Masahisa Wada Shigenori Kuga | 1998 | Colloids Surf A:Physicochem Eng Aspects1998，142，1： | 1 |
| 7 | Comparison of serum uric acid levels between Japanese with and without metabolic syndrome显示文摘 | Numata T Miyatake N Wada Jun | 2008 | Diabetes Res Clin Pract2008，80，1： | 1 |
| 8 | Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via ceU-cycle-depen dent mechanisms J Am Soc显示文摘 | Masako Baba Jun Wada | 2005 | Nephrol Nov2005，16，1： | 1 |
| 9 | Flow properties of microcrystalline cellulose suspension prepared by acid treatment of native cellulose 显示文摘 | Jun Araki Masahisa Wada Shigenori Kuga | 1998 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1998，142，： | 1 |
| 10 | Variations in the FTO gene are associated with severe obesity in the Japanese显示文摘 | Kikuko Hotta Yoshio Nakata Tomoaki Matsuo Seika Kamohara Kazuaki Kotani Ryoya Komatsu Naoto Itoh Ikuo Mineo Jun Wada Hiroaki Masuzaki Masato Yoneda Atsushi Nakajima Shigeru Miyazaki Katsuto Tokunaga Manabu Kawamoto Tohru Funahashi Kazuyuki Hamaguchi Kenta | 2008 | Journal of Human Genetics2008，，6： | 1 |
| 11 | Comparison of serum uric acid levels between Japanese with and without metabolic syndrome显示文摘 | Numata T Miyatake N Wada Jun | 2008 | Diabetes Res Clin Pract2008，80，1： | 1 |
| 12 | Dubin-Johnson-like black liver with normal bilirubin level显示文摘 | Yoshinao Kobayashi Tomoaki Ishihara Morimasa Wada Susumu Kajihara Jun Araki Rumi Mifuji Toshio Itani Makoto Kuroda Fumihito Urawa Masahiko Kaito Yukihiko Adachi | 2004 | Journal of Gastroenterology2004，，9： | 1 |
| 13 | Urinary PGDS levels are associated with vascular injury in type 2 diabetes patients显示文摘 | Ritsuko Yoshikawa Jun Wada Kousuke Seiki Takashi Matsuoka Satoshi Miyamoto Kenji Takahashi Sachiko Ota Kazuhi Taniai Kazuyuki Hida Minoru Yamakado Kenichi Shikata Yoshio Uehara Yoshihiro Urade Hirofumi Makino | 2006 | Diabetes Research and Clinical Practice2006，，3： | 1 |
| 14 | Clinical features of non-diabetic renal diseases in patients with type 2 diabetes显示文摘 | Atsuhito Tone Kenichi Shikata Mitsuhiro Matsuda Hitomi Usui Shinichi Okada Daisuke Ogawa Jun Wada Hirofumi Makino | 2005 | Diabetes Research and Clinical Practice2005，，3： | 1 |
| 15 | The combination of the expression of hexokinase 2 and pyruvate kinaseM2 is a prognostic marker in patients with pancreatic cancer显示文摘 | Hisataka Ogawa Hiroaki Nagano Masamitsu Konno Hidetoshi Eguchi Jun Koseki Koichi Kawamoto Naohiro Nishida Hugh Colvin Akira Tomokuni Yoshito Tomimaru Naoki Hama Hiroshi Wada Shigeru Marubashi Shogo Kobayashi Masaki Mori Yuichiro Doki Hideshi Ishii | 2015 | Molecular and Clinical Oncology2015，，3： | 1 |
| 16 | Huge capacity spacial division multiplexing transmission and integrated optical switching technologies(Invited Paper)显示文摘We review the research and development of beyond Pb/s capacity space-division-multiplexed transmission technology using multi-core optical fibers for satisfying the ever-increasing traffic demand. Moreover, we present an optical packet and circuit integrated network technology to improve switching capacity and flexibility in network nodes for the rapid traffic fluctuation and the data service diversification. | Naoya Wada Ben J.Puttnam Ruben S.Luis Werner Klaus Jun Sakaguchi Jose M.D.Mendinueta Yoshinari Awaji Satoshi Shinada Hideaki Furukawa | 2016 | Chinese Optics Letters2016，14，12： | 0 |
| 17 | Mesenchymal stem cells-derived extracellular vesicles as‘natural’drug delivery system for tissue regeneration显示文摘Mesenchymal stem cells(MSCs)have abilities to mediate tissue protection through mechanisms of antiapoptosis,anti-oxidative stress and anti-fibrosis as well as tissue regeneration through mechanisms of cell proliferation,differentiation and angiogenesis.These effects by MSCs are mediated by a variety of factors,including growth factors,cytokines and extracellular vesicles(EVs).Among these factors,EVs,containing proteins,mRNA and microRNAs(miRNA),may carry their contents into distant tissues with high stability.Therefore,the treatment with MSC-derived EVs may be promising as‘natural’drug delivery systems(DDS).Especially,the treatment of MSCderived EVs with the manipulation of specific miRNAs expression has been reported to be beneficial under a variety of diseases and tissue injuries.The overexpression of specific miRNAs in the EVs might be through pre-loading method using the gene editing system by plasmid vector or post-loading method to load miRNA mimics into EVs by electroporation or calcium chloride-mediated transfection.Despite current several challenges for clinical use,it should open the next era of regenerative medicine for a variety of diseases.In this article,we highlight the therapeutic potential of MSC-derived EVs as‘natural’DDS and current challenges. | KENJI TSUJI SHINJI KITAMURA JUN WADA | 2022 | BIOCELL2022，46，4： | 0 |
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