|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis显示文摘Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from surgery.Methods: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December 2012.These patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate analyses.Results: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL. | Tadafumi Asaoka Atsushi Miyamoto Sakae Maeda Naoki Hama Masanori Tsujie Masataka Ikeda Mitsugu Sekimoto Shoji Nakamori | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，1： | 4 |
| 2 | Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia显示文摘 | Seiji Hama Hidehisa Yamashita Masaya Shigenobu Atsuko Watanabe Kaoru Kurisu Shigeto Yamawaki Tamotsu Kitaoka | 2007 | European Archives of Psychiatry and Clinical Neuroscience2007，，3： | 3 |
| 3 | Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend显示文摘The ultrastructure of the bone provides a unique mechanical strength against compressive, torsional andtensional stresses. An elastin-like recombinamer (ELR) with a nucleation sequence for hydroxyapatitewas incorporated into films prepared from a collagen-silk fibroin blend carrying microchannel patternsto stimulate anisotropic osteogenesis. SEM and fluorescence microscopy showed the alignment ofadipose-derived stem cells (ADSCs) and the human osteoblasts (HOBs) on the ridges and in the groovesof microchannel patterned collagen-fibroin-ELR blend films. The Young's modulus and the ultimatetensile strength (UTS) of untreated films were 0.58 ± 0.13 MPa and 0.18 ± 0.05 MPa, respectively. After 28days of cell culture, ADSC seeded film had a Young's modulus of 1.21 ± 0.42 MPa and UTS of0.32 ± 0.15 MPa which were about 3 fold higher than HOB seeded films. The difference in Young'smodulus was statistically significant (p: 0.02). ADSCs attached, proliferated and mineralized better thanthe HOBs. In the light of these results, ADSCs served as a better cell source than HOBs for bone tissueengineering of collagen-fibroin-ELR based constructs used in this study. We have thus shown theenhancement in the tensile mechanical properties of the bone tissue engineered scaffolds by usingADSCs. | Esen Sayin Rosti Hama Rashid JoséCarlos Rodríguez-Cabello Ahmed Elsheikh Erkan Türker Baran Vasif Hasirci | 2017 | Bioactive Materials2017，2，2： | 2 |
| 4 | Evaluation of mercury methylation in fresh and pre dried sediments using ^(203)Hg radioisotope显示文摘Mercury methylation rates in fresh and pre dried river sediments were determined in sediment water systems spiked with 203 HgCl 2 at a level of 0.75—0.95 ppm as Hg. At the end of the incubation period (21—38 days), methylmercury production in the fresh sediments was in the order of 3.0% to 13.75%, whereas in the pre dried sediments the methylation was much lower, at 0.6% to 3.9%. The highest methylation levels were generally recorded in the uppermost, 1 cm layer of the sediment column. Total mercury concentration in water in equilibrium with the 203 Hg spiked fresh sediments was in the range of 44.7 to 634 ng/L, whereas in equilibrium with the pre dried sediments the concentration was in the range of 19.5 to 34.5 ng/L. The proportion of methylmercury to total mercury in the water varied from 9.4% to 66.6% over the fresh sediments, and from 7.1% to 10.8% over the pre dried sediments. In the system consisting of water, sediment and sediment inverterbrates the concentrations of methylmercury were 8.61 to 15.69 ng/g in the sediment, 0.011 ng/ml in the water, and 9.22 to 40.69 ng/g in the inverterbrates. Methylmercury bioaccumualtion factors (BAFs) were in the order of 274 to 8087 relative to the water, and 0.25 to 7.31 relative to the sediment. These results provide further evidence for the tendency of methylmercury to accumulate in high concentrations in aquatic organisms, even at very low total mercury concentration in water. | J.R.Ikingura 1, H.Akagi 2, J.R.D.Guimaraes 3 (1. University of Dar es Salaam, P.O.Box 35052, Dar es Salaam, Tanzania 2. Nat. Inst. for Minamata Disease, 4058 Hama, Minamata, 867 Kumamoto, Japan 3. Lab. de Radioisotopos, Universidade Federal Do Rio | 2000 | Journal of Environmental Sciences2000，12，S1： | 2 |
| 5 | Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells显示文摘 | Dai Shida Joji Kitayama Hironori Yamaguchi Kotaro Hama Junken Aoki Hiroyuki Arai Hiroharu Yamashita Ken Mori Akihiro Sako Tsuyoshi Konishi Toshiaki Watanabe Teruyuki Sakai Rika Suzuki Hideo Ohta Yoh Takuwa Hirokazu Nagawa | 2004 | Experimental Cell Research2004，，2： | 2 |
| 6 | Monoeyte transmigration induced by modification of low density lipoprotein in eocultures of human aortic wall cells is due to induction of monoeyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein显示文摘 | Imes SS Hama SY | 1991 | J Clin Invest1991，88，： | 1 |
| 7 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction显示文摘 | Hama N Itoh H Shirakami G | 1995 | Circulation1995，92，6： | 1 |
| 8 | The Evaluation of Duct-to-mucosal Pancreaticojejunostomy in pancreaticoduodenectomy显示文摘 | Masaji Tani M.D. Hironobu Onishi M.D. Hiroyuki Kinoshita M.D. Manabu Kawai M.D. Masaki Ueno M.D. Takashi Hama M.D. Kazuhisa Uchiyama M.D. Hiroki Yamaue M.D | 2005 | World Journal of Surgery2005，，1： | 1 |
| 9 | Circulation显示文摘 | Hama N Rapid ventricular induction ofbrain natriuretic peptide geneexpression in experimental acute myocardial infarction | 1995 | 92(6): 1558- 15641995，92，6： | 1 |
| 10 | Simultaneous two-color spectral fluorescence lymphangiography with near infrared quan- tum dots to map two lymphatic flows from the breast and the up- per extremity显示文摘 | Hama Y Koyama Y Urano Y | 2007 | Breast Cancer Res Treat2007，103，1： | 1 |
| 11 | Skin compatibility andecotoxicity of ethoxylated fatty methyl ester nonionics 显示文摘 | HAMA 1 SASAMOTO H TAMLRA T | 1998 | J SurfadDeterg1998，，： | 1 |
| 12 | Are adolescents with frequent pain symptoms more depressed显示文摘 | Hama A M Kaltiana-heino R Rimpela M | 2002 | Scand J Prim Health Care2002，20，2： | 1 |
| 13 | Recurrence of men- ingiomas 显示文摘 | Yamasaki F Yoshioka H Hama S | 2000 | Cancer2000，89，5： | 1 |
| 14 | 显示文摘 | Tatsumisago M Hama S Hayashi A | 2002 | Solid State Ionies2002，，34： | 1 |
| 15 | Expression of survivin in astrocytic tumors:correlation with malignant grade and prognosis显示文摘 | KAJIWARA Y YAMASAKI F HAMA S | 2003 | Cancer2003，97，4： | 1 |
| 16 | Effect of ocean acidification on coastal phytoplankton composition and accompanying organic nitrogen production 显示文摘 | Hama T Kawashima S Shimotori K | 2011 | Journal of Oceanography2011，68，1： | 1 |
| 17 | Adenovirus-mediated p16 gene transfer changes the sensitivity to taxanes and Vinca alkaloids of human ovarian cancer cells显示文摘 | Kawakami Y Hama S Hiura M | 2001 | Antieancer Res2001，21，4： | 1 |
| 18 | Rapid ventricular induc- tion of brain na - triuretic gene expression in experimental acute myocardial infartion 显示文摘 | Hama N Itoh H Shirakami G | 1995 | Grculation1995，92，： | 1 |
| 19 | MR imaging of medullary carcinoma of the breast显示文摘 | Tominaga J Hama H Kimura N | 2009 | European Journal of Radiology2009，70，： | 1 |
| 20 | Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute my- ocardial infarction 显示文摘 | Hama N Itoh H Shirakami G | 1995 | Circulation1995，92，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员